Premature infants who experience cerebrovascular injury frequently have acute and long-term neurologic complications. In this article, we explore the relationship between systemic hemodynamic insults and brain injury in this patient population and the mechanisms that might be at play.
Shalak L., Perlman JMHemorrhagic-ischemic cerebral injury in the preterm infant: current concepts . Clin Perinatol. 2002;29(4):745-763.
2.
Khwaja O., Volpe JJPathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed. 2008; 93(2):F153-F161.
3.
Ment LR, Duncan CC, Ehrenkranz RA, et al. Intraventricular hemorrhage in the preterm neonate: timing and cerebral blood flow changes. J Pediatr. 1984 ;104(3):419-425.
4.
Miall-Allen VM, de Vries LS, Whitelaw AGMean arterial blood pressure and neonatal cerebral lesions. Arch Dis Child.1987;62(10):1068-1069.
5.
Watkins AM, West CR, Cooke RWBlood pressure and cerebral haemorrhage and ischaemia in very low birthweight infants. Early Hum Dev. 1989;19(2):103-110.
Armstrong D. , Norman MGPeriventricular leucomalacia in neonates. Complications and sequelae. Arch Dis Child. 1974; 49(5):367-375.
9.
Nwaesei CG, Pape KE, Martin DJ, Becker LE, Fitz CRPeriventricular infarction diagnosed by ultrasound: a postmortem correlation . J Pediatr. 1984;105(1):106-110.
10.
De Reuck J.The human periventricular arterial blood supply and the anatomy of cerebral infarctions. Eur Neurol. 1971;5(6):321-334.
11.
De Vries LS , Wigglesworth JS, Regev R., Dubowitz LMEvolution of periventricular leukomalacia during the neonatal period and infancy: correlation of imaging and postmortem findings. Early Hum Dev. 1988;17(2-3):205-219.
12.
Maalouf EF, Duggan PJ, Counsell SJ, et al. Comparison of findings on cranial ultrasound and magnetic resonance imaging in preterm infants. Pediatrics. 2001 ;107(4):719-727.
13.
Volpe JJCerebral white matter injury of the premature infant-more common than you think. Pediatrics. 2003;112(1 pt 1): 176-180.
14.
Dyet LE, Kennea N., Counsell SJ, et al. Natural history of brain lesions in extremely preterm infants studied with serial magnetic resonance imaging from birth and neurodevelopmental assessment. Pediatrics. 2006;118(2):536-548.
15.
De Reuck JLCerebral angioarchitecture and perinatal brain lesions in premature and full-term infants. Acta Neurol. Scand . 1984;70(6):391-395.
16.
Takashima S. , Armstrong DL, Becker LESubcortical leukomalacia. Relationship to development of the cerebral sulcus and its vascular supply . Arch Neurol. 1978;35(7):470-472.
17.
De Reuck J.The cortico-subcortical arterial angio-architecture in the human brain. Acta Neurol Belg. 1972 ;72(5):323-329.
18.
Rorke LBAnatomical features of the developing brain implicated in pathogenesis of hypoxic-ischemic injury. Brain Pathol. 1992 ;2(3):211-221.
19.
Takashima S. , Tanaka K.Development of cerebrovascular architecture and its relationship to periventricular leukomalacia. Arch Neurol. 1978;35(1):11-16.
20.
Nakamura Y. , Okudera T., Hashimoto T.Vascular architecture in white matter of neonates: its relationship to periventricular leukomalacia . J Neuropathol Exp Neurol. 1994;53(6):582-589.
21.
Powers WJ, Grubb RL Jr, Darriet D., Raichle MECerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab. 1985;5(4):600-608.
22.
Greisen G.Cerebral blood flow in preterm infants during the first week of life . Acta Paediatr Scand. 1986;75(1):43-51.
23.
Greisen G.Cerebral blood flow in mechanically ventilated, preterm neonates. Dan Med Bull.1990;37(2):124-131.
24.
Greisen G.Thresholds for periventricular white matter vulnerability in hypoxia-ischemia . In: Lou H, Greisen G, Larsen J, eds. Brain Lesions in the Newborn. Copenhagen : Munksgaard; 1994:222-229.
25.
Greisen G., Johansen K., Ellison PH, Fredriksen PS, Mali J., Friis-Hansen B.Cerebral blood flow in the newborn infant: comparison of Doppler ultrasound and 133xenon clearance. J Pediatr. 1984;104(3):411-418.
26.
Greisen G., Pryds O.Low CBF, discontinuous EEG activity, and periventricular brain injury in ill, preterm neonates. Brain Dev.1989;11(3):164-168.
27.
Pryds O., Christensen NJ, Friis-Hansen B.Increased cerebral blood flow and plasma epinephrine in hypoglycemic, preterm neonates. Pediatrics. 1990;85(2):172-176.
28.
Pryds O., Greisen G., Friis-Hansen B.Compensatory increase of CBF in preterm infants during hypoglycaemia . Acta Paediatr Scand. 1988;77(5):632-637.
29.
Pryds O., Greisen G., Johansen KHIndomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus. Eur J Pediatr. 1988;147(3):315-316.
Altman DI, Powers WJ, Perlman JM, Herscovitch P., Volpe SL, Volpe JJCerebral blood flow requirement for brain viability in newborn infants is lower than in adults. Ann Neurol. 1988; 24(2):218-226.
32.
Børch K., Greisen G.Blood flow distribution in the normal human preterm brain. Pediatr Res. 1998 ;43(1):28-33.
33.
Volpe JJHypoxic-ischemic encephalopathy: biochemical and physiological aspects. Neurology of the Newborn. 5th ed. Philadelphia, PA: WB Saunders; 2008 :247-324.
34.
Oka A., Belliveau MJ, Rosenberg PA, Volpe JJVulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J Neurosci. 1993;13(4):1441-1453.
35.
Fern R., Moller T.Rapid ischemic cell death in immature oligodendrocytes: a fatal glutamate release feedback loop. J Neurosci. 2000;20(1):34-42.
36.
Larroche JCIntraventricular hemorrhage in the premature neonate. In: Korobkin R, Guilleminault C, eds. Advances in Perinatal Neurology. New York, NY: S. P. Medical and Scientific Books; 1979:115.
37.
