Physiological Parameter Values for Physiologically Based Pharmacokinetic Models

Adolph, E.F. (1949). "Quantitative relations in the physiological constitutions of mammals." Science 109:579-585.

Allen, B.C. and Fisher, J.W. (1993). "Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans." Risk Anal. 13:71-86.

Altman, P.L. and Dittmer, D.S. (1971). "Respiration and circulation." In: Biological Handbooks, Federation of American Societies for Experimental Biology, Bethesda, MD.

Altman, P.L. and Dittmer, D.S. , (eds). (1972). Biology Data Book, 2nd Edition, Federation of American Societies for Experimental Biology, Bethesda, MD.

Altman, P.L. and Katz, D.D. (1977). Inbred and Genetically Defined Strains of Laboratory Animals. Part 2: Hamster, Guinea Pig, Rabbit, and Chicken. Federation of American Societies for Experimental Biology. Bethesda, MD.

Andersen, A.C. (1970). Introduction. In: The Beagle as an Experimental Dog. ( A.C. Andersen , ed.) Iowa State University Press, Ames, IO. pp. 3-9.

Andersen, A.C. and Goldman, M. (1970). "Growth and development." In: The Beagle as an Experimental Dog. ( A.C. Andersen , ed.) Iowa State University Press, Ames, IO. pp. 43-105.

Andersen, M.E. , Clewell, H.J. , III, Gargas, M.L. , Smith, F.A. , and Reitz, R.H. (1987). "Physiologically based pharmacokinetics and the risk assessment process for methylene chloride." Toxicol. Appl. Pharmacol. 87:185-205.

Anderson, Y.B. , Jackson, J.A. , and Birnbaum, L.S. (1993). "Maturational changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Fischer 344 rats." Toxicol. Appl. Pharmacol. 119:214-220.

Arms, A.D. and Travis, C.C. (1988). Reference Physiological Parameters in Pharmacokinetic Modeling. U.S. Environmental Protection Agency, EPA 600/6-88/004. Washington, DC.

Armstrong, R.B. and Laughlin, M.H. (1984). "Exercise blood flow patterns within and among rat muscles after training." Am. J. Physiol. 246 (Heart Circ. Physiol. 15): H59-H68.

Armstrong, R.B. , Delp, M.D. , Goljan, E.F. , and Laughlin, M.H. (1987). "Distribution of blood flow in muscles of miniature swine during exercise." J. Appl. Physiol. 62:1285-1298.

Armstrong, R.B. , Hayes, D.A. , and Delp, M.D. (1989). "Blood flow distribution in rat muscle during preexercise anticipatory response." J. Appl. Physiol. 67:1855-1861.

Astrand, I. (1983). "Effect of physical exercise on uptake, distribution, and elimination of vapors in man," (Ch.5). In: Modeling of Inhalation Exposure to Vapors: Uptake, Distribution, and Elimination. Vol. 2. ( V. Fiserova-Bergerova , ed.) CRC Press, Inc., Boca Raton, FL. pp. 107-130.

Atal, S. , Zarnowski, M.J. , Cushman, S.W. , and Sampugna, J. (1994). "Comparison of body weight and adipose tissue in male C57BL/6J mice fed diets with and without trans fatty acids." Lipids. 29:319-325.

Austin, R.E. , JR., Hauck, W.W. , Aldea, G.S. , Flynn, A.E. , Coggins, D.L. , and Hoffman, J.I.E. (1989). "Quantitating error in blood flow measurements with radioactive microspheres.' Am. J. Physiol. 26:H280-H288.

Bailey, J.W. , Andersen, D.B. , Verstegen, M.W.A. , and Curtis, S.E. (1980). "Relative growth rates of various fat depots in Sprague Dawley rats." Growth. 44:220-229.

Bair, W.J. and Willard, D.H. (1962). "Plutonium inhalation studies. IV. Morality in dogs after inhalation of Pu229O2." Radiat. Res. 16:811-821 (as cited in Park et al., 1970).

Banks, Y.B. , Brewster, D.W. , and Birnbaum, L.S. (1990). "Age-related changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran." Fund. Appl. Toxicol. 15:163-173.

Barbee, R.W. , Perry, B.D. , Re, R.N. and Murgo, J.P. (1992). "Microsphere and dilution techniques for the determination of blood flows and volumes in conscious mice." Am. J. Physiol. , 263:728-733.

Bartlett D. , JR. and Tenney, S.M. (1970). "Control of breathing in experimental anemia." Resp. Physiol. 10:384-395.

Bauer, L.A. , O'Sullivan, T. , Reiss, W.G. , Horn, J.R. , Opheim, K. , Strandness, D.E. , and Carithers, R.L. (1994). "Liver blood flow, anitpyrine clearance, and antipyrine metabolite formation clearance in patients with chronic active hepatitis and alcoholic cirrhosis." Br. J. Clin. Pharmacol. 37:375-381.

Baxter, L.T. , Zhu, H. , Mackensen, D.G. , and Jain, R.K. (1994). "Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice." Canc. Res. 54:1517-1528.

Beischer, N.A. , and Furry, D.E. (1964). "Organ weights of the squirrel monkey." Lab. Anim . Sci. 14:345.

Bennett, F.M. and Tenney, S.M. (1982). "Comparative mechanics of mammalian respiratory system." Respir. Physiol. 49:131-140.

Bergø, G.W. , Risberg, J. , and Tyssebotn, I. (1989). "Effect of 5 bar oxygen on cardiac output and organ blood flow in conscious rats." Undersea Biomed. Res. 15:457-470.

Birnbaum, L.S. (1993). Personal Communication during ILSI Physiological Parameters Working Group Meeting, September 10, 1993.

Bischoff, K.B. and Brown, R.G. (1966). "Drug distribution in mammals." Chem. Eng. Prog. Symp. Ser. 66:33-45.

Blizard, K.B. and Welty, R. (1971). "Cardiac activity in the mouse: strain differences ." J. Compar. Psychol. 77(2):337-334.

Blume, W. and Zollmer, R. (1943). "Uber die Wirkung des Pervitina suf die Atmung der Ratte und des Meerschweinchens." Arch. Exptl. Pathol. Pharmakol. 202:21-43 (as cited in Arms and Travis, 1988).

Bois, F.Y. , Zeise, L. , and Tozer, T.N. (1990). "Precision and sensitivity of pharmacokinetic models for cancer risk assessment: tetrachloroethylene in mice, rats, and humans." Toxicol. Appl. Pharmacol. 102:300-315.

