Regulations and Advisories

ACGIH . Threshold limit values for chemical substances and physical agents and biological exposure indices. American Conference of Governmental Industrial Hygienists, Cincinnati, OH, 1990.

Acott P. D. , Murphy M. G. , Ogborn M. R. , et al. Measurement of phthalates in small samples of mammalian tissue. Bull. Environ. Contam. Toxicol. 1987: 38: 363-368.

Agarwal D. K. [Letters to the editor.] Toxicol. Appl. Pharmacol. 1986: 83: 383-387.

Agarwal D. K. , Agarwal S. , and Seth P. K. Effect of di(2-ethylhexyl)phthalate on drug metabolism, lipid peroxidation, and sulfhydryl content of rat liver. Drug Metab. Dispos. 1982a: 10: 77-80.

Agarwal D. K. , Agarwal S. , and Seth P. K. Interaction of di-(2-ethylhexyl)phthalate with the pharmacological response and metabolic aspects of ethanol in mice. Biochem. Pharmacol. 1982: 31 (21): 3419-3423.

Agarwal D. K. , Eustis S. , Lamb J. C. , et al. Effects of di-(2-ethylhexyl)phthalate on the gonadal pathophysiology, sperm morphology, and reproductive performance of male rats. Environ. Health Perspect. 1986: 65: 343-350.

Ahmed R. S. , Price S. C. , Grasso P. , et al. Effects of intermittent feeding of rats with di-2-ethylhexylphthalate. Biochem. Soc. Trans. 1989: 17: 1073-1074.

Alarie Y. , Iwasaki M. , Stock M. F. , et al. Effects of inhaled municipal refuse incinerator fly ash in the guinea pig. J. Toxicol. Environ. Health 1989: 28: 13-25.

Albro P. W. Absorption, metabolism and excretion of di(2-ethylhexyl)phthalate by rats and mice. Environ. Health Perspect. 1986: 65: 293-298.

Albro P. W. , and Gorbett J. T. Distribution of di-mono-(II-ethylhexyl)phthalate in human plasma. Transfusion 1978: 18: 750-755.

Albro P. W. , Thomas R. , and Fishbein L. Metabolism of diethylhexyl phthalate by rats: isolation and characterization of the urinary metabolites. J. Chromatogr. 1973: 76: 321-330.

Albro P. W. , Hass J. R. , Peck C. C. , et al. Identification of the metabolites of di(2-ethylhexyl)phthalate in urine from the African green monkey. Drug Metab. Dispos. 1981: 9: 223-225.

Albro P. W. , Corbett J. T. , Schroeder J. L. , et al. Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP. Environ. Health Perspect. 1982: 45: 19-25.

Albro P. W. , Hass J. R. , Peck C. C. , et al. Applications of isotope differentiation for metabolic studies with di(2-ethylhexyl)phthalate. J. Environ. Sci. Health, Part B 1982: 17: 701-714.

Albro P. W. , Tondeur I. , Marbury D. , et al. Polar metabolites of di(2-ethylhexyl)phthalate in the rat. Biochim. Biophys. Acta 1983: 760: 283-292.

Albro P. W. , Jordan S. , Gorbett J. T. , et al. Determination of total phthalate in urine by gas chromatography. Anal. Chem. 1984: 56: 247-250.

Albro P. W. , Corbett J. T. , Schroeder J. , et al. Beta-oxidation of 2-ethyl-5-carboxypentyl phthalate in rodent liver. Biochim. Biophys. Acta 1987: 923: 196-205.

Albro P. W. , Chapin R. E. , Corbett J. T. , et al. Mono-2-ethylhexyl phthalate, a metabolite of di-(2-ethylhexyl)phthalate, causally linked to testicular atrophy in rats. Toxicol. Appl. Pharmacol. 1989: 100: 193-200.

Aldrich . Aldrich Chemical Catalog. Aldrich Chemical Company, 1987.

Al-Omran L. A. , and Preston M. R. The interactions of phthalate esters with suspended particulate material in fresh and marine waters. Environ. Pollut. 1987: 46: 177-186.

APHA . Standard Methods for the Examination of Water and Wastewater, 17th edn. American Public Health Association, Washington, DC, 1989.

Arcos J. C. , Woo Y.-T. , and Lai D. Y. Database on binary combination effects of chemical carcinogens. J. Environ. Sci. Health, Part C: Environ. Carcinog. Rev. 1988: V-XIV: 1-150.

Ashby J. The prospects for a simplified and internationally harmonized approach to the detection of possible human carcinogens and mutagens. Mutagenesis 1986: 1: 3-16.

Ashby J. , de Serres F. J. , Draper M. , et al. Overview and conclusions of the IPCS collaborative study on in vitro assay systems. Prog. Mutat. Res. 1985: 5: 117-174.

Astill B. D. Metabolism of DEHP: effects of prefeeding and dose variation, and comparative studies in rodents and the cynomolgus monkey (CMS studies). Drug Metab. Rev. 1989: 21: 35-53.

Astill D. , Barber E. , Lington A. , et al. Chemical industry voluntary test program for phthalate esters: health effects study. Environ. Health Perspect. 1986: 65: 329-336.

Atlas E. , and Giam C. S. Global transport of organic pollutants: ambient concentrations in the remote marine atmosphere. Science 1981: 211: 163-165.

ATSDR . Toxicological Profile For Di(2-Ethylhexyl)Phthalate (Update). Agency for Toxic Substances and Disease Registry, Atlanta, GA. NTIS Publication Number PB/93/182400. 1993.

ATSDR . 1999 CERCLA Priority List of Hazardous Substances That Will Be The Subject of Toxicological Profiles: Support Document. Agency for Toxic Substances and Disease Registry, Atlanta, GA. 1999.

Badr M. Z. , Handler J. A. , Whittaker M. , et al. Interactions between plasticizers and fatty acid metabolism in the perfused rat liver and in vivo: inhibition of ketogenesis by 2-ethylhexanol. Biochem. Pharmacol. 1990: 39: 715-722.

Bailey G. L. The sick kidney and sex. N. Engl. J. Med. 1977: 296: 1288-1289.

Baker R. W. Gel filtration of phthalate esters. J. Chromatogr. 1978: 154: 3-11.

Bannai M. , Mazda T. , Ishikawa Y. , et al. The effect of di-(2-ethylhexyl)phthalate, a chemical leached from blood bags on platelet adenosine diphosphate aggregability. Chem. Pharmacol. Bull. 1987: 35: 4328-4331.

Barber E. D. , Astill B. D. , Moran E. J. , et al. Peroxisome induction studies on seven phthalate esters. Toxicol. Ind. Health 1987: 3: 7-24.

Barnes D. G. , and Dourson M. Reference dose (RfD): description and use in health risk assessments. Regul. Toxicol. Pharmacol. 1988: 8: 471-486.

Barrows M. E. , Tetrocelli S. R. , Macek K. J. , et al. Bioconcentration and elimination of selected water pollutants by bluegill sunfish (Lepomis macrochirus). In: Haque R. (Ed.), Dynamics, Exposure and Hazard Assessment of Toxic Chemicals. Ann Arbor Science Publishers, Inc., Ann Arbor, MI, 1980, pp. 379-393.

Barry Y. A. , Labow R. S. , Keon W. J. , et al. Perioperative exposure to plasticizers in patients undergoing cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 1989: 97: 900-905.

Barry Y. A. , Labow R. S. , Keon W. J. , et al. Atropine inhibition of the cardiodepressive effect of mono(2-ethylhexyl)phthalate on human myocardium. Toxicol. Appl. Pharmacol. 1990: 106: 48-52.

Bartles J. R. , Khoun S. , Lin X. , et al. Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins. Cancer Res. 1990: 506: 669-676.

Benford D. J. , Patel S. , Reavy H. J. , et al. Species differences in the response of cultured hepatocytes to phthalate esters. Food Chem. Toxicol. 1986: 24: 799-800.

Bickers D. R. , Dutta-Choudhury T. , and Mukhtar H. Epidermis: a site of drug metabolism in neonatal rat skin. Studies on cytochrome P-450 content and mixed-function oxidase and epoxide hydrolase activity. Mol. Pharmacol. 1982: 21: 239-247.

Birnbaum L. S. Age-related changes in carcinogen metabolism. J. Am. Geriatr. Soc. 1987: 35: 51-60.

Bommer J. , Ritz E. , and Andrassy K. Side effects due to material used in hemodialysis equipment. In: Grunfeld J. P. , Maxwell M. H. (Eds.), Advances in Nephrology. Year Book Publishing, Chicago, IL, 1984, pp. 409-431.

Bove J. L. , and Dalven T. A GC/MF method of determining airborne di-n-butyl-di-(2-ethylhexyl)phthalate. Int. J. Environ. Anal. Chem. 1981: 10: 189-196.

Bove J. L. , Dalven P. , and Kukreja V. P. Airborne di-butyl and di-(2-ethylhexyl)-phthalate at three New York City air sampling stations. Int. J. Environ. Anal. Chem. 1978: 5: 189-194.

Boylan J. L. , Egle J. L. , and Guzelian P. D. Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning. Science 1978: 199: 893-895.

Branson D. R. Prioritization of chemicals according to degree of hazard in the aquatic environment. Environ. Health Perspect. 1980: 34: 133-138.

Bridges J. W. Use of toxicity data—a case study of di-(2-ethylhexyl)phthalate. In: Richardson M. L. (Ed.), Toxic Hazard Assessment of Chemicals. The Royal Society of Chemistry, London, England, 1986, pp. 233-546.

Brodsky J. , Andersson J. T. , and Ballschmiter K. Chemical degradation of xenobiotics II. Simulation of the biotic transformation of bis(2-ethylhexyl)phthalate and dioctylphthalate by abiotic means. Chemosphere 1986: 15: 139-148.

Brown K. W. , and Donnelly K. C. An estimation of the risk associated with the organic constituents of hazardous and municipal waste landfill leachates. Hazard. Waste Hazard. Mater. 1988: 5: 1-30.

Budavari S. , O'Neil M. J. , Smith A. , et al. The Merck Index: An encyclopedia of chemicals, drugs, and biologicals, 11th edn. Merck and Co., Inc., Rahway, NJ, 1989, 194-194 pp.

Busser M.-T. , and Lutz W. K. Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters. Carcinogenesis 1987: 8: 1433-1437.

Butterworth B. E. The genetic toxicology of di(2-ethylhexyl)phthalate. Chem. Ind. Inst. Toxicol. (CIIT) 1984: 4: 1-8.

Butterworth B. E. Genetic toxicology of di(2-ethylhexyl)phthalate. Banbury Rep. 1987: 25: 257-276.

Butterworth B. E. , Loury D. J. , Smith-Oliver T. , et al. The potential role of chemically induced hyperplasia in the carcinogenic activity of the hypolipidemic carcinogens. Toxicol. Ind. Health 1987: 3: 129-149.

Butterworth B. E. , Smith-Oliver T. , Earle L. , et al. Use of primary cultures of human hepatocytes in toxicology studies. Cancer Res. 1989: 49: 1075-1084.

Cairns T. , Chiu K. S. , Siegmund E. G. , et al. Levels of plasticizer in the frequent plasma donor. Biomed. Environ. Mass Spectrom. 1986: 13: 357-360.

Callahan M. A. , Slimak M. W. , Gael N. W. , et al. Water-related environmental fate of 129 priority pollutants. Halogenated aliphatic hydrocarbons, halogenated ethers, monocyclic aromatics, phthalate esters, polycyclic aromatic hydrocarbons, nitrosamines, and miscellaneous compounds, Vol. II. Report to U.S. Environmental Protection Agency, Office of Water Planning and Standards, Washington, DC, by Versar Incorporated, Springfield VA, 1979. EPA-440/4-79-029a. NTIS No. PB80-204373.

