PYST1/MKP3 is a negative feedback modulator of fibroblast growth factor 8 (Fgf8) signaling in the mammalian isthmic organizer of the brain, which affects the development of the midbrain and the hindbrain. The Dusp6 (Mkp3) gene is also highly expressed in the mouse embryonic forebrain. However, its role in forebrain development and function remains largely unknown. In this study, association analyses were preformed in silico between the variation I62M (rs13480726) of the Dusp6 (Mkp3) gene and the mouse forebrain weight/structure in 385 mice of 20 strains. It was found that I62M (allele A) was associated with reduced mouse forebrain structure in both sexes and lower brain weight in males.
Dickinson RJ , Eblaghie MC, Keyse SM, Morriss-Kay GMExpression of the ERK-specific MAP kinase phosphatase PYST1/ MKP3 in mouse embryos during morphogenesis and early organogenesis . Mech Dev. 2002;113:193-196.
2.
Echevarria D. , Martinez S., Marques S., et al. Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer. Dev Biol. 2005;277:114-128.
3.
Wahlsten D., Metten P., Crabbe JCSurvey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum . Brain Res. 2003;971:47-54.
4.
Bishop KM, Wahlsten D.Sex and species differences in mouse and rat forebrain commissures depend on the method of adjusting for brain size. Brain Res. 1999;815:358-366.
5.
Evans PD, Anderson JR, Vallender EJ, et al. Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans. Hum Mol Genet. 2004 ;13:489-494.
6.
Woods CG, Bond J., Enard W.Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings. Am J Hum Genet. 2005;76:717-728.
7.
Zhang J.Evolution of the human ASPM gene, a major determinant of brain size. Genetics. 2003;165:2063-2070.
8.
Kusek GK, Wahlsten D., Herron BJ, et al. Localization of two new X-linked quantitative trait loci controlling corpus callosum size in the mouse. Genes Brain Behav. 2007;6:359-363.
9.
Wahlsten D., Bishop KM, Ozaki HSRecombinant inbreeding in mice reveals thresholds in embryonic corpus callosum development. Genes Brain Behav. 2006;5:170-188.
Kawakami Y. , Rodriguez-Leon J., Koth CM, et al. MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nat Cell Biol. 2003;5:513-519.
12.
Castelli M. , Camps M., Gillieron C., et al. MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha. J Biol Chem. 2004;279:44731-44739.
13.
Guerra B., Siemer S., Boldyreff B., Issinger OGProtein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles. FEBS Lett. 1999;462:353-357.
14.
Moreno FJ, Díaz-Nido J., Jiménez JS, Avila J.Distribution of CK2, its substrate MAP1B and phosphatases in neuronal cells . Mol Cell Biochem. 1999;191:201-205.
15.
Eblaghie MC, Song SJ, Kim JY, et al. Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos. J Anat. 2004;205:1-13.
16.
The Chimpanzee Sequencing and Analysis Consortium.Initial sequence of the chimpanzee genome and comparison with the human genome. Nature. 2005;437:69-87.
17.
Wood ET, Stover DA, Slatkin M., et al. The beta-globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria. Am J Hum Genet. 2005;77:637-642.
18.
Massingham T., Goldman N.Detecting amino acid sites under positive selection and purifying selection. Genetics. 2005;169: 1753-1762.
