Immunologic and Biologic Markers for Silicone

Alfred L.J. and Vojdani, A. (1983). "Effects of methylcholanthrene and benzanthracene on blastogenesis and aryl hydrocarbon hydroxylase induction in splenic lymphocytes from three inbred strains of mice." Int. J. Immunopharmacol , 5:123-129.

Baba, H. , Duane, G.C. , Ilyasl, A.A. , Pestron, A. , Cornblath, D.R. , Chaudhry, V. , Griffin, J.W. , and Quarles, R.H. , (1989). "Anti GM1, Ganglioside Antibodies with differing fine specificities in patients with multifocal motor neuropathy." J. Neuroimmunology. 25:143-150.

Baldwin, C.M. JR.. and Kaplan, E.N. (1983a). "Silicone-induced human adjuvant disease?" Ann. Plast. Surg. 10:270-3.

Becker, C.G. , Becker, E.L. , Maher, J.F. , and Schreiner, G. (1962). "Nephrotic syndrome after contact with mercury. A report of five cases, three after the use of ammoniated mercury ointment." Arch. Intern. Med. 110:178-186.

Bencko, V. , Vasileva, E.V. , and Symon, K. (1980). "Immunological aspects of exposure to emissions from burning coal of high beryllium content." Environ. Res . 22:439.

Bernaudin, J.F. , Druet, E. , Druet, P. , and Masse, R. (1981). "Inhalation or ingestion of organic and inorganic mercurials produces autoimmune disease in rats." Clin. Immunol. Immunopathol. 20:129-135.

Blakley, B.R. , Sisora, C.S. , and Mukkur, T.K. (1980). "The effect of methylmercury, tetraethyl lead and sodium arsenite on the humoral immune response in mice." Toxical Appl. Pharmacol. 52:245-254.

Bridges, A.J. , Connelly, C. , Wong, G. , Burns, D.E. , and Vassey, F.B. (1993). "A clinical and immunological evaluation of women with silicone breast implants and symptoms of rheumatic disease." Annals of Internal Medicine. 118/12:929-36.

Broughton, A. , and Thrasher, L. (1988). "Autoantibodies and altered cell-mediated immunity in formaldehyde-exposed humans." Comments Toxicol. 2:155.

Brozena S.J. , Fenske,N.A. Cruse C.W. , Espinoza C.G. Vasey, F.B. Germain B.F et al. ,.?? (1988). "Human adjuvant disease, following augmentation mammoplasty." Arch. Dermatol. 1383-6.

Caren, L.D. , (1981). "Environmental Pollutants: Effects on the immune system and resistance to infectious diseases." Bioscience 31:585-586.

Chan, S.C. , Bridsell, D.C. , and Cradeen, C.Y. (1991). "Detection of Toluenediamines in the ring if a patient with polyurethan-covered breast implants." Clin. Chem. 37/5:756-758.

Claman, H.N. and Robertson, D.L. (1994). "Anti nuclear antibodies and breast implants." West J. Med. 160:225-228.

Clarke, S.M. , (1991). "A novel enzyme-linked immunosorbent assay (ELISA) for the detection of beryllium antibodies." J. Immunological Methods 137:65-72.

Diebler, G.E. , Matenson, R.E. , and Kies, M.W. (1972). "Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species." Prep. Biochem. 2:139-165.

Endo, L.P. , Edwards, B. , Longly, S. , Corman, L.C. , and Panush, R.S. (1987). Silicone and Rheumatic Disease. Seminars in Arthritis and Rheumatism. 17/2:112-18.

Faith, R.E. , M.I. Luster , and J.G. Vos (1980). "Effects on immunocompetence by chemicals of an environmental cancer." In: Reviews in Biochemical Toxicology, Vol. 2. (E. Hodgson JR., R. Bend, and R. M. Philpot, eds.) Elsevier North Holland, New York. Pages 173-211

Farrant, J. , Clark, J.C. , Lee, H. , Knight, S.C. , and O'Brien, J. (1980). "Conditions for measuring DNA synthesis in PHA stimulated human lymphocytes in 20μl hanging drops with various cell concentrations and periods of culture." J. Immunol. Methods . 33:301-312.

Forster, M.J. , Retz, K.L. and Lal, H. (1988). "Learning and memory deficits associated with autoimmunity: significance in aging and Alzheimer's disease." Drug Dev. Res. 15:253-273.

Fredman, P. , Lycke, J. , Andersen, O. , Vrethem, M. , Ernerud, H. , and Svennerholm, L. (1993). "Peripheral neuropathy associated with monoclonal IgM antibody to glycolipids with a terminal glucuronyl - 3-sulfate epitope." J. Neurol. 240:381-387.