Bois, F.Y. , Woodruff, T.J. , and Spear, R.C. (1991). "Comparison of three physiologically based pharmacokinetic models of benzene disposition." Toxicol. Appl. Pharmacol. 110:79-88.

Bolme, P. and Novotny, J. (1969). "Conditional reflex activation of the sympathetic cholinergic vasodilator nerves in the dog." Acta. Physiol. Scand. 77:58-67.

Borkan, G.A. , Hults, D.E. , Gerzof, A.F. , Robbins, A.H. , and Silbert, C.K. (1983). "Age changes in body composition revealed by computer tomography." J. Gerontol. 38:673-677.

Bourne, D.W.A. , Jacobs, J.J. , Awaluddin, A. , Maddalena, D.J. , Wilson, J.G. , and Boyd, R.E. (1992). "Physiological modeling of disposition of potential tumor-imaging radiopharmaceuticals in tumor-bearing mice." J. Pharm. Sci. 81(5):408-412.

Boxenbaum, H. (1980). "Interspecies variation in liver weight, hepatic blood flow, antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin." J. Pharmacokin. Biopharm. 8:165-173.

Brandfonbrenner, M. , Landowne, M. , and Shock, N.W. (1955). "Changes in cardiac output with age." Circulation. 12:557-566.

Breazile, J.E. and Brown, E.M. (1976). "Anatomy." In: The Biology of the Guinea Pig. ( J.E. Wagner and P.J. Manning , eds.) Academic Press, New York, NY.

Brobeck, J.R. (ed.) (1979). Best and Taylor's Physiological Basis of Medical Practice, 10th ed. Williams and Wilkins Company. Baltimore, MD.

Bronaugh, R.L. , Stewart, R.F. , and Congdon, E.R. (1983). "Differences in permeability of rat skin related to sex and body site." J. Soc. Cosmet. Chem. 34:127-135.

Brown, H.S. , Halliwell, M. , Qamar, M. , Read, A.E. , Evans, J.M. , and Wells, P.N.T. (1989). "Measurement of normal portal venous blood flow by Doppler ultrasound." Gut. 30:503-509.

Bulow, J. and Madsen, J. (1978). "Human adipose tissue blood flow during prolonged exercise II." Pfluegers Arch. 376:41-45.

Cameron, T.P. , Hickman, R.L. , Kornreich, M.R. , and Taylor, R.E. (1985). "History, survival, and growth patterns of B6C3F1 mice and F344 rats in the National Cancer Institute Carcinogenesis Testing Program." Fundam. Appl. Toxicol. 5:526-538.

Carmichael, F.J. , Saldivia, V. , Varghese, G.A. , Israel, Y. , and Orrego, H. (1988). "Ethanol-induced increase in portal blood flow: role of acetate and A1- and A2- adenosine receptors." Am. J. Physiol. 255:G417-G423.

Carter, W.J. , Dang, A.Q. , Faas, F.H. , and Lynch, M.E. (1991). "Effects of clenbuterol on skeletal muscle mass, body composition, and recovery from surgical stress in senescent rats." Metabolism. 40(8):855-860.

Carter, R. , Anderson, J.H. , Cooke, T.G. , Baxter, J.N. , and Angerson, W.J. (1994). "Splanchnic blood flow changes in the presence of hepatic tumour: Evidence of a humoral mediator." Br. J. Cancer. 69:1025-1026.

Caster, W.O. , Poncelet, J. , Simon, A.B. , and Armstrong, W.D. (1956). "Tissue weights of the rat. I. Normal values determined by dissection and chemical methods." Proc. Soc. Biol. Med. 91:122-126.

Clarys, J.P. , Martin, A.D. , and Drinkwater, D.T. (1984). "Gross tissue weights in the human body by cadaver dissection." Human Biol. 56:459-473.

Clewell, H.J. (1994) Personal discussion.

Clewell, H.J. and Jarnot, B.M. (1994). "Incorporation of pharmacokinetics in noncancer risk assessment: Example with chloropentafluorobenzene." Risk Anal. 14(3):265-273.

Clewell, H.J. , Lee, T. , and Carpenter, R.L. (1994). "Sensitivity of physiologically based pharmacokinetic models to variation in model parameters: methylene chloride." Risk Anal. 14(4).

Coleman, T.G. (1974). "Cardiac output by dye dilution in the conscious rat." J. Appl. Physiol. 37(3):452-455.

Coniglio, J.J. , Liu, D.S. , and Richardson, A. (1979). "A comparison of protein synthesis by liver parenchymal cells isolated from Fischer 344 rats of various ages." Mech. Age. Devel. 11:77-90.

Cowan, R.E. , Jackson, B.T. , Grainger, S.L. , and Thompson, R.P.H. (1991). "Effects of anesthetic agents and abdominal surgery on liver blood flow." Hepatology . 14:1161-1166.

Cowles, A.L. , Borgstedt, H.H. , and Gillies, A.J. (1971). "Tissue weights and rates of blood flow in men for the prediction of anesthetic uptake and distribution." Anesthesiol. 35(5):523-526.

Crile, G. and Quiring, D.P. (1940). "A record of the body weight and certain organ and gland weights of 3,690 animals." Ohio J. Sci. 15:219-259.

Crispens, C.G. , JR. (1975). Handbook on the Laboratory Mouse. Charles C. Thomas Publisher, Springfield, IL.

Csanady, G.A. , Mendrala, A.L. , Nolan, R.J. , and Filser, J.G. (1994). "A physiologic pharmacokinetic model for styrene and styrene-7,8-oxide in mouse, rat and man." Arch. Toxicol. 68:143-157.

Dallas, C.E. , Chen, X.M. , Muralidhara, S. , Varkonyi, P. , Tackett, R.L. , and Bruckner, J.V. (1994). "Use of tissue disposition data from rats and dogs to determine species differences in input parameters for a physiological model for perchloroethylene." Environ. Res. 67:54-67.

Dankovic, D. and Bailer, A.J. (1994). "The impact of exercise and intersubject variability on dose estimates for dichloromethane derived from a physiologically based pharmacokinetic model." Fundam. Appl. Toxicol. 22:20-25.

Davies, B. and Morris, T. (1993). "Physiological parameters in laboratory animals and man." Pharm. Res. 10(7):1093-1095.

