Vertebrate Circadian and Photoperiodic Systems: Role of the Pineal Gland and Melatonin

Abstract

References

Almeida, O.F.X. , and G.A. Lincoln (1982) Photoperiodic regulation of reproductive activity in the ram: Evidence for the involvement of circadian rhythms in melatonin and prolactin secretion. Biol. Reprod. 27: 1062-1075.

Anderson, K.D. , and F.W. Turek (1985) Photoperiodic control of testicular size in the golden hamster: Lack of a role for the deep pineal gland. J. Pineal Res. 2: 99—107.

Arendt, J. (1985) Mammalian pineal rhythms. In Pineal Research Reviews, Vol. 3, R. J. Reiter , ed., pp. 161-213, Alan R. Liss, New York.

Arendt, J. , C. Bojkowski , C. Franey , J. Wright , and V. Marks (1985) Immunoassay of 6-hydroxy-melatonin sulfate in human plasma and urine: Abolition of the urinary 24-hour rhythm with atenolol. J. Clin. Endocrinol. Metab. 60: 1166-1173.

Bagnara, J.T. (1963) The pineal and the body lightening reaction of larval amphibians. Gen. Comp. Endocrinol. 3: 86-100.

Bartness, T.J. , and B.D. Goldman (1986) Timed melatonin infusions in adult Siberian hamsters: Effect on body weight, body fat, lipid metabolism and gonadal activity. Soc. Neurosci. Abstr. 12: 843.

Besharse, J.C. , and D.A. Dunis (1983) Methoxyindoles and photoreceptor metabolism: Activation of rod shedding. Science 219: 1341-1343.

Besharse, J.C. , and P.M. Iuvone (1983) Circadian clock in Xenopus eye controlling retinal serotinin N-acetyltransferase. Nature 305: 133-135.

Binkley, S. , S.E. Macbride , D.C. Klein , and C.L. Ralph ( 1975) Regulation of pineal enzymes in chicks: Refractory period and nonvisual light perception. Endocrinology 96: 848—853.

10.

Bittman, E.L. (1978) Hamster refractoriness: The role of insensitivity of pineal target tissues. Science 202: 648-649.

11.

Bittman, E.L. , R.J. Dempsey , and F.J. Karsch (1983) Pineal melatonin secretion drives the reproductive response to daylength in the ewe. Endocrinology 113: 2276-2283.

12.

Bittman, E.L. , B.D. Goldman , and I. Zucker (1979) Testicular responses to melatonin are altered by lesions of the suprachiasmatic nuclei in golden hamsters. Biol. Reprod. 21: 647-656.

13.

Boissin-Agasse, L. , J.M. Jacquet , A. Lacroix , and J. Boissin (1986) Circadian participation in the photoregulation of testis activity and prolactin secretion in the mink, a short-day breeder . J. Biol. Rhythms I: 231-241.

14.

Brackmann, M. , and K. Hoffmann (1977) Pinealectomy and photoperiod influence testicular development in the Djungarian hamster. Naturwissenschaften 64: 341.

15.

Brainard, C. , B.A. Richardson , L.J. Petter-Born , and R.J. Reiter (1982) The effect of different light intensities on pineal melatonin content. Brain Res. 233: 75-81.

16.

Carter, D.S. , and B.D. Goldman (1983a) Antigonadal effects of timed melatonin infusion in pinealectomized male Djungarian hamsters (Phodopus sungorus sungorus): Duration is the critical parameter. Endocrinology 113: 1261-1267.

17.

Carter, D.S. , and B.D. Goldman (1983b) Progonadal role of the pineal in the Djungarian hamster (Phodopus sungorus sungorus): Mediation by melatonin. Endocrinology 113: 1268- 1273.

18.

Cassone, V.M. , M.J. Chesworth , and S.M. Armstrong (1986a) Entrainment of rat circadian rhythms by daily injection of melatonin depends upon the hypothalamic suprachiasmatic nuclei . Physiol. Behav. 36: 1111-1121.

19.

Cassone, V.M. , J.M. Chesworth , and S.M. Armstrong (1986b) Dose-dependent entrainment of rat circadian rhythms by daily injection of melatonin. J. Biol. Rhythms 1: 219-229.

20.

Cassone, V.M. , and M. Menaker (1983) Sympathetic regulation of chicken pineal rhythms . Brain Res. 272: 311-317.

21.

Cheung, P.W. , and C.E. Mccormack (1982) Failure of pinealectomy or melatonin to alter circadian activity rhythm of the rat. Amer. J. Physiol. 242: R261-R264.

22.

Collin, J.P. , H. Meissl , P. Voisin , P. Brisson , and J. Falcon (1986) Rhythmic signals of pineal transducers: Physiological, biochemical and cytochemical evidence. In Advances in Pineal Research, Vol. 1, R. J. Reite r and M. Karasek , eds., pp. 41-50, John Libbey, London.

23.

Czyba, J.C. , C. Girod , and N. Durand (1964) Sur l'antagonisme epiphyseo-hypophysaire et les variations saisonnières de la spermatogenèse chez le hamster dore (Mesocricetus auratus). Compt. Rend. Soc. Biol. 158: 742-745.

24.

Daan, S. , D. Damassa , C.S. Pittendrigh , and E. Smith (1975) An effect of castration and testosterone replacement on a circadian pacemaker in mice (Mus musculus). Proc. Natl. Acad. Sci. USA 72: 3744-3747.

