We report a 16-month-old girl who presented with global developmental delay and hearing loss. Cranial magnetic resonance imaging demonstrated a pattern that could be interpreted as a "new leukoencephalopathy " Etiologic investigations revealed a positive polymerase chain reaction for cytomegalovirus DNA using her stored Guthrie card, indicating a congenital cytomegalovirus infection. (J Child Neurol 2005;20:525-527).
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References
1.
Demmler GJ: Infectious Diseases Society of America and Centers for Disease Control . Summary of a workshop on surveillance for congenital cytomegalovirus disease. Rev Infect Dis 1991 ;13:315-329.
Ramsey MEB , Miller E., Peckham CS: Outcome of confirmed symptomatic congenital CMV infection. Arch Dis Child1991;66:1068-1069.
4.
Haginoya K., Ohura T., Kon K., et al: Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards. Brain Dev2002;24:710-714.
5.
Malm G., Grondahl EH, Lewensohn-Fuchs I.: Congenital cytomegalovirus infection: A retrospective diagnosis in a child with pachygyria. Pediatr Neurol2000 ;22:407-408.
6.
Williamson WD , Demmler GJ, Percy AK, Catlin FI: Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection. Pediatrics1992;90:862-866.
7.
Johansson PJ , Jonsson M., Ahlfors K., et al: Retrospective diagnostics of congenital cytomegalovirus infection performed by polymerase chain reaction in blood stored on filter paper. Scand J Infect Dis1997;29:465-468.
8.
van der Knaap MS, Vermeulen G., Barkhof F., et al: A pattern of white matter abnormalities on MRI: Polymerase chain reaction on Guthrie cards to link the pattern with congenital CMV. Radiology2004;230:529-536.
9.
Istas AS, Demmler GJ, Dobbins JG, Stewart JA, the National Cytomegalovirus Disease Registry Collaborating Group: Surveillance for congenital cytomegalovirus disease: A report from the National Congenital Cytomegalovirus Disease Registry. Clin Infect Dis1995;20:665-670.
10.
Boesch C., Issakainen J., Kewitz G., et al: Magnetic resonance imaging of the brain in congenital cytomegalovirus infection. Pediatr Radiol1989;19:91-93.
11.
Boppana SB, Fowler KB, Vaid Y., et al: Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection . Pediatrics1997;99:409-414.
Ball WS: Pediatric Neuroradiology. New York: Lippincott-Raven, 1997,276-277.
14.
van der Knaap MS, Valk J., Barth PG, et al: Leukoencephalopathy with swelling in children and adolescents: MRI pattern and differential diagnosis . Neuroradiology1995;37:679-683.
15.
Alford A., Stagno S., Pass RF, Britt WJ: Congenital and perinatal cytomegalovirus infections. Rev Infect Dis1990;12:745-753.
16.
Binda S., Caroppo S., Dido P., et al: Cytomegalovirus DNA detection on Guthrie cards: A useful method to identify hearing loss cases due to congenital infection. Int Pediatr2001;16:1-3.
