O'ShaughnessyWB. On the preparation of Indian hemp or gunjah. Trans Med Physio Soc Bombay1842; 8: 421–461.
2.
OsierW, McRaeT.The Principles and Practice of Medicine. Appleton, New York, 1915; p. 1225.
3.
BerardCM, MollereauG, VassartH, ParmentierM.Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J1991; 279; 129–134.
4.
MunroS, ThomasKL, Abu-ShaarM.Molecular characterization of a peripheral receptor for cannabinoids. Nature1993; 365: 61–65.
5.
GaliegueS, MaryS, MarchandJ, DussossoyD, CarriereD, CarayonP, . Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem1995; 232: 54–61.
6.
DevaneWA, HanusL, BreuerA, PertweeRG, StevensonLA, GriffinG, . Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science1992; 258: 1946–1949.
7.
MechoulamR, Ben-ShabatS, HanusL, LigumskyM, KaminskiNE, SchatzAR, . Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharm1995; 50: 83–90.
8.
HirstRA, LambertDG, NotcuttWG. Pharmacology and potential therapeutic uses of cannabis. Br J Anaesth1998; 81: 77–84.
9.
AmeriA.The effects of cannabinoids on the brain. Prog Neuro1999; 58: 315–348.
10.
PiomelliD, GiuffridaA, CalignanoA, Rodriguez deFonseca F.The endocannabinoid system as a target for therapeutic drugs. Trends Pharmacol Sci2000; 21: 218–224.
11.
JoyJE, WatsonSJ, BensonJA (eds). U.S. Institute of Medicine (IOM).Marijuana and Medicine: Assessing the Science Base. National Academy Press, Washington, DC, 1999. Available at: www2.nas.edu.
12.
Di MarzoV, MelckD, BisognoT, De PetrocellisL.Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosci1998; 22 (2):80.
13.
CareyMP, BurishTG, BrennerDE. Delta-9-tetracannabinol in cancer chemotherapy: research problems and issues. Ann Intern Med1983; 99: 106–114.
14.
VothEA, SchwatrzRH. Medicinal applications of delta-9-tet-rahydrocannabinol and marijuana. Ann Intern Med1997; 126: 791–798.
15.
DansakDA. Medical use of recreational drugs by AIDS patients. J Addict Dis1997; 16 (3):25–30.
AbramsDI, LeiserRJ, ShadeSB, HiltonJ, ElbeikT(THC Study Group). Short-term effects of cannabinoids on HIV-1 viral load [abstract]. Proc World AIDS Congress, 2000.
18.
MikuriyaTH. International Classification of Diseases 9 CM 1996: Conditions Treated with Cannabis Encountered Between 1994–1998.1998. Available at: www.drugsense.org/CCUA/ICD9.html.
19.
Health Canada.Research Plan for Marijuana for Medicinal Purposes: a Status Report. Therapeutics Products Programme. 1999. Available at: <http://www.hc-sc.gc.ca>
20.
Canadian Pharmacists Association.Compendium of Pharmaceuticals and Specialities. 1999; 34: 330, 999.
21.
BlockRl, WittenbornJR. Marijuana effects on the speed of memory retrieval in the letter-matching task. Int J Addict1986; 21: 281–285.
22.
SchwartzRH, GruenewaldPJ, KlitznerM, FedioP.Short-term memory impairment in cannabis-dependent adolescents. Am J Dis Child1989; 143: 1214–1219.
23.
PopeHG, Yurgelun-ToddD.The residual cognitive effects of heavy marijuana use in college students. JAMA1996; 275: 521.
24.
SoderstromCA, TrifillisAL, ShankarBS, ClarkWE, CowleyRA. Marijuana and alcohol use among 1023 trauma patients. Arch Surg1988; 123: 733–737.
25.
MoskowitzH.Marijuana and driving. Accid Anal Prev1985; 17: 323–345.
26.
WuTC, TashkinDP, DjahedB, RoseJE. Pulmonary hazards of smoking marijuana smoke. N Engl J Med1988; 318: 347–351.
27.
HoffmanD, BrunnemanDK, GoriGB, WyderEL. On the carcinogenicity of marijuana smoke. Recent Adv Phytochem1975; 126: 63–81.