Hambleton G. , Wigglesworth JSOrigin of intraventricular haemorrhage in the preterm infant. Arch Dis Child. 1976 ; 51(9):651-659.
38.
Rorke LBPathology of Perinatal Brain Injury. New York: Raven Press; 1982.
39.
Nakamura Y. , Okudera T., Fukuda S., Hashimoto T.Germinal matrix hemorrhage of venous origin in preterm neonates. Hum Pathol . 1990;21(10):1059-1062.
40.
Moody DM, Brown WR, Challa VR, Block SMAlkaline phosphatase histochemical staining in the study of germinal matrix hemorrhage and brain vascular morphology in a very-low-birth-weight neonate . Pediatr Res. 1994;35(4 pt 1):424-430.
41.
Ghazi-Birry HS, Brown WR, Moody DM, Challa VR, Block SM, Reboussin DMHuman germinal matrix: venous origin of hemorrhage and vascular characteristics. Am J Neuroradiol. 1997;18(2):219-229.
42.
Anstrom JA, Brown WR, Moody DM, Thore CR, Challa VR, Block SMSubependymal veins in premature neonates: implications for hemorrhage . Pediatr Neurol. 2004;30(1):46-53.
43.
Yakovlev PI, Rosales RKDistribution of the terminal hemorrhages in the brain wall in stillborn premature and nonviable neonates. In: Angle CR, Bering EA Jr, eds. Physical Trauma as an Etiologic Agent in Mental Retardation. Washington, DC : U.S. Government Printing Office;1970:67.
44.
Gruenwald P.Subependymal cerebral hemorrhage in premature infants, and its relation to various injurious influences at birth. Am J Obstet Gynecol.1951;61(6):1285-1292.
45.
Leech RW, Kohnen P.Subependymal and intraventricular hemorrhages in the newborn. Am J Pathol. 1974;77(3):465-475.
46.
Ahmann PA, Lazzara A., Dykes FD, Brann AW Jr, Schwartz JFIntraventricular hemorrhage in the high-risk preterm infant: incidence and outcome. Ann Neurol. 1980;7(2):118-124.
47.
Holt PJ, Allan WFThe natural history of ventricular dilatation in neonatal intraventricular hemorrhage and its therapeutic implication. Ann Neurol. 1981;10(3):293.
48.
Levene MI, Starte DRA longitudinal study of post-haemorrhagic ventricular dilatation in the newborn . Arch Dis Child. 1981;56(12):905-910.
49.
Lipscomb AP , Thorburn RJ, Reynolds EO, et al. Pneumothorax and cerebral haemorrhage in preterm infants. Lancet. 1981;1(8217):414-416.
50.
McMenamin JB , Shackelford GD, Volpe JJOutcome of neonatal intraventricular hemorrhage with periventricular echodense lesions. Ann Neurol. 1984;15(3):285-290.
51.
Papile LA, Burstein J., Burstein R., Koffler H.Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr.1978;92(4):529-534.
52.
Horbar JD, Badger GJ, Carpenter JH, et al. Trends in mortality and morbidity for very low birth weight infants, 1991-1999. Pediatrics. 2002;110(1 pt 1):143-151.
53.
Cust AE, Darlow BA, Donoghue DAfor the Australian and New Zealand Neonatal Network (ANZNN).Outcomes for high risk New Zealand newborn infants in 1998-1999: a population based, national study. Arch Dis Child Fetal Neonatal Ed. 2003;88(1):F15-F22.
54.
Larroque B. , Marret S., Ancel PY, et al, for the EPIPAGE Study Group.White matter damage and intraventricular hemorrhage in very preterm infants: the EPIPAGE study . J Pediatr.2003;143(4):477-483.
55.
Hamrick SE, Miller SP, Leonard C., et al. Trends in severe brain injury and neurodevelopmental outcome in premature newborn infants: the role of cystic periventricular leukomalacia . J Pediatr. 2004;145(5):593-599.
56.
Davis DWCognitive outcomes in school-age children born prematurely. Neonatal Netw. 2003;22(3):27-38.
57.
Wilson-Costello D., Friedman H., Minich N., Fanaroff AA, Hack M.Improved survival rates with increased neurodevelopmental disability for extremely low birth weight infants in the 1990s. Pediatrics. 2005;115(4):997-1003.
58.
Chatow U., Davidson S., Reichman BL, Akselrod S.Development and maturation of the autonomic nervous system in premature and full-term infants using spectral analysis of heart rate fluctuations. Pediatr Res. 1995;37(3):294-302.
59.
Drouin E., Gournay V., Calamel J., Mouzard A., Rozé JCAssessment of spontaneous baroreflex sensitivity in neonates. Arch Dis Child Fetal Neonatal Ed. 1997;76(2):F108-F112.
60.
Andriessen P. , Koolen AMP, Berendsen RCM, et al. Cardiovascular fluctuations and transfer function analysis in stable preterm infants. Pediatr Res. 2003;53(1):89-97.
61.
Evans N., Osborn D., Kluckow M.Preterm circulatory support is more complex than just blood pressure . Pediatrics. 2005; 115(4):1114-1115; author reply 1115-1116.
62.
Kluckow M., Evans N.Low superior vena cava flow and intraventricular haemorrhage in preterm infants . Arch Dis Child Fetal Neonatal Ed. 2000;82(3):F188-F194.
63.
Hunt RW, Evans N., Rieger I., Kluckow M.Low superior vena cava flow and neurodevelopment at 3 years in very preterm infants. J Pediatr. 2004;145(5):588-592.
64.
Kluckow M., Evans N.Low systemic blood flow and hyperkalemia in preterm infants. J Pediatr. 2001;139(2):227-232.
65.
Osborn D., Evans N., Kluckow M.Randomized trial of dobutamine versus dopamine in preterm infants with low systemic blood flow. J Pediatr. 2002 ;140(2):183-191.
66.
Jones MD Jr , Sheldon RE, Peeters LL, Makowski EL, Meschia G.Regulation of cerebral blood flow in the ovine fetus. Am J Physiol.1978;235(2):H162-H166.
67.
Hernandez MJ , Brennan RW, Bowman GSAutoregulation of cerebral blood flow in the newborn dog. Brain Res. 1980; 184(1):199-202.
68.
