We accumulated 440 cases of intracranial meningiomas in patients under 16 years of age, and another 27 personal. This review confirms the existence of specific clinical features of spontaneous and radiation-induced meningioma in children. In addition, we discuss various points that suggest a more aggressive behavior of meningiomas in children than in adults. (J Child Neurol 2006;21:31—36).
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References
1.
Bodian M., Lawson D.: Intracranial neoplastic diseases of childhood: A description of their natural history based on a clinicopathological study of 129 cases. Br J Surg1953;40:368—392.
2.
Cuneo HM, Rand CW: Brain Tumors of Childhood, vol XV. Springfield, IL, Charles C Thomas, 1952.
3.
Cusching H., Eisenhardt L.: Meningioma: Their Classification, Regional Behavior, Life History and Surgical Results. Springfield, IL, Charles C Thomas, 1938.
4.
French L.: Intracranial and cranial tumor. In: Jackson P, Thompson F (eds): Pediatric Neurosurgery. Oxford, UK, Blackwell, 1959, 226—294.
5.
Globus JH, Zucker LJ, Rubinstein JM: Tumors of the brain in children and in adolescents: A clinical and anatomic survey of ninety-two verified cases. Am J Dis Child1943;65:604—663.
6.
Herz DA, Shapiro K., Schulman K.: Intracranial meningiomas of infancy, childhood and adolescence: Review of the literature and addition of 9 case reports. ChildsBrain1980;7.43—56.
7.
Keith HM, Craig W.K., Kernohan JW: Brain tumors in children. Pediatrics1949;3:839—844.
8.
Leibel SA, Wara WM, Sheline GE, et al: The treatment of meningiomas in childhood. Cancer1976;37:2709—2712.
9.
Matson DD: Neurosurgery of Infancy and Childhood, vol III. Springfield, IL, Charles C Thomas , 1969.
Deen HG, Scheithauer BW, Ebersold MJ: Clinical and pathological study of meningiomas of the first two decades of life. J Neurosurg1982;56:317—322.
12.
Drake JM, Hendrick EB, Beker LE, et al: Intracranial meningiomas in children. Pediatr Neurosci1985—1986;12:134—139.
13.
Eisberg CA, Hare CC, Dyke CG: Unilateral exophthalmos in intracranial tumors with special reference to its occurrence in the meningioma. Surg Gynecol Obstet1932;55:681—699.
14.
Baumgartner JE, Soreson JM: Meningioma in the pediatric population. J Neurooncol1996;29:223—228
15.
Cahan WG, Woodard HQ, Higginbotham NL, et al: Sarcomas arising in irradiated bone: Report of eleven cases . Cancer1998;1:3—29.
16.
Odom GL, Davis CH, Woodhall B.: Brain tumors in children—Clinical analysis of 164 cases. Pediatrics1956;18:856—869.
17.
Crouse SK, Berg BO: Intracranial meningioma in childhood and adolescence. Neurology1972;22:135—141.
18.
Russel EJ, George AE, Kricheff II, et al: Atypical computed tomographic features of intracranial meningioma . Radiology1980;135:673—682.
19.
Ferrante L. , Acqui M., Artico M., et al: Cerebral meningiomas in children. Childs Nerv Syst1989;5:83—86.
20.
Ferrante L. , Acqui M., Artico M., et al: Paediatric intracranial meningiomas . Br J Neurosurg1989;3:189—196.
21.
Kleihues P., Burger PC, Schethauer BW: Histological Typing of Tumors of the Central Nervous System. New York, Springer-Verlag, 1993.
22.
Aibara T., Onogi H., Kobayashi M., et al: A huge brain tumor in an infant. Proc JpnPediatr Neurosurg1975;96: 140—143 [in Japanese].
23.
Amano K., Miura N., Tajika Y., et al: Cystic meningioma in a 10-month-old infant: Case report. J Neurosurg1980;52:829—833.
24.
