Evaluation of Pesticide Immunotoxicity 4

Abstract

Immunotoxicologic effects have been reported for a number of pesticides. Since pesticides represent a large range of chemical classes, different types of chemicals may affect the complex immune system by a variety of mechanisms. A preliminary evaluation of pesticides for immunotoxicologic potential can best be incorporated in general subacute and chronic toxicity testing, with additional groups assigned for initial host-sensitivity assays. For chemicals that are possible candidates for immunotoxicity in preliminary assays, a comprehensive immunotoxicity screening has been suggested. Finally, emphasis should be given to mechanistic investigations to objectively assess the immunotoxicity of a new chemical and possible extrapolation to man. Animal models need to be developed for detecting the autoimmunologic potential of pesticides. This paper provides a brief listing of various approaches currently employed in the evaluation of immunotoxicity.

Keywords

Immunotoxicology pesticides immune responses chemical testing ELISA,enzyme linked immunosorbent assay DNP,dinitrophenol Ig,immunoglobulin LPS,lipopolysaccharide MLR,mixed lymphocyte response SRBC,sheep red blood cells

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