28.
UngerleiderJT, AndrysiakT, TashkinDP, GaleDP. Contamination of marihuana cigarettes with pathogenic bacteria—possible sources of infection in cancer patients. Can Treat Rev1982; 66: 589–591.
29.
HembreeWC, NahasGG, ZeidenbergP, DyrenfurthI.Marihuana effects in human testis. Clin Res1976; 24: 272A.
30.
CohenS.Marijuana on reproductive function. Drug Abuse & Alcoholism News1985; 13: 1.
31.
FriedPA, WatkinsonB, WillanA.Marijuana use during pregnancy and decreased length of gestation. Am J Obstet Gynecol1984; 150: 23–27.
32.
RobisonLL, BuckleyJD, DaigleAE, WellsR, BenjaminD, ArthurDC, HammondGD. Maternal drug use and risk of childhood nonlymphoblastic leukemia among offspring. Cancer1989; 63: 1904–1911.
33.
SolomonsK, NeppeVM, KuylJM. Toxic cannabis psychosis is a valid entity. S Afr Med J1990; 78: 476–481.
34.
JonesRT, BenowitzNL, HerningRI. Clinical relevance of cannabis tolerance and dependence. J Clin Pharmacol1981; 21: 143S–152S
35.
PertweeRG. Tolerance to and dependence on psychotropic cannabinoids. In: PrattJA (ed). The Biological Basis of Drug Tolerance and Dependence. New York: Academic Press, 1991; pp. 231–263.
36.
HaneyM, WardAS, ComerSD, FoltinRW, FischmanMW. Abstinence symptoms following oral THC administration to humans. Psychopharmacology1999; 141: 385–394.
37.
HaneyM, WardAS, ComerSD, FoltinRW, FischmanMW. Abstinence symptoms following smoked marijuana in humans. Psychopharmacology1999; 141: 395–404.
38.
GoddardIW. Proven: Cannabis is Safe Medicine.1996. Available at: www.erols.com/igoddard.
39.
Health Canada.Regulation of Marihuana for Medical Purposes. 1998. Available at: www.hc-sc.gc.ca.
40.
Health Canada.Interim Guidance Document: Therapeutic Products Programme, Exemption under Section 56 for Medical Purposes. 2000. Available at: www.hc-sc.gc.ca.
41.
HallW.The cannabis policy debate: finding a way forward. CMAJ2000; 162: 1690–1692.
42.
PentaJS, PosterDS, BrunoS, MacdonaldJS. Clinical trials with antiemetic agents in cancer patients receiving chemotherapy. J Clin Pharmacol1981; 21: 11S–22S.
SallanSE, ZinbergNE, FreiE.Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy. N Engl J Med1975; 293 (16):795–797.
45.
Kluin-NelemanJC, NelemanFA, MeuwissenOJ, MaesRA. delta-9-tetrahydrocannabinol (THC) as an anti-emetic in patients treated with cancer chemotherapy: a double-blind, cross-over trial against placebo. Vet Hum Toxicol1979; 21 (5):338–340.
46.
LucasVC, LaszloJ.Delta-9-tetrahydrocannabinol for refractory vomiting induced by chemotherapy. JAMA1980; 243:1241–1243
47.
SweetDL, MillerNJ, WeddingtonW, SenayE, SushelskyL.Delta-9-Tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A pilot study. J Clin Pharmacol1981; 21: 70S–75S.
48.
ChangAE, ShilingDJ, StillmanRC, GoldbergNH, SeippCABarofskyI, RosenbergSA. A prospective evaluation of delta-9-tetrahydrocannabinol as an antiemetic in patients receiving adriamycin and Cytoxan chemotherapy. Cancer1981; 47: 1746–1751.
49.
FrytakS, MoertelCG, O'FallonJr, RubinJ, CreaganET, O'ConnellMJ, . Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo. Ann Intern Med1979; 91 (6):825–830.
50.
UngerleiderJT, AndrysiakT, FairbanksL, GoodnightJ, SarnaG, JamisonK.Cannabis and cancer chemotherapy: a comparison of oral delta-9-tetrahydrocannabinol and prochlorperazine. Cancer1982; 50: 636–645.
