Three patients, a 2-year-old girl, a 14-month-old girl, and a 15-month-old boy, were admitted with multiple episodes of benign afebrile seizures. Electroencephalograms recorded 1 or 2 days after the last seizure revealed epileptiform discharges. All 3 patients developed a fulminant Rotazymepositive diarrhea toward the end of their respective hospital stay. The prospects of immunological detection in diagnosis and treatment are discussed.
Sweetman LL, Ng YT, Butler IJ, Bodensteiner.Neurological complications associated with respiratory syncytial virus. Pediatr Neurol.2005;32:307-310.
2.
Salmi TT, Arstila P., Koivikko A.Central nervous system involvement in patients with rotavirus gastroenteritis . Scand J Infect Dis.1978;10:29-31.
3.
Jones PD, Roddick LG, Wilkinson IARotavirus and seizures. Med J Aust.1995;162:223.
4.
Komori H., Wada M., Eto M., Oki H., Aida K., Fujimoto T.Benign convulsions with mild gastroenteritis: a report of 10 recent cases detailing clinical varieties. Brain Dev.1995 ;17:334-337.
5.
Wong V.Acute gastroenteritis-related encephalopathy. J Child Neurol.2001;16:906-910.
6.
Lin SC, Hsu HY, Wang PJ, et al. Rotavirus gastroenteritis associated with afebrile seizure in childhood. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1996;37:204-207.
7.
Repetto T., Materassi D., Lacitignola L., Alvarez K.[Afebrile seizures in rotavirus gastroenteritis.]Minerva Pediatr.1997;49:429-431.
8.
Fukuyama Y.Borderland of childhood epilepsy, with special reference to febrile convulsions and so-called infantile convulsions (in Japanese). Seishin Igaku. 1963;5:211-223.
9.
Morooka K.Convulsions and mild diarrhea (in Japanese). Shonika.1982;35:2855-2859.
10.
Ushijima H. , Bosu K., Abe T., Shinozaki T.Suspected rotavirus encephalitis. Arch Dis Child.1986;61:692-694.
11.
Contino MF, Lebby T., Arcinue ELRotaviral gastrointestinal infection causing afebrile seizures in infancy and childhood. Am J Emerg Med.1994;12:94-95.
12.
Lynch M., Lee B., Azimi P., et al. Rotavirus and central nervous system symptoms: cause or contaminant? Case reports and review. Clin Infect Dis.2001;33:932-938.
13.
Zerr DM, Yeung LC, Obrigewitch RM, et al. Case report: primary human herpes virus 6 associated with an afebrile seizure in a 3-week-old infant. J Med Virol.2002;66:384-387.
14.
Imai K., Otani K., Yanagihara K., et al. Ictal video-EEG recording of three partial seizures in a patient with the benign infantile convulsions associated with mild gastroenteritis . Epilepsia. 1999;40:1455-1458.
15.
Nishimura S. , Ushijima H., Nishimura S., et al. Detection of rotavirus in cerebrospinal fluid and blood of patients with convulsions and gastroenteritis by means of the reverse transcription polymerase chain reaction. Brain Dev.1993;15:457-459.
16.
Ushijima H. , Kim B., Tajima T., et al. Epidemiology of rotavirus infection in Tokyo during two winter seasons, as revealed by analyses of recovered viral RNA. Eur J Pediatr.1984;142:71-72.
17.
Saulsbury FT , Winkelstein JA, Yolken RHChronic rotavirus infection in immunodeficiency . J Pediatr.1980;97:61-65.
18.
Chen HJ, Chen BA, Wang SF, Lai MHRotavirus gastroenteritis in children: a clinical study of 125 patients in Hsin-Tien area. Acta Pediatrics Sinica.1991 ;32:73-78.
19.
Centers for Disease Control Advisory Committee on Immunization Practices (ACIP).Prevention of rotavirus gastroenteritis among infants and children. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5512a1.htm?s_cid=rr5512a1_e.
20.
Lee WL, Ong HTAfebrile seizures associated with minor infections: comparison with febrile seizures and unprovoked seizures. Pediatr Neurol.2004;31:157-164.