Pediatric movement disorders constitute a relatively small cluster of symptoms that can be associated with many different underlying diseases. To provide effective treatment, it is essential to understand the relationship between etiology and clinical expression. This article reviews the recent literature on several common pediatric movement disorders, including spasticity, dystonia, chorea, myoclonus, bradykinesia, and tics, and it discusses current models of physiology that may help link the cellular pathology of specific diseases to the expression of clinical symptoms. (J Child Neurol 2003:18:S9—S24).
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References
1.
Sanger T., Delgado M., Gaebler-Spira D., et al: Classification and definition of disorders causing hypertonia in childhood. Pediatrics2003;111:e89—e97.
2.
Crothers B., Paine R.: The NaturalHistory of Cerebral Palsy. Vol 2, Classics in Developmental Medicine, Mitchell R (ed). Philadelphia, JB Lippincott, 1959.
3.
Wagley PF: A study of spasticity and paralysis. Bull Johns Hopkins Hosp1945;77:218—273.
4.
Myklebust BM , Gottlieb GL, Penn RD, Agarwal GC: Reciprocal excitation of antagonistic muscles as a differentiating feature in spasticity. Ann Neurol1982; 12: 367—374.
5.
Leonard CT, Hirschfield H., Moritoni T., Forssberg H.: Myotatic reflex development in normal children and children with cerebral palsy. Exp Neurol1991;111:379—382.
6.
Lance JW: Pathophysiology of spasticity and clinical experience with baclofen, in Feldman RG, Young RR, Koella WP (eds): Spasticity: Disordered Motor Control. Chicago, Year Book Medical Publishers, 1980, 185—220.
7.
O'Dwyer NJ, Ada L., Neilson PD: Spasticity and muscle contracture following stroke. Brain1996:119(Pt 5):1737—1749.
8.
Sinkjaer T., Toft E., Larsen K., et al: Non-reflex and reflex mediated ankle joint stiffness in multiple sclerosis patients with spasticity. Muscle Nerve1993;16:69—76.
9.
Dietz V., Trippel M., Berger W.: Reflex activity and muscle tone during elbow movements in patients with spastic paresis. Ann Neurol1991;30:767—779.
10.
Burke D.: Spasticity as an adaptation to pyramidal tract injury. Adv Neurol1988;47:401—423.
11.
Dietz V.: Supraspinal pathways and the development of muscle-tone dysregulation. Dev Med Child Neurol1999;41:708—715.
12.
Hiersemenzel LP, Curt A., Dietz V.: From spinal shock to spasticity: N e u r o n a l a d a p t a t i o n s t o a s p i n a l c o r d i n j u r y. N e u r o l o g y2000;54:1574—1582.
13.
Katz RT, Rymer WZ: Spastic hypertonia: Mechanisms and measurement. Arch Phys Med Rehabil1989;70:144—155.
14.
Jobin A., Levin MF: Regulation of stretch reflex threshold in elbow flexors in children with cerebral palsy: a new measure of spasticity. Dev Med Child Neurol2000;42:531—540.
15.
Levin MF, Feldman AG: The role of stretch reflex threshold regul a t i o n i n n o r m a l a n d i m p a i r e d m o t o r c o n t r o l . B r a i n R e s1994;657:23—30.
16.
Lin FM, Sabbahi M.: Correlation of spasticity with hyperactive stretch reflexes and motor dysfunction in hemiplegia. Arch Phys Med Rehabil1999;80:526—530.
17.
Mayer NH: Clinicophysiologic concepts of spasticity and motor dysfunction in adults with an upper motoneuron lesion. Muscle Nerve Suppl1997;6:S1—S13.
18.
O'Dwyer NJ, Ada L.: Reflex hyperexcitability and muscle contract u r e i n r e l a t i o n t o s p a s t i c h y p e r t o n i a . C u r r O p i n N e u r o l1996;9:451—455.
19.
Sheean G.: The pathophysiology of spasticity. Eur J Neurol2002:9(Suppl 1):3—9; discussion 53—61.
20.
Brown P.: Pathophysiology of spasticity. J Neurol Neurosurg Psychiatry1994;57:773—777.
21.
Dietz V.: Human neuronal control of automatic functional movements: interaction between central programs and afferent input. Physiol Rev1992;72:33—69.
22.
Sheean GL: Botulinum treatment of spasticity: why is it so difficult t o s h o w a f u n c t i o n a l b e n e f i t ? C u r r O p i nNeurol2 0 0 1; 14:771—776.
23.
Hinderer SR , Dixon K.: Physiologic and clinical monitoring of spas-t i c h y p e r t o n i a . P h y s M e d R e h a b i l C l i n N o r t h A m2 0 0 1; 12:733—746.
24.
