Microcephaly,Cerebellar Atrophy,and Focal Segmental Glomerulosclerosis in Two Brothers: A Possible Mild Form of Galloway-Mowat Syndrome

Abstract

We report two brothers with microcephaly, cerebellar atrophy, and focal segmental glomerulosclerosis. The elder brother showed nephrotic syndrome from 2 years of age and died of renal failure at 8 years of age. The younger brother showed mild proteinuria from 2 years of age, and his renal function was still preserved at 15 years of age. We propose that our patients may be affected with a mild form of Galloway-Mowat syndrome or another autosomal recessive syndrome with focal segmental glomerulosclerosis and central nervous system abnormalities. ( J Child Neurol 2003;18:147—149).

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