25.

Darrow, J.M. , and B.D. Goldman (1986) Circadian regulation of pineal melatonin and reproduction in the Djungarian hamster. J. Biol. Rhythms I: 39-53.

26.

Darrow, J.M. , L. Tamarkin , M.J. Duncan , and B.D. Goldman (1986) Pineal melatonin rhythms in female Turkish hamsters: Effects of photoperiod and hibernation. Biol. Reprod. 35: 74-83.

27.

Deguchi, T. (1979) A circadian oscillator in cultured cells of chicken pineal gland. Nature 282: 94-96.

28.

Dubocovitch, M.L. (1983) Melatonin is a potent modulator of dopamine release in the retina. Nature 306: 782-784.

29.

Dubocovitch, M.L. (1985) Characterization of a retinal melatonin receptor . J. Pharmacol. Exp. Therapeut. 234: 395-401.

30.

Duncan, M.J. , and B.D. Goldman (1984) Hormonal regulation of the annual pelage color cycle in the Djungarian hamster, Phodopus sungorus: II. Role of prolactin . J. Exp. Zool. 230: 97-103.

31.

Duncan, M.J. , and B.D. Goldman (1985) Physiological doses of prolactin stimulate pelage pigmentation in Djungarian hamster. Amer. J. Physiol. 248: R664-R667.

32.

Duncan, M.J. , B.D. Goldman , M.N. Dipinto , and M.H. Stetson (1985) Testicular function and pelage color have different critical daylengths in the Djungarian hamster, Phodopus sungorus sungorus. Endocrinology 116: 424-430.

33.

Ebihara, S. , and H. Kawamura (1981) The role of the pineal organ and the suprachiasmatic nucleus in the control of circadian locomotor rhythms in the Java sparrow , Padda oryzivora. J. Comp. Physiol. 141: 207-214.

34.

Ebihara, S. , K. Uchiyama , and I. Oshima (1984) Circadian organization in the pigeon, Columba livia: The role of the pineal organ and the eye. J. Comp. Physiol. A 154: 59-69.

35.

Ehrenkranz, J.R. , L. Tamarkin , and F. Comite (1982) Daily rhythms of plasma melatonin in normal and precocious puberty. J. Clin. Endocrinol. Metab. 55: 307-310.

36.

Elliott, J.A. (1976) Circadian rhythms and photoperiodic time measurement in mammals. Fed. Proc. 35: 2339-2346.

37.

Elliott, J.A. , M.H. Stetson , and M. Menaker (1972) Regulation of testis function in golden hamsters: A circadian clock measures photoperiodic time. Science 178: 771-773.

38.

Eskes, G.A. , and I. Zucker (1978) Photoperiodic regulation of the hamster testis: Dependence on circadian rhythms. Proc. Natl. Acad. Sci. USA 75: 1034-1038.

39.

Finkelstein, J.S. , F.R. Baum , and C.S. Campbell (1978) Entrainment of the female hamster to reversed photoperiod: Role of the pineal. Physiol. Behav. 21: 105—111.

40.

Foster, D.L. , F.J. Karsch , D.H. Ostler , K.D. Ryan , and S.M. Yellon (1986) Determinants of puberty in a seasonal breeder. Rec. Prog. Horm. Res. 42: 331-378.

41.

Fuchs, J.L. (1983) Effects of pinealectomy and subsequent melatonin implants on activity rhythms in the house finch (Carpodacus mexicanus). J. Comp. Physiol. 153: 413-419.

42.

Gern, W.A. , D. Duvall , and J.M. Nervina (1986) Melatonin: A discussion of its evolution and actions in vertebrates. Amer. Zool. 26: 985-996.

43.

Gern, W.A. , T.A. Gorell , and D.W. Owens (1981) Melatonin and pigment cell rhythmicity. In Melatonin: Current Status and Perspectives, N. Birau and W. Schloot , eds., pp. 223-233, Pergamon Press, New York.

44.

Gern, W.A. , and C.M. Karn (1983) Evolution of melatonin's functions and effects . In Pineal Research Reviews, Vol. 1, R. J. Reiter , ed., pp. 49-90, Alan R. Liss, New York.

45.

Glass, J.D. , and G.R. Lynch (181) Melatonin: Identification of sites of antigonadal action in mouse brain. Science 214: 821-823.

46.

Glass, J.D. , and G.R. Lynch (1982) Diurnal rhythm of response to chronic intrahypothalamic melatonin injections in the white-footed mouse, Peromyscus leucopus. Neuroendocrinology 35: 117-122.

47.

Goldman, A.I. , P.S. Tierstein , and P.J. O'Brien (1980) The role of ambient lighting in circadian

48.

disc shedding in the rod outer segment of the rat retina. Invest. Ophthalmol. Vis. Sci. 19: 1257-1267.

49.

Goldman, B.D. (1983) The physiology of melatonin in mammals. In Pineal Research Reviews, Vol. 1, R. J. Reiter , ed., pp. 145-182, Alan R. Liss , New York.

50.

Goldman, B.D. , and J.M. Darrow (1983) The pineal gland and mammalian photoperiodism. Neuroendocrinology 37: 386-396.

51.

