The present experiments were designed to evaluate whether the intraventricular administration of excitatory amino acid (EAA) receptor antagonists would prevent light-induced phase shifts of the circadian rhythm of wheel-running activity in the hamster. Administration of the non-N-methyl-D-aspartate (non-NMDA) antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) blocked light-induced phase advances and delays. Similarly, administration of the competitive NMDA receptor antagonist, 3(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), prevented light-induced phase advances and delays. Neither drug by itself caused any consistent effect on the phase of the rhythm. These data provide further evidence that EAA receptors mediate the effects of light on the circadian system, and suggest that both NMDA and non-NMDA receptor types may be involved.
Aizenman, E., M.P. Frosch, and S.A. Lipton (1988) Responses mediated by excitatory ammo acid receptors in solitary retinal ganglion cells from rat. J. Physiol396: 75-91.
2.
Ascher, P., and L. Nowak (1988) The role of cations in the N-methyl-D-aspartate responses of mouse central neurons in culture. J. Physiol.399: 247-266.
3.
Birch, P.J., C.J. Grossman, and A.G. Hayes (1988) DNQX and CNQX antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor . Eur. J. Pharm.156(1): 177-180.
4.
Cahill, G.M., and M. Menaker (1987). Kynurenic acid blocks suprachiasmatic nucleus responses to optic nerve stimulation. Brain Res.410: 125-129.
5.
Cahill, G.M., M.R. Ralph, and M. Menaker (1989) Effects of excitatory ammo acid receptor antagonists and agonists on suprachiasmatic nucleus responses to retmohypothalamic tract volleys. Brain Res.479: 76-82.
6.
Collingridge, G.L., and S.N. Davis (1989) NMDA receptors and long-term potentiation in the hippocampus. In The NMDA Receptor, J. C Watkms and G. L. Collingndge, eds., pp. 123-135, Oxford University Press, New York.
7.
Collingridge, G.L., S.J. Kehl, and H. Mclemman (1983) The antagonism of ammo acid-induced excitations of rat hippocampal CA1 neurons in vitroJ Physiol. 334: 19-34.
8.
Colwell, C.S. , R.G. Foster, and M. Menaker (1991b) NMDA receptor antagonists block the effects of light on circadian behavior in the mouse. Brain Res.554. 105-110.
9.
Colwell, C.S., M. Max, D. Hudson, and M. Menaker (1991a) Excitatory amino acid receptors may mediate the effects of light on the reproductive system of the golden hamster. Biol. Reprod44: 604-608
10.
Colwell, C.S., M.R. Ralph, and M. Menaker (1990) Do NMDA receptors mediate the effects of light on circadian behavior? Brain Res.523: 117-120
11.
Crunelli, V., J.S. Kelly, N. Leresche, and M. Pirchio (1987) On the excitatory post-synaptic potential evoked by stimulation of the optic tract in the rat lateral geniculate nucleus. J. Physiol. (Lond.) 384: 603-618.
12.
Evans, R.H., and S.K. Long (1989) Primary afferent depolarization in the rat spinal cord is mediated by pathways utilizing NMDA and non-NMDA receptors. Neurosci. Lett.100: 231-236.
13.
Harris, K.M., and R.J. Miller (1989) CNQX antagonizes NMDA-evoked [3H]GABA release from cultured cortical neurons via an inhibitory action at the strychnine-insensitive glycme site. Brain Res.489: 185-189.
14.
Hartveit, E., and P. Heggelund (1990) Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus: Nonlagged cells. J Neurophysiol.63: 1361-1372.
15.
Heggelund, P., and E. Hartveit (1990) Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus: Lagged cells. J Neurophysiol. 63. 1347-1360.
16.
Honore, T. , S.N. Davies, J. Drejer, E.J. Fletcher, P. Jacobsen, D. Lodge, and F.E. Nielsen (1988) Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science241. 701-703.
17.
Ito, C. , M. Wakamori, and N. Akaike (1991) Dual effect of glycine on isolated rat suprachiasmatic neurons. Am. J. Physiol.260: C213-C218.
18.
Kay, C.D., and H. Ikeda (1989) The quinoxalinediones antagonise the visual firing of sustained retinal ganglion cells. Eur. J. Pharm. 164(2): 381-384.
19.
Khalsa, S.B.S., and G.D. Block (1988) Calcium channels mediate phase shifts of the Bulla circadian pacemaker. J. Comp. Physiol.164: 195-206
20.
Kim, Y.I., and F.E. Dudek (1991) Intracellular electrophysiological study of suprachiasmatic nucleus neurons in rodents. J. Physiol.444: 269-287
21.
Lehmann, J., J. Schneider, S. Mcpherson, D.E. Murphy, P. Bernard, C. Tsai, D.A. Bennett, G. Pastor, D.J. Steel, C. Boehm, D.L.Cheney, J.M. Liebman, M. Williams, and P.L. Wood (1987) CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: Characterization in vitro and in vivo. J. Pharmacol. Exp. Ther.240. 737-746.
22.