51.
SallanSE, CroninC, ZelenM, ZinbergNE. Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. N Engl J Med1980; 302 (3):135–138.
52.
OrrLE, McKernanJF. Antiemetic effect of delta-9-tetrahydrocannabinol in chemotherapy-associated nausea and emesis as compared to placebo and compazine. J Clin Pharmacol1981; 21(8–9 suppl): 76S–80S.
53.
LevittM, WilsonA, BowmanD, KernelS, KrepartG, MarksV. Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, 15 mg of delta-9-tetrahydrocannabiinol in cancer chemotherapy. J Clin Pharmacol1981; 21: 103S–109S.
54.
McCabeM, SmithFP, MacdonaldJS, WoolleyPV, GoldbergD, ScheinPS. Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy. Invest New Drugs1988; 6 (3):243–246.
55.
NiiranenA, MattsonK.A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy. Am J Clin Oncol1985; 8 (4):336–340.
56.
HermanTS, EinhornLH, JonesSE, NagyC, ChesterAB, DeanJC. Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. N Engl J Med1979; 300 (23):1295–1297.
57.
SteeleN, GrallaRJ, BraunDW, YoungCW. Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis. Cancer Treat Rep1980; 64: 219–224.
58.
EinhornLHH, NagyC, FurnasB, WilliamsSD. Nabilone: a effective antiemetic in patients receiving cancer chemotherapy. J Clin Pharmacol1981; 21: 64S–69S.
59.
AhmedzaiS, CarlyleDL, CalderIt, MoranF.Antiemetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy. Br J Cancer1983; 48 (5):657–663.
60.
GarbS, BeersAL, BogradM, McMahonRT, MangalikA, AshmannAC, LevineS.Two-pronged study of tetrahydrocannabinol (THC) prevention of vomiting from cancer chemotherapy. IRCS Med Sci1980; 8: 203–204.
61.
McCabeM, SmithFP, GoldbergD, MacdonaldJ, WooleyPV, WarrenR, . Comparative trial of oral delta-9-tetrahydrocannabinol (THC) and prochlorperazine (PCZ) for cancer chemotherapy-related nausea and vomiting. Proc Am Assoc Cancer Res/Am Soc Clin Oncol1981; 22: 416.
62.
LaneM, VogelCL, FergusonJ, KrasnowS, SaiersJL, HammJ, . Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomitingJ Pain Symptom Manage1991; 6: 352–359.
63.
CunninghamD, ForrestGJ, SoukopM, GilchristNL, CalderIT, McArdleCS. Nabilone and prochlorperazine: a useful combination for emesis induced by cytotoxic drugs. Br Med J1985; 291: 864–865.
64.
Gonzales-RosalesF, WalshD.Intractable nausea and vomiting due to gastrointestinal mucosal metastases relieved by tetrahydrocannabinol (dronabinol). J Pain Symptom Manage1997; 14: 311–314.
65.
EkertH, WatersKD, JurkIH, MobiliaJ, LoughnanP.Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol. Med J Aust1979; 2: 657–659.
66.
DalzellAM, BartlettH, LilleymanJS. Nabilone: an alternative antiemetic for cancer chemotherapy. Arch Dis Child1986; 61 (5):502–505.
67.
ChanHS, CorreiaJA, MacLeodSM. Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial. Pediatrics1987; 79 (6):946–952.
68.
CollsBM, FerryDG, GrayAJ, HarveyVJ, McQueenEG. The antiemetic activity of tetrahydrocannabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy. NZ Med J1980; 91: 449–451.
69.
MeyerBr, LewinM, DrayerDE, PasmantierM, LonskiL, ReidenbergMM. Optimizing metoclopramide control of cisplatin induced emesis. Ann Int Med1984; 100: 393–395.
70.
KerrDJ, GrahamJ, BlackieRG, McGovernE, KelmanAW, CunninghamD, KayeSB. The relationship between steady state metoclopramide levels and control of emesis during treatment with cis-platinum. Br J Clin Pharmacol1985; 20: 426–427.