Camp D., Kotagal UR, Kleinman LIPreservation of cerebral autoregulation in the unanesthetized hypoxemic newborn dog. Brain Res. 1982;241(2):207-213.
69.
Tweed WA, Cote J., Wade JG, Gregory G., Mills A.Preservation of fetal brain blood flow relative to other organs during hypovolemic hypotension. Pediatr Res. 1982 ;16(2):137-140.
70.
Tweed WA, Cote J., Pash M., Lou H.Arterial oxygenation determines autoregulation of cerebral blood flow in the fetal lamb. Pediatr Res. 1983;17(4):246-249.
71.
Papile LA, Rudolph AM, Heymann MAAutoregulation of cerebral blood flow in the preterm fetal lamb. Pediatr Res. 1985;19(2):159-161.
72.
Tweed A., Cote J., Lou H., Gregory G., Wade J.Impairment of cerebral blood flow autoregulation in the newborn lamb by hypoxia . Pediatr Res. 1986;20(6):516-519.
73.
Armstead WM , Leffler CWNeurohumoral regulation of the cerebral circulation . Proc Soc Exp Biol Med. 1992;199(2):149-157.
74.
Pasternak JF , Groothuis DRAutoregulation of cerebral blood flow in the newborn beagle puppy. Biol Neonate. 1985; 48(2):100-109.
75.
Szymonowicz W., Walker AM, Yu VY, Stewart ML, Cannata J., Cussen L.Regional cerebral blood flow after hemorrhagic hypotension in the preterm, near-term, and newborn lamb. Pediatr Res. 1990;28(4):361-366.
76.
Hohimer AR, Bissonnette JMEffects of cephalic hypotension, hypertension, and barbiturates on fetal cerebral flood flow and metabolism. Am J Obstet Gynecol . 1989;161(5):1344-1351.
77.
Young RS, Hernandez MJ, Yagel SKSelective reduction of blood flow to white matter during hypotension in newborn dogs: a possible mechanism of periventricular leukomalacia. Ann Neurol. 1982;12(5):445-448.
78.
Arnold BW, Martin CG, Alexander BJ, Chen T., Fleming LRAutoregulation of brain blood flow during hypotension and hypertension in infant lambs. Pediatr Res. 1991;29(1):110-115.
79.
Monin P., Stonestreet BS, Oh W.Hyperventilation restores autoregulation of cerebral blood flow in postictal piglets. Pediatr Res. 1991;30(3):294-298.
80.
Hascoet JM, Monin P., Vert P.Persistence of impaired autoregulation of cerebral blood flow in the postictal period in piglets. Epilepsia. 1988 ;29(6):743-747.
81.
Del Toro J. , Louis PT, Goddard-Finegold J.Cerebrovascular regulation and neonatal brain injury. Pediatr Neurol. 1991;7(1): 3-12.
82.
van Os S., Liem D., Hopman J., Klaessens J., van de Bor M.Cerebral O2 supply thresholds for the preservation of electrocortical brain activity during hypotension in near-term-born lambs. Pediatr Res.2005;57(3):358-362.
83.
van Os S., Klaessens J., Hopman J., Liem D., van De Bor M.Cerebral oxygen supply during hypotension in near-term lambs: a near-infrared spectroscopy study. Brain Dev.2006;28(2): 115-121.
84.
Lassen NACerebral blood flow and oxygen consumption in man. Physiol Rev. 1959;39(2):183-233.
Heistad DD, Kontos HACerebral circulation. In: Shepherd JT, Abboud FM, eds. Handbook of Physiology . Bethesda, MD: American Physiological Society;1983:137-182.
87.
Gebremedhin D., Lange AR, Lowry TF, et al. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res. 2000;87(1):60-65.
88.
Lou HC, Lassen NA, Friis-Hansen B.Impaired autoregulation of cerebral blood flow in the distressed newborn infant . J Pediatr.1979;94(1):118-121.
89.
Tsuji M., Saul JP, du Plessis A., et al. Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics. 2000;106(4):625-632.
90.
Soul JS, Hammer PE, Tsuji M., et al. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res. 2007 ;61(4):467-473.
91.
Pryds O.Control of cerebral circulation in the high-risk neonate. Ann Neurol. 1991;30(3):321-329.
92.
Milligan DWFailure of autoregulation and intraventricular haemorrhage in preterm infants. Lancet. 1980 ;1(8174): 896-898.
93.
Miall-Allen VM, de Vries LS, Dubowitz LM, Whitelaw AGBlood pressure fluctuation and intraventricular hemorrhage in the preterm infant of less than 31 weeks’ gestation. Pediatrics. 1989;83(5):657-661.
94.
Ramaekers VT , Casaer P., Daniels H., Marchal G.Upper limits of brain blood flow autoregulation in stable infants of various conceptional age. Early Hum Dev . 1990;24(3):249-258.
95.
Verma PK, Panerai RB, Rennie JM, Evans DHGrading of cerebral autoregulation in preterm and term neonates. Pediatr Neurol. 2000;23(3):236-242.
96.
Lou HC, Lassen NA, Friis-Hansen B.Low cerebral blood flow in the hypotensive distressed newborn. Acta Neurol Scand Suppl.1977;64:428-429.
97.
Lou HC, Skov H., Pedersen H.Low cerebral blood flow: a risk factor in the neonate. J Pediatr . 1979;95(4):606-609.
98.
Younkin DP, Reivich M., Jaggi J., Obrist W., Delivoria-Papadopoulos M.Noninvasive method of estimating human newborn regional cerebral blood flow . J Cereb Blood Flow Metab. 1982;2(4):415-420.
99.
Boylan GB, Young K., Panerai RB, Rennie JM, Evans DHDynamic cerebral autoregulation in sick newborn infants. Pediatr Res. 2000;48(1):12-17.
100.
Anthony MY, Evans DH, Levene MINeonatal cerebral blood flow velocity responses to changes in posture . Arch Dis Child.1993;69(3 spec no):304-308.
101.
van de Bor M. , Walther FJCerebral blood flow velocity regulation in preterm infants. Biol Neonate. 1991;59(6):329-335.
Richardson BS , Carmichael L., Homan J., Tanswell K., Webster ACRegional blood flow change in the lamb during the perinatal period. Am J Obstet Gynecol. 1989;160(4): 919-925.
104.