Calley D. , Autian J. , and Guess W. Toxicology of a series of phthalate esters. J. Pharmacol. Sci. 1966: 55: 158-161.

Carpenter C. P. , Weil C. S. , and Smyth H. F. Chronic oral toxicity of DEHP for rats, guinea pigs, and dogs. AMA Arch. Ind. Hyg. 1953: 8: 219-226.

Carter J. H. , Carter H. W. , Deangelo A. B. , et al. Sub-lethal autolysis in livers of rats exposed to phthalates. J. Cell Biol. 1989: 109: 182A-182A.

Castle L. , Mercer A. J. , Startin J. R. , et al. Migration from plasticized film into foods: III. Migration of phthalate, sebacate, citrate and phosphate esters from films used for retail food packaging. Food Addit. Contam. 1988: 5: 9-20.

Castle L. , Mayo A. , and Gilbert J. Migration of plasticizers from printing inks into food. Food Addit. Contam. 1989: 6: 437-443.

Cattley R. C. , Conway J. G. , and Popp J. A. Association of persistent peroxisome proliferation and oxidative injury with hepatocarcinogenicity in female F-344 rats fed di(2-ethylhexyl)phthalate for 2 years. Cancer Lett. 1987: 38: 15-21.

Cattley R. C. , Smith-Oliver T. , Butterworth B. E. , et al. Failure of the peroxisome proliferator WY-14,643 to induce unscheduled DNA synthesis in rat hepatocytes following in vivo treatment. Carcinogenesis 1988: 9: 1179-1183.

CCRIS . Chemical Carcinogenesis Research Information System. National Library of Medicine, National Toxicology Information Program, Bethesda, MD, July 6, 1990.

Cerbulis J. , and Byler D. M. Isolation and detection of dialkyl phthalates from pork. J. Agric. Food Chem. 1986: 34: 198-200.

Chapin R. E. , Gray T. J. , Phelps J. L. , et al. The effects of mono-(2-ethylhexyl)-phthalate on rat Sertoli cell-enriched primary cultures. Toxicol. Appl. Pharmacol. 1988: 92: 467-479.

Chemical Regulations and Guidelines. Dialog Information Systems, Inc., Palo Alto, CA, July 19, 1990.

Chemline. Chemical dictionary online. National Library of Medicine, National Toxicology Information Program, Bethsda, MD, July 5, 1990.

Ching N. P. , Jham G. N. , Subbarayan C. , et al. Gas chromatographic-mass spectrometric detection of circulating plasticizers in surgical patients. J. Chromatogr. 1981: 222: 171-177.

Ching N. P. , Jham G. N. , Subbarayan C. , et al. Gas chromatographic quantitation of two plasticizers contaminating IV fluids stored in plastic containers. J. Chromatogr. Biomed. Appl. 1981: 225: 196-201.

CHRIS. Chemical Hazard Response Information System. Data manual. U.S. Coast Guard, 1978.

Clayton C. G. , and Clayton F. E. (Eds.), Patty's Industrial Hygiene and Toxicology, Vol. IIA, 3rd rev. edn. John Wiley and Sons, New York, NY, 1981, pp. 2344-2347.

CLPSD. Contract Laboratory Program Statistical Database. Viar & Company, Management Service Division, Alexandria, VA, July, 1990.

CMA . Analysis of bis(2-ethylhexyl)phthalate (DEHP) by gas chromatography-mass spectrometry in dairy and meat products. Hazleton Laboratories America, Inc., Madison, WI, 1986. [Peer-reviewed unpublished study].

Cohen A. J. , and Grasso P. Review of the hepatic response to hypolipidemic drugs in rodents and assessment of its toxicological significance to man. Food Cosmet. Toxicol. 1981: 19: 585-606.

Colburn N. H. , Smith B. M. , Wendel E. J. , et al. Comparison of mouse pro-1 and pro-2 transfectants for responses to tumor promoters and antipromoters. Cancer Res. 1988: 48: 6076-6080.

Cole R. H. , Frederick R. E. , Healy R. P. , et al. Preliminary findings of the priority pollutant monitoring project of the nationwide urban runoff program. J. Water Pollut. Control Fed. 1984: 56: 898-908.

Conway J. G. , Tomaszewski K. E. , Olson M. J. , et al. Relationship of oxidative damage to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and Wy-14,643. Carcinogenesis 1989: 10: 513-519.

CPSC. Report to the U.S. Consumer Product Safety Commission by the Chronic Hazard Advisory Panel on DEHP, 1985.

Creasy D. M. , Jones H. B. , Beech L. M. , et al. The effects of two testicular toxins on the ultrastructural morphology of mixed cultures of Sertoli and germ cells: a comparison with in vivo effects. Food Chem. Toxicol. 1986: 24: 655-656.

Crebelli R. , and Carere A. Chemical and physical agents assayed in tests for mitotic intergenic and intragenic recombination in Aspergillus nidulans diploid strains. Mutagenesis 1987: 2: 469-476.

Cripe C. R. , Walker W. W. , Pritchard P. H. , et al. A shake-flask test for estimation of biodegradability of toxic organic substances in the aquatic environment. Ecotoxicol. Environ. Safety 1987: 14: 239-251.

CRISP. Computer Retrieval of Information on Scientific Projects. National Institutes of Health, Division of Research Grants, Bethesda, MD, July 16, 1990.

CRIS/USDA. Current Research Information System, U.S. Department of Agriculture. Dialog Information Systems, Inc., Palo Alto, CA, July 6, 1990.

Crocker J. F. , Safe S. H. , and Acott P. Effects of chronic phthalate exposure on the kidney. J. Toxicol. Environ. Health 1988: 23: 433-444.

Dabholkar A. S. Peroxisomes in the rat brain and the effects of di-(2-ethyl)hexyl phthalate during postnatal development: an electron-microscopic study. Acta Anat. 1988: 131: 218-221.

DART. Developmental and Reproductive Toxicology. National Library of Medicine, National Toxicology Information Program, Bethesda, MD, July 6, 1990.

De Flora S. , Bennicelli C. , Camoirano A. , et al. In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds. Carcinogenesis 1985: 6: 1735-1745.

De La Iglesia F. A. , Sturgess J. M. , and Feuer G. New approaches for the assessment of hepatotoxicity by means of quantitative functional-morphological interrelationships. In: Plaa G. , Hewitt W. R. (Eds.), Toxicology of the Liver. Raven Press, New York, NY, 1982, pp. 47-102.

DeAngelo A. B. , and Chavis C. Phthalate ester inhibition of glucocorticoid receptor (GR) binding activity in B6C3F1 mouse liver [abstract]. Proc. - Annu. Meet. Am. Assoc. Cancer Res. 1990: 31: 86-86.

DeAngelo A. B. , Garrett C. T. , Queral A. E. , et al. Phosphorylation of specific rat plasma membrane proteins during promotion of gamma-glutamyl transpeptidase-positive hepatic foci and inhibition by DEHP. Cancer Res. 1985: 45: 2654-2660.

DeAngelo A. B. , Queral A. E. , and Garrett C. T. Concentration-dependent inhibition of development of GGT positive foci in rat liver by the environmental contaminant di(2-ethylhexyl)phthalate. Environ. Health Perspect. 1985: 60: 381-385.

DeAngelo A. B. , Garrett C. T. , Manolukas L. A. , et al. Di-n-octyl phthalate (DOP), a relatively ineffective peroxisome-inducing straight chain isomer of the environmental contaminant di-(2-ethylhexyl)phthalate, enhances the development of putative preneoplastic lesions in rat liver. Toxicology 1986: 41: 279-288.

DeAngelo A. B. , Daniel F. B. , McMillan L. , et al. Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids. Toxicol. Appl. Pharmacol. 1989: 101: 285-298.

Deisinger P. J. , Barber E. D. , Schum D. B. , et al. A combined in vitro/in vivo model for estimating the dermal absorption of di(2-ethylhexyl)phthalate (DEHP) in man from contact with PVC film. Toxicologist 1991: 11: 95-95.

DeLeon I. R. , Byrne C. J. , Peuler E. A. , et al. Trace organic and heavy metal pollutants in the Mississippi River. Chemosphere 1986: 15: 795-805.

DeVault D. S. Contaminant in fish from Great Lakes harbors and tributary mouths. Arch. Environ. Contam. Toxicol. 1985: 14: 587-594.

Diwan B. A. , Ward J. M. , Rice J. M. , et al. Tumor-promoting effects of di(2-ethylhexyl)phthalate in JB6 mouse epidermal cells and mouse skin. Carcinogenesis 1985: 6: 343-397.

Doelman C. J. , Borm P. J. , and Bast A. Plasticisers and bronchial hyperreactivity [letter]. Lancet 1990: 335: 725-725.

Dostal L. A. , Jenkins W. L. , and Schwetz B. A. Hepatic peroxisome proliferation and hypolipidemic effects of di(2-ethylhexyl)phthalate in neonatal and adult rats. Toxicol. Appl. Pharmacol. 1987: 87: 81-90.

Dostal L. A. , Weaver R. P. , and Schwetz B. A. Transfer of di(2-ethylhexyl)phthalate through rat milk and effects on milk composition and the mammary glands. Toxicol. Appl. Pharmacol. 1987: 91: 315-325.

Dostal L. A. , Chapin R. E. , Stefanski S. A. , et al. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults. Toxicol. Appl. Pharmacol. 1988: 95: 104-121.

Douglas G. R. , Hugenholtz A. P. , and Blakey D. H. Genetic toxicology of phthalate esters: mutagenic and other genotoxic effects. Environ. Health Perspect. 1986: 65: 255-262.

Edlund C. , Ericsson J. , and Dallner G. Changes in hepatic dolichol and dolichyl monophosphate caused by treatment of rats with inducers of the endoplasmic reticulum and peroxisomes and during ontogeny. Chem.-Biol. Interact. 1987: 62: 191-208.

Egestad B. , and Sjoberg P. Analysis by fast atom bombardment mass spectrometry of conjugated metabolites of bis(2-ethylhexyl)phthalate. Biomed. Environ. Mass Spectrom. 1988: 16: 151-154.

Eisenreich S. J. , Looney B. B. , and Thornton J. D. Airborne organic contaminants in the Great Lakes ecosystem. Environ. Sci. Technol. 1981: 15: 30-38.

Elliott B. M. , and Elcombe C. R. Lack of DNA damage or lipid peroxidation measured in vivo in the rat liver following treatment with peroxisomal proliferators. Carcinogenesis 1987: 8: 1213-1218.

Elsisi A. E. , Carter D. E. , and Sipes I. G. Dermal absorption and tissue distribution of phthalate diesters [abstract]. Toxicologist 1985: 5: 246-246.

Elsisi A. E. , Carter D. E. , and Sipes I. G. Dermal absorption of phthalate diesters in rats. Fundam. Appl. Toxicol. 1989: 12: 70-77.

Elzerman A. W. , and Coates J. T. Hydrophobic organic compound on sediments: equilibria and kinetics of sorption. In: Hites R. A. , Eisenreich S. J. (Eds.), Sources and Fates of Aquatic Pollutants. Advances in Chemistry Series 216. American Chemical Society, Washington, DC, 1987, pp. 263-317.

EPA . Ambient water quality criteria for phthalate esters. U.S. Environmental Protection Agency, Office of Water Regulations and Standards, Washington, DC, 1980. EPA-440/5-80-067.

