In this report, the newest of the functional imaging methods, magnetoencephalography, is described, and its use in addressing the issue of brain reorganization for basic sensory and linguistic functions is documented in a series of 10 children and young adults. These patients presented with a wide variety of conditions, ranging from tumors and focal epilepsy to reading disability. In all cases, clear evidence of reorganization of the brain mechanisms of either somatosensory or linguistic functions or both was obtained, demonstrating the utility of magnetoencephalography in studying, completely noninvasively, the issue of plasticity in the developing brain. (J Child Neurol 2001;16:241-252).
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References
1.
Papanicolaou AC, Levin HS, Eisenberg HM, et al: Evoked potential correlates of post-traumatic amnesia after closed head injury. Neurosurgery1984;14:676-678.
2.
Papanicolaou AC, Moore BD, Levin HS, Eisenberg HM: Evoked potential correlates of right hemisphere involvement in language recovery following stroke. Arch Neurol1987;44:521-524.
3.
Papanicolaou AC, Moore BD, Deutsch G., et al: Evidence for right hemisphere involvement in recovery from aphasia. Arch Neurol1988 ;45:1025-1029.
4.
Papanicolaou AC, DiScenna A., Gillespie L., Aram DM: Probe evoked potential findings following unilateral left hemisphere lesions in children. Arch Neurol1990;47:562-566.
5.
Dobie R., Simmons B.: A dichotic threshold test: Normal and brain damaged subjects. J Speech Hear Res1971;14:71-81.
6.
Pettit J.: Cerebral dominance and the process of language recovery in aphasia . Diss Abst Int1970;5278-B.
7.
Schulhoff C. , Goodglass H.: Dichotic listening, side of brain injury, and cerebral dominance. Neuropsychologia1969;7:149-160.
8.
Shanks J., Ryan W.: A comparison of aphasic and non-brain-injured adults on a dichotic CV-syllable listening task. Cortex1976; 12: 100-112.
9.
Sparks G., Goodglass H., Nickel B.: Ipsilateral versus contralateral extinction in dichotic listening resulting from hemispheric lesions. Cortex1970;6:249-260.
10.
Moore BD, Papanicolaou AC: Dichotic listening evidence of right hemisphere involvement in recovery from aphasia following stroke. J Clin Exp Neuropsychol1988;10:380-386.
11.
Bittar RG, Ptito A., Reutens DC: Somatosensory representation in patients who have undergone hemispherectomy: A functional magnetic resonance imaging study. JNeurosurg2000;92:45-51.
12.
Meyer JS, Sakai F., Yamaguchi F., et al: Regional changes in cerebral bloodflow during standard behavioral activation in patients with disorders of speech and mentation comparted to normal volunteers. Brain Lang1980;9:61-77.
13.
Ingvar DH, Risberg J.: Increase of regional cerebral bloodflow during mental effort in normals and in patients with focal brain disorders. Exp Brain Res1967;3:195-211.
14.
Musso M., Weiller C., Kiebel S., et al: Training-induced brain plasticity in aphasia. Brain1999;122:1781-1790.
15.
Maegaki Y., Maeoka Y., Ishii S., et al: Central motor reorganization in cerebral palsy patients with bilateral cerebral lesions. Pediatr Res1999 ;45(4 Pt 1):559-567.
16.
Flor H., Elbert T., Knecht S., et al: Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature1995;375:482-484.
17.
Elbert T., Flor H., Birbaumer N., et al: Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury. Neuroreport1994;5:2593-2597.
18.
Kew JJ, Ridding MC, Rothwell, et al: Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation. J Neurophysiol1994;72: 2517-2524.
19.
Gur RC, Reivish M.: Cognitive task effects of hemispheric bloodflow in humans: Evidence for individual differences in hemispheric activation. Brain Lang1980;9:78-92.
20.
Yang TT, Gallen CC, Schwartz BJ, Bloom FE: Noninvasive somatosensory homunculus mapping in humans by using a large-array biomagnetometer. Proc Natl Acad Sci U S A1993;90: 3098-4102.
21.
Rossini PM, Martino G., Narici L., et al: Short-term brain plasticity in humans: Transient finger representation changes in sensory cortex somatotopy following ischemic anesthesiaBrain Res1994;642: 169-177.
22.
Rossini PM, Tecchio F., Pizzella V., et al: On the reorganization of sensory hand areas after mono-hemispheric lesion: A functional (MEG)/anatomical (MRI) integrative study. Brain Res1998;782: 153-166.
23.
Pantev C., Wollbrink A., Roberts LE, et al: Short-term plasticity of the human auditory cortex. Brain Res1999;842:192-199.
24.
Papanicolaou AC: Fundamentals of Functional Brain Imaging: A Guide to the Methods and Their Applications to Psychology and Behavioral Neurosciences. Lisse, Netherlands, Swets & Zeitlinger , 1998.
