Recent progress in our understanding of Rett syndrome has been dramatic. Against the background that the clinical features of Rett syndrome may be reversible, in part or in whole, substantial optimism has emerged regarding possible therapies. As such, it is timely to update recent research progress. This update summarizes research advances during the past 18 to 24 months in terms of clinical and translational research, as well as basic research.
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Stauder JE, Smeets EE, van Mil SG, Curfs LGThe development of visual- and auditory processing in Rett syndrome: an ERP study. Brain Dev. 2006;28(8):487-494.
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Motil KJ, Schultz RJ, Abrams S., et al. Fractional calcium absorption is increased in girls with Rett syndrome. J Pediatr Gastroenterol Nutr. 2006 ;42(4):419-426.
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Dragich JM, Kim YH, Arnold AP, Schanen NCDifferential distribution of the MeCP2 splice variants in the postnatal mouse brain. J Comp Neurol. 2007;501(4):526-542.
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Miyake K., Nagai K.Phosphorylation of methyl-CpG binding protein 2 (MeCP2) regulates the intracellular localization during neuronal cell differentiation. Neurochem Int. 2007;50(1):264-270.
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Amaral MD, Chapleau CA, Pozzo-Miller L.Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome. Pharmacol Ther. 2007;113(2):394-409.
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Sherren N., Pappas BASelective acetylcholine and dopamine lesions in neonatal rats produce distinct patterns of cortical dendritic atrophy in adulthood. Neuroscience . 2005;136(2):445-456.
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