71.
AllanSG, CornbleetMA, WarringtonPS, GollandIM, LeonardRC, SmythJN. Dexamethasone and high-dose metoclopramide: efficacy in controlling cisplatin induced nausea and vomiting. Br Med J1984; 289: 878–879.
72.
GrallaRJ, TysonLB, ClarkRA, BordinLA, KelsenDP, KalmanLB. Antiemetic trials with high dose metoclopramide: superiority over THC, and preservation of efficacy in subsequent chemotherapy courses [abstract]. Proc Am Soc Clin Oncol1982; 1: 58.
73.
CunninghamD, BradleyCJ, ForrestGJ, HutcheonAW, AdamsL, SneddonM, . A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues. Eur J Cancer Clin Oncol1988; 24: 685–689.
74.
VinciguerraV, MooreT, BrennanE.Inhalation marijuana as an antiemetic for cancer chemotherapy. N Y State J Med1988; 88: 525–527.
75.
ChangAE, ShilingDJ, StillmanRC, GoldbergNH, SeippCA, BarofskyI, . Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation. Ann Intern Med1979; 91 (6):819–824.
76.
LevittM, FaimanC, HawksR, WilsonA.Randomized double blind comparison of delta-9-tetrahydrocannabinol and marijuana as chemotherapy antiemetics [abstract]. Proc Am Soc Clin Oncol1984; 3: 91.
77.
NeidhartJA, GagenMM, WilsonHE, YoungDC. Comparative trial of the antiemetic effects of THC and haloperidol. J Clin Pharmacol1981; 21: 38S–42S.
78.
PomeroyM, FennellyJJ, TowersM.Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis. Cancer Chemother Pharmacol1986; 17 (3):285–288.
79.
LucraftHH, PalmerMK. Randomized clinical trial of levonantradol and chlorpromazine in the prevention of radiotherapy-induced vomiting. Clin Radiol1982; 33 (6):621–622.
80.
StaquetM, BronD, RozencweigM, KenisY.Clinical studies with a THC analog (BRL-4664) in the prevention of cisplatin-induced vomiting. J Clin Pharmacol1981; 21: 60S–63S.
81.
DiasioRB, EttingerDS, SatterwhiteBE. Oral levonantradol in the treatment of chemotherapy-induced emesis: preliminary observations. J Clin Pharmacol1981; 21: 81S–85S.
HeimME, RomerW, QueisserW.Clinical experience with levonantradol hydrochloride in the prevention of cancer chemotherapy-induced nauseas and vomiting. J Clin Pharmacol1981; 21: 86S–89S.
84.
StambaughJE, McAdamsJ, VreelandF.Dose ranging evaluation of the antiemetic efficacy and toxicity of intramuscular levonantradol in cancer subjects with chemotherapy-induced emesis. J Clin Pharmacol1984; 24(11–12): 480–485.
85.
CroninCM, SallanSE, GelberR, LucasVS, LaszloJ.Antiemetic effect of intramuscular levonantradol in patients receiving anticancer chemotherapy. J Clin Pharmacol1981; 21: 43S–50S.
86.
SheilderVR, EttingerDS, DiasioRB, EnterlineJP, BrownMD. Double-blind multiple-dose crossover study of the antiemetic effect of intramuscular levonantradol compared to prochlorperazine. J Clin Pharmacol1984; 24 (4):155–159.
87.
HutcheonAW, PalmerJB, SoukopM, CunninghamD, McArdleC, WelshJ, . A randomized multicentre single blind comparison of a cannabinoid antiemetic (levonantradol) with chlorpromazine in patients receiving their first cytotoxic chemotherapy. Eur J Cancer Clin Oncol1983; 19 (8):1087–1090.
88.
CitronML, HermanTS, VreelandF, KrasnowSH, FossieckBE, HarwoodS, . Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting. Cancer Treat Rep1985: 69(1): 109–112.
89.
FlynnJ, HanifN.Nabilone for the management of intractable nausea and vomiting in terminally staged AIDS. J Palliat Care1992; 8: 46–47.
90.
