Neuroblastoma is, at once, the most common and deadly extracranial solid tumor of childhood. Efforts aimed at targeting the neural characteristics of these tumors have taught us much about neural crest cell biology, apoptosis induction in the nervous system, and neurotrophin receptor signaling and intracellular processing. But neuroblastoma remains a formidable enemy to the oncologist and an enigmatic target to the neuroscientist.
SchorNF. Neurology of Neuroblastoma: Neuroblastoma as a Neurobiological Disease. Boston, MA: Kluwer Academic; 2002.
2.
SchorNF. Neuroblastoma as a neurobiological disease. J Neuro-oncol. 1999;41:159–166.
3.
MirnicsZKYanCPortugalCF. Presenilin 1, through intramembrane proteolysis of p75, regulates expression of neural cell adhesion molecule 1. Neurobiol Dis. 2005;20:969–985.
4.
Tabachnik SchorNF. Adjunctive use of ethiofos (WR-2721) with free radical-generating chemotherapeutic agents in mice: new caveats for therapy. Cancer Res. 1987;47:5411–5414.
5.
ZigmondMJStrickerEM. Parkinson's disease: studies with an animal model. Life Sci. 1984;35:5–18.
6.
Chelmicka-SchorrEArnasonBG. Modulatory effect of the sympathetic nervous system on neuroblastoma tumor growth. Cancer Res. 1978;38:1374–1375.
7.
YuhasJM. Differential protection of normal and malignant tissues against the cytotoxic effects of mechlorethamine. Cancer Treat Rep. 1979;63:971–976.
8.
TabachnikNFPetersonCMCeramiA. Studies on the reduction of sputum viscosity in cystic fibrosis using an orally absorbed protected thiol. J Pharmacol Exp Ther. 1980;214:246–249.
9.
SchorNF. Depletion of glutathione by the radioprotective agent S-2-(3-aminopropylamino)ethyl phosphorothioic acid (WR2721). Biochem Pharmacol. 1988;37:562–563.
10.
SchorNF.Mechanisms of synergistic toxicity of the radioprotective agent, WR2721, and 6-hydroxydopamine. Biochem Pharmacol. 1988;37:1751–1762.
11.
HospersGAEisenhauerEAde VriesEG. The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects. Br J Cancer. 1999;80:629–638.
12.
SchorNFSiudaJFLomisTJChengB.Structural studies on the inactivation of gamma-glutamylcysteine synthetase by the disulphide analogues of radioprotective cysteamine derivatives. Effects of aminoalkyl and hydroxyalkyl chain length and beta beta-bis-dimethylation. Biochem J. 1990;267:291–296.
13.
BeadleGWTatumEL. Genetic control of biochemical reactions in Neurospora. Proc Natl Acad Sci U S A. 1941;27:499–506.
14.
MattickJSGagenMJ. The evolution of controlled multitasked gene networks: the role of introns and other noncoding RNAs in the development of complex organisms. Mol Biol Evol. 2001;18:1611–1630.
15.
MattickJSTaftRJFaulknerGJ. A global view of genomic information—moving beyond the gene and the master regulator. Trends Genet. 2010;26:21–28.
16.
SeidlerNW. Functional diversity. Adv Exp Med Biol. 2013;985:103–147.
17.
HaughJM. Localization of receptor-mediated signal transduction pathways: the inside story. Mol Interv. 2002;2:292–307.
18.
SchorNF. Signal transduction for clinicians: why should we care?Pediatr Neurol. 2001;25:361–367.
19.
SchorNF.p75NTR in development and disease. Prog Neurobiol. 2005;77:201–214.
20.
MardySMiuraYEndoF. Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor. Am J Hum Genet. 1999;64:1570–1579.
21.
YanCLiangYNylanderKDSchorNF. TrkA as a life-and-death receptor: receptor dose as a mediator of function. Cancer Res. 2002;62:4867–4875.
22.
MiZRogersDKorade MirnicsZ, Schor NF. p75NTR-dependent modulation of cellular handling of reactive oxygen species. J Neurochem. 2009;110:296–306.
23.
YanCMirnicsZKPortugalCF. Cholesterol biosynthesis and the pro-apoptotic effects of the p75 nerve growth factor receptor. Mol Brain Res. 2005;139:225–234.