Back SA, Han BH, Luo NL, et al: Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia. J Neurosci2002;22: 455—463.
25.
Dewald JP, Pope PS, Given JD, et al: Abnormal muscle coactivation patterns during isometric torque generation at the elbow and shoulder in hemiparetic subjects. Brain1995;118(Pt 2):495—510.
26.
Kuchler M., Fouad K., Weinmann O., et al: Red nucleus projections to distinct motor neuron pools in the rat spinal cord. J Comp Neurol2002;448:349—359.
27.
Yeomans JS, Li L., Scott BW, Frankland PW: Tactile, acoustic and vestibular systems sum to elicit the startle reflex . Neurosci Biobehav Rev2002;26:1—11.
28.
Heffner R., Masterton B.: Variation in form of the pyramidal tract and its relationship to digital dexterity . Brain Behav Evol1975; 12: 161—200.
29.
Heffner RS, Masterton RB: The role of the corticospinal tract in the e v o l u t i o n o f h u m a n d i g i t a l d e x t e r i t y. B r a i n B e h a v E v o l1983;23:165—183.
30.
Chen XY, Feng-Chen KC, Chen L., et al: Short-term and medium-term effects of spinal cord tract transections on soleus H-reflex in freely moving rats. J Neurotrauma2001;18:313—327.
31.
Maier MA, Oliver E., Baker SN, et al: Direct and indirect corticospinal control of arm and hand motoneurons in the squirrel monkey (Saimiri sciureus). J Neurophysiol1997; 78: 721—733.
32.
Iwaniuk AN, Pellis SM, Whishaw IQ: Is digital dexterity really related to corticospinal projections?: A re-analysis of the Heffner and Masterton data set using modern comparative statistics . Behav Brain Res1999;101:173—187.
33.
Young RR: Spasticity: A review. Neurology1994;44(11 Suppl 9):S12—S20.
34.
Petersen MC, Palmer FB: Advances in prevention and treatment of cerebral palsy. Ment Retard Dev Disabil Res Rev2001;7(1):30—37.
35.
Hill AV: The mechanics of active muscle. Proc R Soc Lond B Biol Sci1953;141:104—117.
36.
Noth J., Schwarz M.: Muscle tone: The neurophysiological basis and pathological changes. KlinNeurophysiol1999;30:69—80.
37.
Tardieu C., Lacert P., Lombard M., et al: H reflex and recovery cycle in spastic and normal children: intra- and inter-individual and inter-groups comparisons. Arch Phys Med Rehabil1977;58:561—567.
38.
Hagberg B.: Pre-, peri- and postnatal prevention of major neuropediatric handicaps. Neuropadiatrie1975;6:331—338.
39.
Kyllerman M. , Bager B., Bensch J., et al: Dyskinetic cerebral palsy. I. Clinical categories, associated neurological abnormalities and incidences. Acta Paediatr Scand1982;71:543—550.
40.
Kyllerman M. : Dyskinetic cerebral palsy. II. Pathogenetic risk factors a n d i n t r a - u t e r i n e g r o w t h . A c t a P a e d i a t r S c a n d1 9 8 2; 71:551—558.
41.
Kyllerman M. : Reduced optimality in pre- and perinatal conditions in dyskinetic cerebral palsy—Distribution and comparison to controls . Neuropediatrics1983;4:29—36.
42.
Nordmark E. , Hagglund G., Lagergren J.: Cerebral palsy in southern Sweden II. Gross motor function and disabilities. Acta Paediatr2001;90:1277—82.
43.
Nordmark E. , Hagglund G., Lagergren J.: Cerebral palsy in southern Sweden I. Prevalence and clinical features. Acta Paediatr2001;90:1271—1276.
44.
Lehericy S. , Vidailhet M., Dormont D., et al: Striatopallidal and thalamic dystonia. A magnetic resonance imaging anatomoclinical study. Arch Neurol1996;53:241—250.
45.
Karsidag S. , Ozer F., Sen A., Arpaci B.: Lesion localization in developing poststroke hand dystonia. Eur Neurol1998; 40: 99—104.
46.
Lenz FA, Suarez JI, Metman LV, et al: Pallidal activity during dystonia: Somatosensory reorganisation and changes with severity. J Neurol Neurosurg Psychiatry1998;65:767—770.
47.
Hallett M.: Physiology of dystonia. Adv Neurol1998;78:11—18.
48.
Hallett M.: The neurophysiology of dystonia. Arch Neurol1998; 55:601—603.
49.
John B., Klemm E., Haverkamp F.: Evidence for altered basal ganglia and cortical functions in transient idiopathic dystonia. J Child Neurol2000;15:820—822.
50.
Krageloh-Mann I., Helber A., Mader I., et al: Bilateral lesions of thalamus and basal ganglia: Origin and outcome. Dev Med Child Neurol2002;44:477—484.