25.
Breier JI, Simos PG, Zouridakis G., et al: Relative timing of neuronal activity in distinct temporal lobe areas during a recognition task for words. J Clin Exp Neuropsychol1998;20:782-790.
26.
Breier JI, Simos PG, Zouridakis G., et al: Temporal course of regional brain activation associated with phonological decoding. J Clin Exp Neuropsychol1999;21:465-476.
27.
Breier JI, Simos PG, Zouridakis G., Papanicolaou AC: Lateralization of cerebral activation in verbal and non-verbal recognition memory tasks using magnetoencephalography. Brain Topogr1999; 12:89-97.
28.
Papanicolaou AC, Simos PG, Breier JI, et al: Magnetoencephalographic mapping of the language specific cortex. JNeurosurg1999 ; 90:85-93.
29.
Simos PG, Breier JI, Zouridakis G., Papanicolaou AC: Assessment of cerebral dominance for language using magnetoencephalography . J Clin Neurophysiol1998;15:364-372.
30.
Simos PG, Breier JI, Zouridakis G., Papanicolaou AC: Identification of language-related brain activity using magnetoencephalography. J ExpClin Neuropsychol1998;20:707-720.
31.
Breier JI, Simos PG, Zouridakis G., et al: Language dominance determined by magnetic source imaging: A comparison with the Wada procedure. Neurology1999;53:938-945.
32.
Simos PG, Breier JI, Maggio WW, et al: Atypical temporal lobe language representation revealed by MEG and intraoperative stimulation mapping. Neuroreport1999;10:139-142.
33.
Simos PG, Papanicolaou AC, Breier JI, et al: Localization of language-specific cortex using MEG and intraoperative stimulation mapping. J Neurosurg1999;91:787-796.
34.
Lewine JD: Neuromagnetic techniques for the noninvasive analysis of brain function , in SE Freeman, E Fukushima, ER Greene (eds): Noninvasive Techniques in Biology and Medicine . San Francisco, San Francisco Press , 1990, 33-74.
35.
Papanicolaou AC, Tarkka IM: Magnetoencephalography, in Bigler ED (ed): Neuroimaging I: Basic Science . New York, Plenum Press, 1996, 161-180.
36.
Sobel DF, Gallen CC, Schwartz BJ, et al: Locating the central sulcus: Comparison of anatomic and magnetoencephalographic functional methods. AJNR Am J Neuroradiol1993;14:915-925.
37.
Nakasato N. , Toshihiro K., Kanno A., et al: Neuromagnetic evaluation of cortical auditory function in patients with temporal lobe tumors . J Neurosurg1997;86:610-618.
38.
Ruohonen JO , Ravazzani P., Ilmoniemi RJ, et al: Motor cortex mapping with combined MEG and magnetic stimulation. Electroencephalogr Clin Neurophysiol Suppl1996;46:317-322.
39.
Seki K., Nakasato N., Fujita S., et al: Neuromagnetic evidence that the P100 component of the pattern reversal visual evoked response originates in the bottom of the calcarine fissure. Electroencephalogr Clin Neurophysiol1996;100:436-442.
40.
Salmelin R. , Hari R., Lounasmaa OV, Sams M.: Dynamics of brain activation during picture naming. Nature1994;368:463-465.
41.
Rogers RL, Basile Lfh, Papanicolaou AC, Eisenberg HM: Magnetoencephalography reveals two distinct sources associated with late positive evoked potentials during visual oddball task. Cereb Cortex1993;2:163-169.
42.
Simos PG, Basile Lfh, Zouridakis G., Papanicolaou AC: Source localization of the N400 response in a sentence-reading paradigm using evoked magnetic fields and magnetic resonance imaging. Brain Res1997;762:29-39.
43.
Eisenberg HM , Papanicolaou AC, Baumann SB, et al: Magnetoencephalographic localization of interictal spike sources. J Neurosurg1991 ;74:660-664.
44.
Squires KC, Ebersole JD, Eliashiv SD, Smith JR: Applications of magnetic resonance imaging in evaluation of candidates for epilepsy surgery. Neuroimaging Clin N Am1995 ;5:1-22.
45.
Smith JR, Gallen CC, Schwartz BJ: Multichannel magnetoencephalographic mapping of sensorimotor cortex for epilepsy surgery. J Funct StereotactNeurosurg1994 ;62:245-251.
46.
Sutherling W. , Crandall PH, Darcey TM, et al: The magnetic and electric fields agree with intracranial localizations of somatosensory cortex. Neurology1988;38:1705-1714.
47.
Wheless JW, Willmore LJ, Breier JI, et al: A comparison of magnetoencephalography, MRI, and V-EEG in patients evaluated for epilepsy surgery. Epilepsia1999;40:931-941.
48.