Deavers, S. , Huggins, R.A. , and Smith, E.L. (1972). "Absolute and relative organ weights of the growing beagle." Growth 36:195.

Decad, G.M. , Birnbaum, L.S. , and Matthews, H.B. (1981). "Distribution and excretion of 2,3,7,8-tetrachlorodibenzofuran in C57BL/6J and DBA/2J Mice." Toxicol. Appl. Pharmacol. 59:564-573.

Dedrick, R.L. and Bischoff, K.B. (1968). "Pharmacokinetics in applications of the artificial kidney." Chem. Eng. Prog. Symp. Ser. No. 84, 64:32-44.

Dedrick, R.L. , Flessner, M.F. , Collins, J.M. , and Schultz, J.S. (1982). "Is the peritoneum a membrane?" ASAIO J. 5(1):1-9.

Delp, M.D. , Manning, R.O. , Bruckner, J.V. , and Armstrong, R.B. (1991). "Distribution of cardiac output during diurnal changes of activity in rats." Am. J. Physiol. 261:H1487-H1493.

Demarte, M.L. and Enesco, H.E. (1986). "Influence of low tryptophan diet on survival and organ growth in mice." Mech. Ageing Dev. 36:161-171.

Detweiler, D.K. , Buchanan, J.W. , Fregin, G.F. , and Hill, J.D. (1970). "Cardiovascular System A. Heart." In: The Beagle as an Experimental Dog. Iowa State University Press, Ames, IO. pp. 232-245.

Deurenberg, P. , Weststrate, J.A. , and Seidell, J.C. (1991). "Body mass index as a measure of body fatness: Age-and sex- specific prediction formulas." Br. J. Nutr. 65:105-114.

Donaldson, H.H. (1924). The Rat. Data and Reference Tables. Wistar Institute, Philadelphia, PA.

Dowell, R.T. , Gairola, C.G. , and Diana, J.N. (1992). "Reproductive organ blood flow measured using radioactive microspheres in diestrous and estrous mice." Am. J. Physiol. 262(4 Pt 2):R666-670.

Durbin, P.W. , Jeung, N. , Kullgren, B. , and Clemons, G.K. (1992). Gross Composition and Plasma and Extracellular Water Volumes of Tissues of a Reference Mouse. Manuscript Health Physics Society.

Engasser, J.M. , Sarhan, F. , Falcoz, C. , Minier, M. , Letourneur, P. , and Siest, G. (1981). "Distribution, metabolism, and elimination of phenobarbital in rats: physiologically based pharmacokinetic model." J. Pharm. Sci. 70(11):1233-1240.

Evans, M.V. , Crank, W.D. , Yang, H.M. , and Simmons, J.E. (1994). "Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats." Toxicol. Appl. Pharmacol. 128:36-44.

Everett, N.B. , Simmons, B. , and Lasher, E.P. (1956). "Distribution of blood (59Fe) and plasma (1311) volumes of rats determined by liquid nitrogen freezing." Circ. Res. 4:419-424.

Faraci, F.M. , Chilian, W.M. , Williams, J.K. , and Heistad, D.D. (1989). "Effects of reflex stimuli on blood flow to the adrenal medulla." Am. J. Physiol. 257:H590-H596.

Farris, F.F. , Dedrick, R.L. , Allen, P.V. , and Smith, J.C. (1993). "Physiological model for the pharmacokinetics of methyl mercury in the growing rat." Toxicol. Appl. Pharmacol. 119:74-90.

Fixler, D.E. , Atkins, J.M. , Mitchell, J.H. , and Horwitz, L.D. (1976). "Blood flow to respiratory, cardiac, and limb muscles in dogs during graded exercise." Am. J. Physiol. 231:1515-1519.

Fiserova-Bergerova, V. (1992). "Inhalation anesthesia using physiologically based pharmacokinetic models." Drug Metab. Rev. 24(4):531-557.

Fisher, J.W. , Whittaker, T. , Taylor, D.H. , Clewell, H.J. , and Andersen, M.E. (1989). "Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure for trichloroethylene and its metabolite, trichloroacetic acid." Toxicol. Appl. Pharmacol. 99:395-414.

Fisher, J.W. , Whittaker, T. , Taylor, D.H. , Clewell, H.J. , and Andersen, M.E. (1990). "Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid." Toxicol. Appl. Pharmacol. 102:497-513.

Flaim, S.F. , Stranieri, M.T. , Gill, A. , Carson, J.R. , and Brannan, M.D. (1990). "Effects of the novel coronary selective calcium channel blocker, McN-6186, on cardiocirculatory dynamics, coronary vascular resistance, and cardiac output distribution in normal, conscious rats." J. Cardiovasc. Pharmacol. 15:780-790.

Frank, D.W. (1976). "Physiological data of laboratory animals." In: Handbook of Laboratory Animal Science. Volume III, ( E.C. Melby and N.H. Altman , eds.) CRC Press, Cleveland, OH.

Frederick, C.B. , Potter, D.W. , Chang-Mateu, M.I. , and Andersen, M.E. (1992). "A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment." Toxicol. Appl. Pharmacol. 114:246-260.

Friedman, J.J. (1955). "Organ plasma volume of normal unanesthetized mice." Proc. Soc. Exptl. Biol. Med. 88:323-325.

Fremming, B.D. , Benson, R.E. , and Young, R.J. (1955). "Weight of organs in sixty-six male Macaca mulatta monkeys." J. Appl. Physiol. 8:155-158.

Frostell, C. , Pande, J.N. , and Hedenstierna, G. (1983). "Effects of high-frequency breathing on pulmonary ventilation and gas exchange." J. Appl. Physiol. 55:1854-1861.

Gasiewicz, T.A. , Geiger, L.E. , Rucci, G. , and Neal, R.A. (1983). "Distribution, excretion, and metabolism of 2,3,7,8-tertrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice." Drug. Metab. Dispos. 11(5):397-403.

Gearhart, J.M. , Mahle, D.A. , Greene, R.J. , Seckel, C.S. , Flemming, C.D. , Fisher, J.W. , and Clewell, H.J. , III (1993). "Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effect on PBPK model predictions in a risk assessment for perchloroethylene (PCE)." Toxicol. Let. 68:131-144.

Gjedde, S.B. and Gjedde, A. (1980). "Organ blood flow rates and cardiac output of the Balb/c mouse." Comp. Biochem. Physiol. 67A:671-674.

Goldman, H. and Sapirstein, L.A. (1973). "Brain blood flow in the conscious and anesthetized rat." Am. J. Physiol. 224(1): 122-126.