51.
Bara-Jimenez W., Shelton P., Sanger TD, Hallett M.: Sensory discrimination capabilities in patients with focal hand dystonia. Ann Neurol2000;47:377—380.
52.
Sanger TD, Pascual-Leone A., Tarsy D., Schlaug G.: Nonlinear sensory cortex response to simultaneous tactile stimuli in writer's cramp. Mov Disord2002;17:105—111.
53.
Sanger TD, Tarsy D., Pascual-Leone A.: Abnormalities of spatial and temporal sensory discrimination in writer's cramp . Mov Disord2001;16:94—99.
54.
Bara-Jimenez W., Shelton P., Hallett M.: Spatial discrimination is abnormal in focal hand dystonia. Neurology2000;55:1869—1873.
55.
Bara-Jimenez W., Catalan MJ, Hallett M., Gerloff C.: Abnormal somatosensory homunculus in dystonia of the hand. Ann Neurol1998;44:828—831.
56.
Hallett M.: Is dystonia a sensory disorder?Ann Neurol1995; 38:139—140.
57.
Sanger TD, Merzenich MM: Computational model of the role of sensory disorganization in focal task-specific dystonia. J Neurophysiol2000;84:2458—2464.
58.
Lenz FA, Byl NN: Reorganization in the cutaneous core of the human thalamic principal somatic sensory nucleus (ventral caudal) in patients with dystonia. J Neurophysiol1999;82:3204—3212.
59.
Lenz FA, Jaeger CJ, Seike MS, et al: Thalamic single neuron activity in patients with dystonia: Dystonia-related activity and somatic sensory reorganization. J Neurophysiol1999;82:2372—2392.
60.
Pizoli CE, Jinnah HA, Billingsley ML, Hess EJ: Abnormal cerebellar signaling induces dystonia in mice. J Neurosci2002;22:7825—7833.
61.
Alarcon F., Tolosa E., Munoz E.: Focal limb dystonia in a patient with a cerebellar mass. Arch Neurol2001;58:1125—1127.
62.
Mink JW: The basal ganglia: focused selection and inhibition of competing motor programs . Prog Neurobiol1996;50:381—425.
63.
Tijssen MA, Marsden JF, Brown P.: Frequency analysis of EMG activity in patients with idiopathic torticollis . Brain2000:123(Pt 4):677—686.
64.
Berardelli A., Rothwell JC, Hallett M., et al: The pathophysiology of primary dystonia . Brain1998;121(Pt 7):1195—1212.
65.
Nobrega JN, Richter A., Tozman N., et al: Quantitative autoradiography reveals regionally selective changes in dopamine D1 and D2 receptor binding in the genetically dystonic hamster . Neuroscience1996;71:927—937.
66.
Burgunder J. , Richter A., Loscher W.: Expression of cholecystokinin, somatostatin, thyrotropin-releasing hormone, glutamic acid decarboxylase and tyrosine hydroxylase genes in the central nervous motor systems of the genetically dystonic hamster . Exp Brain Res1999;129:114—120.
67.
Peacock L., Lublin H., Gerlach J.: The effects of dopamine D1 and D2 receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment. Eur J Pharmacol1990; 186: 49—59.
68.
Segawa M., Hosaka F., Miyagawa F., et al: Hereditary progressive dystonia with marked diurnal fluctuation . Adv Neurol1976; 14:215—233.
Reiner A., Albin RL, Anderson KD, et al: Differential loss of striatal projection neurons in Huntington disease. Proc Natl Acad Sci U S A1988;85:5733—5737.
74.
Casey DE: Dopamine D1 (SCH 23390) and D2 (haloperidol) antagonists in drug-naive monkeys . Psychopharmacology1992; 107:18—22.
75.
Gerlach J., Kistrup K., Korsgaard S.: Effect of selective D1 and D2 dopamine receptor antagonists and agonists in Cebus monkeys: Implications for acute and tardive dyskinesias. A preliminary report. Psychopharmacol Ser1987;3:236—242.
76.
Kistrup K.Gerlach J.: Selective D1 and D2 receptor manipulation in Cebus monkeys: Relevance for dystonia and dyskinesia in humans. Pharmacol Toxicol1987;61:157—161.
77.
Albin RL, Young AB, Penney JB: The functional anatomy of basal ganglia disorders. Trends Neurosci1989;12:366—375.
78.
Alexander GE,Crutcher MD: Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci1990;13:266—271.
79.
DeLong MR: Primate models of movement disorders of basal ganglia origin. Trends Neurosci1990;13:281—285.
80.
Fahn S.: Systemic therapy of dystonia. Can J Neurol Sci1987;14(3 Suppl):528—532.
81.
