Abstract
The brain is the most energy-demanding organ, yet whether cerebral energy homeostasis exhibits seasonal rhythmicity remains unclear. In this study, 432 healthy men underwent a health checkup program with fasting-state brain [18F]fluorodeoxyglucose positron emission tomography (PET) scanning twice: first at the baseline and then at the 5-year follow-up. We analyzed the effect of day length on brain glucose uptake separately for both time points. In both baseline and follow-up scans, day length on the day of imaging significantly predicted glucose uptake in the socio-emotional circuit. A longer day length was associated with increased glucose uptake in the cuneus, precuneus, orbitofrontal cortex, pre- and postcentral gyrus, superior and middle temporal gyrus, posterior cingulate cortex, insula, and frontal pole. This large-scale longitudinal PET study provides landmark evidence for the impact of daylight exposure on brain glucose metabolism. Findings disclose the baseline seasonal variation of brain energy consumption in men.
Get full access to this article
View all access options for this article.
References
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
