Restricted accessResearch articleFirst published online 1993-5
Effect of Lithium Salts on the Microstructure of the Thymus and on Vitamin C Content in Some Lymphatic Organs,the Liver and Suprarenal Glands in F1 Mouse Crosses (CBA X C57BL)
The administration of lithium chloride (LiCl) to mice by intraperitoneal injection caused involution in the thymus, both in the cortex and medulla. Lithium also considerably decreased vitamin C (ascorbic acid) content in all of the organs that were studied: thymus, lymph nodes, spleen, suprarenal glands, and liver.
BlockG. (1991). Vitamin C and cancer prevention the epidemiologic evidence. Am. J. Clin. Nutr. 53:270–282.
2.
ChanH.S.L.SaundersE.F.FreedmanM.H. (1980). Modulation of human hematopoiesis by prostaglandins and lithium. J. Lab. Clin. Med. 95:125–132.
3.
CzaplinskaT. (1984). Wplyw chlorku litu na obraz morfotyczny krwi obwodowej szczura. Zeszyty Naukowe U. J. Ser. Zool. 30:21–28.
4.
EnglardS.SeifterS. (1986). The biochemical function of ascorbic acid. Ann. Rev. Nutr. 6:346–406.
5.
GreeneyH.J.Jr.StacpooleP.W. (1985). Ascorbic acid regulation of 3-hydroxy-3-methyl coenzyme A reductase activity and cholesterol synthesis in guinea pig liver. Biochem. Biophys. Acta. 834:134–138.
6.
HollowayD.E.RiversJ.M. (1981). Influence of chronic ascorbic acid deficiency and excessive ascorbic acid intake on bile acid metabolism and bile composition in the guinea pigs. J. Nutr. 111:412–415.
7.
HorowitzH.A. (1975). The use of lithium in the treatment of the drug-induced psychotic reaction. Dis. Nerv. Systems36:159–163.
8.
KempK.LionJ.R.MagramG. (1977). Lithium in the treatment of a maniac patient with multiple sclerosis: A case report. Dis. Nerv. System38:210–211.
9.
KlingM.A.ManowitzP.PollackI.W. (1978). Rat brain and serum lithium concentrations after acute injections of lithium carbonate and orotate. J. Pharm. Pharmac. 30:368–370.
10.
KuemmerleH.P.GarretE.R.SpitzyK.H. (1976). Farmakologia kliniczna i farmakoterapia. PZWL: 314–318.
11.
MallingerA.G.KupferD.J.PoustR.I.HaninJ. (1975). In vitro and in vivo transport lithium by human erythrocytes. Clin. Pharmacol. Therapeutics18:467–474.
12.
NelsonS.C.HermanM.M.BenschK.G.BarchasJ.D. (1980). Localization and quantitation of lithium in rat tissue following intraperitoneal injections of lithium chloride. II. Brain. J. Pharmacol. Exp. Ther. 212:11–15.
13.
OdaH.YamashitaK.SasakiS.HorioF.YoshidaA. (1987). Long-term effects of dietary polychlorinated biphenyl and high-level of vitamin E on ascorbic acid and lipid metabolism in rats. J. Nutri. 117:1217–1223.
14.
OmayeS.T.TurnbullJ.D.SauberlichH.E. (1979). Selected methods for determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol. 62:1–11.
15.
Opienska-BlauthJ.MasiakM.KuleszaS. (1977). Lit w biologii i medycynie. Post. Hig. Med. Dosw. 31:569–599.
16.
OrrL.E.McKernanJ.F. (1979). Lithium reinduction of acute myeloblasts leukemia. Lancet24:449–450.
17.
PaulingL.CameronE.LeibovitzB. (1979). Ascorbic acid and cancer: A review. Canc. Res. 39:663–681.
18.
PopeskovicL.JankovicB.D.IsakovicK. (1979). Effect of lithium on immunological reactivity in CBA mice. Periodicum Biol. 81:179–180.
19.
RateyJ.J.MallingerA.G. (1977). The relationship between extra- and intracellular lithium concentration in human red blood cells: In vitro study. Brit. J. Psychiat. 131:59–62.
20.
RokickiW. (1968). Uklad dokrewny a witamina C. Folia Med. Crac. 10:515–529.
21.
SiegelB. V.MortonJ.I. (1977). Vitamin C and immune response. Expcrientia33:393–395.
22.
SoulairacA.AymardN. (1972). Variations des electrolytes sanguins et urinaires au cours du traitement par les sels de lithium. Extrait Ann. Medico-Psychologiques1:257–260.
23.
WekslerM.E. (1983). The thymus gland and aging. Ann. Inter. Med. 98:105–107.
24.
YonemotoR.H.ChretienP.B.FehnigerT.F. (1976). Enhanced lymphocyte blastogenesis by oral ascorbic acid. Proc. Am. Assoc. Cancer Res. 17:288–289.