EPA . An exposure and risk assessment for phthalate esters. U.S. Environmental Protection Agency, Washington, DC, 1980.

EPA . U.S. Environmental Protection Agency. Fed. Regist. 1980: 45: 33132-33133.

EPA. U.S. Environmental Protection Agency: Part V. 1980: 45: 79339.

EPA . An exposure and risk assessment for phthalate esters. Final draft report. U.S. Environmental Protection Agency, Office of Water Regulations and Standards, Washington, DC, 1981.

EPA . Base/neutrals and acids—method 625. In: Longbotten J. E. , Lichtenberg J. J. (Eds.), Test Methods: Methods for Organic Chemical Analysis of Municipal and Industrial Wastewater. U.S. Environmental Protection Agency, Environmental Monitoring and Support Laboratory, Cincinnati, OH, 1982. EPA-600/4-82-057.

EPA . Phthalate esters—method 606. In: Longbotten J. E. , Lichtenberg J. J. (Eds.), Test Methods: Methods for Organic Chemical Analysis of Municipal and Industrial Wastewater. U.S. Environmental Protection Agency, Environmental Monitoring and Support Laboratory, Cincinnati, OH, 1982. EPA-600/4-82-057.

EPA . U.S. Environmental Protection Agency. Fed. Regist. 1982: 47: 26992-26992, 27007-27008.

EPA . Methods for chemical analysis of water and wastes. U.S. Environmental Protection Agency, Office of Research and Development, Environmental Monitoring and Support Laboratory, Cincinnati, OH, 1983. EPA-600/4-79-020.

EPA . Treatability Manual, Vol. I. Treatability data. U.S. Environmental Protection Agency, Office of Research and Development, Washington, DC, 1983. EPA-600/2-82-001a.

EPA . Summary of environmental profiles and hazard indices for constituents of municipal sludge. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC, 1985.

EPA . Drinking water criteria document for phthalic acid esters (PAE)s. External Review Draft. U.S. Environmental Protection Agency ECAO-CIN-D009, Cincinnati, OH, 1986.

EPA . Evaluation of the potential carcinogenicity of bis(2-ethylhexyl)phthalate. Draft Report. U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Carcinogen Assessment Group, OHEA-C-073-45, Washington, DC, 1986.

EPA . Gas chromatography/mass spectrometry for semivolatile organics: capillary column technique—method 8270. Test Methods for Evaluating Solid Waste, 3rd edn., SW-846. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC, 1986.

EPA . Phthalate esters—method 8060. In Test Methods for Evaluating Solid Waste, 3rd edn., SW-846. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC, 1986.

EPA . U.S. Environmental Protection Agency. Fed. Regist. 1986: 51: 33992-34003.

EPA . Health effects assessment for selected phthalic acid esters. U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Cincinnati, OH, 1987. EPA-600/8-88/053. NTIS No. PB88-178934.

EPA . U.S. Environmental Protection Agency: Part II. Fed. Regist. 1987: 52: 25942-25953.

EPA . Determination of organic compounds in drinking water by liquid-solid extraction and capillary column gas chromatography/mass spectrometry—method 525. In: Methods for the Determination of Organic Compounds in Drinking Water. U.S. Environmental Protection Agency, Environmental Monitoring Systems Laboratory, Cincinnati, OH, 1988. EPA-600/4-88/039.

EPA . Drinking water criteria document for phthalic acid esters (PAEs). U.S. Environmental Protection Agency, Office of Drinking Water, Cincinnati, OH, 1988.

EPA . U.S. Environmental Protection Agency: Part II. Fed. Regist. 1988: 53: 31138-31142, 31211-31222.

EPA . U.S. Environmental Protection Agency: Part II. Fed. Regist. 1988: 53: 4500-4501.

EPA . U.S. Environmental Protection Agency: Part V. Fed. Regist. 1988: 53: 38642-38653.

EPA . Interim methods for development of inhalation reference doses. U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Washington, DC, 1989. EPA-600/8-88/066F.

EPA . NHATS broad scan analysis: population estimates from fiscal year 1982 specimens. Report to U.S. Environmental Protection Agency, Office of Toxic Substances, Washington, DC, by Batelle, Arlington, VA, 1989. EPA-569/5-90-001.

EPA . U.S. Environmental Protection Agency: Fed. Regist. 1989: 54: 618-621.

EPA . U.S. Environmental Protection Agency: Part III. Fed. Regist. 1989: 54: 26594-26594, 26647-26652.

EPA . U.S. Environmental Protection Agency: Part V. Fed. Regist. 1989: 54: 33426-33426, 33452-33452.

EPA . Toxics in the community. 1988. National and local perspectives. U.S. Environmental Protection Agency, Office of Toxic Substances, Economics and Technology Division, Washington, DC, 1990.

EPA . U.S. Environmental Protection Agency: Part II. Fed. Regist. 1990: 55: 22520-22536, 22683-22714.

EPA . U.S. Environmental Protection Agency: Part II. Fed. Regist. 1990: 55: 30370-30373, 30398-30400.

EPA . U.S. Environmental Protection Agency: Part III. Fed. Regist. 1990: 55: 47229-47231.

EPA . U.S. Environmental Protection Agency. Fed. Regist. 1992: 57 (138): 31776-31849.

Eriksson P. , and Darnerud P. O. Distribution and retention of some chlorinated hydrocarbons and a phthalate in the mouse brain during the preweaning period. Toxicology 1985: 37: 189-203.

Fallon M. E. , and Horvath F. J. Preliminary assessment of contaminants in soft sediments of the Detroit River. J. Great Lakes Res. 1985: 11: 373-378.

Feiler H. D. , Storch T. J. , and Southworth R. Organics in municipal sludges: survey of forty cities. Proceedings of The National Conference on Municipal Industrial Sludge Utility Disposal, 1980, pp. 53-57.

Fernandez A. C. , Vedanarayanan P. V. , and Bai M. V. A simple and sensitive method to monitor the presence of di(2-ethylhexyl)phthalate (DEHP) in I.V. fluids. Curr. Sci. 1987: 56: 1230-1230.

Flaminio L. M. , Bergia R. , De Angelis L. , et al. The fate of leached di-2(ethylhexyl)phthalate (DEHP) in patients on chronic hemodialysis. Int. J.Artif. Organs 1988: 11: 428-434.

Foster P. M. M-Dinitrobenzene: studies on its toxicity to the testicular Sertoli cell. Arch. Toxicol. 1989: (suppl 13): 3-17.

FSTRAC . Summary of state and federal drinking water standards and guidelines. Report to U.S. Environmental Protection Agency, Washington, DC, by Chemical Communications Subcommittee, Federal-State Toxicology and Regulatory Alliance Committee, 1990.

Gangolli S. D. Testicular effects of phthalate esters. Environ. Health Perspect. 1982: 45: 77-84.

Ganning A. E. , Brunk U. , and Dallner G. Phthalate esters and their effect on the liver. Hepatology 1984: 4: 541-547.

Ganning A. E. , Brunk U. , Edlund C. , et al. Effects of prolonged administration of phthalate ester on the liver. Environ. Health Perspect. 1987: 73: 251-258.

Ganning A. E. , Olsson M. J. , Peterson E. , et al. Fatty acid oxidation in hepatic peroxisomes and mitochondria after treatment of rats with di(2-ethylhexyl)phthalate. Pharmacol. Toxicol. 1989: 65: 265-268.

Ganning A. E. , Olsson M. J. , Brunk U. , et al. Effects of prolonged treatment with phthalate ester on rat liver. Pharmacol. Toxicol. 1991: 68: 392-401.

Garman J. R. , Fieund T. , and Lawless E. W. Testing for groundwater contamination at hazardous waste sites. J. Chromatogr. Sci. 1987: 25: 328-337.

Garvey L. K. , Swenberg J. A. , Hamm T. E., Jr. , et al. Di(2-ethylhexyl)phthalate: lack of initiating activity in the liver of female F-344 Rats. Carcinogenesis 1987: 8: 285-290.

Gaylor D. W. Preliminary estimates of the virtually safe dose for tumors obtained from the maximum tolerated dose. Regul. Toxicol. Pharmacol. 1989: 9: 101-108.

Gerbracht U. , Einig C. , Oesterle D. , et al. Di(2-ethylhexyl)phthalate alters carbohydrate enzyme activities and foci incidence in rat liver. Carcinogenesis 1990: 11 (12): 2111-2115.

Gerlai I. , Pinter J. , and Pick J. Determination of DEHP in blood products stored in plastic bags by HPLC. Chromatographia 1987: 24: 403-406.

Germolec D. R. , Yang R. S. H. , Ackermann M. F. , et al. Toxicology studies of a chemical mixture of 25 groundwater contaminants: II. Immuno-suppression in B6C3F1 mice. Fundam. Appl. Toxicol. 1989: 13: 377-387.

Geyer H. , Scheunert I. , and Korte F. Bioconcentration potential of organic environmental chemicals in humans. Regul. Toxicol. Pharmacol. 1986: 6: 313-347.

Ghassemi M. , Quinlivan S. , and Bachmaier J. Characteristics of leachates from hazardous waste landfills. J. Environ. Sci. Health 1984: 19: 579-620.

Giam C. S. , and Atlas E. Accumulation of phthalate ester plasticizers in Lake Constance sediments. Naturwissenschaften 1980: 67: 598-598.

Giam C. S. , and Wong M. K. Plasticizers in food. J. Food Prot. 1987: 50: 769-782.

Giam C. S. , Chan H. S. , and Neff G. S. Sensitive method for determination of phthalate ester plasticizers in open-ocean biota samples. Anal. Chem. 1975: 47: 2225-2228.

Giam C. S. , Chan H. S. , Neff G. S. , et al. Phthalate ester plasticizers: a new class of marine pollutant. Science 1978: 199: 419-421.

Giam C. S. , Chan H. S. , and Meff G. S. Phthalate ester plasticizers, DDT, DDE and polychlorinated biphenyls in biota from the Gulf of Mexico. Mar. Pollut. Bull. 1978: 9: 249-251.

Giam C. S. , Atlas E. , Chan H. S. , et al. Phthalate esters, PCB and DDT residues in the Gulf of Mexico atmosphere. Atmos. Environ. 1980: 14: 65-69.

Gill S. S. , and Kaur S. Hepatic epoxide hydrolase activities and their induction by clofibrate and diethylhexylphthalate in various strains of mice. Biochem. Pharmacol. 1987: 36: 4221-4227.

Giust J. A. , Seipelt C. T. , Anderson B. K. , et al. Determination of bis(2-ethylhexyl)phthalate in cows milk and infant formula by high-performance liquid chromatography. J. Agric. Food Chem. 1990: 38: 415-418.

Gollamudi R. , Prasanna H. R. , Rado R. H. , et al. Impaired metabolism of di(2-ethylhexyl)phthalate (DEHP) in old rats—An in vitro study. J. Toxicol. Environ. Health 1983: 12: 623-632.

Gollamudi R. , Rao R. H. , Lawrence W. H. , et al. Effects of phthalic acid esters on drug metabolizing enzymes of rat liver. J. Appl. Toxicol. 1985: 5: 368-371.

Gosselin R. E. , Smith R. P. , and Hodge H. C. Clinical Toxicology of Commercial Products, Vol. II, 5th edn. Williams and Wilkins, Baltimore, MD, 1984, 204-204.

Gray T. J. Testicular toxicity in vitro: Sertoli-germ cell co-cultures as a model system. Food Chem. Toxicol. 1986: 24: 601-605.