Burke RE, Fahn S., Marsden CD: Torsion dystonia: A double-blind, prospective trial of high-dosage trihexyphenidyl . Neurology1986;36:160—164.
82.
Burke RE, Fahn S.: Serum trihexyphenidyl levels in the treatment of torsion dystonia. Neurology1985;35:1066—1069.
83.
Fahn S.: High dosage anticholinergic therapy in dystonia. Neurology1983;33:1255—1261.
84.
Burke RE, Fahn S.: Double-blind evaluation of trihexyphenidyl in dystonia. Adv Neurol1983;37:189—192.
85.
Fahn S.: High-dosage anticholinergic therapy in dystonia. Adv Neurol1983;37:177—188.
86.
de la Vega MT, Nunez A., Arias Montano JA: Muscarinic M-1 and M-3 receptors in rat striatum: A binding study. Arch Med Res1997;28:493—497.
87.
Hussain N., Flumerfelt BA, Rajakumar N.: Muscarinic, adenosine A(2) and histamine H(3) receptor modulation of haloperidol-induced c-fos expression in the striatum and nucleus accumbens. Neuroscience2002;112:427—438.
88.
Puri SK, Volicer L., Choma P.: Effect of dopamine and acetylcholine-receptor agonists and antagonists on cyclic nucleotide levels in rat cerebellum and striatum. Pharmacologist1976;18:131.
89.
Galarraga E. , Hernandez-Lopez S., Reyes A., et al: Cholinergic modulation of neostriatal output: A functional antagonism between different types of muscarinic receptors . J Neurosci1999; 19:3629-3638.
Burke RE, Fahn S., Gold AP: Delayed-onset dystonia in patients with “static” encephalopathy . J Neurol Neurosurg Psychiatry1980;43:789—797.
92.
Scott BL, Jankovic J.: Delayed-onset progressive movement disorders after static brain lesions. Neurology1996;46:68—74.
93.
Kumar R., Dagher A., Hutchinson WD, et al: Globus pallidus deep brain stimulation for generalized dystonia: Clinical and PET investigation. Neurology1999;53:871—874.
94.
Volkmann J. , Benecke R.: Deep brain stimulation for dystonia: Patient selection and evaluation. Mov Disord2002;17(Suppl 3): S112—S115.
95.
Vercueil L. , Krack P., Pollak P.: Results of deep brain stimulation for dystonia: A critical reappraisal. Mov Disord2002;17(Suppl 3):S89—S93.
96.
Roubertie A. , Echenne B., Cif L., et al: Treatment of early-onset dystonia: Update and a new perspective. Childs Nerv Syst2000; 16:334—340.
97.
Coubes P., Roubertie A., Vayssiere N., et al: Treatment of DYT1-generalised dystonia by stimulation of the internal globus pallidus. Lancet2000;355:2220—2221.
98.
Centonze D. , Picconi B., Gubellini P., et al: Dopaminergic control of synaptic plasticity in the dorsal striatum. Eur J Neurosci2001 ;13:1071—1077.
99.
Calabresi P. , Pisani A., Centonze D., Bernardi G.: Role of dopamine receptors in the short- and long-term regulation of corticostriatal transmission. Nihon Shinkei Seishin Yakurigaku Zasshi1997;17:101—104.
100.
Calabresi P., Pisani A., Centonze D., Bernardi G.: Synaptic plasticity and physiological interactions between dopamine and glutamate in the striatum. Neurosci Biobehav Rev1997;21:519—523.
101.
Calabresi P., Saiardi A., Pisani A., et al: Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors. J Neurosci1997;17:4536—4544.
102.
Calabresi P., Pisani A., Mercuri NB, Bernardi G.: Long-term potentiation in the striatum is unmasked by removing the voltage-dependent magnesium block of NMDA receptor channels. Eur J Neurosci1992;4:929—935.
103.
Calabresi P., Maj R., Pisani A., et al: Long-term synaptic depression in the striatum: Physiological and pharmacological characterization. J Neurosci1992;12:4224—4233.
104.
Narabayashi H.: The neural mechanisms and progressive nature of symptoms of Parkinson's disease—Based on clinical, neurophysiological and morphological studies. J Neural Transm Park Dis Dement Sect1995;10:63—75.
105.
Yokochi M. : Familial juvenile parkinsonism. Eur Neurol1997;38(Suppl 1):29—33.
106.
Gibb WR: Functional neuropathology in Parkinson's disease. Eur Neurol1997;38(Suppl 2):21—25.
107.
Kingston D. : Tetrabenazine for involuntary movement disorders . Med J Aust1979;1:628—630.
108.
Marsden CD , Marion MH, Quinn N.: The treatment of severe dystonia in children and adults. J Neurol Neurosurg Psychiatry1984;47:1166—1173.
