The case of an adolescent with Kleine-Levin syndrome is presented who exhibited a consistent and predictable photoparoxysmal self-limited response to intermittent photic stimulation during all relapses of his hypersomnic phase. A possible cause of this association that has not been previously reported is speculated based on observations concerning the two disorders. (J Child Neurol 2003;18:432—433).
Get full access to this article
View all access options for this article.
References
1.
Reynolds CF, Kupfer DJ, Christiansen CL, et al: Multiple Sleep Latency Test findings in Kleine-Levin syndrome . J Nerv Ment Dis1984;172:41—44.
2.
McGilchrist I., Goldstein LH, Jadresic D., et al: Thalamo-frontal psychosis. Br J Psychiatry1993;163:113—115.
3.
Papacostas SS , Hadjivasilis V.: The Kleine-Levin syndrome. Report of a case and review of the literature. Eur Psychiatry2000;15:231—235.
4.
Wilkus RJ, Chiles JA: Electrophysiological changes during episodes of the Kleine-Levin syndrome . J Neurol Neurosurg Psychiatry1975; 38:1225—1231.
5.
Green LN, Cracco RQ: Kleine-Levin syndrome. A case with EEG evidence of periodic brain dysfunction . Arch Neurol1970;22:166—175.
6.
Elian M., Bornstein B.: The Kleine-Levin syndrome with intermittent abnormality in the EEG . Electroencephalogr Clin Neurophysiol1969 ;27:601—604.
7.
Daly DD: Epilepsy and Syncope, in Daly DD, Pedley TA (eds): Current Practice of Clinical Electroencephalography, 2nd ed. New York, Raven Press, 1990, 321—324.
8.
So EL, Ruggles KH, Ahmann PA, et al: Prognosis of photoparoxysmal response in nonepileptic patients . Neurology1993;43:1719—1722.
9.
Takahashi Y. , Fujiwara T., Yagi K., et al: Photosensitive epilepsies and pathophysiologic mechanisms of the photoparoxysmal response . Neurology1999;53:926—932.
10.
Reilly EW, Peters JF: Relationship of some varieties of electroencephalographic photosensitivity to clinical convulsive disorders. Neurology1977;23:1040—1057.
11.
Fernandez JM , Lara I., Gila L., et al: Disturbed hypothalamic-pituitary axis in idiopathic recurring hypersomnia syndrome. Acta Neurol Scand1990;82:361—363.
12.
Malhotra S. , Kumar Das M., Gupta N., et al: A clinical study of Kleine-Levin syndrome with evidence for hypothalamic-pituitary axis dysfunction . Biol Psychiatry1997;42:299—301.
13.
Chesson AL, Levine SN, Kong Ls, et al: Neuroendocrine evaluation in Kleine-Levin syndrome: Evidence of reduced dopaminergic tone during periods of hypersomnolence. Sleep1991;14:226—232.
14.
Livrea P., Puca FM, Barnaba A., et al: Abnormal central monoamine metabolism in humans with “true hypersomnia” and “sub-wakefulness.” Eur Neurol1977;15:71—76.
15.
Koerber RK, Torkelson R., Haven G., et al: Increased cerebrospinal fluid 5-hydroxyptryptamine and 5-hydroxyindoleacetic acid in Kleine-Levin syndrome. Neurology1984 ;34:1597—1600.
16.
Chesson AL, Lenine SN: Neuroendocrine function and sleep evaluations in the Kleine-Levin syndrome . Sleep Res1989;18:88.
17.
Gloor P.: Electrophysiology of generalized epilepsy, in Schwartzcroin PA, Wheal H (eds): Electrophysiology of Epilepsy. New York, Academic Press, 1984, 107—136.