Electrophysiology encompasses a multifaceted group of diagnostic tests which have been validated through clinical use. These evaluate not only CNS and PNS function, but also the function of the cardiovascular system, which affects the nervous system indirectly. As the many positive attributes of these tests become more widely recognized, it seems likely that the use of electrophysiologic tests will expand in the future.
AngerK.W. (1985). Neurobehavioral tests used in NIOSH-supported worksite studies, 1973–1983.Neurobehav. Toxicol. Teratol.7: 359–368.
2.
ArezzoJ.C., SimpsonR., and BrennanN.E. (1985). Evoked potentials in the assessment of neurotoxicity in humans.Neurobehav. Toxicol. Teratol.7: 299–304.
3.
BenignusV.A. (1984). EEG as a cross species indicator of neurotoxicity.Neurobehav. Toxicol. Teratol.6: 473–483.
4.
BlairE. (1971). Hypothermia. In: Textbook of Veterinary Anesthesia (SomaL.R., ed.), Ch. 38, pp. 555–579. The Williams and Wilkins Co., Baltimore.
5.
BoyesW.K., and DyerR.S. (1983). Pattern reversal and flash evoked potentials following acute triethyltin exposure.Neurobehav. Toxicol. Teratol.5: 571–77.
6.
BurchfielJ.L., and DuffyF.H. (1982). Organophosphate neurotoxicity: chronic effects of sarin on the electroencephalogram of monkey and man.Neurobehav. Toxicol. Teratol.4: 767–778.
7.
ChangY.-C. (1987). Neurotoxic effects of n-hexane on the human central nervous system: evoked potential abnormalities in n-hexane polyneuropathy.J. Neurol.50: 269–74.
8.
ChungK., SchwenR.J., and CoggeshallR.E. (1985). Ureteral axon damage following subcutaneous administration of capsaicin in adult rats.Neuroscience Letters53: 221–26.
9.
CrillW.E., and SwansonP.D. (1984). Paroxysmal disorders and disturbances of consciousness. In: Signs and Symptoms in Neurology.SwansonP. D., ed. Chapter 2., pp. 23–49. J. B. Lippincott Co., Philadelphia, PA.
10.
DafnyN. (1983). Interferon modifies EEG and EEG-like activity recorded from sensory, motor and limbic system structures in freely behaving rats.Neurotoxicol.4(2): 235–240.
11.
DesiI. (1983). Neurotoxicological investigation of pesticides in animal experiments.Neurobehav. Toxicol. Teratol.5: 503–515.
12.
DyerR.S. (1985a). The use of sensory evoked potentials in toxicology.Fundam. Appl. Toxicol.5: 24–40.
13.
DyerR.S. (1985b). Neurophysiological consequences of acute exposure to methylpyridines.Fundam. Appl. Toxicol.5: 920–32.
14.
EdwardsP., and ParkerV.H. (1977). A simple, sensitive, and objective method for early assessment of acrylamide neuropathy in rats.Toxicol. Appl. Pharmacol.40: 589–91.
15.
HarbinT.J. (1985). The late positive component of the evoked cortical potential: application to neurotoxicity testing.Neurobehav. Toxicol. Teratol.7: 339–44.
16.
HoyesA.D., BarberP., and JagessarH. (1981). Effect of capsaicin on the intraperitoneal axons of the rat trachea.Neuroscience Letters26: 329–34.
17.
InnisJ.D., and HigginsJ.M. (1986). Progressive electrocardiogram (ECG) changes in rabbits after subchronic dermal exposure to dimethyl dioctyl ammonium chloride (DMD8AC).The Pharmacologist28(3): 178.
18.
Jansco-GaborA., SzolcsanyiJ., JancsoN. (1970). Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea-pigs.J. Physiol.206: 495–507.
19.
JewettD.L. (1984). Planning experiments relevant to public policy: Peripheral nerve electrical activity.Neurobehav. Toxicol. Teratol.6: 419–424.
20.
KrarupC., and BuchthalF. (1985). Conduction studies in peripheral nerve.Neurobehav. Toxicol. Teratol.7: 319–323.
21.
Le QuesneP.M. (1978). Clinical expression of neurotoxic injury and diagnostic use of electromyography.Env. Health Pers.26: 89–95.
22.
Le QuesneP.M., MaxwellI.C., ButterworthS.T.G. (1980). Transient facial sensory symptoms following exposure to synthetic pyrethroids: a clinical and electrophysiological assessment.Neurotoxicology2: 1–11.