Goldman, B.D. , J.M. Darrow , and L. Yogev (1984) Effects of timed melatonin infusions on reproductive development in the Djungarian hamster (Phodopus sungorus). Endocrinology 114: 2074-2083.

52.

Goldman, B.D. , and J.A. Elliott (in press) Photoperiodism and seasonality in hamsters: Role of the pineal gland.

53.

Goldman, B.D. , V. Hall , C. Hollisters , P. Roychoudhury , L. Tamarkin , and W. Westrom (1979) Effects of melatonin on the reproductive system in intact and pinealectomized male hamsters maintained under various photoperiods . Endocrinology 104: 82-88.

54.

Groos, G. , R. Mason , and J. Meijer (1983) Electrical and pharmacological properties of the suprachiasmatic nuclei. Fed. Proc. 42: 2790-2795.

55.

Gwinner, E. (1978) Effects of pinealectomy on circadian locomotor activity rhythms in European starlings, Sturnus vulgaris, J. Comp. Physiol. 126: 123-129.

56.

Gwinner, E. , and I. Benzinger (1978) Synchronization of a circadian rhythm in pinealectomized European starlings by daily injections of melatonin. J. Comp. Physiol. 127: 209-213.

57.

Hamasaki, D.I. , D.J. Eder (1977) Adaptive radiation of the pineal system. In Handbook of Sensory Physiology, F. Crescitelli , ed., pp. 497-548, Springer, New York.

58.

Hamm, H.E. , J.S. Takahashi , and M. Menaker (1983) Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal gland and retina. Brain Res. 266: 287-293.

59.

Harlow, H.J. , J.A. Phillips , and C.L. Ralph (1982) Circadian rhythms and the effects of exogenous melatonin in the nine-banded armadillo, Dasypus novemcinctus: A mammal lacking a distinct pineal gland. Physiol. Behav. 29: 307-313.

60.

Heath, H.W. , and G.R. Lynch (1982) Intra-specific differences for melatonin-induced reproductive regression and the seasonal molt in Peromyscus leucopus. Gen. Comp. Endocrinol. 48: 289-295.

61.

Heldmaier, G. , S. Steinlechner , J. Rafael , and P. Vsiansky (1981) Photoperiodic control and effects of melatonin on nonshivering thermogenesis and brown adipose tissue. Science 212: 917-919.

62.

Herbert, J. (1969) The pineal gland and light-induced oestrus in ferrets . J. Endocrinol. 43: 625-636.

63.

Hoffman, R.A. , and R.J. Reiter (1965) Pineal gland: Influence on gonads of male hamsters . Science 148: 1609-1611.

64.

Hoffman, K. (1973) The influence of photoperiod and melatonin on testes size, body weight, and pelage colour in the Djungarian hamster (Phodopus sungorus) . J. Comp. Physiol. 95: 267-282.

65.

Hoffmann, K. (1984) Photoperiodic reaction in the Djungarian hamster is influenced by previous light history. Soc. Study Reprod. 30 (abstract 50): 55.

66.

Hoffman, K. , H. Illnerová , and J. Vanēček (1986). Change in duration of the nighttime melatonin peak may be a signal driving photoperiodic responses in the Djungarian hamster (Phodopus sungorus). Neurosci. Lett. 67: 68-72.

67.

Horton, T.H. (1985) Cross-fostering of voles demonstrates in utero effect of photoperiod. Biol. Reprod. 33: 934-939.

68.

Iguchi, H. , K.I. Kato , and H. Ibayashi (1982) Age-dependent reduction in serum melatonin concentrations in healthy human subjects. J. Clin. Endocrinol. Metab. 55: 27-29.

69.

Illnerová and J. Vanēček (1982). Two-oscillator structure of the pacemaker controlling the circadian rhythm of N-acetyltransferase in the rat pineal gland. J. Comp. Physiol. 145: 539-548.

70.

Illnerová, H. , and J. Vanēček (1984) Circadian rhythm in individuality of rat pineal N-acetyltransferase after light pulses at night: Control by a morning oscillator. J. Comp. Physiol. A 154: 739-744.

71.

Iuvone, P.M. , and J.C. Besharse (1983) Regulation of indoleamine N-acetyltransferase activity in the retina: Effects of light and dark, protein synthesis inhibitors and cyclic nucleotide analogs. Brain Res. 273: 111-119.

72.

Inouye, S.-I.T. , and F.W. Turek (1986) Horizontal knife cuts either ventral or dorsal to the hypothalamic paraventricular nucleus block testicular regression in golden hamsters maintained in short days. Brain Res. 370: 102-107.

73.

Karsch, F.J. , E.L. Bittman , D.L. Foster , R.L. Goodman , S.J. Legan , and J.E. Robinson (1984) Neuroendocrine basis of seasonal reproduction. Rec. Prog. Horm. Res. 40: 185-225.

74.

Kennaway, D.J. , R.J. Frith , G. Phillipow , C.D. Matthews , and R.F. Seamark (1977) A specific radioimmunoassay for melatonin in biological tissue and fluids and its validation by gas chromatography-mass spectrometry . Endocrinology 101: 119-128.

75.

Kincl, F.A. , C.C. Chang , and V. Zluzkova (1970) Observation on the influence of changing photoperiod on spontaneous wheel-running activity of neonatally pinealectomized rats. Endocrinology 87: 38-42.