Goodhead, B. (1969). "Blood flow in different areas of the gastrointestinal tract in the anesthetized dog." Can. J. Physiol. Pharmacol. 47:787-790.

Greenway, C.V. and Stark, R.D. (1971). "Hepatic vascular bed." Physiol Rev. 51:23-65.

Gur, E. and Waner, T. (1993). "The variability of organ weight background data in rats." Laboratory Animals 27:65-72.

Haberer, J.P. , Audibert, G. , Saunier, C.G. , Muller, C. , Laxenaire, M.C. , and Hartemann, D. (1993). "Effect of propofol and thiopentone on regional blood flow in brain and peripheral tissues during normoxia and hypoxia in the dog." Clin. Physiol. 13:197-207.

Hachamovitch, R. , Wicher, P. , Capasso, J.M. , and Anversa, P. (1989). "Alterations of coronary blood flow and reserve with aging in Fischer 344 rats." Am. J. Physiol. 256:H66-H73.

Hadidian, Z. and Pawlowski, A.A. (1964). "Hematologic, biochemical and organ weight characteristics of Beagles." Cancer Chemotherapy Rept. 38:17-23 (as cited in Park et al., 1970).

Hartling, O.J. , Kelbaek, H. , Gjorup, T. , Schibye, B. , Klausen, K. , and Trap-Jensen, T. (1989). "Forearm oxygen uptake during maximal forearm dynamic exercise." Eur. J. Appl. Physiol. 58:466-470.

Hattis, D. , White, P. , and Koch, P. (1993). "Uncertainties in pharmacokinetic modeling for perchloroethylene: II. Comparison of model predictions with data for a variety of different parameters." Risk Anal. 13:599-610.

Hemingway, D.M. , Cooke, T.G. , Grime, S.J. , and Jenkins, S.A. (1993). "Changes in liver blood flow associated with the growth of hepatic LV10 and MC28 sarcomas in rats." Br. J. Surg. 80:495-498.

Herd, J.A. , Goodman, H.M. , and Grose, S.A. (1968). "Blood flow rates through adipose tissues of unanesthetized rats." Am. J. Physiol. 214:263-268.

Hetrick, D.M. , Jarabek, A.M. , and Travis, C.C. (1991). "Sensitivity analysis for physiologically based pharmacokinetic models." J. Pharm. Biopharm. 19(1):1-20.

Hintze, T.H. , Wang, J. , Patel, M. , Schustek, M. , Ochoa, M. , Dean, R. , Chiruzzo, F. , and Zeballos, G. (1990). "Dynamics of atrial peptide secretion in the coronary circulation of the conscious dog." Circ. Res. 67:609-614.

Hof, R.P. , Wyler, F. , and Stadler, G. (1980). "Validation studies for the use of the microsphere method in cats and young minipigs." Basic Res. Cardiol. 75:747-756.

Hoffman, J.I.E. , Heyman, M.A. , Rudolph, A.M. , and Payne, B.D. (1977). "Uses and abuses of the radioactive microsphere method of measuring regional blood flow." Biol. Anat. 15:20-23.

Hoffman, W.E. , Miletich, D.J. , and Albrecht, R.F. (1982). "Cardiovascular and regional blood flow changes during halothane anesthesia in the aged rat." Anesthesiol . 56:444-448.

Houben, A.J.H.M. , Slaaf, D.W. , Huvers, F.C. , De Leeuw, P.W. , Nieuwenhuijzen Kruseman, A.C. , and Schaper, N.C. (1994). "Diurnal variations in total forearm and skin microcirculatory blood flow in man." Scand. J. Clin. Lab. Invest. 54:161-168.

International Commission Of Radiological Protection (Icrp) (1975). No. 23: Report of the Task Group on Reference Man. Pergamon Press, New York, NY .

Igari, Y. , Sugiyama, Y. , Sawada, Y. , Iga, T. , and Hanano, M. (1983). "Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model." J. Pharm. Biopharm. 11:577-585.

In-Nami, H. , Kawaguchi, T. , Kosugi, I. , Yamaguchi, Y. , Okada, K. , Kawashima, Y. , and Yamamura, H. (1974). "Effects of acute administration of isoproterenol on the systemic and regional blood flow in the dog." Resuscitation . 3:285-294.

Jansky, L. and Hart, J.S. (1968). "Cardiac output and organ blood flow in warm- and cold-acclimated rats exposed to cold." Can. J. Physiol. Pharmacol. 46:653-659.

Johanson, G. and Filser, J.G. (1992). "Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation." Arch. Toxicol. 66:291-295.

Johanson, G. and Filser, J.G. (1993). "A physiologically based pharmacokinetic model for butadiene and its metabolite butadiene monoxide in rat and mouse and its significance for risk extrapolation." Arch. Toxicol. 67:151-163.

Kahn, D. , Weiner, G.J. , BEN-HAIM, S., BOLES PONTO, L.L., MADSEN, M.T., BUSHNELL, D.L., WATKINS, G.L., ARGENYI, E.A., and HICHWA, R.D. (1994). "Positron emission tomographic measurement of bone marrow blood flow to the pelvis and lumbar vertebrae in young normal adults." Blood. 83(4):958-963.

Kajita, J. , Kobayashi, S. , and Yoshida, T. (1994). "Effect of benidipine hydrochloride on regional blood flow." Arzneimittel-Forschung. 44(3)297-300.

Kaliss, N. and Pressman, D. (1950). "Plasma and blood volumes of mouse organs, as determined with radioactive iodoproteins." Proc. Soc. Exp. Biol. Med. 75:16-20.

Kedderis, L.B. , Mills, J.J. , Andersen, M.E. , and Birnbaum, L.S. (1993). "A physiologically based pharmacokinetic model for 2,3,7,8- tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A induction." Toxicol. Appl. Pharmacol. 121:87-98.

Kerr, G.R. , Scheffler, G. , and Waisman, H.A. (1969). "Growth and development of infant M. mulatta fed a standardized diet." Growth 33:185.

Khor, S.P. and Mayersohn, M. (1991a). "Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood I. Theoretical considerations." Drug Metab. Dispos. 19(2):478-485.

Khor, S.P. and Mayersohn, M. (1991b). "Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood II. Distribution of phencyclidine in the rat." Drug Metab. Dispos. 19(2):486-492.