Asenjo A., Donoso P., Colin E.: Tumeurs ventriculaires peu fréquentes. Neurochirurgie1973;19:308—312.
25.
Avman N., Dineer C.: Meningiomas of the third ventricle. Acta Neurochir (Wien) 1978;42:217—224.
26.
Aydin Y., Yolas C., Konte H., et al: Cystic meningiomas: Report of two cases. Neurosurgery1985;16:87—89.
Heppner F.: Uber meningiome des III Ventrikels. Acta Neurochir (Wien) 1954;4:55—67.
49.
Heppner F.: Meningioma of the third ventricle in children. Review of the literature and report of two cases with uneventful recovery after surgey. Acta Psychiatr1955;30:471—481.
50.
Higier A.: Endothelioma psammosum am Boden des III Hirnventrikels und interpendiculare Arachnoidalzyste, einen Tumor des Kleinhirnbrukenwinkels vortauschend. Operation Neurol Zbl1913;32:741—750.
51.
Catayama Y. , Tsubokawa T., Yoshita K.: Cystic menigiomas in infancy. Surg Neurol1986;25:43—48.
52.
Kepes JJ, Goldware S., Leoni R.: Meningioma with pseudoglandular pattern. A case report. J Neuropathol Exp Neurol1983:42:61—68.
53.
Klump TE, McDonald JV: Successful removal of a large meningioma in the three year-old boy. J Neurosurg1971;34:92—94.
54.
Koos WT, Miller MH: Intracanial tumor of infants and children. Stuttgart, Georg Thieme, 1971.
55.
Lecuire J., Lapras C., Tomasi M., et al: Les méningiomes sustentoreales de l'enfant. Neurochirurgie1960;6:147—155.
56.
Lee YY, Lin SR, Horner FA: Third ventricle meningioma mimicking a colloid cyst in a child. AJR Am J Roentgenol1979;132: 669—671.
57.
Markwalder TM, Seiler R., Markwalder R., et al: Meningioma of the anterior part of the third ventricle in a child. Surg Neurol1979;12:29—32.
58.
McCarty CS, Gogela LJ: Meningioma of the sphenoid ridge in a child. J Neurosurg1949;6:182—186.
59.
Merten DF, Gooding CA, Newton TH, et al: Meningioma of childhood and adolescence. J Pediatr1974;84:696—700.
60.
Numaguchi Y. , Hoffman JC, O'Brien MS, et al: Meningiomas in childhood and adolescence . Neurol Med Chir1978;18:119—127.
61.
Paillas JE, Vigoroux R., Piganiol G., et al: Les tumeurs supratentorielles de l'enfant. Neurochirurgie1957;3:165—179.
62.
Palmer H., Murphy E.: Expanding intracranial lesions in childhood. JAMA1952;49:220—227.
63.
Pendl G.: Meningiomas in childhood, In: Klug R, Brock G, Klinger F, Spoerri L (eds): Advances in Neurosurgery 2. New York, Springer, 1975, 121—124.
64.
Piatt JH, Campbell GA, Oakes WJ: Papillary meningioma involving the oculomotor nerve in an infant. Case report . J Neurosurg1986;64:808—812.
65.
Porras CL: Meningioma in the foramen magnum in a boy aged 8 years. J Neurosurg1963;20:167—168.
66.
Raja Reddy D., Sastry Kolluri VR, Subba Rao K., et al: Cystic meningioma in children. Childs Nerv Syst1986 ;2:317—319.
67.
Reigh EE, Decker JT: Meningeal sarcoma in a two week old infant simulating hydrocephalus. J Neurosurg1962;19:427—430.
68.
Roberts B. Jr, Horner FH, McDonald J.: Anterior third ventricle meningioma in a child. ChildsBrain1981;8:145—148.
69.
Roux FX, Rose CS, Reiner D., et al: Les meningiomes du nourrisson et du l'enfant. Neurochirurgie1980;26:341—347.
70.
