Risk Factors for Acute Symptomatic Seizure in Bacterial Meningitis in Children

Abstract

The aim of this study was to investigate the association between clinical and laboratory parameters at admission and the occurrence of in-hospital symptomatic seizures in children with acute bacterial meningitis in Brazil. A retrospective case-control study in 270 children with confirmed bacterial meningitis, aged from 1 month to 14 years, was conducted between January 2004 and December 2008. Associations with the occurrence of in-hospital epileptic seizures were adjusted using stepwise multiple logistic regression analysis. Sixty-seven children suffered at least one in-hospital epileptic seizure. After multivariate analysis, the independent predictors considered for in-hospital epileptic seizures were as follows: age less than 2 years (odds ratio = 0.97; 95% confidence interval 0.97-0.98), pneumococcal etiology (odds ratio = 4.55; 95% confidence interval 1.88-11.0); altered mental status (odds ratio = 3.47; 95% confidence interval 1.66-7.26) and cerebrospinal fluid leukocyte count below 1000 cells (odds ratio = 2.14; 95% confidence interval 0.99-4.60). Mortality was higher in patients with intrahospital epileptic seizures compared to those without (25/67 [37.3%] vs 9/203 [4.43%], P < .001].