BantleJ.A., and DawsonD.A. (1988). Uninduced rat liver microsomes as a metabolic activating system for the frog embryo teratogenesis assay—Xenopus (FETAX), in Aquatic Toxicology and Hazard Assessment, vol. 10 (AdamsW.J., ChapmanG.A., LindisW.G., eds.), American Society for Testing and Materials STP 971, Philadelphia, in press.
2.
BestJ.B., and MoritaM. (1982). Planarians as a model system for in vitro teratogenesis studies.Teratogen. Carcinogen. Mutagen.2: 277–291.
3.
BirgeW.J., BlackJ.A., WestermanA.G., and RameyB.A. (1983). Fish and amphibian embryos—a model system for evaluating teratogenicity.Fund. Appl. Toxicol.3: 237–242.
4.
Bournias-VardiabasisN., TeplitzR.L., ChernoffG.F., SeecofR.L. (1983). Detection of teratogens in the Drosophila embryonic cell culture test: Assay of 100 chemicals.Teratology28: 109–122.
5.
Bournias-VardiabasisN., TeplitzR.L. (1982). Use of Drosophila embryo cell cultures as an in vitro teratogen assay.Teratogen. Carcinogen. Mutagen. 2.
6.
BraunA.G., BucknerC.A., EmersonD.J., and NichisonB.B. (1982). Quantitative correspondence between the in vitro activity of teratogenic agents.Proc. Natl. Acad. Sci. USA79: 2056–2060.
7.
BraunA.G., EmersonD.J., and NichisonB.B. (1979). Teratogenic drugs inhibit tumor cell attachment to lectin-coated surfaces.Nature282: 507–509.
8.
BraunA.G., and HorowiczP.B. (1983). Lectin-mediated attachment assay for teratogens: Results with 32 pesticides.J. Toxicol. Environ. Health11: 275–286.
9.
BrownL.P., FlintO.P., OrtonT.C., and GibsonG.G. (1986). Chemical teratogenesis: Testing methods and the role of metabolism.Drug Metab. Rev.17: 221–260.
10.
BrownN.A. (1986). Alternative tests for teratogenicity of petroleum products.Critical review prepared for the American Petroleum Institute.
11.
BrownN.A., and KramD. (1982). Intact human and rodent hepatic cells used for bioactivation in an embryo culture system.Teratology25: 30A.
12.
CameronI.L., LawrenceW.C., and LumJ.B. (1985). Medaka eggs as a model system for screening potential teratogens, in Prevention of Physical and Mental Congenital Defects, Part C: Basic and Medical Science, Education, and Future Strategies, Alan R. Liss, New York, pp. 239–243.
13.
ChatotC.L., KleinN. W., PiatekJ., and PierroL.J. (1980). Successful culture of rat embryos on human serum: Use in the detection of teratogens.Science207: 1471–1473.
14.
DaresteC. (1877). Recherches sur la production artificielle des monstruosites, ou Essais de teratogenic experimentale.C. Reinwald, Paris.
15.
DastonG.P., EbronM.T., CarverB., and StefanandisJ.G. (1987). In vitro teratogenicity of ethylenethiourea in the rat.Teratology35: 239–245.
16.
DastonG.P., and YonkerJ.E. (1987). Chick embryo retina cell culture as an in vitro teratogen screen.The Toxicologist7: 141.
17.
DastonG.P., YonkerJ.E., BainesD., and PoynterJ.I. (1988). Chick embryo retina cell culture: Teratogen screen and mechanistic probe.The Toxicologist8: 114.
18.
DastonG.P., YonkerJ.E., and PowersJ.F. (1987). Studies of the teratogenicity of ETU to rat and mouse embryos in vitro.Teratology35: 72A–73A.
19.
DawsonD.A., and BantleJ.A. (1987). Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.Teratology35: 221–227.
20.
DawsonD. A., McCORMICKC.A., and BantleJ.A. (1985). Detection of teratogenic substances in acidic mine water samples using the frog embryo teratogenesis assay—Xenopus (FETAX).J. Appl. Toxicol.5: 234–244.
21.
DoucetE., BurbonJ., RieutortM., MarinL., and TordetC. (1987). Optimization of fetal lung organ culture for surfactant biosynthesis.In vitro Cell. Devel. Biol.23: 189–198.
22.
DumontJ.N., SchultzT.W., BuchananM., and KaoG. (1983). Frog embryo teratogenesis assay: Xenopus (FETAX)—A short-term assay applicable to complex environmental mixtures. In: Symposium on the Application of Short-Term Bioassays in the Analysis of Complex Environmental Mixtures, M.D., WatersS.S., SandhuJ. Lewtas, ClaxtonL., NesnowS., eds. Plenum Press, New York, pp. 393–405.