24.
KoradeZMiZSchorNF. Expression and p75 neurotrophin receptor dependence of cholesterol synthetic enzymes in adult mouse brain. Neurobiol Aging. 2007;28:1522–1531.
25.
SchorNF. What the halted γ-secretase inhibitor trial may (or may not) be telling us. Ann Neurol. 2011;69:237–239.
26.
TyurinaYYNylanderKDMirnicsZK. The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress. Aging Cell. 2005;4:187–196.
27.
CortazzoMHKassisESSproulKASchorNF. Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis. J Neurosci. 1996;16:3895–3899.
28.
VillablancaJGLondonWBNaranjoA. Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group. Clin Cancer Res. 2011;17:6858–6866.
29.
CuperusRLeenRTytgatGA. Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma. Cell Mol Life Sci. 2010;67:807–816.
30.
GaneshanVSchorNF. Role of p75NTR and its signaling pathways in fenretinide-induced apoptosis in neuroblastoma cells. Neurology. 2011;76(S4):A295.
31.
JungKMTanSLandmanN. Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem. 2003;278:42161–42169.
32.
ParkhurstCNZampieriNChaoMV. Nuclear localization of the p75 neurotrophin receptor intracellular domain. J Biol Chem. 2010;285:5361–5368.
33.
CaritoVPingitoreACioneE. Localization of nerve growth factor (NGF) receptors in the mitochondrial compartment: characterization and putative role. Biochim Biophys Acta. 2012;1820:96–103.
34.
SherrattHS.Mitochondria: structure and function. Rev Neurol (Paris). 991;147:417–430.
35.
HenniganAO’CallaghanAMKellyAM. Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection. Biochem Soc Trans. 2007;35:424–427.
36.
MirnicsZKMirnicsKTerranoDLewisDASisodiaSSSchorNF. DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes. Mol Psychiatry. 2003;8:863–878.
37.
De StrooperBSaftigPCraessaertsK. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 1998;91:387–390.
38.
RogersDSchorNF. The child is father to the man: developmental roles for proteins of importance for neurodegenerative disease. Ann Neurol. 2010;67:151–158.
39.
TsudaTChiHLiangY. Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases. Neurosci Lett. 1995;201:188–190.
40.
GreenDRReedJC. Mitochondria and apoptosis. Science. 1998;281:1309–1312.
41.
KaneDJSarafianTAAntonR. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science. 1993;262:1274–1277.
42.
TyurinaYYTyurinVACartaGQuinnPJSchorNFKaganVE. Direct evidence for antioxidant effect of Bcl-2 in PC12 rat pheochromocytoma cells. Arch Biochem Biophys. 1997;344:413–423.
43.
CortazzoMHSchorNF. Potentiation of enediyne-induced apoptosis and differentiation by Bcl-2. Cancer Res. 1996;56:1199–1203.
44.
GoldbergIHKappenLSBeermanTA. The nature and mechanism of the damage induced in DNA by a protein antibiotic. Adv Enzyme Regul. 1977;16:239–254.
45.
KluckRMBossy-WetzelEGreenDRNewmeyerDD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 1997;275:1132–1136.
46.
MiZHongBMirnicsZK. Bcl-2-mediated potentiation of neocarzinostatin-induced apoptosis: requirement for caspase-3, sulfhydryl groups, and cleavable Bcl-2. Cancer Chemother Pharmacol. 2005;57:357–367.
47.
ChengEHKirschDGClemRJ. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science. 1997;278:1966–1968.
48.
LiangYNylanderKDYanCSchorNF. Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2. Mol Pharmacol. 2002;61:142–149.
49.
RogersDNylanderKDHuTSchorNF. Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy. Cancer Chemother Pharmacol. 2008;62:699–706.
50.
SchorNF. Chapter 11: the enediynes. In TeicherBA, ed Cancer Therapeutics: Experimental and Clinical Agents. Totowa: Humana Press; 1997:229–240.
51.
RogersDASchorNF. Kidins220/ARMS depletion is associated with the neural-to Schwann-like transition in a human neuroblastoma cell line model. Exp Cell Res. 2013;319:660–669.
52.
QuinlanCLOrrALPerevoshchikovaIVTrebergJRAckrellBABrandMD. Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. J Biol Chem. 2012;287:27255–27264.