76.

King, T.S. , and S. Steinlechner (185) Pineal indolalkylamine synthesis and metabolism: Kinetic considerations. In Pineal Research Reviews, Vol. 3, R. J. Reiter , ed., pp. 69-113, Alan R. Liss, New York.

77.

Kitay, J.I. (1954) Pineal lesions and precocious puberty: A review . J. Clin. Endocrinol. Metab. 14: 622-625.

78.

Klein, D.C. (1986) Photoneural regulation of the mammalian pineal gland. In Photoperiodism, Melatonin and the Pineal, Ciba Foundation Symposium No. 117, pp. 38-51, Pitman , London.

79.

Klein, D.C. , M. Buda , C. Kapoor , and G. Krishna (1978) Pineal serotonin N-acetyltransferase activity: Abrupt decrease in adenosine 3',5'monophosphate may be "signal" for turnoff . Science 199: 309-311.

80.

Klein, D.C. , and R.Y. Moore (1979) N-acetyltransferase and 5-hydroxyindole-O-methyltransferase : Control by the retinohypothalamic tract and the suprachiasmatic nucleus . Brain Res. 174: 245-262.

81.

Klein, D.C. , R. Smoot , J.L. Weller , S. Higa , S.P. Markey , G.J. Creed , and D.M. Jaco-Bowitz (1983) Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic spinal cord circuit in the melatonin rhythm generating system. Brain Res. Bull. 10: 647-652.

82.

Konishi, H. , M. Ohta , and K. Homma (1985) Important role of the eyes controlling the locomotor rhythm in quail. J. Interdiscipl. Cycle Res. 16: 217-226.

83.

Korf, H.-W. , and M. Møller (1984) The innervation of the mammalian pineal with special reference to central pinealopetal projections. In Pineal Research Reviews, Vol. 2, R. J. Reiter , ed., pp. 41-86, Alan R. Liss, New York.

84.

Lang, U. , M.L. Aubert , B.S. Conne , J.C. Bradtke , and P.C. Sizonenko (1983) Influence of exogenous melatonin on melatonin secretion and on the neuroendocrine reproductive axis of intact male rats during sexual maturation. Endocrinology 112: 1578-1584.

85.

Lavail, M.M. (1980) Circadian nature of rod outer segment disc shedding in the rat. Invest. Ophthalmol. Vis. Sci. 19: 407-411.

86.

Lavail, M.M. , and P.A. Ward (1978) Studies on the hormonal control of circadian outer segment disc shedding in the rat retina. Invest. Ophthalmol. Vis. Sci. 17: 1189-1193.

87.

Lehman, M.N. , E.C. Bittman , and S.W. Newman (1984) Role of the hypothalamic paraventricular nucleus in neuroendocrine responses to daylength in the golden hamster. Brain Res. 308: 25-32.

88.

Lewy, A.J. , M. Tetsuo , S.P. Markey , F.K. Goodwin , and I.J. Kopin (1980a) Pinealectomy abolishes plasma melatonin in the rat. J. Clin. Endocrinol. Metab. 50: 204-205.

89.

Lewy, A.J. , T.A. Wehr , F.K. Goodwin , D.A. Newsome , and S.P. Markey (1980b) Light suppresses melatonin secretion in humans . Science 210: 1267-1269.

90.

Logan, A. , and B. Weatherhead (1980) Post-tyrosinase inhibition of melanogenesis by melatonin in hair follicles in vitro. J. Invest. Dermatol. 74: 47-50.

91.

Loudon, A.S.I. , J.D. Curlewis , and J. English (1985) The effect of melatonin on the seasonal embryonic diapause of the Bennett's wallaby (Macropus rufogriseus rufogriseus). J. Zool. Lond. A 206: 35-39.

92.

Lynch, G.R. , and A.L. Epstein (1976) Melatonin induced changes in gonads, pelage and thermogenic characters in the white-footed mouse, P. leucopus. Comp. Biochem. Physiol. A 53: 67-68.

93.

Martin, C.R. (1985) Textbook of Endocrine Physiology, Williams & Wilkins, Baltimore.

94.

Martin, J.E. , and C. Sattler (1979) Developmental loss of the acute inhibitory effect of melatonin on the in vitro pituitary luteinizing hormone and follicle-stimulating hormone response to luteinizing hormone-releasing hormone. Endocrinology 105: 1007-1012.

95.

Martinet, L. , D. Allain , and C. Winer (1984) Role of prolactin in the photoperiodic control of moulting in the mink (Mustela vison). J. Endocrinol. 103: 9-15.

96.

Martinet, L. , and I. Zucker (1985) Role of the pineal gland in circadian organization of diurnal ground squirrels. Physiol. Behav. 34: 799-803.

97.

Mcmillan, J.P. (1972) Pinealectomy abolishes the circadian rhythm of migratory restlessness. J. Comp. Physiol. 79: 105-112.

98.

Menaker, M. , and S. Wisner (1983) Temperature-compensated circadian clock in the pineal of Anolis. Proc. Natl. Acad. Sci. USA 80: 6119-6121.

99.

Messenger, E.A. , and A.E. Warner (1977). The action of melatonin on single amphibian pigment cells in tissue culture. Brit. J. Pharmacol. 61: 607-614.

100.