Derrick M., Drobyshevsky A., Ji X., Tan S.A model of cerebral palsy from fetal hypoxia-ischemia. Stroke . 2007; 38(2 suppl): 731-735.
105.
Goddard-Finegold J., Michael LHCerebral blood flow and experimental intraventricular hemorrhage. Pediatr Res.1984; 18(1):7-11.
106.
Goddard J. , Lewis RM, Armstrong DL, Zeller RSModerate, rapidly induced hypertension as a cause of intraventricular hemorrhage in the newborn beagle model. J Pediatr. 1980;96(6):1057-1060.
107.
Ment LR, Stewart WB, Duncan CC, Lambrecht R.Beagle puppy model of intraventricular hemorrhage. J Neurosurg . 1982;57(2):219-223.
108.
Pasternak JF, Groothuis DR, Fischer JM, Fischer DPRegional cerebral blood flow in the beagle puppy model of neonatal intraventricular hemorrhage: studies during systemic hypertension. Neurology. 1983;33(5):559-566.
109.
Matsuda T. , Okuyama K., Cho K., et al. Induction of antenatal periventricular leukomalacia by hemorrhagic hypotension in the chronically instrumented fetal sheep. Am J Obstet Gynecol. 1999;181(3):725-730.
110.
Back SA, Riddle A., Hohimer ARRole of instrumented fetal sheep preparations in defining the pathogenesis of human periventricular white-matter injury. J Child Neurol . 2006;21(7): 582-589.
111.
Reddy K., Mallard C., Guan J., et al. Maturational change in the cortical response to hypoperfusion injury in the fetal sheep. Pediatr Res. 1998 ;43(5):674-682.
112.
Mallard C. , Welin AK, Peebles D., Hagberg H., Kjellmer I.White matter injury following systemic endotoxemia or asphyxia in the fetal sheep. Neurochem Res. 2003;28(2):215-223.
113.
Greisen G.Effect of cerebral blood flow and cerebrovascular autoregulation on the distribution, type and extent of cerebral injury. Brain Pathol.1992;2(3):223-228.
114.
Edwards AD , Wyatt JS, Richardson C., Delpy DT, Cope M., Reynolds EOCotside measurement of cerebral blood flow in ill newborn infants by near infrared spectroscopy . Lancet . 1988;2(8614):770-771.
115.
Wyatt JS, Cope M., Delpy DT, Wray S., Reynolds EOQuantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectrophotometry. Lancet. 1986;2(8515):1063-1066.
116.
Meek JH, Tyszczuk L., Elwell CE, Wyatt JSLow cerebral blood flow is a risk factor for severe intraventricular haemorrhage . Arch Dis Child Fetal Neonatal Ed. 1999;81(1):F15-F18.
117.
Kluckow M. , Evans N.Superior vena cava flow in newborn infants: a novel marker of systemic blood flow. Arch Dis Child Fetal Neonatal Ed. 2000;82(3):F182-F187.
118.
Kluckow M. , Evans N.Low systemic blood flow in the preterm infant . Semin Neonatol. 2001;6(1):75-84.
119.
Miletin J. , Dempsey EMLow superior vena cava flow on day 1 and adverse outcome in the very low birthweight infant. Arch Dis Child Fetal Neonatal Ed. 2008;93(5):F368-F371.
120.
Kissack CM , Garr R., Wardle SP, Weindling AMCerebral fractional oxygen extraction in very low birth weight infants is high when there is low left ventricular output and hypocarbia but is unaffected by hypotension. Pediatr Res . 2004;55(3): 400-405.
121.
Evans N., Kluckow M., Simmons M., Osborn D.Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants. Arch Dis Child Fetal Neonatal Ed. 2002;87(3):F181-F184.
122.
Osborn DA, Evans N., Kluckow M.Hemodynamic and antecedent risk factors of early and late periventricular/intraventricular hemorrhage in premature infants. Pediatrics. 2003; 112(1 pt 1):33-39.
123.
Moran M., Miletin J., Pichova K., Dempsey EMCerebral tissue oxygenation index and superior vena cava blood flow in the very low birth weight infant. Acta Paediatr. 2009;98(1):43-46.
124.
Goddard J. , Lewis RM, Alcala H., Zeller RSIntraventricular hemorrhage-an animal model . Biol Neonate.1980; 37(1-2): 39-52.
125.
Goddard-Finegold J., Armstrong D., Zeller RSIntraventricular hemorrhage following volume expansion after hypovolemic hypotension in the newborn beagle . J Pediatr.1982;100(5): 796-799.
126.
Meek JH, Elwell CE, McCormick DC, et al. Abnormal cerebral haemodynamics in perinatally asphyxiated neonates related to outcome. Arch Dis Child Fetal Neonatal Ed. 1999;81(2): F110-F115.
127.
Perlman JM , Goodman S., Kreusser KL, Volpe JJReduction in intraventricular hemorrhage by elimination of fluctuating cerebral blood-flow velocity in preterm infants with respiratory distress syndrome. N Engl J Med. 1985;312(21):1353-1357.
128.
Perlman JM , McMenamin JB, Volpe JJFluctuating cerebral blood-flow velocity in respiratory-distress syndrome: relation to the development of intraventricular hemorrhage. N Engl J Med. 1983;309(4):204-209.
129.
van Bel F. , van de Bor M., Stijnen T., Baan J., Ruys JHAetiological role of cerebral blood-flow alterations in development and extension of peri-intraventricular haemorrhage. Dev Med Child Neurol. 1987;29(5):601-614.
130.
Wimberley PD, Lou HC, Pedersen H., Heji M., Lassen NA, Friis-Hansen B.Hypertensive peaks in the pathogenesis of intraventricular hemorrhage in the newborn. Abolition by phenobarbitone sedation . Acta Paediatr Scand. 1982;71(4):537-542.
131.
Kuban KC, Skouteli H., Cherer A., et al. Hemorrhage, phenobarbital, and fluctuating cerebral blood flow velocity in the neonate. Pediatrics. 1988;82(4):548-553.
132.
Limperopoulos C., Bassan H., Kalish LA, et al. Current definitions of hypotension do not predict abnormal cranial ultrasound findings in preterm infants. Pediatrics. 2007; 120(5): 966-977.
133.