23.
EisenJ.S., MyersP.Z., and WesterfieldM. (1986). Pathway selection by growth cones of identified motoneurons in live zebrafish embryos.Nature320: 269–271.
24.
FabroS., ShullG., and BrownN.A. (1982). The relative teratogenic index and teratogenic potency: Proposed components of developmental toxicity risk assessment.Teratogen. Carcinogen. Mutagen.2: 61–76.
25.
FantelA.G., GreenawayJ.C., JuchauM.R., and ShephardT.H. (1979). Teratogenic bioactivation of cyclophosphamide in vitro.Life Sci.25: 67–72.
26.
FlintO.P., and OrtonT.C. (1984). An in vitro assay for teratogens with cultures of rat embryo midbrain and limb bud cells.Toxicol. Appl. Pharmacol.76: 383–395.
27.
FreemanS.J., and LloydJ.B. (1986). Evidence that suramin and aurothiomalate are teratogenic in rat by disturbing yolk sac-mediated embryonic protein nutrition.Chem.-Biol. Interactions58: 149–160.
28.
GreenbergJ.H. (1982). Detection of teratogens by differentiating embryonic neural crest cells in culture: Evaluation as a screening system.Teratogen. Carcinogen. Mutagen.2: 319–323.
29.
GuntakattaM., MatthewsE.J., and RundellJ.O. (1984). Development of a mouse embryo limb bud cell culture system for the estimation of chemical teratogenic potential.Teratogen. Carcinogen. Mutagen.4: 349–364.
30.
HalesB.F. (1981). Modification of the mutagenicity and teratogenicity of cyclophosphamide in rats with inducers of the cytochromes P-450.Teratology24: 1–11.
31.
HallstromI., BlanckA., and AtumaS. (1984). Genetic variation in cytochrome P-450 and xenobiotic metabolism in Drosophila melanogaster.Biochem. Pharmacol.33: 13–20.
32.
HassellJ.R., and HoriganE.A. (1982). Chondrogenesis: A model developmental system for measuring teratogenic potential of compouneds.Teratogen. Carcinogen. Mutagen.2: 325–331.
33.
HoseJ.E. (1985). Potential uses of sea urchin embryos for identifying toxic chemicals: Description of a bioassay incorporating cytologic, cytogenetic and embryologic endpoints.J. Appl. Toxicol.5: 245–254.
34.
JelinekR. (1982). Use of chick embryo in screening for embryotoxicity.Teratogen. Carcinogen. Mutagen.2: 255–261.
35.
JelinekR., PeterkaM., and RychterZ. (1985). Chick embryotoxicity screening test—130 substances tested.Indian J. Exp. Biol.23: 588–595.
36.
JohnsonE.M. (1980). A subvertebrate system for rapid determination of potential teratogenic hazards.J. Environ. Pathol. Toxicol.4: 153–156.
37.
JohnsonE.M. (1981). Screening for teratogenic hazards: Nature of the problems.Ann. Rev. Pharmacol. Toxicol.21: 417–429.
38.
JohnsonE.M. (1987). A tier system for developmental toxicity evaluations based on considerations of exposure and effect relationships.Teratology35: 405–427.
39.
JohnsonE.M., ChristianM.S. (1984). When is a teratology study not an evaluation of teratogenicity? J.Amer. Coll. Toxicol.3: 431–434.
40.
JohnsonE.M., ChristianM.S., DanskyL., and GabelB.E.G. (1987). Use of the adult developmental relationship in prescreening for developmental hazards.Teratogen. Carcinogen. Mutagen.7: 273–285.
41.
JohnsonE.M., and GabelB.E.G. (1983). An artificial “embryo” for detection of abnormal development.Fundam. Appl. Toxicol.3: 243–249.
42.
JohnsonE.M., GabelB.E.G., and LarsonJ. (1984). Developmental toxicity and structure/activity correlates of glycols and glycol ethers.Environ. Health Perspect.57: 135–139.
43.
KellerS.J., and SmithM.K. (1982). Animal virus screens for potential teratogens. I. Poxvirus morphogenesis.Teratogen. Carcinogen. Mutagen.2: 361–374.
44.
KimmelG.L., SmithK., KochharD.M., and PrattR.M. (1982). Overview of in vitro teratogenicity testing: Aspects of validation and application to screening.Teratogen. Carcinogen. Mutagen.2: 221–229.
45.
KistlerA. (1987). Limb bud cell cultures for estimating the teratogenic potential of compounds.Arch. Toxicol.60: 403–414.
46.
KitchinK.T., and EbronM.T. (1984). Further development of rodent whole embryo culture: Solvent toxicity and water insoluble compound delivery system.Toxicology30: 45–57.
47.