Meyer, A.C. , W. Wasserman , B.J. Meyer , W.S. Joubert , S. Roux , and R. Biagio (1981) Melatonin rhythm in the Chacma baboon (Papio ursinus) and the effect of pinealectomy and superior cervical ganglionectomy on the rhythm. S. Afr. J. Sci. 77: 39-41.

101.

Moore, R.Y. , and J.P. Card (1986) Visual pathways and the entrainment of circadian rhythms. In The Medical and Biological Effects of Light, R. J. Wurtman , M. J. Baum , and J. T. Potts , Jr., eds., pp. 123-133, New York Academy of Sciences, New York .

102.

Moore-Ede, M.C. , F.M. Sulzman , and C.A. Fuller (1982) The Clocks That Time Us: Physiology of the Circadian Timing System, Harvard University Press, Cambridge, MA.

103.

Morin, L.P. , K.M. Fitzgerald , and I. Zucker (1977) Estradiol shortens the period of hamster circadian rhythms. Science 196: 305-307.

104.

Nelson, R.J. , M.K. Bamat , and I. Zucker (1982) Photoperiodic regulation of testis function in rats: Mediation by a circadian mechanism. Biol. Reprod. 26: 329-336.

105.

Osol, G. , B. Schwartz , and D.C. Foss (1985) Effects of time, photoperiod, and pinealectomy on ocular and plasma melatonin concentrations in the chick. Gen. Comp. Endocrinol. 58: 415-420.

106.

Ozaki, Y. , and H.J. Lynch (1976) Presence of melatonin in plasma and urine of pinealectomized rats. Endocrinology 9: 641-644.

107.

Pang, S.F. (1985) Melatonin concentrations in blood and pineal gland . In Pineal Research Reviews, Vol. 3, R. J. Reiter , ed., pp. 115-159, Alan R. Liss, New York.

108.

Pang, S.F. , and D.T. Yew (1979) Pigment aggregation by melatonin in the retinal pigment epithelium and choroid of guinea-pigs, Cavia porcellus. Experientia 35: 231-233.

109.

Parfitt, A.G. , and D.C. Klein (1976) Sympathetic nerve endings in the pineal gland protect against acute stress-induced increase in N-acetyltransferase (EC2.3.1.5) activity . Endocrinology 99: 840-851.

110.

Pickard, G.E. , and F.W. Turek (1983) The hypothalamic paraventricular nucleus mediates the photoperiodic control of reproduction but not the effects of light on the circadian rhythm of activity. Neurosci. Lett. 43: 67-72.

111.

Pierce, M.E. , and J.C. Besharse (1985) Circadian regulation of retinomotor movements: I. Interaction of melatonin and dopamine in the control of cone length. J. Gen. Physiol. 86: 671-689.

112.

Pittendrigh, C.S. , and S. Daan (1976) A functional analysis of circadian pacemakers in nocturnal rodents: V. Pacemaker structure: A clock for all seasons. J. Comp. Physiol. 106: 333-355.

113.

Plant, T. , and D.S. Zorub (1986) Pinealectomy in agonadal infantile male rhesus monkeys (Macaca mulatta) does not interrupt initiation of the prepubertal hiatus in gonadotropin secretion. Endocrinology 118: 227-232.

114.

Quay, W.B. (1965) Retinal and pineal hydroxyindole-O-methyltransferase activity in vertebrates. Life Sci. 4: 983-991.

115.

Quay, W.B. (1970) Precocious entrainment and associated characteristics of activity patterns following pinealectomy and reversal of photoperiod. Physiol. Behav. 5: 1281-1290.

116.

Quay, W.B. (1979) The parietal eye-pineal complex. In Biology of the Reptilia, C. Gans , ed., pp. 245-406, Academic Press, New York.

117.

Ralph, C.L. (1981) Melatonin production by extra-pineal tissues. In Melatonin: Current Status and Perspectives, N. Birau and W. Schloot , eds., pp. 35-46, Pergamon Press, New York.

118.

Redman, J. , S. Armstrong , and K.T. Ng (1982) Free-running activity rhythms in the rat: Entrainment by melatonin. Science 219: 1089-1091.

119.

Reiter, R.J. (1986) The pineal gland and gonadal development in male rats and hamsters, Fert. Steril. 19: 1009-1017.

120.

Reiter, R.J. (1973) Pineal control of a seasonal reproductive rhythm in male golden hamsters exposed to natural daylight and temperature. Endocrinology 92: 423-430.

121.

Reiter, R.J. (1974) Circannual reproductive rhythms in mammals related to photoperiod and pineal function: A review. Chronobiologia 1: 365-395.

122.

Reiter, R.J. (1985) Action spectra, dose-response relationships, and temporal aspects of light's effects on the pineal gland. In The Medical and Biological Effects of Light, R. J. Wurtman , M. J. Baum , and J. T. Potts , Jr., eds., pp. 215-230, New York Academy of Sciences, New York.

123.

Reiter, R.J. , E.C. Hurlbut , B.A. Richardson , T.S. King , and L.C.H. Wang (1982) Studies on the regulation of pineal melatonin production in the Richardson's ground squirrel (Spermophilus richardsonii). In The Pineal and Its Hormones, R. J. Reiter , ed., pp. 57-65, Alan R. Liss, New York.

124.

