Comparison of Autologous Platelet-Rich Plasma with Bone Dust versus Platelet-Rich Plasma Alone and Bone Dust Alone in a Rabbit Model

Abstract

Introduction:

When reconstructing bony defects created secondary to tumor excision or remodeling, there exists a need to increase the rate of bone graft acceptance and the degree of development. In our study we intend to show that platelet-rich plasma can be used in craniofacial defects to increase graft densities.

Methods and Materials:

Twenty-seven New Zealand white rabbits were used as specimens in which cranial osteotomies were performed to create a critical size defect that was then repaired with several combinations of substances. Either the bone dust from the defect, bone dust plus autologous platelet-rich plasma, or autologous plateletrich plasma alone was placed into the graft site. Each specimen was evaluated by DEXA Scan as well as histologic examination.

Results:

All 27 specimens survived and remained infection free. Thus, the results showed that the combination of platelet-rich plasma and bone dust allowed for superior bone mineral density and prevention of bone reabsorption.