Abstract
Since the withdrawal of silicone-gel implants from the market by the Federal Drug Administration in 1992 except for research protocol, there has been continued research to find a substitute filler which is nontoxic and biodegradable. The gel of carboxymethylcellulose has been found to have a mild local tissue reaction which is short in duration, and the substance apparently completely degrades without toxicity. Early research into carboxymethylcellulose is described.
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