Russel DS, Ellis Rwb: Circumscribed cerebral tumors in young infants. Arch Dis Child1933;8:329—342.
71.
Sakaki S., Nakagawa K., Kimura H., et al: Intracranial meningioma in infancy. Surg Neurol1987;28:51—70.
72.
Satyanarayana K., Chandy SM, Rao TS, et al: Congenital meningioma with subdural hygroma and porencephaly. A case report. Neurol India1975;23:57—58.
73.
Sciffer J., Mundel G., Lahat E., Schwarmann M., Shental I.Multiple meningiomas in separate neuroaxial compartments in a child. Childs Brain1980;6:281—288.
74.
Sedzimir CB , Frazer AK, Roberts JR: Cranial and spinal meningiomas in a pair of identical twin boys. J Neurol Neurosurg Psychiatry1973;36:368—376.
75.
Smith WA, Fincher EF: Intracranial tumors in children: A preliminary study of 100 cases. South Med J1942;35:547—554.
76.
Solitare GB , Krigman MR: Congenital intracranial neoplasm. A case report and review of the literature. J Neuropathol Exp Neurol1964;23:280—292.
Suematsu K. , Tokuda S., Miyazaki Y.: Intracranial meningioma in a five-month-old infant. Brain Nerve1974;26:453—464.
79.
Sunder-Plassmann M., Jellinger K., Kraus H., et al: Intraventriculare meningioma im Kindesalter . Neurochirurgia (Stuttg) 1971;14: 54—56.
80.
Tamaki N., Kawamura K., Kudo H., et al: Meningioma in the interpeduncular cistern in child. Childs Nerv Syst1985;18:120—124.
81.
Taptas JN: Intracranial meningioma in a four-month-old infant simulating subdural hematoma . J Neurosurg1961;18:120—124.
82.
Teng P., Papatheodoru C.: Suprachiasmal and intraventricular meningiomas in a four-year-old child. J Neurosurg1963;20:174—176.
83.
Tomita T., Radkowski MA, Gonzales-Crussi F., et al: Multiple meningiomas in a child. Surg Neurol1988;29:131—136.
84.
Smith WA, Fincher EF: Intracranial tumors in children: A preliminary study of 100 cases. South Med J1942;35:547—554.
85.
Vigoroux R. , Choux M., Baurand C., et al: Tumeurs de la voute chez l'enfant avec lacune cranienne. Neurochirurgie1964 ;10:231—250.
86.
Waga S., Matsuda M., Baurand C., et al: Multiple meningioma: Report of four cases. J Neurosurg1972;37:348—351.
87.
Wald U., Zagzag D., Umansky F., et al: Hyperostotic meningioma presenting as an asymptomatic forehead bulge in a 7-year-old girl. Eur J Pediatr1985;144.419—420.
88.
Wall A.: Meningiomas within the lateral ventricle. J Neurol Neurosurg Psychiatry1954;17:91—103.
89.
White JC, Bidwell RL, Kubik CS: Meningioma of record size with unusual features. J Neurosurg1950;7:455—460.
90.
Zuleta EB, Londono LR: Meningiomas del IV ventricolo. Acta Neurochir (Wien) 1955;4:228—232.
91.
Artico M., Ferrante L., Cervoni L., Fortuna A.: Pediatric cystic meningioma: Report of three cases. Childs Nerv Syst1995;11:137—140.
92.
Mallucci CL , Parkes SE, Barber P., et al: Paediatric meningeal tumors. Childs Nerv Syst1996;12:582—589.
93.
Kloc W., Imielinski LB, Wasilewski W., et al: Meningiomas of the lateral ventricles of the brain in children . Childs Nerv Syst1998;14:350—353.
94.
Chidambaram B. , Balasubramaniam V.: Meningioma without dural attachment in a child. Childs Nerv Syst1997;13:639—641.
95.
Kobata H., Kondo A., Iwasaki K., et al: Chordoid meningioma in a child. J Neurosurg1998;88:319—323.
96.