Gainer, J.H. (1972). "Increased mortality in enephalomyocarditis virus-infected mice consuming cobalt sulfate; tissue concentrations of cobalt." Am. J. Vet. Res. 33:2067-2073.

Geffon, I.A. and Orfova, A.A. (1964). "Blood serum protein fractions in berylliosis." Gig. Truda Prof. Zab. 8:16.

Goldblum, R.M. , Pelley, R.P. , O'Donell, A.A. , Pyron, D. , and Heggers, J.P. (1992). "Antibodies to silicone elastomers and reactions to ventriculor peritoneal shunts." Lancet. 340:510-13.

Gratzner, H.G. (1982). "Monoclonal antibody to 5-bromo and 5-iododeoxyuridine: A new reagent for the detection of DNA replication." Science 218:474.

Gutierrez, F.J. and Espinoza, L.R. (1990). "Progressive systemic sclerosis complicated by severe hypertension; reversal after silicone implant removal." Am. J. Med. 89:390-2.

Hardy, H.L. and Stoeckle, J.D. (1959). "Beryllium disease. J. Chronic Dis. 9:152.

Jansen, L.H. , Berges, L. , and Van Delden, J. (1964). "Contact hypersensitivity to simple chemical compounds: The role of intermediate products in the process of sensitization." Dermatological 128:490-501.

Koller, L.D. , Exon, J.H. , and Rowan, J.G. (1975). "Antibody suppression by cadmium." Environ. Health 30:598-601.

Kervliet, N.I. , Baecher-Steppan L. , and Schmitz J.A. (1982a). "Immunotoxicty of pentachlorophenol (PCP): increased susceptibility to tumor growth in adult mice fed technical PCP-contaminated diets." Toxicol Appl. Pharmacol. 62:55.

Kerkvliet, N.I. , Baecher-Steppan L. Claycomb A.T. , Craig A.M. , Sheggerby, C.C. (1982b). "Immunotoxicity of technical pentachlorophenol (PCP-T); depressed humoral immune responses to T-dependent and T-independent antigen stimulation in PCP-T exposed mice." Fund. Appl. Toxicol . 2:90.

Klimas, N.G. , Salvato, F.R. , Morgan, R. , and Fletcher, M.A. (1990). "Immunologic abnormalities in chronic fatigue syndrome." J. Clin. Microbiol. 28:1403-10.

Koller, L.D. (1982). "In vitro assessment of humoral immunity following exposure to heavy metals." Environ. Health Perspect. 43:37-39.

Koski, C.L. , Humphrey, R. , and Shin, M.L. (1985). "Anti-peripheral myelin antibody in patients with demyelinating neuropathy: quantitative and kinetic determination of serum antibody by complement component 1 fixation." Proc. Natl. Acad. Sci. 82:905-909

Kossovsky, N. , Zeidler, Z. , Chun, G. , Papasian, N. , Nguyen, A. , Rajguru, S. , Stassi, J. , and Sponsler, E.D. (1993). "Surface dependent antigens identified by high binding avidity of serum antibodies in a subpopulation of patients with breast prostheses." J. Applied Blomaterials. 4:281-288.

Kumagai, Y. , Shiokawa, Y. , Medsger, JR., T.A. , and Rednan, G.P. (1984). "Clinical spectrum of connective tissue disease after cosmetic surgery." Arthritis and Rheumatism 2791:9-12.

Kumar, M. , Resnick, L. , Loewenstein, D.A. , Berger, J. , and Eisdorfer, C. (1989). "Brain-reactive antibodies and the AIDS dementia complex." J. Acquired Immune Defic Syndr..2:469-471.

Lerner, M.R. and Steitz, J.A. (1979). "Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus." Proc. Natl. Acad. Sci. 76:5405-5499.

Lerner, E.A. , Lerner, M.R. , Janeway, Jr C.A. ,, and Steitz, J.A. (1981). "Monoclonal antibodies to nucleic acid containing cellular constituents: probes for molecular biology and autoimmune disease." Proc. Natl. Acad. Sci. 78:2736-2741.

Maag, T.J. and Hoffman, A. (1993). "Anti-brain antibodies in the sera of rheumatoid arthritis patients: relation to disease activity and psychological status." J. Neuro. Immunology. 45:37-46.

Matter, L.K. , Schopfer , Willhelm, J.A. , Nyffenegger, T. , Parisot, R.F. , and De Robertis, E.M. (1982). "Molecular characterization of ribonucleoprotein antigens bound by antinuclear antibodies: a diagnostic evaluation." Arthritis Rheum. 25:1278-1283.

McConnachie, P.R. and Zahalsky, A.C. (1991). "Immunological consequence of exposure to pentachlorophenol." Arch. Environ. Health 46:249-253.

McGrath K.G. , Zeiss, C.R. , and Patterson, R. (1983). "Allergic reactions to industrial chemicals." Clinical Immunology Rev. 2:1-58.