Reiter, R.J. , L.J. Peterborg , and R.C. Philo (1979) Refractoriness to the antigonadotrophic effects of melatonin in male hamsters and its interruption by exposure of the animals to long daily photoperiods. Life Sci. 25: 1571-1576.

125.

Reiter, R.J. , M.K. Vaughan , D.E. Blask , and L.Y. Johnson (1975) Pineal methoxyindoles: New evidence concerning their function in the control of pineal-mediated changes in the reproductive physiology of male golden hamsters. Endocrinology 96: 206-213.

126.

Renfree, M.B. , D.W. Lincoln , O.F.X. Almeida , and R.V. Short (1981) Abolition of a seasonal enbryonic diapause in a wallaby by pineal denervation. Nature 293: 138-140.

127.

Reuss, S. , and L. Vollrath (1984) Electrophysiological properties of rat pinealocytes: Evidence for circadian and ultradian rhythms. Exp. Brain Res. 55: 455-461.

128.

Rissman, E.F. (1980) Prepubertal sensitivity to melatonin in male hamsters . Biol. Reprod. 22: 277-280.

129.

Robinson, J.E. , and B.K. Follett (1982) Photoperiodism in Japanese quail: The termination of seasonal breeding by photorefactoriness. Proc. Roy. Soc. Lond. B 215: 95-116.

130.

Robinson, J.E. , and F.J. Karsch (1987) Photoperiodic history and a changing melatonin pattern can determine the neuroendocrine response of the ewe to daylength . J. Reprod. Fert. 80: 159-165.

131.

Rollag, M.D. (1982) Ability of tryptophan derivatives to mimic melatonin's action upon the Syrian hamster reproductive system. Life Sci. 31: 2699-2707.

132.

Rollag, M.D. , M.N. Dipinto , and M.H. Stetson (1982) Ontogeny of the gonadal response of golden hamsters to short photoperiod, blinding, and melatonin. Biol. Reprod. 27: 898-902.

133.

Rollag, M.D. , and G.D. Niswender (1976) Radioimmunoassay of serum concentrations of melatonin in sheep exposed to different lighting regimens. Endocrinology 98: 482-489.

134.

Rusak, B. (1980) Suprachiasmatic lesions prevent an antigonadal effect of melatonin. Biol. Reprod. 22: 148-154.

135.

Rusak, B. (1982) Circadian organization in mammals and birds: Role of the pineal gland. In The Pineal Gland: Extrareproductive Effects, Vol. 3, R. J. Reiter , ed., pp. 29-51, CRC Press, Boca Raton, FL.

136.

Rusak, B. , and I. Zucker (1979) Neural regulation of circadian rhythms. Physiol. Rev. 59: 449-526.

137.

Sheridan, M.N. , and Reiter, R.J. (1970) Observations on the pineal system in the hamster: I. Relations of the superficial and deep pineal to the epithalamus. J. Morphol. 131: 153-162.

138.

Sheridan, M.N. , and M.D. Rollag (1983) Development and melatonin content of the deep pineal gland in the Syrian hamster. Amer. J. Anat. 168: 145-156.

139.

Simpson, S.M. , and B.K. Follett (1981) Pineal and hypothalamic pacemakers: Their role in regulating circadian rhythmicity in Japanese quail. J. Comp. Physiol. 144: 381-389.

140.

Sizonenko, P.C. , U. Lang , R.W. Rivest , and M.L. Aubert (1986) The pineal and pubertal development. In Photoperiodism, Melatonin and the Pineal, Ciba Foundation Symposium No. 117, pp. 208-225, Pitman, London.

141.

Snyder, D.L. , R.L. Cowan , D.R. Hagen , and B.D. Schanbacher (1983) Effect of pinealectomy on concentrations of testosterone and prolactin in white-tailed deer. Biol. Reprod. 29: 63-71.

142.

Steinlechner, S. , T.S. King , T.H. Champney , B.A. Richardson , and R.J. Reiter (1985) Pharmacological studies on the regulation of N-acetyltransferase activity and melatonin content of the pineal gland of the Syrian hamster. J. Pineal Res. 2: 109-119.

143.

Stetson, M.H. , J.A. Elliott , and B.D. Goldman (1986a) Maternal transfer of photoperiodic information influences the photoperiodic response of prepubertal Djungarian hamsters. Biol. Reprod. 34: 664-669.

144.

Stetson, M.H. , J.A. Elliott , and M. Menaker (1975) Photoperiodic regulation of the hamster testis: Circadian sensitivity to the effects of light. Biol. Reprod. 13: 329-339.

145.

Stetson, M.H. , E. Sarafidis , and M.D. Rollag (1986b) Sensitivity of adult male Djungarian hamsters (Phodopus sungorus sungorus) to melatonin injections throughout the day: Effects on the reproductive system and the pineal. Biol. Reprod. 35: 618-623.

146.

Stetson, M.H. , and D.E. Tay (1983) Time course of sensitivity of golden hamsters to melatonin injections throughout the day. Biol. Reprod. 29: 432-438.

147.

Stetson, M.H. , and M. Watson-Whitmyre (1984) The physiology of the pineal and its hormone melatonin in annual reproduction in rodents. In The Pineal Gland, R. J. Reiter , ed., pp. 109-153, Raven Press, New York.

148.

Sullivan, J.K. , and G.R. Lynch (1983) Photoperiodic time measurement for activity, torpor, molt and reproduction in mice. Physiol. Behav. 36: 167-164.