Pasternak JF, Groothuis DR, Fischer JM, Fischer DPRegional cerebral blood flow in the newborn beagle pup: the germinal matrix is a ‘‘low-flow’’ structure. Pediatr Res. 1982;16(6):499-503.
134.
Pasternak JF , Groothuis DRRegional variability of blood flow and glucose utilization within the subependymal germinal matrix. Brain Res. 1984;299(2):281-288.
135.
Ment LR, Stewart WB, Petroff OA, Duncan CCThromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia . Stroke. 1989;20(6):809-814.
136.
Goddard-Finegold J., Donley DK, Adham BI, Michael LHPhenobarbital and cerebral blood flow during hypertension in the newborn beagle. Pediatrics. 1990;86(4):501-508.
137.
Reynolds ML , Evans CA, Reynolds EO, Saunders NR, Durbin GM, Wigglesworth JSIntracranial haemorrhage in the preterm sheep fetus. Early Hum Dev. 1979;3(2):163-186.
138.
Trounce JQ, Shaw DE, Levene MI, Rutter N.Clinical risk factors and periventricular leucomalacia. Arch Dis Child.1988;63(1):17-22.
139.
Bada HS, Korones SB, Perry EH, et al. Frequent handling in the neonatal intensive care unit and intraventricular hemorrhage. J Pediatr. 1990;117(1 pt 1):126-131.
140.
Bada HS, Korones SB, Perry EH, et al. Mean arterial blood pressure changes in premature infants and those at risk for intraventricular hemorrhage. J Pediatr. 1990;117(4):607-614.
141.
Low JA , Froese AB, Smith JT, Galbraith RS, Sauerbrei EE, Karchmar EJHypotension and hypoxemia in the preterm newborn during the four days following delivery identify infants at risk of echosonographically demonstrable cerebral lesions . Clin Invest Med. 1992;15(1):60-65.
142.
Perlman JM , Risser R., Broyles RSBilateral cystic periventricular leukomalacia in the premature infant: associated risk factors. Pediatrics . 1996;97(6 pt 1):822-827.
143.
Murphy DJ, Hope PL, Johnson A.Neonatal risk factors for cerebral palsy in very preterm babies: case-control study. BMJ. 1997;314(7078):404-408.
144.
Fanaroff JM , Wilson-Costello DE, Newman NS, Montpetite MM, Fanaroff AATreated hypotension is associated with neonatal morbidity and hearing loss in extremely low birth weight infants. Pediatrics. 2006;117(4):1131-1135.
145.
Weindling AM, Wilkinson AR, Cook J., Calvert SA, Fok TF, Rochefort MJPerinatal events which precede periventricular haemorrhage and leukomalacia in the newborn . Br J Obstet Gynaecol . 1985;92(12):1218-1223.
146.
Cunningham S., Symon AG, Elton RA, Zhu C., McIntosh N.Intra-arterial blood pressure reference ranges, death and morbidity in very low birthweight infants during the first seven days of life. Early Hum Dev.1999;56(2-3):151-165.
147.
Dammann O. , Allred EN, Kuban KC, et al. Systemic hypotension and white-matter damage in preterm infants. Dev Med Child Neurol. 2002;44(2):82-90.
148.
D’Souza SW, Janakova H., Minors D., et al. Blood pressure, heart rate, and skin temperature in preterm infants: associations with periventricular haemorrhage . Arch Dis Child Fetal Neonatal Ed. 1995;72(3):F162-F167.
149.
Kluckow M. , Evans N.Relationship between blood pressure and cardiac output in preterm infants requiring mechanical ventilation. J Pediatr. 1996;129(4):506-512.
150.
Fujimura M. , Salisbury DM, Robinson RO, et al. Clinical events relating to intraventricular haemorrhage in the newborn. Arch Dis Child. 1979;54(6):409-414.
151.
McDonald MM , Koops BL, Johnson ML, et al. Timing and antecedents of intracranial hemorrhage in the newborn. Pediatrics . 1984 ;74(1):32-36.
152.
Perlman J. , Thach B.Respiratory origin of fluctuations in arterial blood pressure in premature infants with respiratory distress syndrome. Pediatrics. 1988;81(3):399-403.
153.
Low JA , Froese AB, Galbraith RS, Smith JT, Sauerbrei EE, Derrick EJThe association between preterm newborn hypotension and hypoxemia and outcome during the first year. Acta Paediatr . 1993;82(5):433-437.
154.
de Vries LS , Regev R., Dubowitz LM, Whitelaw A., Aber VRPerinatal risk factors for the development of extensive cystic leukomalacia. Am J Dis Child. 1988;142(7):732-735.
155.
Bejar RF, Vaucher YE, Benirschke K., Berry CCPostnatal white matter necrosis in preterm infants. J Perinatol . 1992;12(1):3-8.
156.
Tyszczuk L. , Meek J., Elwell C., Wyatt JSCerebral blood flow is independent of mean arterial blood pressure in preterm infants undergoing intensive care. Pediatrics. 1998;102(2 pt 1): 337-341.
157.
Meek JH, Tyszczuk L., Elwell CE, Wyatt JSCerebral blood flow increases over the first three days of life in extremely preterm neonates. Arch Dis Child Fetal Neonatal Ed. 1998;78(1):F33-F37.
158.
Lassen NAControl of cerebral circulation in health and disease. Circ Res. 1974;34(6):749-760.
159.
Greisen G. , Pryds O.Intravenous 133Xe clearance in preterm neonates with respiratory distress. Internal validation of CBF infinity as a measure of global cerebral blood flow. Scand J Clin Lab Invest. 1988;48(7):673-678.
160.
Park CH, Spitzer AR, Desai HJ, Zhang JJ, Graziani LJBrain SPECT in neonates following extracorporeal membrane oxygenation: evaluation of technique and preliminary results. J Nucl Med . 1992;33(11):1943-1948.
161.
Powers WJCerebral blood flow and metabolism in newborn infants. What can they teach us about stroke?Stroke. 1993;24(12 suppl):133-134; discussion 135-137.
162.
Soul JS, Taylor GA, Wypij D., Duplessis AJ, Volpe JJNoninvasive detection of changes in cerebral blood flow by near-infrared spectroscopy in a piglet model of hydrocephalus. Pediatr Res . 2000;48(4):445-449.