Gray T. J. , and Butterworth K. R. Testicular atrophy produced by phthalate esters. Arch. Toxicol. 1980: (suppl 4): 452-455.

Gray T. J. , and Gangolli S. D. Aspects of the testicular toxicity of phthalate esters. Environ. Health Perspect. 1986: 65: 229-235.

Gray T. J. , Rowland I. R. , Foster P. M. , et al. Species differences in the testicular toxicity of phthalate esters. Toxicol. Lett. 1982: 11: 141-147.

Gupta C. , Hattori A. , and Shinozuka H. Suppression of EGF binding in the rat liver by the hypolipidemic peroxisome proliferators, 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio-(n-beta-hydroxyethyl) acetamide and di(2-ethylhexyl)phthalate. Carcinogenesis 1988: 9: 167-170.

Hagiwara A. , Tamano S. , Ogiso T. , et al. Promoting effect of the peroxisome proliferator, clofibrate, but not di(2-ethylhexyl)phthalate, on urinary bladder carcinogenesis in F344 rats initiated by n-butyl-n-(4-hydroxybutyl)nitrosamine. Jpn. J. Cancer Res. 1990: 81: 1232-1238.

Hannah F. A. , Austern D. N. , Eralp A. E. , et al. Comparative removal of toxic pollutants by six wastewater treatment processes. J. Water Pollut. Control Fed. 1986: 58: 27-34.

Harris R. S. , Hodge H. C. , Maynard E. A. , et al. Chronic oral toxicity of 2-ethylhexyl phthalate in rats and dogs. Arc. Ind. Health 1956: 13: 259-264.

Haseman J. K. Patterns of tumor incidence in two-year cancer bioassay feeding studies in Fischer 344 rats. Fundam. Appl. Toxicol. 1983: 3: 1-9.

Haseman J. K. Issues in carcinogenicity testing: dose selection. Fundam. Appl. Toxicol. 1985: 5: 66-78.

Hauck R. S. , Wegner C. , Blumtritt P. , et al. Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate. Life Sci. 1990: 46: 513-518.

Hauser T. R. , and Bromberg S. M. EPA's monitoring program at Love Canal 1980. Environ. Monit. Assess. 1982: 2: 249-271.

Havel R. J. , and Kane J. P. Drugs and lipid metabolism. Annu. Rev. Pharmacol. 1973: 13: 287-308.

HAZDAT. Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA, October 30, 1992.

HEAST. Health Effects Assessment Summary Table. Third Quarter FY-1990. U.S. Environmental Protection Agency, Washington, DC, 1990.

Heindel J. J. , and Chapin R. E. Inhibition of FSH-stimulated cAMP accumulation by mono(2-ethylhexyl) phthalate in primary rat Sertoli cell cultures. Toxicol. Appl. Pharmacol. 1989: 97: 377-385.

Heindel J. J. , Gulati D. K. , Mounce R. C. , et al. Reproductive toxicity of three phthalic acid esters in a continuous breathing protocol. Fundam. Appl. Toxicol. 1989: 12: 508-518.

Hillman L. S. , Goodwin S. L. , and Sherman W. R. Identification and measurement of plasticizer in neonatal tissues after umbilical catheters and blood products. N. Engl. J. Med. 1975: 292: 381-386.

Hites R. A. Analysis of trace organic compounds in New England river. J. Chromatogr. Sci. 1973: 11: 570-574.

Ho C. T. , Lee K. N. , and Jin Q. Z. Isolation and identification of volatile flavor compounds in fried bacon. J. Agric. Food Chem. 1983: 31: 336-342.

Hodge H. C. Acute toxicity for rats and mice of 2-ethylhexanol and di(2-ethylhexyl)phthalate. Proc. Soc. Exp. Biol. Med. 1943: 53: 20-23.

Hodgson J. R. Results of peroxisome induction studies on tri(2-ethylhexyl)trimellitate and 2-ethylhexanol. Toxicol. Ind. Health 1987: 3: 49-61.

Hoff R. M. , and Chan K. W. Measurement of polycyclic aromatic hydrocarbons in the air along the Niagara River. Environ. Sci. Technol. 1987: 21: 556-561.

Hopkins J. Is diethylhexyl phthalate genotoxic? Food Chem. Toxicol. 1983: 21: 684-687.

Howard P. H. Handbook of Environmental Fate and Exposure Data of Environmental Chemicals, Vol. 1. Large production and priority pollutants. Lewis Publishing, Inc., Chelsea, MA, 1989, pp. 279-285.

Howard P. H. , Banerjee S. , and Robillard K. H. Measurement of water solubilities, octanol/water partition coefficients and vapor pressures of commercial phthalate esters. Environ. Toxicol. Chem. 1985: 4: 653-661.

HSDB. Hazardous Substances Data Bank. National Library of Medicine, National Toxicology Information Program, Bethesda, MD, July 18, 1990.

HSDB. Hazardous Substance Data Bank. National Library of Medicine, National Toxicology Information System, Bethesda, MD, June, 1992.

Hsia M. T. The relationship between carcinogenesis and peroxisome proliferation in rodent liver after exposure to the plasticizer DEHP and DEHA. Report to U.S. Food and Drug Administration, by the MITRE Corporation, Civil Systems Division, McLean, VA, 1990.

Hutchins S. R. , Tomson M. B. , and Ward C. H. Trace organic contamination of ground water from a rapid infiltration site: a laboratory-field coordinated study. Environ. Toxicol. Chem. 1983: 2: 195-216.

IARC . IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: some industrial chemicals and dyestuffs, Vol. 29. International Agency for Research on Cancer, Lyon, France, 1982, pp. 269-294.

IARC . IARC monograph on the evaluation of carcinogenic risks of chemicals to humans. Overall evaluations of carcinogenicity: an updating of IARC monographs Vols. 1 to 42. World Health Organization, International Agency for Research on Cancer, Lyon, France, 1987, suppl 7, pp. 29-33, 62-62.

IJC . An inventory of chemical substances identified in the Great Lakes ecosystem. Vol 1. Summary. Report to the Great Lakes Water Quality Board by the International Joint Commission, Windsor, Ontario, 1983.

Ikeda G. J. , Sapienza P. P. , Couvillion J. L. , et al. Comparative distribution, excretion and metabolism of di-(2-ethylhexyl)phthalate in rats, dogs and miniature pigs. Food Cosmet. Toxicol. 1980: 18: 637-642.

Inman J. C. , Strachan S. D. , Sommers L. E. , et al. A decomposition of phthalate esters in soil. J. Environ. Sci. Health 1984: B19: 245-257.

IRIS. Integrated Risk Information System. U.S. Environmental Protection Agency, Washington, DC, July 23, 1990.

IRPTC. International Register of Potentially Toxic Chemicals. United Nations Environment Programme, Geneva, Switzerland, July, 1990.

Ishida M. , Suyama K. , and Adachi S. Occurrence of dibutyl and di(2-ethylhexyl) phthalate in chicken eggs. J. Agric. Food Chem. 1981: 29: 72-74.

Jacobson M. S. , Kevy S. V. , and Grand R. J. Effects of a plasticizer leached from polyvinyl chloride on the subhuman primate: a consequence of chronic transfusion therapy. J. Lab. Clin. Med. 1977: 89: 1066-1079.

Jaeger R. J. , and Rubin R. J. Migration of a phthalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissues. N. Engl. J.Med. 1972: 287: 1114-1118.

Johnson B. T. , Stalling D. L. , Hogan J. W. , et al. Dynamics of phthalic acid esters in aquatic organisms. In: Suffet I. H. (Ed.), Fate of Pollutants in the Air and Water Environments: Part 2. Chemical and Biological Fate of Pollutants in the Environment. John Wiley and Sons, New York, NY, 1977, pp. 283-300.

Johnson B. T. , Heitkamp M. A. , and Jones J. R. Environmental and chemical factors influencing the biodegradation of phthalic acid esters in freshwater sediments. Environ. Pollut., Ser. B 1984: 8: 101-118.

Kappus H. Overview of enzymes involved in bioreduction of drugs and in redox cycling. Biochem. Pharmacol. 1986: 35: 1-6.

Keith L. H. , Garrison A. W. , Allen F. R. , et al. Identification of organic compounds in drinking water from thirteen U.S. cities. In: Keith L. H. (Ed.), Identification and Analysis of Organic Pollutants in Water. Ann Arbor Science Publishers, Inc., Ann Arbor, MI, 1976, pp. 329-373.

Keller B. J. , Yamanaka H. , Liang D. , et al. O2-dependent hepatotoxicity due to ethylhexanol in the perfused rat liver: mitochondria as a site of action. J. Pharmacol. Exp. Ther. 1990: 252: 1355-1360.

Kelley M. , Groth-Watson A. , Knoble D. , et al. Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist [Abstract]. Toxicologist 1991: 11: 184-184.

Kenaga E. E. Predicted bioconcentration factors and soil sorption coefficient of pesticides and other chemicals. Ecotoxicol. Environ. Safety 1980: 4: 26-38.

King J. W. Fundamentals and applications of supercritical fluid extraction in chromatographic science. J. Chromatogr. Sci. 1989: 27: 355-364.

Klaassen C. D. Principles of Toxicology, Chap. 3. In: Gilman A. G. , Rall T. W. , Nies A. S. , et al. (Eds.), The Pharmacological Basis of Therapeutics, 8th edn., Pergamon, New York, NY, 1990, pp. 49-61.

Klaunig J. E. , Ruch R. J. , DeAngelo A. B. , et al. Inhibition of mouse hepatocyte intercellular communication by phthalate monoesters. Cancer Lett. 1988: 43: 65-71.

Klein R. G. , Schanezer P. , and Schmahl D. Long-term inhalation study in Syrian golden hamsters with phthalic acid, bis (2-ethylhexyl) ester (DEHP) in relevant concentrations [abstract]. J. Cancer Res. Clin. Oncol. 1987: 113: S24-S24.

Klimisch H. J. , Hellwig J. , Kaufmann W. , et al. Di- (2-ethylhexyl) phthalate (DEHP): investigation of inhalation toxicity in rats after repeated exposure (28 d). Human Exp. Toxicol. 1991: 10: 68-68.

Kluwe W. M. Carcinogenic potential of phthalic acid esters and related compounds: structure-activity relationships. Environ. Health Perspect. 1986: 65: 271-278.

Kluwe W. M. , Haseman J. K. , Douglas J. F. , et al. The carcinogenicity of dietary di(2-ethylhexyl) phthalate in Fischer 344 rats and B6C3F1 mice. J. Toxicol. Environ. Health 1982: 10: 797-815.

Kluwe W. M. , McConnell E. E. , Huff J. E. , et al. Carcinogenicity testing of phthalate esters and related compounds by the National Toxicology Program and the National Cancer Institute. Environ. Health Perspect. 1982: 45: 129-134.

Kluwe W. M. , Haseman J. K. , and Huff J. E. The carcinogenicity of di(2-ethylhexyl) phthalate (DEHP) in perspective. J. Toxicol. Environ. Health 1983: 12: 159-169.

Kodeikh N. [Kinetic study of phthalate accumulation and elimination in a model of inhalational exposure in volunteers]. Probl. Khig. 1985: 10: 81-87 (Bulgarian).

Konishi N. , Diwan B. A. , and Ward J. M. Levels of DNA synthesis induced by di(2-ethylhexyl)-phthalate (DEHP) in the kidney or liver of the B6C3F1 mouse initiated prenatally with n-nitrosoethylurea (NEU) do not correlate with tumor promoting activity of DEHP [abstract]. Proc. Am. Assoc. Cancer Res. 1989: 30: 212-212.

