Delirium in children has received little attention from researchers until very recently, despite being a frequently encountered clinical problem, particularly in the context of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). In this article, we report 3 cases of severe hyperactive delirium occurring in children with advanced HIV/AIDS in the context of probable underlying HIV encephalopathy and complex drug—drug interactions. We also present a hypothesis in relation to HIV-associated delirium as a potential neuropsychiatric manifestation of the immune reconstitution inflammatory syndrome in children commenced on highly active antiretroviral therapy.
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