Red Blood Cell Antioxidants in Human Volunteers Exposed to Ozone

Aris, R.M. , Christian, D. , Hearne, P.Q. , Kerr, K. , Finkbeiner, W.E. , and Balmes, J.R. (1993). "Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy." Am. Rev. Respir. Dis. 148:1363-1372.

Beehler, C.J. , Toth, K.M. , Berger, E.M. , Drake, S.K. , White, C.W. , and Repine, J.E. (1986). "Erythrocyte glutathione levels, but not catalase or glutathione peroxidase activities increase in rats exposed to hyperoxia for 48 hours." Clinical Research 34:410A.

Beutler, E. (1984). Red Cell Metabolism: A Manual Of Biochemical Methods. Grune and Stratton, Orlando, FL. pp. 83-85, 105-106, 131-134.

Boehme, D.S. , Hotchkiss, J.A. , and Henderson, R.F. (1992). "Glutathione and GSHdependent enzymes in bronchoalveolar lavage fluid cells in response to ozone." Exp. Mol. Pathol . 56:37-48

Brown, J.M. , Grosso, M.A. , Terada, L.S. , Beehler, C.J. , Toth, K.M. , Whitman, G.J. , Harken, A.H. , and Repine, J.E. (1989). "Erythrocytes decrease myocardial hydrogen peroxide levels and reperfusion injury." Am. J. Physiol. 256:H584-8.

Buckley, R.D. , Hackney, J.D. , Clark, K. , and Posini, C. (1975). "Ozone and human blood." Arch. Environ. Health 30:40-43.

Chow, C.K. and Tappel, A.L. (1972). "An enzymatic protective mechanism against lipid peroxidation damage to lung of ozone exposed rats." Lipids . 7:518-524

Dawson-Saunders, B. and Trapp, R.G. (1990). Basic and Clinical Biostatistics. Appleton and Lange, Norwalk, CT and San Mateo, CA.

Goldstein, B.D. , Pearson, B. , Lodi, C. , Bucklery, R.D. , and Balchum, O.J. (1968). "The effect of ozone on mouse blood in vivo." Arch. Environ. Health 16:648-650.

Hamburger, S.J. , Goldstein, B.D. , Buckley, R.D. , Hackney, J.D. and Amoruso, M.A. (1979). "Effect of ozone on the agglutination of erythrocytes by concanavalin A." Environ Res. . 19:299-305.

Linn, W.S. , Buckley, R.D. , Spier, C.E. , Blessey, R.L. , Jones, M.P. , Fischer, D.A. , and Hackney, J.D. (1978). "Health effects of ozone exposure in asthmatics." Am. Rev. Respir. Dis. 117:835-843.

Mangione, S. , Patel, D.D. , Levin, B.R. , and Fiel, S.B. (1992). "Erythrocytic glutathione in Cystic Fibrosis: a marker of pulmonary dysfunction." Chest. 102(2):83s.

McDonnell, W.F. , Horstman, D.H. , Hazucha, M.J. , Seal, E. , Haak, E.D. , Salaah, S. , and House, D.E. (1983). "Pulmonary effects of ozone during exercise: dose-response characteristics." J. Appl. Physiol. 54(5):1345-1352.

Menzel, D.B. (1971). "Oxidation of biologically active reducing substances by ozone." Arch. Environ. Health 23:149-153.

Mountain, J.T. (1963). "Detecting hypersusceptibility to toxic substances." Arch. Environ. Health 6:357-365.

Rahman, I. , Clerhc, L.B. , and Massaro, D. (1991). "Rat lung antioxidant enzyme induction by ozone." Am. J. Physiol. 260:L412-L418.

Toth, K.M. , Berger, E.M. , Beehler, C.J. , and Repine, J.E. (1986). "Erythrocytes from cigarette smokers contain more glutathione and catalase and protect endothelial cells from hydrogen peroxide better than do erythrocytes from nonsmokers." Am. Rev. Respir. Dis. 134(28):1-4.

Toth, K.M. , Clifford, D.P. , Berger, E.M. , White, C.W. , and Repine, J.E. (1984). "Intact human erythrocytes prevent hydrogen peroxide-mediated damage to isolated perfused rat lungs and cultured bovine pulmonary artery endothelial cells." J. Clin. Invest. 74(1):292-5.

Van Asbeck, S. , Hoidal, J. , Schwartz, B. , Vercellotti, G.M. , Moldow, C.F. , and Jacob, H.S. (1985). "Protection against lethal hyperoxia by tracheal insufflation of erythrocytes: role of red cell glutathione." Science 227:756-759.