Kool H. J. , van Kreijl C. F. , and Zoeteman D. C. Toxicology assessment of organic compounds in drinking water. CRC Crit. Rev. Environ. Control 1982: 12: 307-350.

Kopfler F. C. , Melton R. G. , Mullaney J. L. , et al. Human exposure to water pollutants. Adv. Environ. Sci. Technol. 1977: 8: 419-433.

Kornbrust D. J. , Barfknecht T. R. , Ingram P. , et al. Effect of di(2-ethylhexyl)phthalate on DNA repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster V-79 cells. J. Toxicol. Environ. Health 1984: 13: 99-116.

Kozumbo W. J. , Kroll R. , and Rubin R. J. Assessment of the mutagenicity of phthalate esters. Environ. Health Perspect. 1982: 45: 103-109.

Krauskopf L. G. Studies on the toxicity of phthalates via ingestion. Environ. Health Perspect. 1973: 3: 61-72.

Krempien B. , and Ritz E. Acquired cystic transformation of the kidneys of haemodialyzed patients. Virchows Arch. A: Pathol. Anat. Histol. 1980: 386: 189-200.

Kurane R. Microbial degradation of phthalate esters. Microbiol. Sci. 1986: 3: 92-95.

Kurane R. , Suzuki T. , and Takahara Y. Microbial population and identification of phthalate ester-utilizing microorganisms in activated sludge inoculated with microorganisms. Agric. Biol. Chem. 1979: 43: 907-917.

Kurokawa Y. , Takamura N. , Matushima Y. , et al. Promoting effect of peroxisome proliferators in two-stage rat renal tumorigenesis. Cancer Lett. 1988: 43: 145-149.

Labow R. S. , Card R. T. , and Rock G. The effect of the plasticizer di(2-ethylhexyl) phthalate on red cell deformability. Blood 1987: 70: 19-323.

Lake B. G. , and Gray T. J. Species differences in hepatic peroxisome proliferation. Biochem. Soc. Trans. 1985: 13: 859-861.

Lake B. G. , Gray T. J. , Foster J. R. , et al. Comparative studies on di(2-ethylhexyl) phthalate induced hepatic peroxisome proliferation in the rat and hamster. Toxicol. Appl. Pharmacol. 1984: 72: 46-60.

Lake B. G. , Rijcken W. R. , Gray T. J. , et al. Comparative studies of the hepatic effects of di- and mono-n-octyl phthalates, di(2-ethylhexyl) phthalate and clofibrate in the rat. Acta Pharmacol. Toxicol. 1984: 54: 167-176.

Lake B. G. , Tredger J. M. , Gray T. J. , et al. The effect of peroxisome proliferators on the metabolism and spectral interaction of endogenous substrates of cytochrome P-450 in rat hepatic microsomes. Life Sci. 1984: 35: 2621-2626.

Lake B. G. , Gray T. J. , and Gangolli S. D. Hepatic effects of phthalate esters and related compounds—in vivo and in vitro correlations. Environ. Health Perspect. 1986: 67: 283-290.

Lake B. G. , Kozlen S. L. , Evans J. G. , et al. Effect of prolonged administration of clofibric acid and di-(2-ethylhexyl) phthalate on hepatic enzyme activities and lipid peroxidation in the rat. Toxicology 1987: 44: 213-228.

Lalwani N. D. , Fahl W. E. , and Reddy J. K. Detection of a nafenopinbinding protein in rat liver cytosol associated with the induction of peroxisome proliferation by hypolipidemic compounds. Biochem. Biophys. Res. Commun. 1983: 116: 388-393.

Lamb J. C. , Chapin R. E. , Teague J. , et al. Reproductive effects of four phthalic acid esters in the mouse. Toxicol. Appl. Pharmacol. 1987: 88: 255-269.

Lao R. C. , Oja H. , Thomas R. S. , et al. Assessment of environmental problems using the combination of gas chromatography in quadrupole mass spectrometry. Sci. Total Environ. 1973: 2: 223-233.

Lawrence W. H. , Malik M. , Turner J. E. , et al. A toxicological investigation of the acute, subchronic, and chronic effects of administering di-2-ethylhexyl phthalate (DEHP) and other phthalate esters. Toxicol. Appl. Pharmacol. 1974: 29: 87-88.

Lawrence W. , Malik M. , Turner J. , et al. A toxicological investigation of some acute, short-term and chronic effects of administering DEHP and other phthalate esters. Environ. Res. 1975: 9: 1-11.

Lay J. O. , and Miller B. J. Plasticizers in pacifiers: direct determination by FAB-MS. Anal. Chem. 1987: 59: 1323-1325.

Lazarow P. B. , and DeDuve C. A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug. Proc. Natl. Acad. Sci. U.S.A. 1976: 73: 2043-2046.

Levy G. Gastrointestinal clearance of drugs with activated charcoal. N. Engl. J.Med. 1982: 307: 676-677.

Lhuguenot J. C. , Mitchell A. M. , Milner G. , et al. The metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono (2-ethylhexyl) phthalate (MEHP) in rats: in vivo and in vitro dose and time dependency of metabolism. Toxicol. Appl. Pharmacol. 1985: 80: 11-22.

Lhuguenot J. C. , Mitchell A. M. , and Elcombe C. R. The metabolism of mono- (2-ethylhexyl) phthalate (MEHP) and liver peroxisome proliferation in the hamster. Toxicol. Ind. Health 1988: 4: 431-441.

Ligocki M. P. , and Pankow J. F. Assessment of adsorption/solvent extraction with polyurethane foam and adsorption/thermal desorption with Tenax-GC for the collection and analysis of ambient organic vapors. Anal. Chem. 1985: 57: 1138-1144.

Ligocki M. P. , Leuenberger C. , and Pankow J. F. Trace organic compounds in rain: II. Gas scavenging of neutral organic compounds. Atmos. Environ. 1985: 19: 1609-1617.

Lindgren I. , Lindquist N. G. , Lyden A. , et al. A whole body autoradiographic study on the distribution of 14C-Labelled di(2-ethylhexyl) phthalate in mice. Toxicology 1982: 23: 149-158.

Liss G. M. , Albro P. W. , Hartle R. W. , et al. Urine phthalate determinations as an index of occupational exposure to phthalic anhydride and di(2-ethylhexyl) phthalate. Scand. J.Work, Environ. Health 1985: 11: 381-387.

Lucas S. V. GC/MS analysis of organics in drinking water concentrates and advanced waste treatment concentrates: Vol. I. Analysis results for 17 drinking water, 16 advanced waste treatment and 3 process blank concentrates. U.S. Environmental Protection Agency, Office of Research and Development, Research Triangle Park, NC, 1984. EPA-600/1-84-020a. NTIS No. PB85-128221.

Lutz W. K. Investigation of the potential for binding of di(2-ethylhexyl) phthalate (DEHP) to rat liver DNA in vivo. Environ. Health Perspect. 1986: 65: 267-269.

Mabey W. R. , Smith J. H. , Podoll R. T. , et al. Aquatic fate process data for organic priority pollutants. Report to U.S. Environmental Protection Agency, Office of Water Regulations and Standards, Washington, DC, by SRI International, Menlo Park, CA, 1982. EPA 440/4-81-014.

Malcolm A. R. , and Mills L. J. Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl) phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA). Cell. Biol. Toxicol. 1989: 5: 145-153

Mangham B. A. , Foster J. R. , and Lake B. G. Comparison of the hepatic and testicular effects of orally administered di(2-ethylhexyl) phthalate and dialkyl 79 phthalate in the rat. Toxicol. Appl. Pharmacol. 1981: 61: 205-214.

Mannsville Chemical Products Corp . Chemical products synopsis: dioctyl phthalate. Mansville Chemical Products Corp., Asbury Park, NJ, 1990.

Marsman D. S. , Cattley R. C. , Conway J. G. , et al. Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (Wy-14,643) in rats. Cancer Res. 1988: 48: 6739-6744.

Marx J. Animal carcinogen testing challenged. Science 1990: 250: 743-745.

Mathur S. Phthalate esters in the environment: pollutants or natural products? J. Environ. Qual. 1974: 3: 189-189.

McFall J. A. , Antoine S. R. , and DeLeon I. R. Base-neutral extractable organic pollutants in biota and sediments from Lake Pontchartrain. Chemosphere 1985: 14: 1561-1569.

McFall J. A. , Antoine S. R. , and DeLeon I. R. Organics in the water column of Lake Pontchartrain. Chemosphere 1985: 14: 1253-1265.

McGilvery R. W. , and Goldstein G. W. Biochemistry, a functional approach. 3rd edn. W. B. Saunders Co., Philadelphia, PA, 1983, pp. 416-416, 456-457.

McMurray W. C. A synopsis of human biochemistry with medical applications. Harper and Row Publishers, Philadelphia, PA, 1982, pp. 167-182.

Melnick R. L. , and Schiller C. M. Effect of phthalate esters on energy coupling and succinate oxidation in rat liver mitochondria. Toxicology 1985: 34: 13-27.

Melnick R. L. , Morrissey R. E. , and Tomaszewski K. E. Studies by the National Toxicology Program on di(2-ethylhexyl) phthalate. Toxicol. Ind. Health 1987: 3: 99-118.

Menzer R. E. , and Nelson J. O. Water and soil pollutants. In: Klaassen C. D. , Amdur M. O. , and Doull J. (Eds.), Casarett and Doull's Toxicology, 3rd edn. Macmillan, New York, 1986, pp. 841-842.

Merkle J. , Klimisch H.-J. , and Jackh R. Developmental toxicity in rats after inhalation exposure of di-2-ethylhexylphthalate (DEHP). Toxicol. Lett. 1988: 42: 215-223.

Mes J. , Coffin D. E. , and Campbell D. S. Di-n-butyl-and di-2-ethylhexyl phthalate in human adipose tissue. Bull. Environ. Contam. Toxicol. 1974: 12: 721-725.

Michael P. R. , Adams W. J. , Werner A. F. , et al. Surveillance of phthalate esters in surface waters and sediments in the U.S. Environ. Toxicol. Chem. 1984: 3: 377-377.

Michael L. C. , Pellizzari E. D. , and Wiseman R. W. Development and evaluation of a procedure for determining volatile organics in water. Environ. Sci. Technol. 1988: 22: 565-570.

Ministry of Agriculture, Fisheries and Food . Plasticisers: continuing surveillance. The thirtieth report of the Steering Group on Food Surveillance. The Working Party on Chemical Contaminants from Food Contact Materials: Sub-group on Plasticisers. Edinburgh Press, London, 1990, pp. 1-53.

Mitchell A. M. , Lhuguenot J. C. , Bridges J. W. , et al. Identification of the proximate peroxisome proliferator(s) derived from di(2-ethylhexyl) phthalate. Toxicol. Appl. Pharmacol. 1985: 80: 23-32.

Mitchell F. E. , Price S. C. , Hinton R. H. , et al. Time and dose-response study of the effects on rats of the plasticizer di(2-ethylhexyl) phthalate. Toxicol. Appl. Pharmacol. 1985: 81: 371-392.

Montgomery J. H. , and Welkom L. M. Groundwater chemicals desk reference. Lewis Publishers, Inc., Chelsea, MI, 1990, pp. 93-95.

Morton S.J. Hepatic effects of dietary DEHP. PhD Thesis at Johns Hopkins, Baltimore, MD, 1979.

Moss E. J. , Cook M. W. , Thomas L. V. , et al. The effect of mono-(2-ethylhexyl) phthalate and other phthalate esters on lactate production by Sertoli cells in vitro. Toxicol. Lett. 1988: 40: 77-84.