GreenST, NathwaniD, GoldbergD, KennedyDH. Nabilone as effective therapy for intractable nausea and vomiting in AIDS. Br J Clin Pharmacol1989; 28: 494–495.
91.
BuxbaumDM. Analgesic activity of delta-9-tetrahydrocannabinol in the rat and mouse. Psychopharmacol1972: 275–280.
92.
MartinBR. Characterization of the antinociceptive activity of intravenously administered delta-9-tetrahydrocannabinol in mice. In: HarveyDJ (ed). Marihuana ‘84.Oxford:IRL Press, 1985; pp. 685–691.
93.
ComptonDR, AcetoMD, LoweJ, MartinBR. In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta-9-tetrahydrocannabinol-induced responses and apparent agonist activity. J Pharmacol Exp Ther1996; 277: 586–594.
94.
MartinWJ, CoffinPO, AttiasE, BalinskyM, TsouK, WalkerJM. Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections. Brain Res1999; 822: 237–242.
95.
LichtmanAH, MartinBR. Spinal and supraspinal components of cannabinoid-induced antinociception. J Pharmacol Exp Ther1991; 258: 517–523.
96.
LichtmanAH, MartinBR. Cannabinoid-induced antinociception is mediated by spinal alpha-2-noradrenergic mechanism. Brain Res1991; 559: 309–314.
WelchSP, StevensDL. Antinociceptive activity of intrathecally administered cannabinoids alone and in combination with morphine, in mice. J Pharmacol Exp Ther1992; 262(1): 10–18
101.
RecheI, FeutesJA, Ruiz-GayoM.Potentiation of D-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of m- and k-opioid receptors. Eur J Pharmacol1996; 318: 11–16.
102.
CichewiczDL, MartinZL, SmithFL, WelchSP. Enhancement of mu opioid antinociception by oral delta-9-tetrahydrocannabinol: dose-response analysis and receptor identification. J Pharmacol Exp Ther1999; 289 (2):859–867.
103.
SmithFL, CichewiczD, MartinZL, WelchSP. The enhancement of morphine antinociception in mice by delta-9-tetrahydrocannabinol. Pharmacol Biochem Behav1998; 60 (2):559–566.
104.
LedentC, ValverdeO, CossuG, PetitetF, AubertJF, BeslotF, . Unresponsiveness to cannabinoids and reduced additive effects of opiates in CB1 receptor knockout mice. Science1999; 283: 401–404.
105.
VelaG, Ruiz-GayoM, FeuntesJA. Anandamide decreases naxolone precipitated withdrawal signs in mice chronically treated with morphine. Neuropharmacology1995; 34: 665–668.
MilsteinSL, MacCannellK, KarrG, ClarkS.Marijuana-produced changes in pain tolerance. Experienced and non-experienced subjects. Int Pharmacopsychiatry1975; 10: 177–182.
115.
HamannW, di VadiPP. Analgesic effect of the cannabinoid analog nabilone is not mediated by opioid receptors. Lancet1999; 353: 560.
116.
HoldcroftA, SmithM, JacklinA, HodgsonH, SmithB, NewtonM, EvansF.Pain relief with oral cannabinoids in familial Mediterranean fever. Anaesthesia1997; 52: 483–486.
117.
RussoE.Cannabis for migraine treatment: the once and future prescription? An historical and scientific review. Pain1998; 76: 3–8.
118.
VolfeZ, DvilanskyA, NathanI.Cannabinoids block release of serotonin form platelets induced by plasma from migraine patients. Int J Clin Pharmacol Res1985; 5: 243–246.
119.
El-MallakhRS. Marijuana and migraine. Headache1987; 27: 442–443.
120.
El-MallakhRF. Migraine headaches and drug abuse. South Med J1989; 82: 805.
NelsonKA, WalshD, DeeterP, SheehanF.A phase II trial of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia. J Palliat Care1994A; 10 (1):14–18.
123.
JakowiakNT, AlexanderHR. The pathophysiology of cancer cachexia. In: DoyleD, HanksG, MacDonaldN (eds). Oxford Textbook of Palliative Medicine (2nd ed.) Oxford: Oxford University Press, 1999; pp. 534–548.
124.