Teo Jgc, Goh Kyc, Rosenblum MK, et al: Intraparenchymal clear cell meningioma of the brainstem in a 2-year-old child. Pediatr Neurosurg1998;28:27—30.
97.
Sheick BY, Siqueira E., Dayel F.: Meningioma in children: A report of nine cases and review of the literature . Surg Neurol1996;45:328—335.
98.
Sandberg DI, Edgar MA, Rech L., et al: MIB-1 staining index of pediatric meningiomas. Neurosurgery2001;48:590—597.
99.
Erdincler P., Lena G., Sarioglu AC, et al: Intracranial meningiomas in children: Review of 29 cases. Surg Neurol1998;49:136—141.
100.
Porto-Rondinelli PI, Ribeiro Viana C., Martinez Osorio CA, Treiger Sredni S.: Extenso meningioma atipico na infanzia: relato de caso. Arq Neuropsiquiatr2003;61:1—10.
101.
Martinez-Lage JF, Poza M., Alcaraz J., Molina E.: Giant meningioma of the III ventricle in a child: Case report and review of the literature. Childs Nerv Syst1993;9:306—308.
102.
Hanel RA, Tatsui CE, Araujo JC, et al: Meningiomas em pacientes pediatricos. Relato de 2 casos. Arq Neuropsiquiatr2001;59:1—9.
103.
Blumenthal D., Berho M., Bloomfield S., et al: Childhood meningioma associated with meningioangiomatosis. J Neurosurg1993;78: 287—289.
104.
Amirjamshidi A., Mehrazin M., Abbassioun K.: Meningiomas of the central nervous system occurring below the age of 17: Report of 24 cases not associated with neurofibromatosis and review of the literature. Childs Nerv Syst2000;16:406—416.
105.
Huang PP, Doyle WK, Abbott IR: Atypical meningioma of the third ventricle in a 6-year-old boyNeurosurgery1993;33:312—316.
106.
Davidson GS , Hope JK: Meningeal tumors of childhood. Cancer1989;63:1205—1210.
107.
Glasier CM , Hasain MM, Chadduck W., Boop FA: Meningiomas in children: MR and histopathologic findings. AJNR Am J Neuroradiol1993;14:237—241.
108.
Im SH, Wang KC, Kim SK, et al: Childhood meningioma: Unusual location, atypical radiological findings, and favorable treatment outcome. Childs Nerv Syst2001;17:656—662.
109.
Darling CF , Byrd SE, Reyes-Mugica M., et al: MR of paediatric intracranial meningiomas . AJNR Am J Neuroradiol1994;15: 435—444.
110.
Heiferman KS, Tomita T., Lissner GS, Gonzalez-Crussi F.: Sphenoid wing meningioma causing a proptosis in a child. Pediatr Neurosci1987;13:210—213.
111.
Cho BK, Wang KC, Chang KH, Chi JG: Deep sylvian meningioma in a child. Childs Nerv Syst1990;6:228—230.
112.
Black P.L. :Meningiomas. Neurosurgery1993;32:643—657.
113.
Simpson D. : The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry1957;20:22—39.
114.
Crompton MF , Gautier-Smith PC: The prediction of recurrence in meningiomas . J Neurol Neurosurg Psychiatry1970;33:80—87.
115.
Giombini S. , Solero CL, Lasio G., Morello G.: Immediate and late outcome of operations for parasagittal and falx meningiomas. Surg Neurol1984;21:427—435.
116.
Mirimanoff RO, Dosoretz DE, Linggood RM, et al: Meningioma: Analysis of recurrence and progression following neurosurgical resection. J Neurosurg1985;62:18—24.
117.
Modan B., Mart H., Baidatz D., et al: Radiation-induced head and neck tumors. Lancet1974;1:277—279.
118.
Iacono RP, Apuzzo Mlj, Davis R., Tsai FY: Multiple meningiomas following radiation therapy for medulloblastoma. J Neurosurg1981;55:282—286.