Mountcastle V. B. Medical Physiology, Vol. 2, 14th edn. C.V. Mosby Company, St. Louis, MO, 1980.

Murature D. A. , Tang S. Y. , Steinhardt G. , et al. Phthalate esters and semen quality parameters. Biomed. Environ. Mass Spectrom. 1987: 14: 473-478.

Murray H. E. , Ray L. E. , and Giam C. S. Analysis of marine sediment, water and biota for selected organic pollutants. Chemosphere 1981: 10: 1327-1334.

Nair N. , and Kurup C. K. Investigations on the mechanism of the hypocholesterolemic action of diethylhexylphthalate in rats. Biochem. Pharmacol. 1986: 35: 3441-3448.

Nair N. , and Kurup C. K. Effect of administration of diethylhexyl phthalate on the function and turnover of rat hepatic mitochondria. Biochem. Biophys. Acta 1987: 925: 332-340.

Nair N. , and Kurup C. K. Increase in hepatic ubiquinone on administration of diethylhexyl phthalate to the rat. J. Biosci. 1987: 11: 391-397.

Nakamura Y. , Yasuoki Y. , Tomita I. , et al. Teratogenicity of di(2-ethylhexyl) phthalate in mice. Toxicol. Lett. 1979: 4: 113-117.

NAS . Drinking Water and Health. National Academy of Sciences, Washington, DC, 1977, pp. 726-729.

NAS/NRC . Biologic Markers in Reproductive Toxicology. National Academy of Sciences/National Research Council, National Academy Press, Washington, DC, 1989, pp. 15-35.

Nassberger L. , Arbin A. , and Ostelius J. Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysis. Nephron. 1987: 45: 286-290.

NATICH . National Air Toxics Information Clearinghouse: NATICH database report on state, local and EPA air toxics activities. Report to U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards, Research Triangle Park, NC, by Radian Corporation, Austin, TX, 1989. EPA-450/3-89-29.

NFPA. Fire Protection Guide for Hazardous Materials. 1978.

NIOSH. NIOSH Manual of Analytical Methods, Vol. 2., 2nd edn. U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, OH, 1977. S40-1-S40-9.

NIOSH . Dibutyl phthalate and di(2-ethylhexyl) phthalate—method 5020. NIOSH Manual of Analytical Methods. 3rd edn. U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, OH, 1985.

NIOSH . NIOSH pocket guide to chemical hazards. U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health, Washington, DC, 1985.

NIOSH . NIOSH recommendations for occupational safety and health: compendium of policy documents and statements. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute of Occupational Safety and Health, Division of Standards Developmental and Technology Transfer, Cincinnati, OH, 1992.

NOES. National Occupational Exposure Survey. National Institute of Occupational Safety and Health, Cincinnati, OH, July 16, 1990.

NOHS. National Occupational Hazard Survey. National Institute of Occupational Safety and Health, Cincinnati, OH, July 16, 1990.

Northup S. , Martis L. , Ulbricht R. , et al. Comment on the carcinogenic potential of bis(2-ethylhexyl) phthalate. J. Toxicol. Environ. Health 1982: 10: 493-518.

NTP. National Toxicology Program. Carcinogenesis bioassay of di(2-ethylhexyl) phthalate (Cas No. 117-81-7) in F344 rats and B6C3F₁ mice (feed study). U.S. Department of Health and Human Services, Public Health Services, National Institute of Health, Research Triangle Park, NC, 1982. NTP publication no. 217.

NTP. National Toxicology Program. Fifth Annual Report on Carcinogens: Summary 1989. Report to the National Institute of Environmental Health Sciences, Research Triangle Park, NC, by Technical Resources, Inc., Rockville, MD, 1989, pp. 116-119. NTP 89-239.

Nyssen G. A. , Miller E. T. , Glass T. F. , et al. Solubilities of hydrophobic compounds in aqueous-organic solvent mixtures. Environ. Monit. Assess. 1987: 9: 1-11.

O'Connor O. A. , Rivera M. D. , and Young L. Y. Toxicity and biodegradation of phthalic acid esters under methanogenic conditions. Environ. Toxicol. Chem. 1989: 8: 569-576.

O'Grady D. P. , and Howard P. H. Activated sludge biodegradation of 12 commercial phthalate esters. Report to Chemical Manufacturers Association by Syracuse Research Corporation, 1984. Contract No. PE-17.0-ET-SRC. SRC L1553-03.

O'Grady D. P. , Howard P. H. , and Werner A. F. Activated sludge biodegradation of 12 commercial phthalate esters. Appl. Environ. Microbiol. 1985: 49: 443-445.

Oesterle D. , and Deml E. Promoting activity of di(2-ethylhexyl) phthalate in rat liver foci bioassay. J. Cancer Res. Clin. Oncol. 1988: 11: 133-136.

OHMTADS. Oil and Hazardous Materials/Technical Assistance Data System. Chemical Information Systems, Inc., Baltimore, MD, July 26, 1990.

Oishi S. Reversibility of testicular atrophy induced by di(2-ethylhexyl) phthalate in rats. Environ. Res. 1985: 36: 160-169.

Oishi S. Testicular atrophy induced by di(2-ethylhexyl) phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis. Arch. Toxicol. 1986: 59: 290-295.

Oishi S. Enhancing effects of luteinizing hormone-releasing hormone on testicular damage induced by di-(2-ethylhexyl) phthalate in rats. Toxicol. Lett. 1989: 47: 271-277.

Oishi S. , and Hiraga K. Effect of phthalic esters on mouse testes. Toxicol. Lett. 1980: 5: 413-416.

Oishi S. , and Hiraga K. Distribution and elimination of di(2-ethylhexyl) phthalate (DEHP) and mono (2-ethylhexyl) phthalate (MEHP) after a single oral administration of DEHP in rats. Arch. Toxicol. 1982: 51: 149-155.

Oishi S. , and Hiraga K. Testicular atrophy induced by di(2-ethylhexyl) phthalate: effect of zinc supplement. Toxicol. Appl. Pharmacol. 1983: 70: 43-48.

Oppelt E. T. Incineration of hazardous waste: a critical review. J. Air Pollut. Control Assoc. 1987: 37: 558-586.

OSHA . Occupational Safety and Health Administration. Fed. Regist. 1986: 51: 42257-42266.

OSHA . Occupational Safety and Health Administration: Part III. Fed. Regist. 1989: 54: 2332-2936.

Overcash M. R. , Weber J. B. , and Tucker W. Toxic and priority organics in municipal sludge land treatment systems. U.S. Environmental Protection Agency, Office of Research and Development, Cincinnati, OH, 1986. EPA/600/2-86/010. NTIS No. PB86-150208.

Overturf M. L. , Druilhet R. E. , Liehr J. G. , et al. Phthalate esters in normal and pathological human kidneys. Bull. Environ. Contam. Toxicol. 1979: 22: 536-542.

Pankow J. F. , Ligocki M. P. , Rosen M. E. , et al. Adsorption/thermal desorption with small cartridges for the determination of trace aqueous semivolatile organic compounds. Anal. Chem. 1988: 60: 40-47.

Parmar D. , Srivastava S. P. , Srivastava S. P. , et al. Hepatic mixed function oxidases and cytochrome P-450 contents in rat pups exposed to di(2-ethylhexyl) phthalate through mother's milk. Drug Metab. Dispos. 1985: 13: 368-370.

Parmar D. , Srivastava S. P. , and Seth P. K. Effect of di(2-ethylhexyl) phthalate (DEHP) on spermatogenesis in adult rats. Toxicology 1986: 42: 47-55.

Parmar D. , Srivastava S. P. , Singh G. B. , et al. Effect of testosterone on the testicular atrophy caused by di(2-ethylhexyl) phthalate (DEHP). Toxicol. Lett. 1987: 36: 297-308.

Parmar D. , Srivastava S. P. , and Seth P. K. Effect of di(2-ethylhexyl) phthalate (DEHP) on hepatic mixed function oxidases in different animal species. Toxicol. Lett. 1988: 40: 209-217.

Parry J. M. , Arni P. , Brooks T. , et al. Summary report on the performance of the yeast and Aspergillus assays. Prog. Mutat. Res. 1985: 5: 25-46.

Peck C. C. , and Albro P. W. Toxic potential of the plasticizer di(2-ethylhexyl) phthalate in the context of its disposition and metabolism in primates and man. Environ. Health Perspect. 1982: 45: 11-17.

Perera M. I. , Katyal S. L. , and Shinozuka H. Suppression of choline-deficient diet-induced hepatocyte membrane lipid peroxidation in rats by the peroxisome proliferators 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio (N-beta-hydroxyethyl) acetamide and di(2-ethylhexyl) phthalate. Cancer Res. 1986: 46: 3304-3308.

Persson P. , Penttinen H. , and Nvortera P. DEHP in the vicinity of an industrial area in Finland. Environ. Pollut. 1978: 16: 163-163.

Perwak J. , Goyer M. , Schimke G. , et al. An exposure and risk assessment for phthalate esters: di(2-ethylhexyl)phthalate, di-n-butyl phthalate, dimethyl phthalate, diethyl phthalate, di-n-octyl phthalate, butyl benzyl phthalate. U.S. Environmental Protection Agency, Office of Water Regulations and Standards, Washington, DC, 1981. EPA-440/4-81-020. NTIS no. PB85-211936.

Peterson A. , Draman A. , All P. , et al. Toxicity of plastic devices having contact with blood. 1974. NTIS no. PB-233701.

Petrasek A. C. , Kugelman I. J. , Austern B. M. , et al. Fate of toxic organic compounds in wastewater treatment plants. J. Water Pollut. Control Fed. 1983: 55: 1286-1296.

Phillips B. J. , James T. E. , and Gangolli S. D. Genotoxicity studies of di(2-ethylhexyl)phthalate and its metabolites in CHO cells. Mutat. Res. 1982: 102: 297-304.

Plumb R. H., Jr. A comparison of ground water monitoring data from CERCLA and RCRA sites. Ground Water Monit. Rev. 1987 (Fall): 94-100.

Pollack G. M. , Buchanan J. F. , Slaughter R. L. , et al. Circulating concentrations of di(2-ethylhexyl)phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis. Toxicol. Appl. Pharmacol. 1985: 79: 257-267.

Pollack G. M. , Li R. C. , Ermer J. C. , et al. Effects of route of administration and repetitive dosing on the disposition kinetics of di(2-ethylhexyl)phthalate and its mono-de-esterified metabolite in rats. Toxicol. Appl. Pharmacol. 1985: 79: 246-256.

Popp J. A. , Garvey L. K. , Hamm T. E. , et al. Lack of hepatic promotional activity by the peroxisomal proliferating hepatocarcinogen di(2-ethylhexyl)phthalate. Carcinogenesis 1985: 6(1): 141-144.

Preston M. R. , and Al-Omran L. A. Phthalate ester speciation in estuarine water, suspended particulates and sediment. Environ. Pollut. 1989: 62: 183-193.

Price C. J. , Tyl R. W. , Marr M. C. , et al. Reproduction and fertility evaluation of diethylhexyl phthalate (CAS No. 117-81-7) in Fischer 344 rats exposed during gestation. Final Report. National Toxicology Program, Research Triangle Park, NC, 1986. NTP-86-309.