KitchinK.T., SchmidB.P., and SanyalM.K. (1981). Teratogenicity of cyclophosphamide in a coupled microsomal activating/embryo culture system.Biochem. Pharmacol.30: 59–64.
48.
KochharD.M., and AydelotteM.B. (1974). Susceptible stages and abnormal morphogenesis in the developing mouse limb, analyzed in organ culture after transplacental exposure to vitamin A (retinoic acid).J. Embryol. Exper. Morphol.31: 721–734.
49.
KollarE.J., and FisherC. (1980). Tooth induction in chick epithelium: Expression of quiescent genes for enamel synthesis.Science207: 993–995.
50.
LewisC.A., ThibaultL., PrattR.M., and BrinkleyL.L. (1980). An improved culture system for secondary palatal evaluation.In Vitro16: 453–460.
51.
LloydJ.B., and BeckF. (1969). Teratogenesis, in Lysosomes in Biology and Pathology, vol. 1 (DingleJ.T., FellH.B., eds.), North Holland, Amsterdam, pp. 433–449.
52.
Loch-CarusoR., TroskoJ.E. (1985). Inhibited intercellular communication as a mechanistic link between teratogenesis and carcinogenesis.CRC Crit. Rev. Toxicol.16: 157–183.
53.
MansonJ.M., and SimonsR. (1979). In vitro metabolism of cyclophosphamide in limb bud culture.Teratology19: 149–158.
54.
MarhanO., and JelinekR. (1979). Efficiency of embryotoxicity testing procedures. II. Comparison between the official, MEST and CHEST methods.Toxicol. Lett.4: 389–392.
55.
McGARRITYC., SamaniN., BeckF., and GulamhuseimA. (1981). The effect of sodium salcylate on the rat embryo in culture: An in vitro model for the morphological assessment of teratogenicity.J. Anat.133: 257–269.
56.
MirkesP.E., FantelA.G., GreenawayJ.C., and ShephardT.H. (1981). Teratogenicity of cyclophosphamide metabolites: Phosphoramide mustard, acrolein and 4-ketocyclophosphamide in rat embryos cultured in vitro.Toxicol. Appl. Pharmacol.58: 322–330.
57.
MirkesP.E., GreenawayJ.C., RogersJ.G., and BrundrettR.B. (1984). Role of acrolein in cyclophosphamide teratogenicity in rat embryos in vitro.Toxicol. Appl. Pharmacol.72: 281–291.
NauH. (1987). Species differences in pharmacokinetics, drug metabolism, and teratogenesis, in Pharmacokinetics in Teratogenesis, vol. 1 (NauH., and ScottW.J.Jr., eds.), CRC Press, Boca Raton, FL, pp. 81–106.
60.
NewD.A.T. (1978). Whole embryo culture and the study of mammalian embryos during organogenesis.Biol. Review53: 81–122.
61.
NTP (1986). Evaluation of two in vitro teratology test systems. Final report. National Toxicology Program, National Institute of Environmental Health Sciences, NTP-86–372.
62.
OglesbyL.A., EbronM.T., BeyerP.E., CarverB.D., and KavlockR.J. (1986). Co-culture of rat embryos and hepatocytes: In vitro detection of a proteratogen.Teratogen. Carcinogen. Mutagen.6: 129–138.
63.
PrattR.M., and WillisW.D. (1985). In vitro screening assay for teratogens using growth inhibition of human embryonic cells.Proc. Natl. Acad. Sci. USA82: 5791–5794.
64.
RanganathanS., DavisD.G., and HoodR.D. (1987). Developmental toxicity of ethanol in Drosophila melanogaster.Teratology36: 45–49.
65.
RawlingsS.J., ShukerD.E.G., WebbM., and BrownN.A. (1985). The teratogenic potential of alkoxy acids in post-implantation rat embryo culture: Structure-activity relationships.Toxicol. Letters28: 49–58.
66.
RogersJ.M. (1987). Comparison of maternal and fetal toxic dose responses in mammals.Teratogen. Carcinogen. Mutagen.7: 297–306.
67.
RogersJ.M., DastonG.P., EbronM.T., CarverB., StefanadisJ.G., and GrabowskiC.T. (1985). Studies on the mechanism of trypan blue teratogenicity in vivo and in vitro.Teratology31: 389–399.
68.
SabourinT.D., FaulkR.T., and GossL.B. (1985). The efficacy of three non-mammalian test systems in the identification of chemical teratogens.J. Appl. Toxicol.5: 227–233.
69.
SadlerT.W., HortonW.E., and HunterE.S. (1985). Mammalian embryos in culture: A new approach to investigating normal and abnormal developmental mechanisms, in Developmental Mechanisms: Normal and Abnormal, Alan R. Liss, New York, pp. 227–240.