149.

Takahashi, J.S. , and M. Menaker (1979) Physiology of avian circadian pacemakers. Fed. Proc. 38: 2583-2588.

150.

Takahashi, J.S. , and M. Menaker (1982) Role of the suprachiasmatic nuclei in the circadian system of the house sparrow, Passer domesticus. J. Neurosci. 2: 815-828.

151.

Takahashi, J.S. , and M. Menaker (1984) Multiple redundant circadian oscillators within the isolated avian pineal gland. J. Comp. Physiol. A 154: 435-440.

152.

Takahashi, J. , H.E. Hamm , and M. Menaker (1980) Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro. Proc. Natl. Acad. Sci. USA 77: 2319-2322.

153.

Tamarkin, K. , P. Abastillas , H.C. Chen , A. McNEMAR, and J.B. Sidbury (1982) The daily profile of plasma melatonin in obese and Prader-Willi syndrome children. J. Clin. Endocrinol. Metab. 55: 491-495.

154.

Tamarkin, L. , C.W. Hollister , N.G. Lefebvre , and B.D. Goldman (1977) Melatonin induction of gonadal quiescence in pinealectomized Syrian hamsters. Science 198: 953-955.

155.

Tamarkin, L. , S.M. Reppert , D.C. Klein , B. Pratt , and B.D. Goldman (1980a) Studies on the daily pattern of pineal melatonin in the Syrian hamster. Endocrinology 107: 1525-1529.

156.

Tamarkin, L. , S.M. Reppert , D.J. Orloff , D.C. Klein , S.M. Yellon , and B.D. Goldman (1980b) Ontogeny of the pineal melatonin rhythm in the Syrian (Mesocricetus auratus) and Siberian (Phodopus sungorus) hamsters and in the rat. Endocrinology 107: 1061-1064.

157.

Tamarkin, L. , W.K. Westrom , A.I. Hamill , and B.D. Goldman (1976) Effect of melatonin on the reproductive systems of male and female hamsters: A diurnal rhythm in sensitivity to melatonin . Endocrinology 99: 1534-1541.

158.

Turek, F.W. (1979) Effect of melatonin on photic-independent and photic-dependent testicular growth in juvenile and adult male golden hamsters. Biol. Reprod. 20: 1119-1122.

159.

Turek, F.W. , C. Desjardins , and M. Menaker (1976a) Differential effects of melatonin on the testes of photoperiodic and nonphotoperiodic rodents. Biol. Reprod. 15: 94-97.

160.

Turek, F.W. , J.P. Mcmillan , and M. Menaker (1976b) Melatonin: Effects on the circadian locomotor rhythm of sparrows. Science 194: 1441-1443.

161.

Tyndale-Biscoe, C.H. , L.A. Hinds , and S.J. Mcconnell (1984) Seasonal breeding in a marsupial: Opportunities of a new species for an old problem. Rec. Prog. Horm. Res. 42: 471-507.

162.

Ueck, M. (1979) Innervation of the vertebrate pineal. In The Pineal Gland of Vertebrates Including Man, J. A. Kappers and P. Pevet , eds., pp. 45-87, Elsevier/North-Holland , New York.

163.

Underwood, H. (1977) Circadian organization in lizards: The role of the pineal organ. Science 195: 587-589.

164.

Underwood, H. (1979) Melatonin affects circadian rhythmicity in lizards . J. Comp. Physiol. 130: 317-323.

165.

Underwood, H. (1981) Circadian organization in the lizard Sceloprous occidentalis: The effect of pinealectomy, blinding, and melatonin. J. Comp. Physiol. 141: 537-547.

166.

Underwood, H. (1983) Circadian organization in the lizard Anolis Carolinensis: A multioscillator system. J. Comp. Physiol. A 152: 265-274.

167.

Underwood, H. (1984) The pineal and circadian rhythms. In The Pineal Gland, R. J. Reiter , ed., pp. 221-251, Raven Press, New York.

168.

Underwood, H. (1985) Pineal melatonin rhythms in the lizard Anolis carolinensis: Effects of light and temperature cycles. J. Comp. Physiol. A 157: 57-65.

169.

Underwood, H. (1986a) Light at night cannot suppress pineal melatonin levels in the lizard Anolis carolinensis. Comp. Biochem. Physiol. 84A: 661-663.

170.

Underwood, H. (1986b) Circadian rhythms in lizards: Phase response curve for melatonin. J. Pineal Res. 3: 187-196.

171.

Underwood, H. and M. Calaban (1987a) Pineal melatonin rhythms in the lizard Anolis carolinensis : I. Response to light and temperature cycles. J. Biol. Rhythms 2: 179-193.

172.

Underwood, H. , and M. Calaban (1987b) Pineal melatonin rhythms in the lizard Anolis carolinensis : II. Photoreceptive inputs. J. Biol. Rhythms 2: 195-206.

173.

Underwood, H. and G.A. Groos (1982) Vertebrate circadian rhythms: Retinal and extraretinal photoreception. Experientia 38: 1113- 1121.

174.

Underwood, H. , and M. Harless (1985) Entrainment of the circadian activity rhythm of a lizard to melatonin injections. Physiol. Behav. 35: 267-270.

175.

