We describe a 56 /12-year-old girl with recurrent episodes of acute disseminated encephalomyelitis following an acute cytomegalovirus infection and associated reactivated Epstein-Barr virus. Complete clinical recovery was obtained with intravenous immunoglobulin. (J Child Neurol 2000;15:421-424).
Get full access to this article
View all access options for this article.
References
1.
Sriram S., Steinman L.: Post infectious and post vaccinial encephalomyelitis. Neurol Clin1984;2:341-353.
2.
Johnson RT, Griffin DE, Gendelman HE: Postinfectious encephalomyelitis. Semin Neurol1992;8:137-139.
3.
Kanzaki A., Yabuki S.: Acute disseminated encephalomyelitis associated with cytomegalovirus infection—A case report, abstract. Rinsho Shinkeigaku1994;34:511-513.
Kesselring J. , Miller D., Robb S., et al: Acute disseminated encephalomyelitis. MRI findings and the distinction from multiple sclerosis. Brain1990;113:291-302.
10.
Luttmann S. , Husstedt IW, Lugering N., et al: Cytomegalovirus encephalomyelomeningoradiculitis in acquired immunodeficiency syndrome (AIDS). J Infect1997;35:78-81.
11.
Imai S., Usui N., Sugiura M., et al: Epstein-Barr virus genomic sequences and specific antibodies in cerebrospinal fluid in children with neurologic complications of acute and reactivated EBV infections. J Med Virol1993;40:278-284.
12.
Merelli E., Bedin R., Sola P., et al: Encephalomyeloradiculopathy associated with Epstein-Barr virus: Primary infection or reactivation?Acta Neurol Scand1997;96:416-20.
Obel N., Hoier-Madsen M., Kangro H.: Serological and clinical findings in patients with serological evidence of reactivated Epstein-Barr virus infection. APMIS1996;104:424-428.
15.
Aalto SM, Linnavuori K., Peltol H., et al: Immunoreactivation of Epstein-Barr virus due to cytomegalovirus primary infection. J Med Virol1998;56:186-191.
16.
Fleisher G. , Starr S., Koven N., et al: A non X-linked syndrome susceptibility to severe Epstein-Barr virus infection. J Pediatr1982;100: 727-730.
17.
Kleiman M., Brunquell P.: Acute disseminated encephalomyelitis: Response to intravenous immunoglobulin?J Child Neurol1995;10: 481-483.
18.
Finsterer J. , Grass R., Stollgerger C., Mamoli B.: Immunoglobulins in acute, parainfectious, disseminated encephalo-myelitis. Clin Neuropharmacol1998;21:258-261.
19.
Yu Z., Lennon V.: Mechanism of intravenous immune globulin therapy in antibody-mediated autoimmune diseases. N Engl J Med1999;340: 227-228.
20.
Tobi M., Straus SE: Chronic Epstein-Barr virus disease: A workshop held by the National Institute of Allergy and Infectious Disease. Ann Intern Med1985;103:951-953.
