Abstract
Solitary tumefactive demyelination is rare in children, and the diagnosis is often conferred after brain biopsy. The authors report 3 children with solitary tumefactive demyelination and provide clinical and paraclinical clues to aid the clinician in reaching a diagnosis using a noninvasive approach.
Get full access to this article
View all access options for this article.
References
1.
Schilder
P
. Zur kenntnis der sogennanten diffusen sklerose . Z Gesamte Neurol Psychiatr . 1912 ;10 :1 –60 .
2.
Ellison
PH
Barron
KD
. Clinical recovery from Schilder disease . Neurology . 1979 ;29 :244 –251 .
3.
Prineas
JW
McDonald
WI
Franklin
RJM
Demyelinating disease . In:
Graham
DI
Lantos
PL
(Eds.), Greenfield’s Neuropathology .7th ed.
London, UK : Arnold ; 2002 : 506 –509 .
4.
McAdam
LC
Blaser
SI
Banwell
BL
. Pediatric tumefactive demyelination: case series and review of the literature . Pediatr Neurol . 2002 ;26 :18 –25 .
5.
Kepes
JJ
. Large focal tumor-like demyelinating lesions of the brain: intermediate entity between multiple sclerosis and acute disseminated encephalomyelitis? A study of 31 patients . Ann Neurol . 1993 ;34 :871 –873 .
6.
Poser
CM
Goutières
F
Carpentier
MA
Aicardi
J
. Schilder’s myelonoclastic diffuse sclerosis . Pediatrics . 1986 ;77 :107 –112 .
7.
Peterson
K
Rosenblum
MK
Powers
JM
. Effect of brain irradiation on demyelinating lesions . Neurology . 1993 ;43 :2105 –2112 .
8.
Kumar
K
Toth
C
Jay
V
. Focal plaque of demyelination mimicking cerebral tumor in a pediatric patient . Pediatr Neurosurg . 1998 ;29 :60 –63 .
9.
Hunter
SB
Ballinger
WE
Rubin
JJ
. Multiple sclerosis mimicking primary brain tumor . Arch Pathol Lab Med . 1987 ;111 :464 –468 .
10.Case Records of the Massachusetts General Hospital . Weekly clinicopathological exercises, case 26-1998: a 15-year-old girl with hemiparesis, slurred speech, and an intracranial lesion . N Eng J Med . 1998 ;339 :542 –549 .
11.
Anderson
RC
Connoly
ES
Komotar
RJ
. Clinicopathological review: tumefactive demyelination in a 12-year-old girl . Neurosurgery . 2005 ;56 :1051 –1057 .
12.
Dagher
AP
Smirniotopoulos
J
. Tumefactive demyelinating lesions . Neuroradiology . 1996 ;38 :560 –565 .
13.
Giang
DW
Poduri
KR
Eskin
TA
. Multiple sclerosis masquerading as a mass lesion . Neuroradiology . 1992 ;34 :150 –154 .
14.
Takahashi
I
Sawaishi
Y
Takeda
O
. Childhood multiple sclerosis treated with plasmapheresis . Pediatr Neurol . 1997 ;17 :83 –87 .
15.
Rusin
JA
Vezina
LG
Chadduck
WM
Chandra
RS
. Tumoral multiple sclerosis of the cerebellum in a child . AJNR Am J Neuroradiol . 1995 ;16 :1164 –1166 .
16.
Metafratzi
Z
Argyropoulou
MI
Tzoufi
M
. Conventional MRI and magnetisation transfer imaging of tumour-like multiple sclerosis in a child . Neuroradiology . 2002 ;44 :97 –99 .
17.
Puri
V
Chaudhry
N
Gulati
P
. Recurrent tumefactive demyelination in a child . J Clin Neurosci . 2005 ;12 :495 –500 .
18.
Yapici
Z
Eraksoy
M
. Bilateral demyelinating tumefactive lesions in three children with hemiparesis . J Child Neurol . 2002 ;17 :655 –660 .
19.
Zagzag
D
Miller
DC
Kleinman
GM
. Demyelinating disease versus tumor in surgical neuropathology . Am J Surg Pathol . 1993 ;17 :537 –545 .
20.
Gourie-Devi
M
Satishchandra
P
. Hyaluronidase as an adjuvant in the management of tuberculous spinal arachnoiditis . J Neurol Sci . 1991 ;102 :105 –111 .
21.
Lechtenberg
R
Vaida
GA
. Schistosomiasis of the spinal cord . Neurology . 1977 ;27 :55 –59 .
22.
Cohen
J
Capildeo
R
Rose
FC
Pallis
C
. Schistosomal myelopathy . Br Med J . 1977 ;2 (6099 ):1418 .
23.
Bourée
P
Hennequin
C
Sébire
G
. Compression médullaire due à Schistosoma Haematobium . Bulletin de la Société Française de Parasitologie . 1989 ;7 :213 –215 .
24.
Petjom
S
Chaiwun
B
Settakorn
J
. Angiostrongylus cantonensis infection mimicking a spinal cord tumor . Ann Neurol . 2002 ;52 :99 –102 .
25.
Hmaimess
G
Kadhim
H
Saint
Martin C
. Cat scratch disease presenting as meningomyeloradiculopathy . Arch Dis Child . 2004 ;89 :691 –692 .