King, F.G. , Dedrick, R.L. , Collins, J.M. , Matthews, H.B. , and Birnbaum, L.S. (1983). "Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species." Toxicol. Appl. Pharmacol. 67:390-400.

Kowaleski, K. (1969). "Effect of pre-pubertal gonadectomy and treatment with sex hormones on body growth, weight of organs and skin collagen of hamsters." Acta. Endocrinol. 61:48.

Kozma, C.K. , Weisbroth, S.H. , Stratman, S.L. , and Conjeros, M. (1969). "Normal biological values for Long-Evans rats ." Lab. Anim. Care. 19:746.

Kozma, C. , Macklin, W. , Cummins, L.M. , and Mauer, R. (1974). "Anatomy, physiology, and biochemistry of the rabbit." In: The Biology of the Laboratory Rabbit. ( S.H. Weisbroth , R.F. Flatt , and A.L. Krause , eds.) Academic Press, New York, NY.

Krishnan, K. and Andersen, M.E. (1994). "Physiologically based pharmacokinetic modeling in toxicology." In: Principles and Methods of Toxicology, 3rd Edition, ( A.W. Hayes , ed.) Raven Press, Ltd., New York, NY.

Kuwahira, I. , Gonzalez, N.C. , Heisler, N. , and Piiper, J. (1993). "Regional blood flow in conscious resting rats determined by microsphere distribution." J. Appl. Physiol. 74:203-210.

Laughlin, M.H. and Armstrong, R.B. (1982). "Muscular blood flow distribution patterns as a function of running speed in rats." Am. J. Physiol. 243:H296-H306.

Laughlin, M.H. and Armstrong, R.B. (1987). "Adrenoreceptor effects on rat muscle blood flow during treadmill exercise." J. Appl. Physiol. 62:1465-1472.

Laughlin, M.H. and Armstrong, R.B. , White, J. , and Rouk, K. (1982). "A method for using microspheres to measure muscle blood flow in exercising rats." J. Appl. Physiol. 52:1629-1635.

Laughlin, M.H. , Burns, J.W. , Fanton, J. , Ripperger, J. , and Peterson, D.F. (1988). "Coronary blood flow reserve during +Gz stress and treadmill exercise in miniature swine." J. Appl. Physiol. 64:2589-2596.

Leenders K.L. , Perani, D. , Lammerstsma, A.A. , Heather, J.D. , Buckingham, P. , Healy, M.J.R. , Gibbs, J.M. , Wise, R.J.S. , Hatazawa, J. , Herold, S. , Beaney, R.P. , Brooks, D.J. , Spinks, T. , Rhodes, C. , Frackowiak, R.S.J. , and Jones, T. (1990). "Cerebral blood flow, blood volume and oxygen utilization." Brain. 113:27-47.

Leggett, R.W. and Williams, L.R. (1991). "Suggested reference values for regional blood volumes in humans." Health Physics. 60(2):139-154.

Lemmer, B. and Nold, G. (1991). "Circadian changes in estimated hepatic blood flow in healthy subjects." Br. J. Clin. Pharmacol. 32:627-629.

Leong, K.J. , Dowd, G.F. , and Macfarland, H.N. (1964). "A new technique for tidal volume measurement in unanesthetized small animals." Can. J. Physiol. Pharamcol. 42:189-198.

Lewis, A.E. , Goodman, R.D. , and Schuck, E. (1952). "Organ blood volume measurements in normal rats ." J. Lab. Clin. Med. 39:704-710.

Liard, J-F. (1986). "Effects of intra-arterial arginine-vasopressin infusions on peripheral blood flows in conscious dogs." Clin. Sci. 71:713-721.

Liard, J-F. (1988). "Effects of a specific antidiuretic agonist on cardiac output and its distribution in intact and anephric dogs." Clin. Sci. 74:293-299.

Lockhart, S. , Rampil, I.J. , Yasuda, N. , Eger, E.I. , II, and Weiskopf, R.B. (1991). "Depression of ventilation by desflurane in humans." Anesthesiology. 74:484-488.

Luecke, R.H. , Wosilait, W.D. , Pearce, B.A. , and Young, J.F. (1994). "A physiologically based pharmacokinetic computer model for human pregnancy." Teratol. 49:90-103.

Lutz, R.J. , Dedrick, R.L. , Matthews, H.B. , Eling, T.E. , and Anderson, M.W. (1977). "A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat." Drug Metab. Dispos. 5(4):386-396.

Macpherson, J.N. and Tothill, P. (1978). "Bone blood flow and age in the rat." Clin. Sci. Mol. Med. 54:111-113.

Mahaney, M.C. , Leland, M.M. , Williams-Blangero, S. , and Marinez, Y.N. (1993a). "Cross-sectional growth standards for captive baboons: I. Organ weight by chronological age." J. Med. Primatol. 22:400-414.

Mahaney, M.C. , Leland, M.M. , Williams-Blangero, S. , and Marinez, Y.N. (1993b). "Cross-sectional growth standards for captive baboons: II. Organ weight by body weight." J. Med. Primatol. 22:415-427.

Malik, A.B. , Kaplan, J.E. , and Saba, T.M. (1976). "Reference sample method for cardiac output and regional blood flow determinations in the rat." J. Appl. Physiol. 40:472-475.

Manning, R.O. , Delp, M.K. , Armstrong, R.B. , and Bruckner, J.V. (1991). "Determination of cardiac output, tissue blood flow, volume and lipid content in Sprague-Dawley rats." The Toxicologist. 11(1):34.

Mapleson, W.W. (1963). "An electric analogue for uptake and exchange of inert gases and other agents." J. Appl. Physiol. 18:197-204.

Martin, R.D. (1981). "Relative brain size and basal metabolic rate in terrestrial vertebrates." Nature 293:57-60.

Matthews, C.A. , Swett, W.W. , and McDowell, R.E. (1975). "External form and internal anatomy of Holsteins and Jerseys." J. Dairy Sci. 58:1453.

McDonald, R.B. , Hamilton, J.S. , Stern, J.S. , and Horwitz, B.A. (1989). "Regional blood flow of exercise-trained younger and older cold-exposed rats." Am. J. Physiol. 256:R1069-R1075.

McDonald, K.S. , Delp, M.D. , and Fitts, R.H. (1992). "Effect of hindlimb unweighting on tissue blood flow in the rat." J. Appl. Physiol. 72:2210-2218.

McDougal, J.N. (1991). "Physiologically based pharmacokinetic modeling." Dermatol. Toxicol. 37:60.