Gallen CC, Schwartz BJ, Bucholz RD, et al: Presurgical localization and functional cortex using magnetic source imaging. J Neurosurg1995;82:988-994.
49.
Morioka T., Yamamoto T., Mizushima A., et al: Comparison of magnetoencephalography, functional MRI, and motor evoked potentials in the localization of the sensory-motor cortex. Neurol Res1995;17:361-367.
50.
Nakasato N. , Fujita S., Seki K., et al: Functional localization of bilateral auditory cortices using an MRI-linked whole head magnetoencephalography (MEG) system. Electroencephalogr Clin Neurophysiol1995;94:183-190.
51.
Papanicolaou AC, Rogers RL, Baumann S., et al: Source localization of two evoked magnetic field components using two alternative procedures. Exp Brain Res1990;80:44-48.
52.
Reite M., Adams M., Simon J., et al: Auditory M100 component: Relationship to Heschl's gyri. Cogn Brain Res1994;2:13-20.
53.
Rogers RL, Baumann SB, Papanicolaou AC, et al: Localization of the P3 sources using magnetoencephalography and magnetic resonance imaging. Electroencephalogr Clin Neurophysiol1991;79: 308-321.
54.
Rogers RL, Basile Lfh, Papanicolaou AC, Eisenberg HM: Magnetoencephalography reveals two distinct sources associated with late positive evoked potentials during visual oddball task. Cereb Cortex1993;2:163-169.
55.
Sarvas J.: Basic mathematical and electromagnetic concepts of the biomagnetic problem . Phys Med Biol1987;32:11-22.
56.
Gallen CC, Schwartz B., Rieke K., et al: Intrasubject variability and validity of somatosensory localization using a large array biomagnetometer. Electroencephalogr Clin Neurophysiol1994;90: 145-156.
57.
Gallen CC, Sobel DF, Waltz T., et al: Nonivasive presurgical neuromagnetic mapping of somatosensory cortex. Neurosurgery1993;33:260-268.
58.
Morioka T., Yamamoto T., Mizushima A., et al: Comparison of magnetoencephalography, functional MRI, and motor evoked potentials in the localization of the sensory-motor cortex. Neurol Res1995;17:361-367.
59.
Hund M., Rezai AR, Kronberg E., et al: Basis of new functional risk profile in the selection of patients with cortical brain lesions. Neurosurgery1997;40:936-940.
60.
Kawamura T. , Nakasato N., Seki K., et al: Neuromagnetic evidence of pre- and post-central cortical sources of somatosensory evoked responses. Electroencephalogr Clin Neurophysiol1996;100:44-50.
61.
Wikstrom H. , Huttunen J., Korvenoja A., et al: Effects of interstimulus interval on somatosensory evoked magnetic fields (SEFs): A hypothesis concerning SEF generation at the primary sensorimotor cortex. Electroencephalogr Clin Neurophysiol1996;100: 479-487.
62.
Wood CC, Cohen D., Cuffin BN, et al: Electrical sources in human somatosensory cortex: Identification by combined magnetic and potential recordings. Science1985;227:1051-1053.
63.
Shimojo M., Kakigi R., Hoshiyama M., et al: Differentiation of receptive fields in the sensory cortex following stimulation of various nerves of the lower limb in humans: A magnetoencephalographic study. J Neurosurg1996;85:255-262.
64.
Hari R., Reinikainen K., Kaukoranta E., et al: Somatosensory evoked cerebral magnetic fields from SI and SII in man. Electroencephalogr Clin Neurophysiol1984;57:254-263.
65.
Simos PG, Breier JI, Fletcher JM, et al: Brain activation profiles in dyslexic children during nonword reading: A magnetic source imaging study. Neurosci Lett2000;290:66-70.
66.
Simos PG, Breier JI, Fletcher JM, et al: Cerebral mechanisms involved in word reading in dyslexic children: A magnetic source imaging approach. Cereb Cortex2000;10:809-816.
67.
Baumgertner C., Doppelbauer A., Deecke L., et al: Neuromagnetic investigation of somatotopy of human hand somatosensory cortex. Exp Brain Res1991;87:641-648.
68.
Hikosaka K. , Iwai E., Saito H., Tanaka K.: Polysensory properties of neurons in the anterior bank of the caudal superior temporal sulcus of the macaque monkey . J Neurophysiol1998;60:1615-1637.
69.
Breier JI, Simos PG, Wheless JW, et al: A magnetoencephalography study of cortical plasticity. Neurocase1999;5:277-284.
70.
Burger PC, Scheitauer BW: Vascular tumors and tumor like lesions, in Tumors of the Central Nervous System. Washington, DC, Armed Forces Institute of Pathology, 1994, 287-299.
71.
Lazar RM, Marshall RS, Pile-Spellman J., et al: Anterior translocation of language in patients with left cerebral arteriovenous malformation. Neurology1997 ;49:802-808.