Mimori, T. , Akizuki, M. , Yamagata, H. , Inada, S. , Yoshida, S. , and Homma, M. (1981). "Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap." J. Clin. Invest. 68:611-620.

Naim, J.O. and Lanzafame, R.J. (1993). "The adjuvant effect of silicone-gel on antibody formation in rats." Immunological Investigations 22:151-161.

Ostermeyer-Shoib, B. and Patten, B.M. (1992). "Rheumatologic and neurologic findings in silicone adjuvant breast disease." Abstract from presentation at the American College of Rheumatology, Atlanta, GA.

Pouplard, A. , Emle, J. , Pouplard, F. , and Hurez, D. (1979). "Parkinsonism and autoimmunity: antibody angainst human sympathetic ganglion cells in Parkinson's disease." Adv. Neurol. 24:321-326.

Press, R.I. , Peebles, C.L. , Kumagai, Y. , Ochs, R.L. , and Tan, N.M. (1992). "Antinuclear autoantibodies in women with silicone breast implants." Lancet. 340:1304-1307.

Raso, D.S. (1994). Breast prostheses, the immune response, and B-and T-lymphocytes. Plastic and Reconstructive Surgery 93:649-650.

Raziuddin, S. , Nur, M.A. and Alwabel, A.A. (1989). "Selective loss of the CD4+ inducers of suppressor T-cell subsets (2H4+) in active systemic lupus erythematosus." J. Rheumatol. 16:13-15-13.

Reinherz, E.L. , Hussey, R.E. , Fitzgerald, K. , Snow, P. , Terhorst C. , and Schlossman, S.F. (1981c). "Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T-lymphocytes." Nature. 294:168-170.

Reinherz, E.L. , Meuer, S.C. , and Schlossman, S.F. (1983). "The delineation of antigen receptors on human T-lymphocytes." Immunol. Today. 4:5-8.

Salvi, M. , Fukazawa, H. , Bernard, N. , Hiromatsu, Y. , How, J. , and Wall, J.R. (1988). "Role of autoantibodies in the pathogenesis and association of endocrine autoimmune disorders." Endocrine Reviews. 9:450-465.

Sann, E.E. , Garen, P.D. , Silver, R.M. , and Maize, J.C. (1990). "Scleredema following augmentation mammoplasty." Arch Dermatol. 126:1198-202.

Sato, K. , Miyasaka, N. , Yamaoka, K. , Okuda, M. , Yata, J. and Nishioka, K. (1987). "Quantitative defect of CD4+2H4 + cells in systemic lupus erythematosus and Sjogretts Syndrome." Arthritis Rheum. 30:1407-1411.

Sharma, R.P. and Reddy, R.V. (1987). "Toxic effects of chemicals on the immune system." In: Handbook of Toxicology. (T. J. HALEY and W. O. BRENDT, eds.) Hemisphere Publishing, Washington, D.C . pp. 294-331.

Sherner, J. and Eisenbud, M. (1951). "Epidemiology of beryllium intoxication." Arch. Ind. Hyg. Occup. Med. 4:123.

Smith, S.D. , Gerber, P.C. , Meade, B.J. , Butterworth L.F. McCay, J.A. , White K.L. , and Munson, A.E. (1994). "Natural killer cell activity is suppressed following exposure to silicone gel." Society of Toxicology.

Smolen, J.S. , Morimoto, C. , Steinberg, A.D. , Wolf, A. , Schlossman, S.F. , Steinberg, R.T. , Penne, E. , Reinherz, E.L. , Rerchin, M. , and Chused, T.M. (1985). "Systemic lupus erythematosus: delineation of subpopulations by clinical, serologic and T-cell marker analysis." Am. J. Med. Sci. 289:139-147.

Schnott, T. and Egilman, D. (1988). "Tolugene dillsocyante and other isocyanates." In: Occupational Medicine, Principles and Practical Applications, 2nd. ed. (Zenzer, ed.) Chicago:Year Medical Publishers 1016-21.

Slade, C.L. and Peterson, H.D. (1982). "Disappearance of the polyurethan cover of the ashley natural prothesis." Plast. Reconstr. Surg. 70:379-82.

Spiera H. (1988). "Scleredema after silicone augmentation mammoplasty." JAMA 260:236:8.

Stejskal, V.D. , Olin, R.G. , and Forsbeck, M. (1986). The lymphocyte transformation test for diagnosis of drug-induced occupational allergy. J. Allergy Clin Immunol . 77:411.

Sullivan, J.M. , Parker , Initilas? and Carson, S.B. (1968). "Tissue cobalt content in 'beer drinkers' myocardiopathy ." J. Lab. Clin Med. 71:893-896.