Price S. C. , Ochieng W. , Weaver R. , et al. Studies on the mechanisms of changes produced in the liver, thyroid, pancreas and kidney by hypolipidemic drugs and di-(2-ethylhexyl)phthalate. In: Reid E. , Cook G. M. , Luzio J. P. (Eds.), Cells, Membranes, and Disease, Including Renal. Vol. 17(B). Plenum, New York, 1987, pp. 67-78.

Price S. C. , Chescoe D. , Grasso P. , et al. Alterations in the thyroids of rats treated for long periods with di-(2-ethylhexyl)phthalate or with hypolipidaemic agents. Toxicol. Lett. 1988: 40: 37-46.

Price S. C. , Ozalp S. , Weaver R. , et al. Thyroid hyperactivity caused by hypolipodaemic compounds and polychlorinated biphenyls: the effect of coadministration in the liver and thyroid. Arch. Toxicol. 1988: (suppl 12): 85-92.

Priston F. A. , and Dean B. J. Tests for the induction of chromosome aberrations, polyploidy and sister chromatid exchanges in rat liver (RL4) cells. Prog. Mutat. Res. 1985: 5: 387-395.

Probst G. S. , and Hill L. E. Tests for the induction of DNA repair synthesis in primary cultures of adult rat hepatocytes. Prog. Mutat. Res. 1985: 5: 381-386.

Putman D. L. , Moore W. A. , Schechtman L. M. , et al. Cytogenetic evaluation of di-(2-ethylhexyl)phthalate and its major metabolites in Fischer 344 rats. Environ. Mutagen 1983: 5: 227-231.

Rao M. S. , and Reddy J. K. Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis 1987: 8: 637-645.

Rao M. S. , Usuda N. , Subbarao V. , et al. Absence of gamma-glutamyl transpeptidase activity in neoplastic lesions induced in the liver of male F-344 rats by di-(2-ethylhexyl) phthalate, a peroxisome proliferator. Carcinogenesis 1987: 8: 1347-1350.

Rao M. S. , Yeldandi A. V. , and Subbarao V. Quantitative analysis of hepatocellular lesions induced by di(2-ethylhexyl)phthalate in F-344 rats. J. Toxicol. Environ. Health 1990: 30: 85-89.

Ray L. E. , Murray H. E. , and Giam C. S. Organic pollutants in marine samples from Portland, Maine. Chemosphere 1983: 12: 1031-1038.

Reddy J. K. Cell specificity in the induction of peroxisome proliferation. In: Fowler B. A. (Ed.), Mechanisms of Cell Injury: Implications for Human Health. John Wiley and Sons, New York, NY, 1987, pp. 83-99.

Reddy J. K. , and Lalwani N. D. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit. Rev. Toxicol. 1983: 12: 1-58.

Reddy J. K. , Moody D. E. , Azarnoff D. L. , et al. Di(2-ethylhexyl)phthalate: an industrial plasticizer induces hypolipidemia and enhances hepatic catalase and carnitine acetyltransferase activities in rats and mice. Life Sci. 1976: 18: 941-946.

Reddy J. K. , Reddy M. K. , Usman M. I. , et al. Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate with a hypolipidemic drug. Environ. Health Perspect. 1986: 65: 317-327.

Reel J. R. , Lawton A. D. , and Lamb J. C. Diethylhexyl phthalate (DEHP): reproduction and fertility assessment in CD-1 mice when administered in the feed. Report to National Toxicology Program, Research Triangle Park, NC, 1982. NTP-82-FACB003.

Rhodes C. , Orton T. C. , Pratt I. S. , et al. Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl)phthalate in rats and marmosets: extrapolation of effects in rodents to man. Environ. Health Perspect. 1986: 65: 299-308.

Risch S. J. Migration of toxicants, flavors, and odor-active substances from flexible packaging materials to food. Food Technol. 1988: 42: 95-102.

Ritter E. J. , Scott W. J., Jr. , Randall J. L. , et al. Teratogenicity of di(2-ethylhexyl)phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. Teratology 1987: 35: 41-46.

Roth B. , Herkenrath P. , Lehmann H.-J. , et al. Di-(2-ethylhexyl)-phthalate as plasticizer in PVC respiratory tubing systems: indications of hazardous effects on pulmonary function in mechanically ventilated, preterm infants. Eur. J. Pediatr. 1988: 147: 41-46.

RTECS. Registry of Toxic Effects of Chemical Substances. National Library of Medicine, National Toxicology Information Program, Bethesda, MD, July 18, 1990.

Sager G. , and Little C. The effect of the plasticizers TBEP tris-2-butoxyethylphosphate and DEHP di-2-ethylhexylphthalate on beta-adrenergic ligand binding to alpha-1 acid glycoprotein and mono-nuclear leukocytes. Biochem. Pharmacol. 1989: 38: 2551-2557.

Sandmeyr E. E. , and Kirwin C. J. Esters. In: Clayton G. D. , Clayton F. E. (Eds.), Patty's Industrial Hygiene and Toxicology, Vol. IIA, 3rd rev. edn. Interscience Publishers, New York, NY, 1981, pp. 2346-2350.

Sanner T. , and Rivedal E. Tests with the syrian hamster embryo (SHE) cell transformation assay. Prog. Mutat. Res. 1985: 5: 665-671.

Sax N. I. , and Lewis R. J., Sr. (Eds.), Hawley's Condensed Chemical Dictionary. 11th edn. Van Nostrand Reinhold Company, New York, NY, 1987, 150-150 pp.

Saxena D. K. , Srivastava S. P. , Chandra S. V. , et al. Testicular effects of di(2-ethylhexyl)phthalate: histochemical and histopathological alterations. Ind. Health 1985: 23: 191-198.

Schmezer P. , Pool B. L. , Klein R. G. , et al. Various short-term assays and two long-term studies with the plasticizer di(2-ethylhexyl)phthalate in the Syrian golden hamster. Carcinogenesis 1988: 9: 37-43.

Schmid P. , and Schlatter C. Excretion and metabolism of di(2-ethylhexyl)phthalate in man. Xenobiotica 1985: 15: 251-256.

Schulz C. O. , and Rubin R. J. Distribution, metabolism and excretion of di(2-ethylhexyl)phthalate in the rat. Environ. Health Perspect. 1973: 3: 123-129.

Scott R. C. , Dugard P. H. , Ramsey J. D. , et al. In vitro absorption of some o-phthalate diesters through human and rat skin. Environ. Health Perspect. 1987: 74: 223-227.

Seed J. L. Mutagenic activity of phthalate esters in bacterial liquid suspension assays. Environ. Health Perspect. 1982: 45: 111-114.

Shafer K. H. , Cooke M. , DeRoos F. , et al. WCOT capillary column GC/FT-IR and GC/MS for identifying toxic organic pollutants. Appl. Spectrosc. 1981: 35: 469-472.

Shaffer C. B. , Carpenter C. P. , and Smyth H. F. Acute and subacute toxicity of di(2-ethylhexyl)phthalate with note upon its metabolism. J. Ind. Hyg. Toxicol. 1945: 27: 130-135.

Shea P. J. , Weber J. B. , and Overcash M. R. Uptake and phytotoxicity of di-n-butyl phthalate in corn (Zea mays). Bull. Environ. Contam. Toxicol. 1982: 29: 153-158.

Sheldon L. S. , and Hites R. A. Sources and movement of organic chemicals in the Delaware River. Environ. Sci. Technol. 1979: 13: 574-579.

Shiota K. , and Mima S. Assessment of the teratogenicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in mice. Arch. Toxicol. 1985: 56: 263-266.

Shiota K. , Chou M. J. , and Nishimura H. Embryotoxic effects of di(2-ethylhexyl)phthalate and di-n-butyl phthalate (DB) in mice. Environ. Res. 1980: 22: 245-253.

Short R. D. , Robinson E. C. , Lington A. W. , et al. Metabolic and peroxisome proliferation studies with di(2-ethylhexyl)phthalate in rats and monkeys. Toxicol. Ind. Health 1987: 3: 185-195.

Singh A. R. , Lawrence W. H. , and Autian J. Teratogenicity of phthalate esters in rats. J. Pharm. Sci. 1972: 61: 51-55.

Singh A. R. , Lawrence W. H. , and Autian J. Maternal-fetal transfer of 14C-di(2-ethylhexyl)phthalate and 14C-diethyl phthalate in rats. J. Pharm. Sci. 1975: 64: 1347-1350.

Sittig M. Handbook of Toxic and Hazardous Chemicals and Carcinogens. 2nd edn. Noyes Publications, Park Ridge, NJ, 1985, pp. 345-346.

Sjoberg P. , and Bondesson U. Determination of di(2-ethylhexyl)phthalate and four of its metabolites in blood plasma by gas chromatography-mass spectrometry. J. Chromatogr. 1985: 344: 167-175.

Sjoberg P. , Bondesson U. , and Hammarlund M. Nonlinearities in the pharmacokinetics of di(2-ethylhexyl)phthalate and metabolites in male rats. Arch. Toxicol. 1985: 58: 72-77.

Sjoberg P. , Bondesson U. , Kjellen L. , et al. Kinetics of di(2-ethylhexyl)phthalate in immature and mature rats and effect on testis. Acta Pharmacol. Toxicol. 1985: 56: 30-37.

Sjoberg P. O. J. , Bondesson U. G. , Sedin E. G. , et al. Disposition of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in newborn infants subjected to exchange transfusions. Eur. J. Clin. Invest. 1985a: 15: 430-436.

Sjoberg P. O. J. , Bondesson U. G. , Sedin E. G. , et al. Exposure of newborn infants to plasticizers: plasma levels of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate during exchange transfusion. Transfusion 1985b: 25: 424-428.

Sjoberg P. , Bondesson U. , Gray T. J. , et al. Effects of di(2-ethylhexyl)phthalate and five of its metabolites on rat testis in vivo and in vitro. Arch. Toxicol. 1986: 58: 225-233.

Sjoberg P. , Lindquist N. G. , and Ploen L. Age-dependent response of the rat testes to di(2-ethylhexyl)phthalate. Environ. Health Perspect. 1986: 65: 237-242.

Smith-Oliver T. , and Butterworth B. E. Correlation of the carcinogenic potential of di(2-ethylhexyl)phthalate (DEHP) with induced hyperplasia rather than with genotoxic activity. Mutat. Res. 1987: 188: 21-28.

SRI . Directory of Chemical Producers. SRI International, Menlo Park, CA, 1987, 890-890 pp.

SRI . Directory of Chemical Producers. SRI International, Menlo Park, CA, 1988, 871-871 pp.

SRI . Directory of Chemical Producers. SRI International, Menlo Park, CA, 1989, 877-877 pp.

SRI . Directory of Chemical Producers. SRI International, Menlo Park, CA, 1990, 883-883 pp.

Stalling D. L. , Hogan J. W. , and Johnson J. L. Phthalate ester residues—their metabolism and analysis in fish. Environ. Health Perspect. 1973: 3: 159-173.

Stanley J. S. Broad scan analysis of FY82 national human adipose tissue survey specimens: Vol. III. Semi-volatile organic compounds. U.S. Environmental Protection Agency, Office of Toxic Substances, Washington, DC, 1986. EPA 560/5-86-035.

Stanley J. S. Broad scan analysis of the FY82 national human adipose tissue survey specimens: Vol. I. Executive summary. U.S. Environmental Protection Agency, Office of Toxic Substances, Washington, DC, 1986. EPA 560/5-86-035.

Staples C. A. , Werner A. F. , and Hoogheem T. J. Assessment of priority pollutant concentrations in the United States using STORET database. Environ. Toxicol. Chem. 1985: 4: 131-142.