109.
Jankovic J. , Orman J.: Tetrabenazine therapy of dystonia, chorea, tics, and other dyskinesias. Neurology1988 ;38:391—394.
Berardelli A., Rothwell JC, Thompson PD, Hallett M.: Pathophysiology of bradykinesia in Parkinson's disease. Brain2001:124(Pt 11):2131—2146.
112.
Hallett M. , Khoshbin S.: A physiological mechanism of bradykinesia . Brain1980;103:301—314.
113.
Hallett M. , Shahani BT, Young RR: Analysis of stereotyped voluntary movements at the elbow in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry1977;40:1129—1135.
114.
Hallett M. : Clinical neurophysiology of akinesia. Rev Neurol1990;146:585—590.
115.
Nagatsu T. , Ichinose H.: GTP cyclohydrolase I gene, dystonia, juvenile parkinsonism, and Parkinson's disease. J Neural Transm Suppl1997;49:203—209.
116.
Segawa M., Nomura Y., Kase M.: Hereditary progressive dystonia with marked diurnal fluctuation: Clinicopathophysiological identification in reference to juvenile Parkinson's disease. Adv Neurol1987;45:227—234.
117.
Olanow CW, Brin MF, Obeso JA: The role of deep brain stimulation as a surgical treatment for Parkinson's disease. Neurology2000;55(12 Suppl 6):S60—S66.
118.
Lang AE: Surgery for levodopa-induced dyskinesias. Ann Neurol2000;47(4 Suppl 1):S193—S199; discussion S199—S202.
119.
Levesque MF , Taylor S., Rogers R., et al: Subthalamic stimulation in Parkinson's disease. Preliminary results. Stereotact Funct Neurosurg1999;72:170—173.
120.
Burchiel KJ , Anderson VC, Favre J., Hammerstad JP: Comparison of pallidal and subthalamic nucleus deep brain stimulation for advanced Parkinson's disease: Results of a randomized, blinded pilot study. Neurosurgery1999;45:1375—1382; discussion 1382—1384.
121.
Nutt JG, Rufener SL, Carter JH, et al: Interactions between deep brain stimulation and levodopa in Parkinson's disease. Neurology2001;57:1835—1842.
122.
Wu YR, Levy R., Ashby P., et al: Does stimulation of the GPi control dyskinesia by activating inhibitory axons?Mov Disord2001;16:208—216.
123.
Berardelli A., Noth J., Thompson PD, et al: Pathophysiology of chorea a n d b r a d y k i n e s i a i n H u n t i n g t o n 's d i s e a s e . M o v D i s o r d1999;14:398—403.
124.
Genel F., Arslanoglu S., Uran N., Saylan B.: Sydenham's chorea: Clinical findings and comparison of the efficacies of sodium valproate and carbamazepine regimens. Brain Dev2002;24:73—76.
125.
Visvanathan K. , Trifiletti RR, Altemus M., Zabriskie JB, et al: Autoimmune mechanisms in movement disorders. SeminPediatr Neurol2000;7:103—107.
126.
Font J., Cervera R., Espinosa G., et al: Systemic lupus erythematosus (SLE) in childhood: Analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults. Ann Rheum Dis1998 ;57:456—459.
127.
Louis ED, Lynch T., Cargan AL, Fahn S.: Generalized chorea in an infant with semilobar holoprosencephaly. Pediatr Neurol1995;13:355—357.
128.
Pranzatelli MR : Movement disorders in childhood. Pediatr Rev1996;17:388—394.
129.
Woods CG, Taylor AM: Ataxia telangiectasia in the British Isles: The clinical and laboratory features of 70 affected individuals. QJM1992;82:169—179.
130.
Singer HS: Current issues in Tourette syndrome. Mov Disord2000;15:1051—1063.
131.
Singer HS, Giuliano JD, Zimmerman AM, Walkup JT: Infection: A stimulus for tic disorders. Pediatr Neurol2000;22:380—383.
132.
Hoekstra PJ , Kallenberg CG, Korf J., Minderoa RB: Is Tourette's syndrome an autoimmune disease?Mol Psychiatry2002;7:437—445.
133.
Murphy ML, Pichichero ME: Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS). Arch Pediatr Adolesc Med2002;156:356—361.
134.
Bottas A., Richter MA: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). Pediatr Infect Dis J2002;21:67—71.
135.
Orvidas LJ , Slattery MJ: Pediatric autoimmune neuropsychiatric disorders and streptococcal infections: Role of otolaryngologist. Laryngoscope2001;111:1515—1519.
136.
Leonard HL , Swedo SE: Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Int J Neuropsychopharmacol2001;4:191—198.
137.