70.
SchmidB.P. (1985). Teratogenicity testing of new drugs with the postimplantation embryo culture system, in In Vitro Embrytoxicity and Teratogenicity Tests (HomburgerF., GoldbergA.M., eds.), S. Karger, Basel, pp. 46–57.
71.
SchmidB.P., CircurelL., and MarazziA. (1987). Correlation between drug concentrations and teratogenicity in vivo and in vitro, in Pharmacokinetics in Teratogenesis, vol. 2 (NauH., and ScottW.J.Jr., eds.). CRC Press, Boca Raton, FL, pp. 209–217.
72.
SchmidB.P., TrippmacherA., and BianchiA. (1983). Validation of the whole-embryo culture method for in vitro teratogenicity testing, in Developments in the Science and Practice of Toxicology (HayesA.W., SchnellR.C., MiyaT.S., eds.), Elsevier, Amsterdam, pp. 563–566.
73.
SchulerR.L., HardinB.D., and NiemeierR.W. (1982). Drosophila as a tool for the rapid assessment of chemicals for teratogenicity.Teratogen. Carcinogen. Mutagen.2: 293–301.
74.
SchulerR.L., RadikeM.A., HardinB.D., and NiemeierR.W. (1985). Pattern of response of intact Drosophila to known teratogens.J. Amer. Coll. Toxicol.4: 291–303.
75.
ScottW.J. (1977). Cell death and reduced proliferative rate, in Handbook of Teratology, vol. 2 (WilsonJ.G., FraserF.C., eds.), Plenum, New York, pp. 81–98.
76.
ShepardT.H., FantelA.G., MirkesP.E., GreenawayJ.C., Faustman-WattsE., CampbellM., and JuchauM.R. (1983). Teratology testing.I. Development and status of short-term prescreens. II. Biotransformation of teratogens as studied in whole embryo culture. Devel. Pharmacol.1: 147–164.
77.
ShumS., JensenN.M., and NebertD.W. (1979). The Ah locus: In utero toxicity and teratogenesis associated with genetic differences in benzo(a)pyrene metabolism.Teratology20: 365–376.
78.
SleetR.B., and BrendelK. (1985). Homogeneous populations of Artemia nauplii and their potential use for in vitro testing in developmental toxicology.Teratogen. Carcinogen. Mutagen.5: 41–54.
79.
SmithM.K., KimmelG.L., KochharD.M., ShepardT.H., SpielbergS.P., and WilsonJ.G. (1983). A selection of candidate compounds for in vitro teratogenesis test validation.Teratogen. Carcinogen. Mutagen.3: 461–480.
80.
SteeleV.E., MorrisseyR.E., LambJ.C., WilkinsonB.P., RochaD.G., MurphyD.D., and ElmoreE.L. (1987). Evaluation of two in vitro assays to screen for potential teratogens. 1987 EMS Abstracts: 103.
81.
SulikK.K., JohnstonM.C., and DehartD.B. (1987). Potentiation of programmed cell death by 13-cis retinoic acid: A common mechanism for early craniofacial and limb malformations?Teratology35: 32A.
82.
TrowellO.A. (1961). Problems in the maintenance of mature organs in vitro, in La Culture Organotypique, Editions du Centre Nationale de la Recherche Scientifique, Paris, 1961, pp. 237–249.
83.
WaltonB.T. (1981). Chemical impurity produces extra compound eyes and heads in cricketsScience212: 51–53.
84.
WaltonB.T., HoC.-H., MaC.Y., O'NEILLE.G., and KaoG.L. (1983). Benzoquinolinediones: Activity as insect teratogens.Science222: 422–423.
85.
WarnerC.W., SadlerT.W., ShockeyJ., and SmithM.K. (1983). A comparison of the in vivo and in vitro response of mammalian embryos to a teratogenic insult.Toxicology28: 271–282.
86.
WelschF., Stedm AnD.B., and CarsonJ.L. (1987). Teratogen interference with cell interactions: Cell-to-cell channel disruption as a potential mechanism of abnormal development. In: Approaches to Elucidate Mechanisms in Teratogenesis, WelschF., ed. Hemisphere Pub. Co., Washington, D.C., in press.
87.
WilkA.L., GreenbergJ.H., HoriganE.A., PrattR.M., and MartinG.R. (1980). Detection of teratogenic compounds using differentiating embryonic cells in culture.In Vitro16: 269–276.
88.
WilsonJ.G. (1973). Environment and Birth Defects, Academic, New York.
89.
ZimmermanE.F. (1985). Role of neurotransmitters in palate development and teratogenic implications, in Developmental Mechanisms: Normal and Abnormal.Alan R. Liss, New York, pp. 283–294.