Staubli W. , and Hess R. Lipoprotein formation in the liver cell. Ultrastructural and functional aspects relevant to hypolipidemic action. In: Kritchersky D. (Ed.), Handbook of Experimental Pathology, Vol. 41. Hypolipidemic/agents. Springer-Verlag, Berlin, 1975, pp. 229-289.

Sternlieb I. Electron microscopy of mitochondria and peroxisomes of human hepatocytes. In: Popper H. , Schaffner F. (Eds.), Progress in Liver Diseases, Vol. 6. Grune and Gratton, New York, NY, 1979, pp. 81-104.

Stott W. T. Chemically induced proliferation of peroxisomes: implications for risk assessment. Regul. Toxicol. Pharmacol. 1988: 8: 125-159.

Stryer L. Biochemistry, 3rd edn. Freeman, New York, NY, 1990.

Sugatt R. H. , O'Grady D. P. , Banerjee S. , et al. Shake flask biodegradation of 14 commercial phthalate esters. Appl. Environ. Microbiol. 1984: 47 (4): 601-606.

Sullivan K. F. , Atlas E. L. , and Giam C. S. Adsorption of phthalic acid esters from seawater. Environ. Sci. Technol. 1982: 16: 428-432.

Svoboda D. J. , and Azarnoff D. L. Tumors in male rats fed ethyl chlorophenoxy-isobutyrate, a hypolipidemic drug. Cancer Res. 1979: 39: 3419-3428.

Swartz R. C. , Schults D. W. , Ditsworth G. R. , et al. Sediment toxicity, contamination, and macrobenthic communities near a large sewage outfall. In: Boyle T. P. (Ed.), Validation and Predictability of Laboratory Methods for Assessing the Fate and Effects of Contaminants in Aquatic Ecosystems. American Society for Testing and Materials, Philadelphia, PA, 1983, pp. 152-175.

Tabak H. H. , Quave S. A. , Mashni C. I. , et al. Biodegradability studies with organic priority pollutant compounds. J. Water Pollut. Control Fed. 1981: 53: 1503-1518.

Takagi A. , Sai K. , Umemura T. , et al. Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate. Jpn. J. Cancer Res. 1990: 81: 213-215.

Tamura H. , Iida T. , Suga T. , et al. Long-term effects of hypolipidemic peroxisome proliferator administration on hepatic hydrogen peroxide metabolism in rats. Carcinogenesis 1990: 11: 445-450.

Teirlynck O. A. , and Belpaire F. Disposition of orally administered di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in the rat. Arch. Toxicol. 1985: 57: 226-230.

Thomas G. H. Quantitative determination and confirmation of identity of trace amounts of dialkyl phthalates in environmental samples. Environ. Health Perspect. 1973: 3: 23-28.

Thomas J. M. , Yordy J. R. , Amador J. A. , et al. Rates of dissolution and biodegradation of water-insoluble organic compounds. Appl. Environ. Microbiol. 1986: 52: 290-296.

Thuren A. Determination of phthalates in aquatic environments. Bull. Environ. Contam. Toxicol. 1986: 36: 33-40.

Thysen B. , Morris P. L. , Gatz M. , et al. The effect of mono (2-ethylhexyl)phthalate on sertoli cell transferrin secretion in vitro. Toxicol. Appl. Pharmacol. 1990: 106: 154-157.

TMA . Voluntary standard specification for the reduction of DEHP (di-(2-ethylhexyl)phthalate) in PVC pacifiers and teethers. Toy Manufacturers of America, Inc., New York, NY, 1986.

Tomaszewski K. E. , Agarwal D. K. , and Melnick R. L. In vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and female B6C3F1 mice to hepatic peroxisome proliferators. Carcinogenesis 1986: 7: 1871-1876.

Tomaszewski K. E. , Montgomery C. A. , and Melnick R. L. Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in F344 rats by di(2-ethylhexyl)phthalate. Chem. Biol. Interact. 1988: 65: 205-222.

Tomita I. , Nakamura Y. , Aoki N. , et al. Mutagenic/carcinogenic potential of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate. Environ. Health Perspect. 1982: 45: 119-125.

Tomita I. , Nakamura Y. , Yagi Y. , et al. Fetotoxic effects of mono2-ethylhexylphthalate (MEHP) in mice. Environ. Health Perspect. 1986: 65: 249-254.

Trebbin W. M. Hemodialysis and pregnancy. JAMA 1979: 241: 1811-1812.

TRI88. Toxic Chemical Release Inventory. National Library of Medicine, National Toxicology Information Program, Bethesda, MD, 1990.

Tugwood J. D. , Issemann I. , Anderson R. G. , et al. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J. 1992: 11 (2): 433-439.

Turnbull D. , and Rodricks J. V. Assessment of possible carcinogenic risk to humans resulting from exposure to di(2-ethylhexyl)phthalate. J. Am. Coll. Toxicol. 1985: 4: 111-146.

Tyl R. W. Developmental toxicity evaluation of 2-ethylhexanoic acid administered by gavage to Fischer 344 rats. Chemical Manufacturers Association, Washington, DC 20037, 1988a.

Tyl R. W. Developmental toxicity evaluation of 2-ethylhexanoic administered by gavage to New Zealand white rabbits. Chemical Manufacturers Association, Washington, DC 20037, 1988b.

Tyl R. W. , Price C. J. , Marr M. C. , et al. Developmental toxicity evaluation of dietary di(2-ethylhexyl)phthalate in Fischer 344 rats and CD-1 mice. Fundam. Appl. Toxicol. 1988: 10: 395-412.

USDHHS. Fourth annual report on carcinogens. Summary 1985. U.S. Department of Health and Human Services, Washington, DC, 1985, pp. 83-85.

Van Lierop J. B. , and Van Veen R. M. Determination of plasticizers in fat by gas chromatography-mass spectrometry. J. Chromatogr. 1988: 447: 230-233.

Veith G. D. , DeFoe D. L. , and Bergstedt B. V. Measuring and estimating the bioconcentration factor of chemicals in fish. J. Fish. Res. Board Can. 1979: 36: 1040-1048.

Verschueren K. Handbook of Environmental Data on Organic Chemicals. 2nd edn. Van Nostrand Reinhold Company, New York, NY, 1983, pp. 575-578.

Vessman J. , and Rietz G. Determination of di(ethylhexyl)phthalate in human plasma and plasma proteins by electron capture gas chromatography. J. Chromatogr. 1974: 100: 153-163.

Vogel E. W. The Drosophila somatic recombination and mutation assay (SRM) using the white-coral somatic eye color systems. Prog. Mutat. Res. 1985: 5: 313-317.

Von Halle E. S. A tabular review of the published mutagenicity literature for IPCS study compounds. Prog. Mutat. Res. 1985: 5: 699-725.

Waldock M. J. Determination of phthalate esters in samples from the marine environment using GC-MS. Chem. Ecol. 1983: 1: 261-261.

Walseth F. , Toftgard R. , and Nilsen O. G. Phthalate esters: I. Effects on cytochrome P-450 mediated metabolism in rat liver and lung, serum enzymatic activities and serum protein levels. Arch. Toxicol. 1982: 50: 1-10.

Wams T. J. Diethylhexylphthalate as an environmental contaminant—a review. Sci. Total. Environ. 1987: 66: 1-16.

Ward J. M. , Rice J. M. , Creasia D. , et al. Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice. Carcinogenesis 1983: 4: 1021-1030.

Ward J. M. , Ohshima M. , Lynch P. , et al. Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice. Cancer Lett. 1984: 24: 49-55.

Ward J. M. , Diwan B. A. , Ohshimna M. , et al. Tumor-initiating and promoting activities of di(2-ethylhexyl)phthalate in vivo and in vitro. Environ. Health Perspect. 1986: 65: 279-291.

Ward J. M. , Konishi N. , and Diwan B. A. Renal tubular cell or hepatocyte hyperplasia is not associated with tumor promotion by di(2-ethylhexyl)phthalate in B6C3F1 mice after transplacental initiation with N-nitrosoethylurea. Exp. Pathol. 1990: 40: 125-138.

Warf Institute. Acute inhalation LC50 Sample LL-1132. Unpublished study. July 23, 1976.

Warren J. R. , Lalwani N. D. , and Reddy J. K. Phthalate esters as peroxisome proliferator carcinogens. Environ. Health Perspect. 1982: 45: 35-40.

Watts P. Di-2-ethylhexylphthalate metabolism in man. Food Chem. Toxicol. 1985: 23: 1023-1023.

White R. D. , Carter D. E. , Earnest O. , et al. Absorption and metabolism of three phthalate diesters by the rat small intestine. Food Cosmet. Toxicol. 1980: 18: 383-386.

Wieboldt R. C. , Adams G. E. , and Later D. W. Sensitivity improvement in infrared detection for supercritical fluid chromatography. Anal. Chem. 1988: 60: 2422-2427.

Williams D. T. Dibutyl- and di-(2-ethylhexyl) phthalate in fish. J. Agric. Food Chem. 1973: 21: 1128-1129.

Williams D. T. , and Blanchfield B. J. Retention, excretion and metabolism of di(2-ethylhexyl)phthalate administered orally to the rat. Bull. Environ. Contam. Toxicol. 1974: 11: 371-387.

Williams M. D. , and Hargadine S. Sediment adsorption isotherm of 14C-di(2-ethylhexyl)phthalate. Report to Chemical Manufacturers Association by Analytical Bio-Chemistry Laboratories, Inc., Columbia, MO, 1991. Final Report No. 38811.

Williams G. M. , Tong C. , and Brat S. V. Tests with the rat hepatocyte primary culture/DNA-repair test. Prog. Mutat. Res. 1985: 5: 341-345.

Wofford H. W. , Wilsey C. D. , Neff G. S. , et al. Bioaccumulation and metabolism of phthalate esters by oysters, brown shrimp, and sheepshead minnows. Ecotoxicol. Environ. Safety 1981: 5: 202-210.

Wolfe N. L. , Burns L. A. , and Steen W. C. Use of linear free energy relationships and an evaluative model to assess the fate and transport of phthalate esters in the aquatic environment. Chemosphere 1980: 9: 393-402.

Wolfe N. L. , Paris D. F. , Steen W. C. , et al. Correlation of microbial degradation rates with chemical structure. Environ. Sci. Technol. 1980: 14: 1143-1146.

Wolkowski-Tyl R., Jones-Price C., and Marr M.C. Teratologic evaluation of diethylhexyl phthalate (CAS No. 117-81-7) in Fischer 344 rats. Report to National Center for Toxicological Research, Jefferson, AR, by Center for Toxicology and Life Sciences, Research Triangle Park, NC, 1984a. NCTR-84/135. NTIS no. PB85-105658/GAR.

Wolkowski-Tyl R., Jones-Price C., Marr M.C., et al. Teratologic evaluation of diethylhexyl phthalate in CD-1 mice. Final Report. National Center for Toxicological Research, Jefferson, AR PB85-105674. Report to National Center for Toxicological Research, Jefferson, AR, by Center for Toxicology and Life Sciences, Research Triangle Park, NC, 1984b. NTIS no. PB85-105674.

Wurgler F. E. , Graf U. , and Frei H. Somatic mutation and recombination test in wings of Drosophila melanogaster. Prog. Mutat. Res. 1985: 5: 325-340.

Yoon J. S. , Mason J. M. , Valencia R. , et al. Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen 1985: 7: 349-367.

Yoshikawa K. , Tanaka A. , Yamaha T. , et al. Mutagenicity study of nine monoalkyl phthalates and a dialkyl phthalate using Salmonella typhimurium and Escherichia coli. Food Chem. Toxicol. 1983: 21: 221-223.