Muller N., Kroll B., Schwarz MJ, et al: Increased titers of antibodies against streptococcal M12 and M19 proteins in patients with Tourette's syndrome. Psychiatry Res2001;101:187—193.
138.
Rosenberg KP: Tourette's syndrome and `PANDAS.' Neurology1998;51:1516.
139.
Swedo SE, Leonard HL, Mittleman BB, et al: Identification of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections by a marker associated with rheumatic fever. Am J Psychiatry1997 ;154:110—112.
140.
Kossoff EH , Singer HS: Tourette syndrome: Clinical characteristics and current management strategies. PaediatrDrugs2001;3: 355—363.
141.
Singer HS: Neurobiology of Tourette syndrome. Neurol Clin1997;15:357—79.
142.
Lees AJ, Robertson M., Trimble MR, Murray NM: A clinical study of Gilles de la Tourette syndrome in the United Kingdom. J Neurol Neurosurg Psychiatry1984;47:1—8.
143.
Dulac O., Plouin P., Shewmon A.: Myoclonus and epilepsy in childhood: 1996 Royaumont meeting. Epilepsy Res1998;30:91—106.
144.
Schor NF: Nervous system dysfunction in children with paraneoplastic syndromes. J Child Neurol1992;7:253—258.
145.
Plioplys AV , Greaves A., Yoshida W.: Anti-CNS antibodies in childhood neurologic diseases. Neuropediatrics1989;20:93—102.
146.
Lopez-Ibor B., Schwartz AD: Neuroblastoma. Pediatr Clin North Am1985;32:755—778.
Rapin I.: Myoclonus in neuronal storage and Lafora diseases. Adv Neurol1986;43:65—85.
149.
Niedermeyer E., Fineyre F., Riley T., Bird B.: Myoclonus and the electroencephalogram, a review. Clin Electroencephalogr1979;10: 75—95.
150.
Wallace SJ : Myoclonus and epilepsy in childhood: A review of treatment with valproate, ethosuximide, lamotrigine and zonisamide. Epilepsy Res1998;29:147—154.
151.
Fukuhara N. , Tokiguchi S., Shirakawa K., Tsubaki T.: Myoclonus epilepsy associated with ragged-red fibres (mitochondrial abnormalities ): Disease entity or a syndrome? Light-and electron-microscopic studies of two cases and review of literature. J Neurol Sci1980;47:117—133.
152.
Garg RK: Subacute sclerosing panencephalitis. Postgrad Med J2002;78:63—70.
Becher MW, Rubinsztein DC, Leggo J., et al: Dentatorubral and pallidoluysian atrophy (DRPLA). Clinical and neuropathological findings in genetically confirmed North American and European pedigrees. Mov Disord1997; 12:519-530.
155.
Oguni H., Fukuyama Y., Tanaka T., et al: Myoclonic-astatic epilepsy of early childhood—Clinical and EEG analysis of myoclonic-astatic seizures, and discussions on the nosology of the syndrome. Brain Dev2001;23:757—764.
156.
Oguni, H., Hayashi K., Awaya Y., et al: Severe myoclonic epilepsy in infants—A review based on the Tokyo Women's Medical University series of 84 cases. Brain Dev2001;23:736—748.
Fejerman N. : Myoclonus and epilepsies. Indian J Pediatr1997; 64:583—602.
159.
Minassian BA, Sainz J., Delgado-Escueta AV: Genetics of myoclonic and myoclonus epilepsies. Clin Neurosci1995 ;3:223—235.
160.
Buchhalter JR: Inherited epilepsies of childhood. J Child Neurol1994;9(Suppl 1):S12—S19.
161.
Panzica F. , Rubboli G., Franceschetti S., et al: Cortical myoclonus in Janz syndrome . Clin Neurophysiol2001;112:1803—1809.
162.
Hallett M. : Myoclonus: Relation to epilepsy. Epilepsia1985;26(Suppl 1):S67—S77.
163.
Livingston S.: Diagnosis and treatment of childhood myoclonic seizures. Pediatrics1974;53:542—548.
164.
Cockerell OC, Rothwell J., Thompson PD, et al: Clinical and physiological features of epilepsia partialis continua. Cases ascertained in the UK. Brain1996;119(Pt 2):393—407.
165.
Hallett M. : Physiology of human posthypoxic myoclonus. Mov Disord2000;15(Suppl 1):8—13.
166.
Rizvi AH, Karetzky MS: Action myoclonus after cerebral anoxia. N J Med1993;90:918—920.
167.
Kuzniecky R., Berkovic S., Andermann F., et al: Focal cortical myoclonus and rolandic cortical dysplasia: Clarification by magnetic resonance imaging. Ann Neurol1988;23:317—325.
168.
Wallace SJ : Management issues in severe childhood epilepsies . Seizure1995;4:215—220.