23.
MattssonJ.L., and AlbeeR.R. (1987). Sensory evoked potentials in neurotoxicology. Presented at Satellite Symposium of the Second World Congress of Neuroscience, International Brain Research Organization (IBRO). Biological Markers of Neurotoxicity. Szeged, Hungary. August 13–14. In press, Neurobehav. Toxicol. Terat.
24.
MeyerO.A., TilsonH.A., ByrdW.C., and RileyM.T. (1979). A method for the routine assessment of fore- and hindlimb grip strength of rats and mice.Neurobehav. Toxicol.1: 233–236.
25.
MullerK.E., BartonC.N., and BenignusV.A. (1984). Recommendations for appropriate statistical practice in toxicologic experiments.Neurotoxicol.5: 113–126.
26.
MuttiA., FerriF., LommiG., LottaS., LucertiniS., and FranchiniI. (1982). n-Hexane-induced changes in nerve conduction velocities and somatosensory evoked potentials.Int. Arch. Occup. Environ. Health51: 45–54.
27.
OnoY., TakeuchiY., and HisangaN. (1981). A comparative study on the toxicity of n-hexane and its isomers on the peripheral nerve.Int. Arch. Occup. Environ. Health48: 289–294.
28.
OnoY., TakeuchiY., HisangaN., IwataM., KitohJ., and SugiuraY. (1982). Neurotoxicity of petroleum benzine compared with n-hexane.Int. Arch. Occup. Environ. Health50: 219–229.
29.
O'SHAUGHNESSYD., GerberG.J. (1986). Damage induced by systemic kainic acid in rats is dependent upon seizure activity—a behavioral and morphological study.Neurotoxicol.7(3): 187–202.
30.
OttoD., BaumannS., and RobinsonG. (1985). Application of a portable microprocessor-based system for electrophysiological field testing of neurotoxicity.Neurobehav. Toxicol. Teratol.7: 409–414.
31.
PryorG.T., UyenoE.T., TilsonH.T., and MitchellC.L. (1983). Assessment of chemicals using a battery of neurobehavioral tests: A comparative study.Neurobehav. Toxicol. Teratol.5: 91–117.
32.
RajaniemiR. (1986). Clinical evaluation of occupational toxicity of methylmethacrylate monomer to dental technicians.J. Soc. Occup. Med.36: 56–9.
33.
RebertC.S. (1983). Multisensory evoked potentials in experimental and applied neurotoxicology.Neurobehav. Toxicol. Teratol.5: 659–71.
34.
RossJ.F., and NewmannE.A. (1986). Acute cardiotoxicity of dimethyldioctyl ammonium chloride in rabbits.The Pharmacologist28(3): 177.
35.
SomaL.R. (1971). Depth of General Anesthesia. In: Textbook of Veterinary Anesthesia (SomaL.R., ed.), Ch. 15, pp. 178–187. The Williams and Wilkins Co., Baltimore.
36.
SzikszayM., ObalF.Jr., and ObalF. (1982). Dose-response relationships in the thermoregulatory effects of capsaicin.Naunyn-Schmiedeberg's Arch. Pharmacol.320: 97–100.
37.
SzolcsanyiJ., Jancso-GaborA., and JooF. (1975). Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin.Naunyn-Schmiedeberg's Arch. Pharmacol.287: 157–169.
38.
TakeuchiY., OnoY., HisangaN., KitohJ., and SugiuraY. (1980). A comparative study on the neurotoxicity of n-pentane, n-hexane, and n-heptane in the rat.Brit. J. Ind. Med.37: 241–247.
39.
TakeuchiY., OnoY., HisangaN., IwataM., AoyamaM., KitohJ., and SugiuraY. (1983). An experimental study of the combined effects of n-hexane and methyl ethyl ketone.Brit. J. Ind. Med.40: 199–203.
40.
U.S. ENVIRONMENTAL PROTECTION AGENCY. OFFICE OF TOXIC SUBSTANCES. (1985). Toxic Substances Control Act test guidelines: Final rule. 40 CFR Part 798: Health effects testing guidelines. Subpart G-Neurotoxicity.Fed. Regist.50: 39458–39470.
41.
WORLD HEALTH ORGANIZATION. (1986). Principles and Methods for the Assessment of Neurotoxicity Associated with Exposure to Chemicals. Environmental Health Criteria Document #60. Geneva.