163.
Bassan H., Gauvreau K., Newburger JW, et al. Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery. Pediatr Res. 2005;57(1):35-41.
164.
Perlman JM , Volpe JJCerebral blood flow velocity in relation to intraventricular hemorrhage in the premature newborn infant. J Pediatr. 1982;100(6):956-959.
165.
Rennie JM, South M., Morley CJCerebral blood flow velocity variability in infants receiving assisted ventilation . Arch Dis Child. 1987;62(12):1247-1251.
166.
van Bel F. , de Winter PJ, Wijnands HB, van de Bor M., Egberts J.Cerebral and aortic blood flow velocity patterns in preterm infants receiving prophylactic surfactant treatment. Acta Paediat. 1992 ;81(6-7):504-510.
Hansen NB, Stonestreet BS, Rosenkrantz TS, Oh W.Validity of Doppler measurements of anterior cerebral artery blood flow velocity: correlation with brain blood flow in piglets. Pediatrics. 1983;72(4):526-531.
169.
Thoresen M. , Haaland K., Steen PACerebral Doppler and misrepresentation of flow changes. Arch Dis Child. 1994;71(2):F103-F106.
170.
Aaslid R., Lindegaard KF, Sorteberg W., Nornes H.Cerebral autoregulation dynamics in humans. Stroke . 1989;20(1): 45-52.
171.
Panerai RB, Kelsall AW, Rennie JM, Evans DHAnalysis of cerebral blood flow autoregulation in neonates. IEEE Trans Biomed Eng. 1996;43(8):779-788.
172.
Panerai RB, Kelsall AWR, Rennie JM, Evans DHMechanism of cerebral autoregulation in neonates. Early Hum Dev. 1997;47(2):206-207.
173.
von Siebenthal K., Beran J., Wolf M., et al. Cyclical fluctuations in blood pressure, heart rate and cerebral blood volume in preterm infants . Brain Dev. 1999;21(8):529-534.
174.
Lemmers PM , Toet M., van Schelven LJ, van Bel F.Cerebral oxygenation and cerebral oxygen extraction in the preterm infant: the impact of respiratory distress syndrome. Exp Brain Res. 2006;173(3):458-467.
175.
Seri I., Abbasi S., Wood DC, Gerdes JSRegional hemodynamic effects of dopamine in the sick preterm neonate . J Pediatr.1998;133(6):728-734.
176.
Nuntnarumit P., Yang W., Bada-Ellzey HSBlood pressure measurements in the newborn . Clin Perinatol. 1999;26(4): 981-996, x.
177.
Gill AB, Weindling AMRandomised controlled trial of plasma protein fraction versus dopamine in hypotensive very low birthweight infants. Arch Dis Child.1993;69(3 spec no):284-287.
178.
Al-Aweel I. , Pursley DM, Rubin LP, Shah B., Weisberger S., Richardson DKVariations in prevalence of hypotension, hypertension, and vasopressor use in NICUs. J Perinatol.2001;21(5):272-278.
179.
Fanaroff JM , Fanaroff AABlood pressure disorders in the neonate: hypotension and hypertension. Semin Fetal Neonatal Med. 2006;11(3):174-181.
180.
Lee JM , Zipfel GJ, Choi DWThe changing landscape of ischaemic brain injury mechanisms. Nature. 1999;399(6738 suppl):A7-A14.
181.
Systolic blood pressure in babies of less than 32 weeks gestation in the first year of life. Northern Neonatal Nursing Initiative. Arch Dis Child Fetal Neonatal Ed. 1999;80(1):F38-F42.
182.
Batton B., Batton D., Riggs T.Blood pressure during the first 7 days in premature infants born at postmenstrual age 23 to 25 weeks. Am J Perinatol. 2007;24(2):107-115.
183.
Victor S., Marson AG, Appleton RE, Beirne M., Weindling AMRelationship between blood pressure, cerebral electrical activity, cerebral fractional oxygen extraction, and peripheral blood flow in very low birth weight newborn infants. Pediatr Res. 2006;59(2):314-319.
184.
Barkovich AJ, Westmark K., Partridge C., Sola A., Ferriero DMPerinatal asphyxia: MR findings in the first 10 days. AJNR Am J Neuroradiol. 1995;16:427-438.
185.
Pasternak JFHypoxic-ischemic brain damage in the term infant. Lessons from the laboratory. Pediatr Clin North Am . 1993;40(5):1061-1072.
186.
Pasternak JF, Gorey MTThe syndrome of acute near-total intrauterine asphyxia in the term infant. Pediatr Neurol. 1998;18(5):391-398.
187.
Goldstein RF, Thompson RJ Jr, Oehler JM, Brazy JEInfluence of acidosis, hypoxemia, and hypotension on neurodevelopmental outcome in very low birth weight infants. Pediatrics. 1995;95(2):238-243.
188.
Urlesberger B., Trip K., Ruchti JJ, Kerbl R., Reiterer F., Müller W.Quantification of cyclical fluctuations in cerebral blood volume in healthy infants. Neuropediatrics . 1998;29(4):208-211.
189.
Mullaart RA , Hopman JC, De Haan AF, Rotteveel JJ, Daniëls O., Stoelinga GACerebral blood flow fluctuation in low-risk preterm newborns. Early Hum Dev . 1992;30(1):41-48.
190.
Dimitriou G., Greenough A., Kavvadia V., Mantagos S.Blood pressure rhythms during the perinatal period in very immature, extremely low birthweight neonates. Early Hum Dev. 1999;56(1):49-56.
191.
Andriessen P., Schoffelen RL, Berendsen RC, et al. Noninvasive assessment of blood pressure variability in preterm infants. Pediatr Res. 2004;55(2):220-223.
192.
Cunningham S., Deere S., McIntosh N.Cyclical variation of blood pressure and heart rate in neonates. Arch Dis Child.1993;69(1 spec no):64-67.
193.
Kusaka T., Okubo K., Nagano K., Isobe K., Itoh S.Cerebral distribution of cardiac output in newborn infants. Arch Dis Child Fetal Neonatal Ed. 2005;90(1):F77-F78.
194.
Weindling AM, Kissack CMBlood pressure and tissue oxygenation in the newborn baby at risk of brain damage. Biol Neonate . 2001;79(3-4):241-245.
