Much has been written on both sides of the debate over the safety of tamoxifen. This paper discusses the toxicity of this chemical and the latest findings supporting the end of tamoxifen trials.
Fendl, K.C. and Zimniski, S.J. (1992). "Role of tamoxifen in the induction of hormone-independent rat mammary tumors."Cancer Res.52:235-237.
2.
Fentiman, I.S. (1990). "The role of tamoxifen in the prevention of breast cancer."Eur. J. Cancer26:655-656.
3.
Fisher, B., Constantino, J., and Redmond, C. (1989). "A randomized clinical trial evaluating tamoxifen in the treatment of patients with node negative breast cancer who have estrogen-positive tumors."N. Engl. J. Med.151:1842-1847.
4.
Grofman, J.W.F. and O'Connor, E. (1985). X-Rays - Health Effects of Common Exams. Sierra Club Books. San Francisco, CA. p. 439.
5.
Han, X. and Liehr, J.G. (1992). "Induction of covalent DNA in rodents by tamoxifen."Cancer Res.53:1369-1373.
6.
Jones, R. (1993). "Frequency, severity, and management of tamoxifen-induced depression in women with node negative breast cancer."Abstract. Proceedings of American Statisticians and Clinicians Organization12:78.
7.
Kelsey, J. and Gammon, M. (1991). "The epidemiology of breast cancer."CA: Cancer J. Clinicians41:146-165.
8.
Love, R.R., Cameron, L., and Connell, B.L. (1991). "Symptoms associated with tamoxifen treatment in postmenopausal women."Arch. Int. Med.1151:1842-1847.
9.
National Cancer Institute (1992). "Lifetime probability of breast cancer in American women."Bethesda, MD. September.
10.
Nevend, P., Demuylder, X., and Vanbelle, Y. (1989). "Tamoxifen and the uteral endometrium."Lancet1:375-382.
11.
Pike, D.E., Spicer, D.V., and Henderson, B.E. (1991). "Ovarian cancer and long-term tamoxifen in premenopausal women."Lancet1:37-41.
12.
University Of Pittsburgh School Of Medicine ( 1992). Consent to act as a participant in a clinical trial (A clinical trial to determine the worth of tamoxifen for preventing breast cancer). January 24.