169.
Shibasaki H.: Electrophysiological studies of myoclonus . Muscle Nerve2000;23:321—335.
170.
Ikeda A., Kakigi R., Funai N., et al: Cortical tremor: A variant of cortical reflex myoclonus. Neurology1990;40:1561—1565.
171.
Shibasaki H., Yamashita Y., Tobimatsu S., Neshige R.: Electroencephalographic correlates of myoclonus . Adv Neurol1986;43: 357—372.
172.
Shibasaki H., Neshige R., Hashiba Y.: Cortical excitability after myoclonus: Jerk-locked somatosensory evoked potentials. Neurology1985;35:36—41.
173.
Hallett M. , Chadwick D., Marsden CD: Cortical reflex myoclonus. Neurology1979;29:1107—1125.
174.
Goetz CG, Carvey PM, Pappert EJ, et al: The role of the serotonin system in animal models of myoclonus . Adv Neurol2002;89:244—248.
175.
Darko W., Guharoy R., Rose F., et al: Myoclonus secondary to the concurrent use of trazodone and fluoxetine . Vet Hum Toxicol2001;43:214—215.
176.
Pappert EJ , Goetz CG, Vu TQ, et al: Animal model of posthypoxic myoclonus: Effects of serotonergic antagonists. Neurology1999;52:16—21.
177.
Pappert EJ , Goetz CG, Stebbins GT, et al: 5-Hydroxytryptophaninduced myoclonus in guinea pigs: Mediation through 5-HT1/2 receptor subtypes. Eur J Pharmacol1998; 347: 51—56.
178.
Gambardella A. , Quattrone A.: Treatment of palatal myoclonus with sumatriptan . Mov Disord1998;13:195.
179.
Jaw SP, Dang T., Truong DD: Chronic treatments with 5-HT1A agonists attenuate posthypoxic myoclonus in rats. Pharmacol Biochem Behav1995;52:577—580.
180.
Pranzatelli MR : The pharmacology of antimyoclonic drugs. Clin Neurosci1995;3:246—252.
181.
Pranzatelli MR : Serotonin and human myoclonus. Rationale for the use of serotonin receptor agonists and antagonists. Arch Neurol1994;51:605—617.
182.
Franz DN: Tremor in childhood. Pediatr Ann1993;22:60—64.
183.
Pranzatelli MR , Mott SH, Pavlakis SG, et al: Clinical spectrum of secondary parkinsonism in childhood: A reversible disorder. Pediatr Neurol1994;10:131—140.
Macfarlane PI , Walters M., Stutchfield P., Smith CS: A prospective study of symptomatic hypoglycaemia in childhood diabetes. Diabet Med1989;6:627—630.
186.
Yancey CL, Doughty RA, Athreya BH: Central nervous system involvement in childhood systemic lupus erythematosus . Arthritis Rheum1981;24:1389—1395.
187.
Louis ED, Dure LS, Pullman S.: Essential tremor in childhood: A series of nineteen cases. Mov Disord2001; 16:921-923.
Growdon JH , Shahani BT, Young RR: The effect of alcohol on essential tremor . Neurology1975;25:259—262.
190.
Koster B., Deuschl G., Lauk M., et al: Essential tremor and cerebellar dysfunction: Abnormal ballistic movements. J Neurol Neurosurg Psychiatry2002 ;73:400—405.
191.
Deuschl G. , Bergman H.: Pathophysiology of nonparkinsonian tremors . Mov Disord2002;17(Suppl 3):S41—S48.
192.
Milanov I. : Motoneuron activity in patients with different types of tremor. Electromyogr Clin Neurophysiol2001;41:479—484.
193.
Deuschl G. , Raethjen J., Lindemann M., Krack P.: The pathophysiology of tremor. Muscle Nerve2001;24:716—735.
194.
Hallett M. : Overview of human tremor physiology. Mov Disord1998;13(Suppl 3):43—48.
195.
Lozano AM: Vim thalamic stimulation for tremor. Arch Med Res2000;31:266—269.
196.
Blond S., Ceparros-Lefebre D., Parker F., et al: Control of tremor and involuntary movement disorders by chronic stereotactic stimulation of the ventral intermediate thalamic nucleus. J Neurosurg1992;77:62—68.
197.
Calzetti S. , Baratti M., Gresty M., Findley L.: Frequency/amplitude characteristics of postural tremor of the hands in a population of patients with bilateral essential tremor: Implications for the classification and mechanism of essential tremor. J Neurol Neurosurg Psychiatry1987;50:561—567.
198.
Lauk M., Timmer J., Guschlbauer B., et al: Variability of frequency and phase between antagonistic muscle pairs in pathological human tremors. Muscle Nerve2001;24:1365—1370.
199.