195.
Bhutta AT, Cleves MA, Casey PH, Cradock MM, Anand KJCognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA. 2002;288(6):728-737.
196.
Msall ME, Tremont MRMeasuring functional outcomes after prematurity: developmental impact of very low birth weight and extremely low birth weight status on childhood disability . Ment Retard Dev Disabil Res Rev. 2002;8(4):258-272.
197.
Allin M., Matsumoto H., Santhouse AM, et al. Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term. Brain. 2001;124(pt 1):60-66.
198.
Greisen G. , Pryds O., Rosén I., Lou H.Poor reversibility of EEG abnormality in hypotensive, preterm neonates. Acta Paediatr Scand. 1988 ;77(6):785-790.
199.
Kurtis PS, Rosenkrantz TS, Zalneraitis ELCerebral blood flow and EEG changes in preterm infants with patent ductus arteriosus. Pediatr Neurol. 1995;12(2):114-119.
200.
Victor S., Appleton RE, Beirne M., Marson AG, Weindling AMThe relationship between cardiac output, cerebral electrical activity, cerebral fractional oxygen extraction and peripheral blood flow in premature newborn infants. Pediatr Res. 2006;60(4):456-460.
201.
Greisen G. , Pryds O.Low CBF, discontinuous EEG activity, and periventricular brain injury in ill, preterm neonates. Brain Dev.1989;11(3):164-168.
202.
Hope PL, Gould SJ, Howard S., Hamilton PA, Costello AM, Reynolds EOPrecision of ultrasound diagnosis of pathologically verified lesions in the brains of very preterm newborn infants. Dev Med Child Neurol . 1988;30(4):457-471.
203.
Paneth N., Rudelli R., Monte W., et al. White matter necrosis in very low birth weight infants: neuropathologic and ultrasonographic findings in infants surviving six days or longer. J Pediatr. 1990;116(6):975-984.
204.
Lou H.The ‘‘lost autoregulation hypothesis’’ and brain lesions in the newborn: an update. Brain Dev. 1988 ;10(3):143-146.
205.
Lou HCAutoregulation of cerebral blood flow and brain lesions in newborn infants . Lancet. 1998;352(9138):1406.
206.
Soul JS, du Plessis AJ, Walter GL, Taylor GA, Volpe JJNear-infrared spectroscopy monitoring detects changes in cerebral blood flow in an animal model of acute hydrocephalus [abstract]. Ann Neurol. 1998;44:535.
207.
O’Leary H., Gregas MC, Limperopoulos C., et al. High magnitude cerebral pressure passivity is associated with germinal matrix-intraventricular hemorrhage in premature infants. Pediatrics. IN PRESS.
208.
Hossmann KA , Lechtape-Gruter H., Hossmann V.The role of cerebral blood flow for the recovery of the brain after prolonged ischemia. Z Neurol.1973;204(4):281-299.
209.
Koch KA, Jackson DL, Schmiedl M., Rosenblatt JITotal cerebral ischemia: effect of alterations in arterial PCO2 on cerebral microcirculation. J Cereb Blood Flow Metab. 1984;4(3):343-349.
210.
Rosenberg AACerebral blood flow and O2 metabolism after asphyxia in neonatal lambs. Pediatr Res. 1986 ;20(8):778-782.
211.
Leffler CW , Busija DW, Beasley DG, Armstead WM, Mirro R.Postischemic cerebral microvascular responses to norepinephrine and hypotension in newborn pigs . Stroke . 1989; 20(4):541-546.
212.
Busija DWCerebral autoregulation. In: Phillis JW, ed. The Regulation of Cerebral Blood Flow. Boca Raton, FL: Chemical Rubber Company;1993:45-64.
213.
Bari F., Louis TM, Meng W., Busija DWGlobal ischemia impairs ATP-sensitive K+ channel function in cerebral arterioles in piglets. Stroke. 1996;27(10):1874-1880; discussion 1880-1881.
214.
Kety SS, Schmidt CFThe effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men . J Clin Invest. 1948;27(4):484-492.
215.
Wyatt JS, Edwards AD, Cope M., et al. Response of cerebral blood volume to changes in arterial carbon dioxide tension in preterm and term infants. Pediatr Res. 1991;29(6):553-557.
216.
Yamashita N., Kamiya K., Nagai H.CO2 reactivity and autoregulation in fetal brain. Child’s Nerv Syst. 1991;7(6):327-331.
217.
Dietz V., Wolf M., Keel M., v Siebenthal K., Baenziger O., Bucher H.CO2 reactivity of the cerebral hemoglobin concentration in healthy term newborns measured by near infrared spectrophotometry. Biol Neonate.1999;75(2):85-90.
218.
Leahy FA, Cates D., MacCallum M., Rigatto H.Effect of CO2 and 100% O2 on cerebral blood flow in preterm infants . J Appl Physiol. 1980;48(3):468-472.
219.
Van Marter LJStrategies for preventing bronchopulmonary dysplasia. Curr Opin Pediatr. 2005;17(2):174-180.
220.
Fabres J., Carlo WA, Phillips V., Howard G., Ambalavanan N.Both extremes of arterial carbon dioxide pressure and the magnitude of fluctuations in arterial carbon dioxide pressure are associated with severe intraventricular hemorrhage in preterm infants. Pediatrics . 2007;119(2):299-305.
221.
Kaiser JR, Gauss CH, Pont MM, Williams DKHypercapnia during the first 3 days of life is associated with severe intraventricular hemorrhage in very low birth weight infants. J Perinatol. 2006;26(5):279-285.
222.
Graziani LJ , Spitzer AR, Mitchell DG, et al. Mechanical ventilation in preterm infants: neurosonographic and developmental studies . Pediatrics . 1992;90(4):515-522.
223.
Calvert SA , Hoskins EM, Fong KW, Forsyth SCEtiological factors associated with the development of periventricular leukomalacia. Acta Paediatr Scand. 1987;76(2):254-259.
224.
Greisen G. , Munck H., Lou H.May hypocarbia cause ischaemic brain damage in the preterm infant? Lancet. 1986; 2(8504):460.
225.
Greisen G. , Munck H., Lou H.Severe hypocarbia in preterm infants and neurodevelopmental deficit. Acta Paediatr Scand. 1987;76(3):401-404.