Medinsky, M.A. , Kimbell, J.S. , Morris, J.B. , Gerde, P. , and Overton, J.H. (1993). "Advances in biologically based models for respiratory tract uptake of inhaled volatiles." Fund. Appl. Toxicol. 20:265-272.

Medinsky, M. , Leavens, T.L. , Csanady, G.A. , Gargas, M.L. , and Bond, J.A. (1994). "In vivo metabolism of butadiene by mice and rats: a comparison of physiological model predictions and experimental data." Carcinogenesis. 15:(7)1329-1340.

Middleton, C.C. and Rosal, J. (1972). "Weights and measurements of normal squirrel monkeys (Saimiri scuireus)." Lab. Anim. Sci. 22:583.

Monteiro-Riviere, N.A. , Bristol, D.G. , Manning, T.O. , Rogers, R.A. , and Riviere, J.E. (1990). "Interspecies and interregional analysis of the comparative histologic thickness and laser Doppler blood flow measurements at five cutaneous sites in nine species." J. Invest. Dermatol. 95:582-586.

Musch, T.L. , Haidet, G.C. , Ordway, G.A. , Longhurst, J.C. , and Mitchell, J.H. (1987). "Training effects on regional blood flow response to maximal exercise in foxhounds." J. Appl. Physiol. 62:1724-1732.

Myhre, L.B. and Kessler, W. (1966). "Body density and potassium 40 measurements of body composition as related to age." J. Appl. Physiol. 21:1251-1255.

Neff-Davis, C. , Davis, L.E. , and Powers, T.E. (1975). Am. J. Vet. Res. 36:309.

Nishiyama, K. , Nishiyama, A. , and Frlohlich, E.D. (1976). "Regional blood flow in normotensive and spontaneously hypertensive rats." Am. J. Physiol. 230:691-698.

National Toxicology Program (Ntp) (1993a). NTP Technical Report on the Toxicology and Carcinogenesis Studies of Mercuric Chloride (CAS No. 7487-94-7) in F344 Rats and B6C3F1 Mice (Gavage Studies) , NTP TR408.

National Toxicology Program (Ntp) (1993b). NTP Technical Report on the Toxicology and Carcinogenesis Studies of Oxzaepam (CAS No. 604-75-1) in Swiss-Webster and B6C3F1 Mice (Feed Studies) , NTP TR443.

O'Flaherty, E.J. (1987). "Modeling: an introduction." In: Pharmacokinetics in RiskAssessment, Drinking Water and Health, Vol. 8. National Academy Press, Washington, D.C. pp. 27-35.

O'Flaherty, E.J. (1991a). "Physiologically based models for bone-seeking elements. I. Rat skeletal and bone growth." Toxicol. Appl. Pharmacol. 111:299-312.

O'Flaherty, E.J. (1991b). "Physiologically based models for bone-seeking elements. II. Human skeletal and bone growth." Toxicol. Appl. Pharmacol. 111:332-341.

O'Flaherty, E.J. , Scott, W. , Schreiner, C. , and Beliles, R.P. (1992). "A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid." Toxicol. Appl. Pharmacol. 112:245-256.

Okazaki, K. , Miyazki, S. , Onishi, S. , and Ito, K. (1986). "Effects of food intake and various extrinsic hormones on portal blood flow in patients with liver cirrhosis demonstrated by pulsed Doppler with the Octoson." Scand. J. Gastroenterol. 21:1029-1038.

Olson, E.B. , JR. and Dempsey, J.A. (1978). "Rat as a model for humanlike ventilatory adaption to chronic hypoxia." J. Appl. Physiol. 44:763-769.

Pace, N. , Rahlmann, D.F. , and Smith, A.H. (1979). "Scale effects in the musculoskeletal system, viscera and skin of small terrestrial mammals." Physiologist 22:51-52.

Park, J.F. , Clarke, W.J. , and Bair, W.J. (1970). "Respiratory system." In: The Beagle as an Experimental Dog. Iowa State University Press, Ames, IO. pp. 285-293.

Pendergast, D.R. , Krasney, J.A. , Ellis, A. , McDonald, B. , Marconi, C. , and Cerretelli, P. (1985). "Cardiac output and muscle blood flow in exercising dogs." Resp. Physiol. 61:317-326.

Perlmutter, J.S. , Powers, W.J. , Herscovitch, P. , Fox, P.T. , and Riachle, M.E. (1987). "Regional asymmetries of cerebral blood flow, blood volume, and oxygen utilization and extraction in normal subjects." J. Cereb. Blood Flow Metab. 7:64-67.

Peters, J.M. and Boyd, E.M. (1966). "Organ weights and water levels of the rat receiving reduced food intake." J. Nutr. 90:354-356.

Pitts, G.C. and Bullard, T.R. (1968). "Some interspecific aspects of body composition in mammals." In: Body Composition in Animals and Man. National Acad. Sci., Publ. No. 1598. p. 45-70.

Plaa, G.L. (1991). "Toxic responses of the liver." In: Cassarett and Doull's Toxicology, 4th Edition, ( M.O. Amdur et al., eds.), Pergamon Press, New York, NY. pp. 334-353.

Prange, H.D. , Anderson, J.F. , and Rahn, H. (1979). "Scaling of skeletal mass to body mass in birds and mammals." The Am. Nat. 113:103-122.

Prothero, J.W. (1982). "Organ scaling in mammals: the liver." Comp. Biochem. Physiol. 71A:567-577.

Prothero, J.W. (1984). "Organ scaling in mammals: the kidneys." Comp. Biochem. Physiol. 77:133-138.

Quillen, E.W. , JR. and Reid, I.A. (1988). "Effect of intravertebral angiotensin II on cardiac output and its distribution in conscious dogs." Circ. Res. 63:702-711.

Quintana, A. , Raczka, E. , and Bonacorsi, A. (1979). "Cardiac output distribution measured with radioactive microspheres in the mouse." Pharmacol. Res. Commun. 11(3):245-252.

Rao, G.N. , Haseman, J.K. , Grumbein, S. , Crawford, D.D. , and Eustis, S.L. (1990a). "Growth, body weight, and tumor trends in (C57BL/6 X C3H/HeN) F1 (B6C3F1) mice during a nine-year period." Tox. Path. 18(1):71-80.

Rao, G.N. , Haseman, J.K. , Grumbein, S. , Crawford, D.D. , and Eustis, S.L. (1990b). "Growth, body weight survival and tumor trends in F344/N rats during an eleven-year period." Toxciol. Pathol. 18:61-70.