Akbostanci MC, Ulkatan S., Yigit A., et al: Difference of disability between electrophysiologic subgroups of essential tremor. Can J Neurol Sci2000;27:60—64.
200.
Bastian AJ , Zackowski KM, Thach WT: Cerebellar ataxia: Torque deficiency or torque mismatch between joints?J Neurophysiol2000 ;83:3019—3030.
201.
Topka H., Konczak K., Schneider K., et al: Multijoint arm movements in cerebellar ataxia: Abnormal control of movement dynamics. Exp Brain Res1998; 119:493-503.
202.
Bastian AJ , Martin TA, Keating JG, Thach WT: Cerebellar ataxia: Abnormal control of interaction torques across multiple joints. J Neurophysiol1996;76:492—509.
203.
Thach WT, Perry JG, Kane SA, Goodkin HP: Cerebellar nuclei: Rapid alternating movement, motor somatotopy, and a mechanism f o r t h e c o n t r o l o f m u s c l e s y n e r g y. R e v N e u r o l1 9 9 3; 149:607—628.
204.
Thach WT, Goodkin HP, Keating JG: The cerebellum and the adaptive coordination of movement. Annu Rev Neurosci1992;15:403—442.
205.
Miller LE, Holdefer RN, Houk JC: The role of the cerebellum in modulating voluntary limb movement commands . Arch Ital Biol2002;140:175—183.
206.
Holdefer RN , Miller LE, Chen LL, Houk JC, et al: Functional connectivity between cerebellum and primary motor cortex in the awake monkey. J Neurophysiol2000;84:585—590.
207.
Iloeje SO: Cerebellar ataxia in childhood: A review of clinical features, investigative findings and aetiology in 30 cases. East Afr Med J1992;69:58—63.
208.
Barto AG, Fagg AH, Sitkoff N., Houk JC: A cerebellar model of timing and prediction in the control of reaching. Neural Comput1999;11:565—594.
209.
Ito M.: Mechanisms of motor learning in the cerebellum. Brain Res2000;886:237—245.
210.
Thach WT: A role for the cerebellum in learning movement coordination. Neurobiol Learn Mem1998;70:177—188.
211.
Glickstein M.: The cerebellum and motor learning. Curr Opin Neurobiol1992;2:802—806.
212.
Kawato M., Gomi H.: The cerebellum and VOR/OKR learning models. Trends Neurosci1992;15:445—453.
213.
Ito M.: Evidence for synaptic plasticity in the cerebellar cortex. Acta Morphol Hung1983;31:213—218.
214.
Ito M.: Experimental verification of Marr-Albus' plasticity assumption for the cerebellum . Acta Biol1982;33:189—199.
215.
Marr D.: A theory of cerebellar cortex. J Physiol1969 ;202:437—470. 216. Bjegovic L.: Acute cerebellar ataxia of childhood. Acta Univ Carol Med Monogr1976 ;75:58—60.
216.
Barth PG: Pontocerebellar hypoplasias. An overview of a group of inherited neurodegenerative disorders with fetal onset. Brain Dev1993 ;15:411—422.
Lentell G. , Baas B., Lopez D., et al: The contributions of proprioceptive deficits, muscle function, and anatomic laxity to functional instability of the ankle. J Orthop Sports Phys Ther1995;21:206—215.
219.
Rozzi SL, Lephart SM, Gear WS, Fu FH: Knee joint laxity and neuromuscular characteristics of male and female soccer and basketball players. Am J Sports Med1999 ; 27:312—319.
220.
Factor SA, Podskalny GD, Molho ES: Psychogenic movement disorders: Frequency, clinical profile, and characteristics . J Neurol Neurosurg Psychiatry1995;59: 406—412.
221.
Marjama J. , Troster AI, Koller WC: Psychogenic movement disorders. Neurol Clin1995;13:283—297.
222.
Graybiel AM : The basal ganglia and cognitive pattern generators . Schizophr Bull1997;23:459—469.
223.
Ghika J., Ghika-Schmid F., Bogousslasvky J.: Parietal motor syndrome: A clinical description in 32 patients in the acute phase of pure parietal strokes studied prospectively. Clin Neurol Neurosurg1998;100:271—282.
224.
Rossi S., Pasqualetti P., Tecchio F., et al., Modulation of corticospinal output to human hand muscles following deprivation of sensory feedback. Neuroimage1998;8:163—175.
225.
Leonard CT , Kane J., Perdaems J., et al: Neural modulation of muscle contractile properties during fatigue: Afferent feedback dependence. Electroencephalogr Clin Neurophysiol1994;93:209—217.
226.
Campbell SK : Quantifying the effects of interventions for movement disorders resulting from cerebral palsy. J Child Neurol1996; 1l(Suppl 1):S61—S70.