Liou, S.Y., S. Shibata, K. Iwasaki, and S. Ueki (1986) Optic nerve stimulation-induced increase of release of 3H-glutamate and 3H-aspartate but not 3H-GABA from the suprachiasmatic nucleus in slices of rat hypothalamus. Brain Res. Bull.16: 527-531.
Massey, S.C., and R.F. Miller (1990) NMDA receptors of ganglion cells in rabbit retinaJ Neurophysiol.63(1): 16-30.
25.
Mayer, M.L., and R.F. Miller (1990) Excitatory ammo acid receptors, second messengers and regulation of intracellular calcium in mammalian neurons. Trends Neurosci.11: 254-260.
26.
Mayer, M.L., A.B. Macdermott, G.L. Westbrook, S.J. Smith, and J.L. Barker (1987) Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III . J. Neurosci7: 3230-3244.
27.
McMahon, D.G., and G.D. Block (1987) The Bulla ocular circadian pacemakerJ. Comp. Physiol161. 335-346.
28.
Meuer, J.M., E.A. Van Der Zee, and M. Dietz (1986) Glutamate phase shifts circadian activity rhythms in hamsters. Neurosci. Lett86: 177-183.
29.
Mittman, S., W.R. Taylor, and D.R. Copenhagen (1990) Concomitant activation of two types of glutamate receptors mediates excitation of salamander retinal ganglion cells. J. Physiol428: 175-197.
30.
Moffett, J.R., L. Williamson, M. Palkovits, and M.A.A. Namboodiri (1990) N-Acetylaspartylglutamate : A transmitter candidate for the retmohypothalamic tract. Proc. Natl. Acad. Sci USA87(20). 8065-8069.
31.
Monaghan, D.T., R.J. Bridges, and C.W. Cotman (1989) Excitatory ammo acid receptors. Ann. Rev. Pharmacol. Toxicol.29: 365-402.
32.
Moore, R.Y. (1983) Organization and function of a central nervous system circadian oscillator: The SCN. Fed. Proc.42: 2783-2789.
33.
Nishino, H., and K. Koizumi (1977) Responses of neurons in the suprachiasmatic nuclei of the hypothalamus to putative neurotransmitters. Brain Res.249: 167-172.
34.
Ralph, M.R., R.G. Foster, F.C. Davis, and M. Menaker (1990) Transplanted suprachiasmatic nucleus determines circadian period. Science247: 975-978.
35.
Rusak, B., and K.G. Bina (1990) Neurotransmitters in the mammalian circadian system . Ann. Rev. Neurosci.13: 387-401.
36.
Salt, T.E., and S.A. Eaton (1989) Functions of nonNMDA receptors and NMDA receptors in synaptic responses to natural somatosensory stimulation in the ventrobasal thalamus. Exp. Brain Res.77(3): 646-652.
37.
Scharfman, H.E., S.M. Lu, W. Guido, P.R. Adams, and S.M. Sherman (1990) NMDA receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices. Proc. Natl. Acad. Sci. USA87(12): 4548-4552.
38.
Shibata, S., S.Y. Liou, and S. Ueki (1986) Influence of excitatory amino acid receptor antagonists and of baclofen on synaptic transmission in the optic nerve of the suprachiasmatic nucleus in slices of rat hypothalamus. Neuropharmacology25: 403-409.
39.
Sillito, A.M., P.C. Murphy, and T.E. Salt (1990a) The contribution of the non-NMDA group of EAA receptors to retmogeniculate transmission in cat. Neuroscience34(2): 273-280.
40.
Sillito, A.M., P.C. Murphy, T.E. Salt, and C.I. Moody (1990b) Dependence of retinogeniculate transmission in cat on NMDA receptors. J. Neurophysiol.63(2): 347-355.
41.
Takahashi, J.S., P.J. Decoursey, L. Bauman, and M. Menaker (1984) Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms. Nature308: 186-188.
42.
Turek, F.W. (1985) Circadian neural rhythms in mammals. Ann. Rev. Physiol.47: 49-64.
43.
Turski, L., K. Bressler, T. Klockgether, and O.N. Stephens (1990) Differential effects of the excitatory amino acid antagonists, CNQX and CPP, on spinal reflex activity in mice. Neurosci. Lett.113(1): 66-71.
44.
Van Den Pol, A. (1991) Glutamate and aspartate immunoreactivity in hypothalamic presynaptic axons. J. Neurosci.11: 2087-2101.
45.
Watkins, J.C., and R.H. Evans (1981) Excitatory amino acid transmitters. Ann. Rev. Pharmacol. Toxicol.21: 165-204.
46.
Watkins, J.C. , P. Krogsgaard-Larsen , and T. Honore (1991) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. In The Pharmacology of Excitatory Amino Acids, D. Lodge and G. L. Collingridge, eds., pp. 4-13, Elsevier, Amsterdam.
47.
Yamanda, K.A., J.M. Dubinsky, and S.M. Rothman (1989) Quantitative physiological characterization of a quinoxalinedione non-NMDA receptor antagonistJ. Neurosci . 9(9). 3230-3236.
