Cerebral artery occlusion in childhood, particularly in the posterior circulation, is a rare neurological complication of Mycoplasma pneumoniae infection. A genetic defect in the methylenetetrahydrofolate reductase gene could result in hyperhomocysteinemia and increased risk of stroke. We report a patient with posterior cerebral artery occlusion after Mycoplasma pneumoniae infection associated with a homozygous, methylenetetrahydrofolate reductase gene mutant type.
Fu M., Wong KS, Lam WW, Wong GWMiddle cerebral artery occlusion after recent Mycoplasma pneumoniae infection . J Neurol Sci. 1998;157:113-115.
5.
Komitopoulou A., Platokouki H., Kapsimali Z., Pergantou H., Adamtziki E., Aronis S.Mutations and polymorphisms in genes affecting hemostasis proteins and homocysteine metabolism in children with arterial ischemic stroke. Cerebrovasc Dis. 2006;22: 13-20.
6.
Ganesan V., Prengler M., McShane MA, Wade AM, Kirkham FJInvestigation of risk factors in children with arterial ischemic stroke. Ann Neurol. 2003;53:167-173.
7.
Lanthier S., Carmant L., David M., Larbrisseau A., Veber G.Stroke in children: the coexistence of multiple risk factors predicts poor outcome. Neurology. 2000;54:371-378.
8.
Prengler M., Sturt N., Krywawych S., Surtees R., Liesner R., Kirkham F.Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: a potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood. Dev Med Child Neurol. 2001;43:220-225.
9.
Welch G., Loscalzo J.Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042-1050.
10.
Nowak-Gottl U., Strater R., Heinecke A., et al. Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood. Blood. 1999;94: 3678-3682.
11.
Vikerfors T. , Brodin G., Grandien M., Hirschberg L., Krook A., Pettersson CADetection of specific IgM antibodies for the diagnosis of Mycoplasma pneumoniae infections: a clinical evaluation. Scand J Infect Dis. 1988;20:601-610.