Rebuffé-Scrive, M. , Surwit, R. , FEINGLOS, M., KUN, C., and RODIN, J. (1993). "Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus." Metabolism. 42(11):1405-1409.

Reiss, W.G. , Bauer, L.A. , Horn, J.R. , Zierler, B.K. , Easterling, T.R. , and Strandness, D.E. , JR. (1991). "The effects of oral nifedipine on hepatic blood flow in humans." Clin. Pharmacol. Ther. 50: 379-384.

Reitz, R.H. , Gargas, M.L. , Anderson, M.E. , Provan, W.F. , and Green, T. (1996). "Predicting cancer risk from vinyl chloride exposure with a physiologically based pharmacokinetic model." Toxicol. Appl. Pharmacol. 136:1-16.

Richter, E.A. , Kiens, B. , Saltin, B. , Christensen, N.J. , and Savard, G. (1988). "Skeletal muscle glucose uptake during dynamic exercise in humans; role of muscle mass." Am. J. Physiol. 254 (Endocrinol. Metab. 17):E555-E561.

Rikans, L.E. , Venkataraman, P.S. , and Cai, Y. (1993). "Evaluation by dual-energy X-ray absorptiometry of age-related changes in body composition of male rats." Mech. Age. Devel. 71:155-158.

Risberg, J. , Hordnes, C. , and Tyssebotn, I. (1987). "The effect of β1-adrenoceptor blockade on cardiac output and orgtan blood flow in conscious rats." Scand. J. Clin. Lab. Invest. 47:521-527.

Rolett, E.L. , Strange, S. , Sjogaard, G. , Kiens, B. , and Saltin, B. (1990). "β2-adrenergic stimulation does not prevent potassium loss from exercising quadriceps muscle." Am. J. Physiol. 258 (Regulatory Integrative Comp. Physiol. 27):R1192-R1200).

Rowe, G.G. , Castillo, C.A. , Maxwell, G.M. , and Crumpton, C.W. (1959). "Comparison of systemic and coronary hemodynamics in the normal human male and female." Circ. Res. 7:728-732.

Rowell, L.B. (1993). Human Cardiovascular Control. Oxford. New York, NY.

Rudolph, A.M. and Heymann, M.A. (1967). "The circulation of the fetus in utero: methods for studying distribution of blood flow, cardiac output and organ blood flow ." Circ. Res. 21:163-184.

Ruebner, B.H. , Gershwin, M.E. , French, S.W. , Meierhenry, E. , Dunn, P. , and Hsich, L.S. (1984). "Mouse hepatic neoplasia: differences among strains and carcinogens (Ch. 9)." In: Mouse Liver Neoplasia. ( J.A. Popp , ed.) McGraw-Hill International Book Co., Washington, DC. pp. 115-143.

Sasaki, Y. and Wagner, H.N. , JR. (1971). "Measurement of the distribution of cardiac output in unanesthetized rats." J. Appl. Physiol. 30:879-884.

Savard, G. , Kiens, B. , and Saltin, B. (1987). "Limb blood flow in prolonged exercise: magnitude and implication for cardiovascular control during muscular work in man." Can. J. Spt. Sci. 12:89S-101S.

Sbarbati, A. , Morroni, M. , Zancanaro, C. , and Cinti, S. (1991). "Rat interscapular brown adipose tissue at different ages: a morphometric study." Intl. J. Obesity. 15:581-588.

Scheuplein, R.J. and Blank, I.H. (1971). "Permeability of the skin." Physiol. Rev. 51(4):702-747.

Schoutens, A. , Bergmann, P. , and Verhas, M. (1979). "Bone blood flow measured by 85Sr microspheres and bone seeker clearances in the rat." Am. J. Physiol. 236(1):H1-H6.

Shepherd, A.N. , Hayes, P.C. , Jacyna, M. , Morrison, L. , and Bouchier, I.A.D. (1985). "The influence of captopril, the nitrates and propranolol on apparent liver blood flow." Br. J. Clin. Pharmacol. 19:393-397.

Singh, P. and Roberts, M.S. (1993). "Blood flow measurements in skin and underlying tissues by microsphere method: application to dermal pharmacokinetics of polar nonelectrolytes." J. Pharm. Sci. 82(9):873-883.

Smith, T.L. , Coleman, T.G. , Stanek, K.A. , and Murphy, W.R. (1987). "Hemodynamic monitoring for 24 hr in unanesthetized rats." Am. J. Physiol. 253:H1335-H1341.

Snell, P.G. , Martin, W.H. , Buckey, J.C. , and Blomqvist, C.G. (1987). "Maximal vascular leg conductance in trained and untrained men." J. Appl. Physiol. 62:606-610.

Sotaniemi, E.A. , Pirttiaho, H.I. , and Stenback, F.G. (1992). "Drug interaction involving changes in liver size and fibrogenesis." Intl. J. Clin. Pharmacol. Ther. Toxicol. 30(11):523-525.

Sothern, R.B. and Gruber, S.A. (1994). "Further commentary: physiological parameters in laboratory animals and humans." Pharm. Res. 11(2):349-350.

Stahl, W.R. (1965). "Organ weights in primates and other mammals." Science 150:1039-1042.

Stahl, W.R. (1967). "Scaling of respiratory variables in mammals." J. Appl. Physiol. 22:453-460.

Stanek, K.A. , Davis, M.H. , and Coleman, T.G. (1988). "Residual effects of ether anesthesia on whole body hemodynamics and organ blood flows in the rat." J. Pharmacol. Meth. 20:95-102.

Stott, W.T. , Dryzga, M.D. , and Ramsey, J.C. (1983). "Blood-flow distribution in the mouse." J. Appl. Toxicol. 3:310-312.

Stoudt, H.W. , Damon, A. , and McFarland, R.A. (1960). "Heights and weights of white Americans." Human Biol. 32:331-341.

Stoudt, H.W. , Damon, A. , McFarland, R.A. , and Roberts, J. (1965). Weight, Height, and Selected Body Dimensions of Adults, United States, 1960-1962. Vital and Health Statistics, Data from the National Health Survey, U.S. Department of Health, Education, and Welfare, National Center for Health Statistics Series 11, No. 8, Government Printing Office, Washington, DC.