226.
Greisen G. , Vannucci RCIs periventricular leucomalacia a result of hypoxic-ischaemic injury? Hypocapnia and the preterm brain. Biol Neonate. 2001;79(3-4):194-200.
227.
Fujimoto S. , Togari H., Yamaguchi N., Mizutani F., Suzuki S., Sobajima H.Hypocarbia and cystic periventricular leukomalacia in premature infants. Arch Dis Child. 1994 ;71(2):F107-F110.
228.
Wiswell T. , Graziani L., Kornhauser M., et al. Effects of hypocarbia on the development of cystic periventricular leukomalacia in premature infants treated with high-frequency jet ventilation. Pediatrics . 1996;98(5):918-924.
229.
Okumura A. , Hayakawa F., Kato T., et al. Hypocarbia in preterm infants with periventricular leukomalacia: the relation between hypocarbia and mechanical ventilation. Pediatrics. 2001; 107(3):469-475.
230.
Shankaran S., Langer JC, Kazzi SN, et al. Cumulative index of exposure to hypocarbia and hyperoxia as risk factors for periventricular leukomalacia in low birth weight infants. Pediatrics. 2006;118(4):1654-1659.
231.
Kaiser JR, Gauss CH, Williams DKThe effects of hypercapnia on cerebral autoregulation in ventilated very low birth weight infants. Pediatr Res. 2005;58(5):931-935.
232.
Wilson DF, Pastuszko A., DiGiacomo JE, Pawlowski M., Schneiderman R., Delivoria-Papadopoulos M.Effect of hyperventilation on oxygenation of the brain cortex of newborn piglets . J Appl Physiol. 1991;70(6):2691-2696.
233.
Kennealy JA , McLennan JE, Loudon RG, McLaurin RLHyperventilation-induced cerebral hypoxia . Am Rev Respir Dis.1980 ;122(3):407-412.
234.
Reuter JH, Disney TARegional cerebral blood flow and cerebral metabolic rate of oxygen during hyperventilation in the newborn dog. Pediatr Res. 1986;20(11):1102-1106.
235.
Hansen NB, Nowicki PT, Miller RR, Malone T., Bickers RG, Menke JAAlterations in cerebral blood flow and oxygen consumption during prolonged hypocarbia. Pediatr Res. 1986;20(2):147-150.
236.
Plum F., Posner JBBlood and cerebrospinal fluid lactate during hyperventilation. Am J Physiol.1967;212(4):864-870.
237.
Granholm L. , Siesjö BK. The effects of hypercapnia and hypocapnia upon the cerebrospinal fluid lactate and pyruvate concentrations and upon the lactate, pyruvate, ATP, ADP, phosphocreatine and creatine concentrations of cat brain tissue. Acta Physiol Scand. 1969 ;75(3):257-266.
238.
Raichle ME , Posner JB, Plum F.Cerebral blood flow during and after hyperventilation . Arch Neurol.1970;23(5):394-403.
239.
Dahlgren N. , Ingvar M., Siesjö BKEffect of propranolol on local cerebral blood flow under normocapnic and hypercapnic conditions . J Cereb Blood Flow Metab. 1981;1(4):429-436.
240.
Brian JE Jr.Carbon dioxide and the cerebral circulation. Anesthesiology. 1998;88(5):1365-1386.
241.
Warner DS, Turner DM, Kassel NFTime-dependent effects of prolonged hypercapnea on cerebrovascular parameters: acid-base chemistry. Stroke. 1987 ;18(1):142-149.
242.
Yang SP, Krasney JACerebral blood flow and metabolic responses to sustained hypercapnia in awake sheep. J Cereb Blood Flow Metab. 1995;15(1):115-123.
243.
Brubakk AM, Oh W., Stonestreet BSProlonged hypercarbia in the awake newborn piglet: effect on brain blood flow and cardiac output. Pediatr Res. 1987;21(1):29-33.
244.
Najarian T. , Marrache AM, Dumont I., et al. Prolonged hypercapnia-evoked cerebral hyperemia via K(+) channel- and prostaglandin E(2)-dependent endothelial nitric oxide synthase induction . Circ Res. 2000 ;87(12):1149-1156.
245.
Garnier Y., Coumans AB, Jensen A., Hasaart TH, Berger R.Infection-related perinatal brain injury: the pathogenic role of impaired fetal cardiovascular control. J Soc Gynecol Investig. 2003;10(8):450-459.
246.
Brian JE Jr , Faraci FMTumor necrosis factor-alpha-induced dilatation of cerebral arterioles. Stroke. 1998;29(2):509-515.
247.
Sibson NR, Blamire AM, Perry VH, Gauldie J., Styles P., Anthony DCTNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway. Brain. 2002;125(pt 11):2446-2459.
248.
Cheranov SY , Jaggar JHTNF-alpha dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation. Am J Physiol Cell Physiol.2006;290(4):C964-C971.
249.
Yanowitz TD , Jordan JA, Gilmour CH, et al. Hemodynamic disturbances in premature infants born after chorioamnionitis: association with cord blood cytokine concentrations. Pediatr Res. 2002;51(3):310-316.
250.
Yanowitz TD , Baker RW, Roberts JM, Brozanski BSLow blood pressure among very-low-birth-weight infants with fetal vessel inflammation . J Perinatol. 2004;24(5):299-304.
251.
Furukawa S. , Sameshima H., Ikenoue T.Circulatory disturbances during the first postnatal 24 hours in extremely premature infants 25 weeks or less of gestation with histological fetal inflammation. J Obstet Gynaecol Res . 2008;34(1): 27-33.
252.
Sarkar S., Kaplan C., Wiswell TE, Spitzer ARHistological chorioamnionitis and the risk of early intraventricular hemorrhage in infants born < or =28 weeks gestation. J Perinatol. 2005; 25(12):749-752.
253.
Babnik J., Stucin-Gantar I., Kornhauser-Cerar L., et al. Intrauterine inflammation and the onset of peri-intraventricular hemorrhage in premature infants. Biol Neonate.2006;90(2): 113-121.
254.
Vergani P. , Patane L., Doria P., et al. Risk factors for neonatal intraventricular haemorrhage in spontaneous prematurity at 32 weeks gestation or less. Placenta. 2000;21(4):402-407.