119.
Di Rocco C., Di Rienzo A.: Meningiomas in childhood. Crit RevNeurosurg1999;9:180—188.
120.
Balasubramanian C., Armstrong D., Cheek W., Laurent J.: Postirradiation meningioma in a child. Pediatr Neurosci1988;14:319—323.
121.
Bojsen-Moller M., Knudsen V.: Radiation-induced meningeal sarcoma. A case report with a review of the literature. Acta Neurochir (Wien) 1977;37:147—152.
122.
Ghim TT, Seo JJ, O'Brien M., et al: Childhood intracranial meningiomas after high-dose irradiation . Cancer1993;71:4091—4095.
123.
Ijiry R., Tanaka Y., Hara M., Sekido K.: Radiation-associated xanthomatous meningioma in a child. Childs Nerv Syst2000; 16:304—308.
124.
Katakura R. , Ohara H., Skurai Y.: Malignant meningioma following irradiation therapy for ependymoma. No Shinkei Geka1978 ; 6:935—939.
125.
Kumar RH, Good RR, Skultety FM, et al: Radiation induced neoplasms of the brain. Cancer1987;59:1274—1282.
126.
Mack EE, Wilson CB: Meningiomas induced by high grade cranial irradiation. J Nerosurg1993;79:28—31.
127.
Mann I., Yates PC, Ainslie JP: Unusual case of double orbital tumor. Br J Ophthalmol1953;37:758—762.
128.
Moss SD, Rockswold GL, Chou SN, et al: Radiation-induced meningiomas in pediatric patients. Neurosurgery1988;22: 758—761.
129.
Norwood CW , Kelly DL Jr, Davis CH Jr, Alexander E.: Irradiation-induced mesodermal tumors of the central nervous system: Report of two meningiomas following x-ray treatment for gliomas. Surg Neurol1974;2:161—164.
130.
Soffer D., Pittaluga S., Feiner M., Beller AJ: Intracranial meningiomas following low dose irradiation to the head. J Neurosurg1983;59:1048—1053.
131.
Starshak RJ : Radiation-induced meningioma in children: Report of two cases and review of the literature. Pediatr Radiol1996;26:537—541.
132.
Taschima T. , Fukui M., Nishio S., et al: Radiation-induced meninigiomas and their proliferation activity. Cytokinetic study using bromodeoxyuridine. Acta Neurochir (Wien) 1990; 102:69-72.
133.
Nishio S., Morioka T., Inamura T., et al: Radiation induced brain tumors: Potential late complications of radiation therapy for brain tumors. Acta Neurochir (Wien) 1998;140:763—770.
134.
Lusins JO, Nakagawa H.: Multiple meningiomas evaluated by computed tomography. Neurosurgery1981;9:137—141.
Markwalder TM, Seiler R., Zava DT: Antiestrogenic therapy of meningiomas: A pilot study. Surg Neurol1985;24:245—249.
137.
Winter Jsd: Pediatric meningioma in: Falkner F, Tanner JM (eds): Human Growth, vol 2. London, Ballière Tindall, 1978.
138.
Donnell MS , Meyer GA, Donegan WL: Estrogen-receptor protein in intracranial meningioma. J Neurosurg1979;50:499—502.
139.
Martuza RL , Miller DC, MacLaughlin DT: Estrogen and progesteron binding by cytosolic and nuclear fractions of human meningiomas. J Neurosurg1985;62:750—756.
140.
Salvati M. , Caroli E., Brogna C., et al: High-dose radiation-induced meningiomas. Report of five cases and critical review of the literature. Tumori2003;89:443—447.
141.
Ron E., ModanB., Boice JD, et al: Tumors of the brain and nervous system after radiotherapy in childhood. New Engl J Med1988;319:1033—1039.
142.
Harrison MJ , Wolfe DE, Lau TS, et al: Radiation induced meningiomas, experience at Mount Sinai Hospital and review of the literature. J Neurosurg1991;75:564—574.