AustinD.F., NelsonV.E., JohnsonL.F.Epidemiologic characteristics of childhood cancer. In: VaethJ.M. (ed): Childhood Cancer: Triumph Over Tragedy. Frontiers of Radiation Therapy and Oncology, Vol. 16.Basel: S Karger, 1982; pp. 9–17.
2.
YoungJ.L., MillerR.W.Incidence of malignant tumors in U.S. children. J Pediatr1975; 86: 254–258.
3.
GoldmanA., BeardmoreS., HuntJ.Palliative care for children with cancer: home, hospital or hospice. Arch Dis Child1990; 65: 641–643.
4.
MiserA.W., McCallaJ., DothageJ.A., WesleyM., MiserJ.S.Pain as a presenting symptom in children and young adults with newly diagnosed malignancy. Pain1987; 29: 85–90.
5.
MiserA.W., DothageJ.A., WesleyR.A., MiserJ.S.The prevalence of pain in a pediatric and young adult cancer population. Pain1987; 29: 73–83.
6.
McGrathP.J., HsuE., CapelliM., LukeB., GoodmanJ.T., Dunn-GeierJ.Pain in pediatric oncology: a survey of an outpatient clinic. J Psychosoc Oncol1990; 8: 109–124.
7.
VentafriddaV., TamburiniM., CaraceniA., De ConnoF., NaldiF.A validation study of the WHO method for cancer pain relief. Cancer1987; 59: 850–856.
8.
WalshT.D.Common misunderstandings about the use of morphine for chronic pain in advanced cancer. CA-A Cancer J Clinicians1985; 35(3): 164–169.
9.
TempestS.Clinical observations on the use of sustained release morphine in 100 patients: a retrospective study. In: BandP.R., StewartJ.H., TowsonR.T. (eds). Advances in the Management of Chronic Pain.Toronto: Purdue Frederick, 1986; 67–68.
10.
MatherL.E., MackieJ.The incidence of postoperative pain in children. Pain1983; 15: 271–282.
11.
SchecterN.L., AllenD.A., HansonK.Status of pediatric pain control: a comparison of hospital analgesic usage in children and adults. Pediatrics1986; 77:11–15.
12.
SwaffordL.I., AllanD.Pain relief in the pediatric patient. Med Clin North Am1968; 52: 131–136.
13.
BeyerJ.E., DeGoodD.E., AshleyL.C., RusselG.A.Patterns of postoperative analgesic use with adults and children following cardiac surgery. Pain1983; 17: 71–81.
14.
AnandJ.S., HickeyP.R.Pain and its effects in the human neonate and fetus. New Engl J Med1987; 317: 1321–1329.
15.
LafrenayeS., TheriaultM.C.Analgesia in children. Clin Invest Med1993; 16(3): A30.
16.
LafrenayeS., TheriaultM.C., DurandP.Knowledge of and attitudes towards pain in children. Clin Invest Med1993; 16(3): A30.
17.
ElandJ.M., AndersonJ.E.The experience of pain in children. In: JacoxA.K. (ed). Pain: A Source Book for Nurses and Other Health Professionals.Boston: Little Brown, 1977; 453–471.
18.
McGrathP.A.Pharmacological intervention for alleviating children's pain. In: McGrath PA (ed.). Pain in Children: Nature, Assessment and Treatment.New York: Guilford Press, 1990; 111–131.
19.
SchecterN.L.The undertreatment of pain in children: an overview. Ped Clin North Am1989; 36: 781–794.
20.
BerdeC.B.Pediatric analgesic trials. In: MaxM.B., PortenoyR.K., LaskaE.M. (eds). Advances in Pain Research and Therapy: The Design of Analgesic Clinical Trials.New York: Raven Press, 1991; 18: 445–555.
21.
McGrathP.A.Pain assessment in infants and children. In: McGrathP.A. (ed). Pain in Children: Nature, Assessment and Treatment.New York: Guilford Press, 1990; 41–87.
22.
McGrathP.A.Evaluating a child's pain. J Pain Sympt Manag1989; 4(4): 198–214.
23.
LynchA.Ethics of research involving children. Annals RCPSC1992; 25(6): 371–372.
24.
Report on Research Involving Children.Revised recommendations of the NCBHR. NCBHR Communiqué1993; 4(1): 8–11.
25.
KorenG.The research ethics board perspective on research involving children: experience of the Hospital for Sick Children. NCBHR Communiqué1993; 4(1): 24–25.
26.
HallenB., OlssonG.L., UppfeldtA.Pain-free venipuncture: effect of timing of application of local anesthetic cream. Anaesthesia1984; 39: 969–972.
27.
MaunukselaE.L., KorpelaR.Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children: effect on the pain associated with venous cannulation. Br J Anaesth1988; 58: 1242–1245.
28.
MottM.G., ChambersT.L.Distress due to venipuncture. Lancet1993; 341: 373.
29.
McRorieT.I., SlatteryJ.T., LynnA.M., OpheimK.E.Maturation of morphine clearance in newborns and infants. Clin Pharmacol Ther1990; 47(2): 132.
LynnA.M., SlatteryJ.T.Morphine pharmacokinetics in early infancy. Anesthesiology1987; 66: 136–139.
35.
OikkolaK.T., MaunukselaE.L., KorpelaR., RosenbergP.H.Kinetics and dynamics of postoperative intravenous morphine in children. Clin Pharmacol Ther1988; 44: 128–136.
36.
NahataM.C., MiserA.W., MiserS.J., ReuningR.H.Variation in morphine pharmacokinetics in children with cancer. Dev Pharmacol Ther1985; 8: 182–188.