Swift, G. , Homeida, M. , Halliwell, M. , and Roberts, C.J. (1978). "Antipyrine disposition and liver size in the elderly." Europ. J. Clin. Pharmacol. 14:149-152.

Tothill, P. and McCormick, J.C. (1976). "Bone blood flow in the rat determined by the uptake of radioactive particles." Clin. Sci. Molec. Med. 51:403-406.

Triplett, J.W. , Hayden, T.L. , McWhorter, L.K. , GAUTAM, S.R., KIM, E.E., and BOURNE, D.W.A. (1985). " Determination of gallium concentration in 'blood-free' tissues using a radiolabeled blood marker." J. Pharm. Sci. 74:1007-1012.

Tsuchiya, M. , Ferrone, R.A. , Walsh, G.M. , and Frohlich, E.D. (1978). "Regional blood flows measured in conscious rats by combined Fick and microsphere methods." Am. J. Physiol. 235:H357-H360.

Tuma, R.F. , Irion, G.L. , Vasthare, U.S. , and Heinel, L.A. (1985). "Age-related changes in regional blood flow in the rat." Am. J. Physiol. 249:H485-H491.

Tuma, R.F. , Vasthare, U.S. , Irion, G.L. , and Weideman, M.P. (1986). "Consideration in use of microspheres for flow measurements in anesthetized rat." Am. J. Physiol. 250:H137-H143.

Tzankoff, S.P. and Norris, A.H. (1977). "Effect of muscle mass decrease on age-related BMR changes." J. Appl. Physiol. 43:1001-1006.

U.S. Environmental Protection Agency (U.S. Epa) ( 1980). Guidelines and Methodology Used in the Preparation of Health Effects Assessment Chapters of the Consent Decree Water Criteria Documents . Federal Register 45(231):79347-73357.

U.S. Environmental Protection Agency (U.S. Epa) ( 1992). Dermal Exposure Assessment: Principles and Applications . Interim Report. EPA/600/8-91/011B.

Vijayaraghavan, M. , Schaper, M. , Thompson, R. , Stock, M.F. , and Alarie, Y. (1993). "Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract." Arch. Toxicol. 67:478-490.

Vinegar, A. , Sinnett, E.E. , and Leith, D.E. (1979). "Dynamic mechanisms determine functional residual capacity in mice, Mus musculus." J. Appl. Physiol. 46:867-871.

Von Ritter, C. , Hinder, R.A. , Womack, W. , Bauerfeind, P. , Fimmel, C.J. , Kvietys, P.R. , Granger, D.N. , and Blum, A.L. (1988). "Microsphere estimates of blood flow: methodological considerations." Am. J. Physiol. 254:G275-G279.

Wang, J. , Dilmanian, F.A. , Thornton, J. , Russell, M. , Burastero, S. , Mazariegos, M. , Heymsfield, S.B. , and Pierson, R.N. , JR. (1993a). "In vivo neutron activation analysis for body fat: comparisons by seven methods." In: Human Body Composition ( K.J. Ellis and J.D. Eastman , eds.), Plenum Press, New York, NY.

Wang, P. , Ba, Z.F. , Burkhardt, J. , and Chaudry, I.H. (1993b). "Trauma-hemorrhage and resuscitation in the mouse: effects on cardiac output and organ blood flow." Am. J. Physiol. 1166-1173.

Warner, R.L. and McFarland, L.Z. (1970). "Integument." In: The Beagle as an Experimental Animal. Iowa State University Press, Ames, IO. pp. 126-148.

Webb, A.I. and Weaver, B.M.Q. (1979). "Equine." Vet. J. 11:39.

Weinberg, S.L. , Cagirgan, C.M. , Grove, G.R. , and Smith, G. (1964). "Measurement of relative coronary blood flow by precordial monitoring." Am. J. Cardiol. 13:801-807.

Wessel, J.A. , Ufer, A. , Van Huss, W.D. , and Cederquist, D. (1963). "Age trends of various components of body composition and functional characteristics in women aged 20-69 years." Ann. NY Acad. Sci. 110:608-622.

West, D.B. , Boozer, C.N. , Moody, D.L. , and Atkinson, R.L. (1992). "Dietary obesity in nine inbred mouse strains ." Am. J. Physiol. 262:R1025-R1032.

Wetterlin, S. and Pettersson, C. (1979). "Determination of cardiac output in the mouse ." Res. Exp. Med. (Berl.) 174:143-151 (as cited in Arms and Travis, 1988).

Wetterlin, S. , Aronsen, K.F. , Bjorkman, I. , and Ahlgren, I. (1977). "Studies of methods for determination of the distribution of cardiac output in the mouse." Scand. J. Clin. Lab. Invest. 37:451-454.

Wilkinson, M.J. and McEwan, N.A. (1991) "Use of ultrasound in the measurement of subcutaneous fat and prediction of total body fat in dogs." J. Nutr. 121(11 Suppl): S47-50.

Williams, L.R. and Leggett, R.W. (1989). "Reference values for resting blood flow to organs of man." Clin. Phys. Meas. 10:187-217.

Woodhouse, K. and Wynne, H.A. (1992). "Age-related changes in hepatic function." Drugs Aging 2(3):243-255.

Woodruff, T.J. , Bois, F.Y. , Auslander, D. , and Spear, R.C. (1992). "Structure and parameterization of pharmacokinetic models: their impact on model predictions." Risk Anal. 12(2).

Wynne, H.A. , Goudevenos, J. , Rawlins, M.D. , James, O.F.W. , Adams, P.C. , and Woodhouse, K.W. (1990). "Hepatic drug clearance: the effect of age using indocyanine green as a model compound." Br. J. Clin. Pharmacol. 30:634-637.

Yates, M.S. and Hiley, C.R. (1978). "The effect of age on cardiac output and its distribution in the rat." Experientia 35(1):78-79.

Zeeman, F.J. (1967). "A semipurified diet for the mongolian gerbil (Meriones unguicalatus)." J. Nutr. 91:415.

Zoller, W.G. , Wagner, D.R. , and Zentner, J. (1993). "Effect of propranolol on portal vein hemodynamics: Assessment by duplex sonography and indocyanine green clearance in healthy volunteers." Clin. Invest. 71:654-658.

Zwissler, B. , Schosser, R. , Weiss, C. , Iber, V. , Weiss, M. , Schwickert, C. , Spengler, P. , and Messmer, K. (1991). "Methodological error and spatial variability of organ blood flow measurements using radiolabeled microspheres." Res. Exp . Med. 191:47-63.