Myasthenia gravis has been associated with other autoimmune disorders. We report two children with myasthenia gravis and another autoimmune disease: an 18-month-old boy with ocular myasthenia gravis and Hashimoto's disease and a 14-year-old girl presenting with autoimmune polymyositis, then generalized myasthenia gravis 2 years later. The rare combinations of myasthenia gravis and Hashimoto's disease or polymyositis in children are discussed, and we also briefly review myasthenia gravis and other associated autoimmune diseases in children. (J Child Neurol 2000;15:767-769).
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References
1.
Simpson JA: Myasthenia gravis as an autoimmune disease: Clinical aspects. Ann N Y Acad Sci1966;135:506-516.
2.
Wolf SM, Rowland LP, Schotland DL, et al: Myasthenia as an autoimmune disease: Clinical aspects. Ann N Y Acad Sci1996;135:517-535.
3.
Drachman DB: Myasthenia gravis. N Engl JMed1994 ;330:1797-1807.
4.
Penn AS, Rowland LP: Myasthenia gravis, in Rowland LP (ed): Merritt's Textbook of Neurology. Philadelphia , Williams & Wilkins, 1995, 754-761.
5.
Engel AG: Myasthenia gravis and myasthenic syndromes. HandbookClin Neurol1992; 18:391-455.
6.
Lisak RP (ed): Handbook of Myasthenia Gravis and Myasthenic Syndromes. New York , Marcel Dekker, 1994.
7.
Engel AG: Acquired autoimmune myasthenia gravis, in Engel AG, Franzini-Armstrong C (eds): Myology. New York, McGraw-Hill , 1994, 1769-1797.
8.
Rodriguez M. , Gomez MR, Howard FM, Taylor WF: Myasthenia gravis in children: Long-term follow-up. Ann Neurol1983;13:504-510.
9.
Kimura K., Nezu A., Kimura S., et al: A case of myasthenia gravis in childhood associated with chronic inflammatory demyelinating polyradiculoneuropathy. Neuropediatrics1998;29:108-112.
10.
Lovelace RE , Youger DS: Myasthenia gravis with thymoma . Neurology1997;48(Suppl 5):S76-S81.
Lennon VA: Serologic profile of myasthenia gravis and distinction from Lambert-Eaton myasthenic syndrome. Neurology1997;48(Suppl 5):S23-S27.
14.
Pescarmona E., Giardini R., Brisigotti M., et al: Thymoma in childhood: A clinicopathological study of five cases. Histopathology1992;21:65-68.
15.
Lennon VA, Howard FM: Serological diagnosis of myasthenia gravis, in Nakamura RM, O'Sullivan MB (eds): Clinical Laboratory Molecular Analysis: New Strategies in Autoimmunity, Cancer and Virology. New York, Grune & Stratton, 1985, 29-44.
16.
Garlepp MJ, Dawkins RL, Christiansen FT, et al: Autoimmunity in ocular and generalized myasthenia gravis. J Neuroimmunol1981;1: 325-332.
17.
Larsen PR, Davies TE, Hay ID: Autoimmune and infectious thyroiditis, in Wilson JD, Foster DW, Kronenberg HM, Larsen PR (eds): Williams Textbook of Endocrinology. Philadelphia, WB Saunders, 1998, 475-479.
18.
Vial C., Charles N., Chauplannaz G., Bady B.: Myasthenia gravis in childhood and infancy: Usefulness of electrophysiologic studies. Arch Neurol1991;48:847-849.
Behan WM, Behan PO, Doyle D.: Association of myasthenia gravis and polymyositis with neoplasia, infection and autoimmune disorders. Acta Neuropathol1982;57:221-229.