HollisterL.Hunger and appetite after single doses of marihuana, alcohol and dextroamphetamine. Clin Pharmacol Ther1970; 12: 44–49.
125.
AbelEL. Effects of marihuana on the solution of anagrams, memory and appetite. Nature1971; 231: 2660–2661.
126.
GagnonMA, ElieR.Effects of marijuana and D-amphetamine in the appetite, food consumption and various cardio-respiratory variables in man. Union Med Can1975; 104 (6):914–921.
RegelsonW, ButlerJr, SchulzJ, KirkT, PeekL, GreenML, ZalisMO. Delta-9-tetracannabinol as an effective antidepressant and appetite-stimulating agent in advanced cancer patients. In: BraudeMC, SzaraS (eds). The Pharmacology of Marijuana. New York: Raven Press, 1976; pp. 763–775.
GorterR, SeefriedM, VolberdingP.Dronabinol effects on weight in patients with HIV infection. AIDS1992; 6: 127.
131.
TimponeJG, WrightDJ, LiN, EgorinMJ, EnamaME, MayersJ, GalettoG.The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. The DATRI 004 Study Group. Division of AIDS Treatment Research Initiative. AIDS Res Hum Retroviruses1997; 1 (13):305–315.
132.
BealJE, OlsonR, LaubensteinL, MoralesJO, BellmanP, YangcoB, . Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. J Pain Symptom Manage1995; 10 (2):89–97.
133.
ConsroeP.Brain cannabinoid systems as targets for the therapy of neurological disorders. Neurobiol Dis1998; 5: 534–551.
134.
ConsroeP, MustyR, ReinJ, TilleryW, PertweeR.The perceived effects of smoked cannabis on patients with multiple sclerosis. Eur Neurol1997: 38(1): 44–48.
135.
PetroDJ, EllenbergerC.Treatment of human spasticity with delta-9-tetrahydrocannabinol. J Clin Pharmacol1981; 21(suppl 8–9): 413S–16S.
136.
UngerleiderJT, AndyrsiakT, FairbanksL, EllisonGW, MyersLW. Delta-9-THC in the treatment of spasticity associated with multiple sclerosis. Adv Alcohol Subst Abuse1987; 7 (1):39–50.
137.
GreenbergHS, WernessSA, PughJE, AndrusRO, AndersonDJ, DominoEF. Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers. Clin Pharmacol Ther1994; 55 (3):324–328.
138.
KiplingerGF, MannoJE, RoddaBE, ForneyRB. Dose-response analysis of the effects of tetrahydrocannabinol in man. Clin Pharmacol Ther1971; 12: 650–657
139.
MartynCN, lllisLS, ThornJ.Nabilone in the treatment of multiple sclerosis. Lancet1995; 345 (8949):597.
140.
MeinckHM, SchonlePW, ConradB.Effect of cannabinoids on spasticity and ataxia in multiple sclerosis. J Neurol1989; 236 (2):120–122.
141.
CliffordDB. Tetrahydrocannabinol for tremor in multiple sclerosis. Ann Neurol1983; 13 (6):669–671.
142.
KarlerR, TurkanisSA. The cannabinoids as potential antiepileptics. J Clin Pharmacol1981; 21: 437S–448S.
143.
CunhaJM, CarliniEA, PereiraAE, RamosOL, PimentelC, GagliardiR, SanvitoWL. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology1980; 21: 175–185.
144.
Perez-ReyesM, WingfieldM.Cannabidiol and electroencephalographic epileptic activity [letter]. JAMA1974; 230 (12):1635.
145.
KeelerMH, ReiferCF. Grand mal convulsions subsequent to marijuana use. Dis Nerv Syst1967; 28: 474–475.
146.
ChiuP, OlsenDM, BorysHK, KarlerR, TurkanisSA. The influence of cannabinoid and delta-9-tetrahydrocannabinol on cobalt epilepsy in rats. Epilepsia1979; 20: 365–375.
147.
KarlerR, TurkanisSA. Subacute cannabinoid treatment: anticonvulsant activity and withdrawal excitability in mice. Br J Pharmacol1980; 68: 479–484.