Tan, E.M. (1989). "Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology." Adv. Immunol . 44:93-151.

Tan, E.G. , Fritzler, M.J. , Ballou, S.P. , Kushner, I. , and Rubin, R.L. (1986). In manual of: Clincial Laboratory Immunology . (N.L. Rose, H. Friedman, and J.L. Fahey, eds.). American Society for Microbiology, Washington, D.C.

Teuber, S.S. , Rowley, M.J. , Yoshida, S.H. , Ansari, A.A. , and Gershwin, M.E. (1993). "Anticollagen autoantibodies are found in women with silicone breast implants." J. Autoimmunity. 6:367-377.

Theosher, J.D. , Wojdani, A. , Cheung, G. , and Heuser, G. (1987). "Evidence for formaldehyde antibodies and altered cellular immunity in subjects exposed to formaldehyde in mobile homes. Arch. Environ. Health. 42:347-350.

Treagen, L. (1983). "Metals and immunity." In: Metal Ions in Biological Systems (H. Siegel, ed.) Mercel Dekker, New York. pp. 27-45.

Varga, J. and Jimenez, S. (1990). "Augmentation mammoplasty and scleroderma." Arch. Dermatol. 126:1220-2.

Varga, J. Schumacher, H.R. , and Jimenez, S.A. (1989). "Systemic sclerosis after augmentation mammoplasty with silicone implants." Ann. Intern. Med. 111:377-83.

Vasilyeva, E.V. , Nikitina, L.S. , and Orlova, A.A. (1977). "Concentrations of immunoglobulins in berylliosis." J. Hyg. Epidemiol. Microbiol. Immunol. 21:254.

Vojdani, A. and Alfred, L.J. (1984). "Alterations in cell-mediated immune functions induced in mouse splenic lymphocytes by polycyclic aromatic hydrocarbons." Cancer Res. 44:942-945.

Vojdani, A. , Brautar, N. , and Campbell, A. (1993). Immune functional abnormalities and autoimmunity in patients with silicone breast implant. J. Immunology. 150:157A. Abstract 894.

Vojdani, A. , Campbell, A. , and Brautbar, N. (1994). "Antibody to silicone and native macromolecules in women with silicone breast implants." Submitted for publication 2/94.

Vojdani, A. , Ghoneum, M. , and Brautbar, N. (1992a). "Immune alteration associated with exposure to toxic chemical." Toxicol. Ind. Health 8:231-246.

Vojdani A. , Nieto M. , and Alfred, L.J. (1983). "Carcinogenic PAH compounds suppressed cell mediated immune functions, and alter T-cell subsets in splenic lymphocyte populations." Proc. Am. Assoc. Cancer Res. 24:242.

Vos, J.G. (1977). "Immune suppression as related to toxicology." Crit. Rev. Toxicol. 5:67-101.

Voumvourakis, C. , Rombos, A. , Konstantoulakis, M.M. , Segditsa, I. , and Papageorgio, C. (1992). "Serum anti-GM, and anti-GD1a antibodies in patients with motor neuron disease." Acta. Neurol. Scand. 86: 599-602.

Weening, J.J. , Fleuren, G.J. , and Hoedemacker, Ph. J. (1978). "Demonstration of antinuclear antibodies in mercuric chloride-induced glomerulopathy in the rat." Lab. Invesi. 39:405-411.

Weiner, S.R. , Clements, P.J. , and Paulus, H.H. (1989). "Connective tissue disease after augmentation mammoplasty." Arthritis and Rheumatism 23:23-24.

Weisman, M.H. , Vecchione, R.R. , Albert, D. , Moore, L.T. , and Mueller, M.R. (1988). "Connective tissue disease following breast augmentation: a preliminary test of the human adjuvant disease hypothesi." Plast. Reconstr. Surg. 82:626-30.

Whiteside, T.L. and Herberman, R.B. (1989). "The role of natural killer cells in human disease." Clin. Immunol. Immunopathology 53:1-28.

Wolin, S.L. and Steitz, J.A. (1984). "The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs . Proc. Natl. Acad. Sci. 81:1996-2000.

Wolf, L.E. , Lappe, M. , Peterson, R.D. , and Ezrailson, E.G. (1993). "Human immune response to polydimethylsiloxane (silicone): screening studies in a breast implant population." J. Faseb. 7:1265-1268.

Yamagata, H. , Harley, J.B. , and Reichlin, M. (1984). "Molecular properties of the Ro/SSA antigen and enzyme-linked immunosorbent assay for quantitation of antibody." J. Clin. Invest. 74:625-633.

Yunus, M. , Masi, A.T. , Calabro, J.J. , Miller, K.A. , and Feigenbaum, S.L. (1981). "Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal controls." Semin. Arthritis Rheum. 11:151-71.