Underwood, H. , and T. Siopes (1984) Circadian organization in Japanese quail. J. Exp. Zool. 232: 557-566.

176.

Underwood, H. , and T. Siopes (1985) Melatonin rhythms in quail: Regulation by photoperiod and circadian pacemakers. J. Pineal Res. 2: 133-143.

177.

Underwood, H. , S. Binkley , T. Siopes , and K. Mosher (1984) Melatonin rhythms in the eyes, pineal bodies, and blood of Japanese quail (Coturnix coturnix japonica). Gen. Comp. Endocrinol. 56: 70-81.

178.

Vakkuri, O. H. Rintamaki , and J. Leppaluoto ( 1985) Plasma and tissue concentrations of melatonin after midnight light exposure and pinealectomy in the pigeon. J. Endocr. 105: 263-268.

179.

Vanēček, J. , L. Jansky , H. Illnerová , and K. Hoffman (1984) Pineal melatonin in aroused golden hamsters (Mesocricetus auratus). Comp. Biochem. Physiol. 77A: 759-762.

180.

Vaughan, G.M. , and R.J. Reiter (1986) Pineal dependence of the Syrian hamster's nocturnal serum melatonin surge. J. Pineal Res. 3: 9-14.

181.

Vitale, P.M. , J.M. Darrow , M.J. Duncan , C.A. Shustak , and B.D. Goldman (1985) Effects of photoperiod, pinealectomy and castration on body weight and daily torpor in Djungarian hamsters (Phodopus sungorus) . J. Endocrinol. 106: 367-375.

182.

Voisin, P. , M. Geffard , M. Delaage. and J.P. Collin (1982) Melatonine dans l'organe pineal, la rétine et la plasma: Étude immunologique chez le pigeon. Reprod. Nutr. Dev. 22: 959-971.

183.

Voisin, P. , M.T. Juillard , and J.P. Collin (1983) Indole metabolism in the pineal organ of the pigeon with special reference to melatonin-synthesizing cells. Cell Tissue Res. 230: 155-169.

184.

Vollrath, L. (1986) Mammalian pinealocytes: Ultrastructural aspects and innervation. In Photoperiodism, Melatonin and the Pineal, Ciba Foundation Symposium No. 117, pp. 9-17, Pitman, London.

185.

Waldhauser, F. , G. Weiszenbacher , H. Frisch , U. Zeithuber , M. Waldhauser , and R.J. Wurtman (1984) Fall in nocturnal serum melatonin during prepuberty and pubescence. Lancet i: 362-365.

186.

Waldhauser, F. , and R.J. Wurtman (1983). The secretion and actions of melatonin. In Biochemical Actions of Hormones, G. Litwack , ed., pp. 187-225, New York: Academic Press.

187.

Watson-Whitmyre, M. , and M.H. Stetson (1983) Simulation of peak pineal melatonin release restores sensitivity to evening melatonin injections in pinealectomized hamsters. Endocrinology 112: 763-765.

188.

Weatherhead, B. , and A. Logan (1981) Interaction of α-melanocyte-stimulating hormone, melatonin, cyclic AMP and cyclic GMP in the control of melanogenesis in hair follicle melanocytes in vitro. J. Endocrinol. 90: 89-96.

189.

Weaver, D.R. , and S.M. Reppert (1986) Maternal melatonin communicates daylength to the fetus in Djungarian hamsters. Endocrinology 119: 2861-2863.

190.

Wiechmann, A.F. (1986) Melatonin: Parallels in pineal gland and retina . Exp. Eye Res. 42: 507-527.

191.

Wiechmann, A.F. , D. Bok , and J. Horwitz (1985) Localization of hydroxyindole-O-methyltransferase in the mammalian pineal gland and retina. Invest. Ophthalmol. Vis. Sci. 26: 253-265.

192.

Whitsett, J.M. , H. Underwood , and J. Cherry (1983) Photoperiodic regulation of pubertal development in male deer mice: Involvement of the circadian system. Biol. Reprod. 28: 652-656.

193.

Wilkinson, M. , J. Arendt , J. Bradtke , and D. De Ziegler (1977) Determination of a dark-induced increase of pineal N-acetyltransferase activity and simultaneous radioimmunoassay of melatonin in pineal, serum and pituitary tissue of the male rat. J. Endocrinol. 72: 243-244.

194.

Yellon, S.M. , L. Tamarkin , B.L. Pratt , and B.D. Goldman (1982) Pineal melatonin in the Djungarian hamster: Photoregulation of a circadian rhythm. Endocrinology 111: 488-492.

195.

Yu, H.S. , S.F. Pang , and P.L. Tong (1981) Increase in the level of retinal melatonin and persistance of its diurnal rhythm in rats after pinealectomy. J. Endocrinol. 91: 477-481.

196.

Zimmerman, N.H. , and M. Menaker (1979) The pineal gland: A pacemaker within the circadian system of the house sparrow. Proc. Natl. Acad. Sci. USA 76: 999-1003.

197.

Zisapel, N. , and M. Laudon (1982) Dopamine release induced by electrical field stimulation of rat hypothalamus in vitro: Inhibition by melatonin. Biochim. Biophys. Res. Commun. 104: 1610-1616.

198.

Zucker, I. (1985) Pineal gland influences period of circannual rhythms of ground squirrels. Amer. J. Physiol. 18: R111-R115.