37.
RobieuxI.C., KellnerJ.D., CoppesM.J.Analgesia in children with sickle cell crisis: comparison of intermittent opioids vs continuous intravenous infusion of morphine and placebo-controlled study of oxygen inhalation. Pediatric Hematology Oncology1992; 9: 317–326.
38.
BrayR.J., BeetonC., HintonW., SeviourJ.A.Plasma morphine levels produced by continuous infusion in children. Anesthesia1986; 41: 753–755.
39.
MillerR.P., RobertR.J., FisherL.J.Acetaminophen elimination kinetics in neonates, children and adults. Clin Pharmacol Ther1976; 19: 284–294.
40.
RollinsD.E., von BahrC., GlaumanH., MoldeusR., RaneA.Acetaminophen: potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal cells. Science1979; 205: 1414–1416.
CederholmI., BengtssonM., BjorkmannS., ChoonaraI.A., RaneA.Long term high dose morphine, ketamine and midazolam infusion in a child with burns. Br J Clin Pharmacol1990; 30: 901–905.
44.
NahataM.C.Plasma concentrations of morphine in children with chronic pain — comparison of controlled release and regular morphine sulphate tablets. J Clin Pharm Ther1991; 3: 193–195.
GoldmanA., BowmanA.The role of oral controlled-release morphine for pain relief in children with cancer. Palliat Med1990; 4: 279–285.
47.
KorenG., MauriceL.Pediatric uses of opioids. Pediatr Clin North Am1989; 36(5): 1141–1152.
48.
WalshT.D., SaundersC.M.Oral morphine for relief of chronic pain from cancer. New Engl J Med1981; 305: 1417.
49.
FerrellB., WisdomC., WenzlC., BrowJ.Effects of controlled-release morphine on quality of life for cancer pain. Oncology Nursing Forum1989; 16(4): 521–526.
50.
TeresiM.E., WicklandB.M., McMillanS., RucknagelD.L., KalinyakK.A., PayneR., deAlacronP.A.Comparison of controlled-release oral morphine to continuous iv morphine in the control of pain in sickle cell crisis (abstract no. 15). Am J Pediatr Hematol Oncol1990; 12(1): 109.
51.
BrookoffD., PolomanoR., CallansD.Management of sicklecell pain with controlled-release morphine. Proceedings of the Eighth Annual Scientific Meeting, American Pain Society, October 1989: 54.
52.
RichterR., SittlR., FenglerR., BeckJ., SorgeJ.First results of a German multicenter study concerning pain therapy in incurable pediatric cancer patients [abstract No. 13]. J Pain Sympt Manag1989; 4(4): S5.
53.
PoulainP.Slow release morphine tablets for children with cancer pain. In: Pain in Children. Mini-symposium “Caring for children with pain”, Maastricht, The Netherlands, 1989; June 2: p. 21.
54.
AtchisonN.E., SzyfelbeinS.K., OsgoodP.F., KazianisA., WolfJ.H., GrandyR.P.MS Contin: Time released pain relief for burn patients. J Pain Sympt Manag1991; 3: 156.
55.
RogersA.G.The successful use of controlled release morphine. J Pain Sympt Manag1990; 5(5): 331–332.
56.
SmithK.J., McKellarJ., SinclairK.A., SmithA.T., YeangY.Y.The influence of food on the pharmacokinetics of morphine from MST Continus suspension. Proceedings of the 7th World Congress on Pain, Paris, 1993: 382.
57.
SmithA.T., McKellarJ., YeangY.Y.A comparative study of MST Continussuspension with MST Continus tablets in the treatment of cancer pain. Proceedings of the 7th World Congress on Pain, Paris, 1993; 332.
58.
BabulN., DarkeA.C.Putative role of hydromorphone metabolites in myoclonus. Pain1992; 2: 260–261.
59.
ConeE.J., PhelpsB.A., GorodetzkyC.W.Urinary excretion of hydromorphone and its metabolites in humans, rats, dogs, guinea pigs and rabbits. J Pharm Sci1977; 12: 1709–1713.
60.
SmallL.Y., EddyN.B., MosettigE., HimmelsbachC.K.Studies on drug addiction: with special reference to chemical structures of opium derivatives and allied synthetic substances and their physiological actions. Public Health Report, U.S. Government Printing Office, Washington, DC, 1938; (Suppl 138): 1–143.
61.
MiserA.W., MiserJ.S.The treatment of cancer pain in children. Ped Clin North Am1989; 4: 979–999.
62.
BerdeC., AblinA., GlazerJ.Report of the subcommittee on disease-related pain in childhood cancer. Pediatrics1990; 5: 818–625.
63.
World Health Organization.Cancer pain relief and palliative care. Report of a WHO Expert Committee, WHO Office of Publications Technical Report 804, Geneva, Switzerland, 1990.
64.
GuayD.R.P., AwniW.M., HalstensonC.E.Pharmacokinetics of codeine after single and multiple oral dose administration to normal volunteers. J Clin Pharmacol1987; 27: 983–987.
65.
JaffeJ.H., MartinW.R.Opioid analgesics and antagonists. In: GilmanA.G., RallT.W., NiesA.S., TaylorP. (eds). Goodman and Gilman's The Pharmacologic Basis of Therapeutics (8th edition) New York: Pergamon Press, 1990; 485–521.
66.
HamunenK.Ventilatory effects of morphine, pethidine and methadone in children. Br J Anaesth1993; 4: 414–418.