Alachlor: Health Advisory

Ahmed, F.E. , Tegeris, A.S. , Underwood, P.C. et al. (1981). Alachlor: Six-month study in the dog: Testing facility's report no. 7952; sponsor's report no. PR-80-015. (Unpublished study including submitter summary, received Dec. 1, 1981 under EPA Reg. No. 524-316; prepared by Pharmacopathics Research Labs., Inc., submitted by Monsanto Co., Washington, D.C., CDL: 246229-A and 246293.

Baker, D. (1982). Herbicide contamination in municipal water supplies in Northwestern Ohio. Final draft report. Prepared for Great Lakes National Program Office, U.S. EPA, cited in ESE ( 1984).

Coleman, D.E. and Gaffey, W.R. (1980). A study of individuals exposed to alachlor: Ocular examinations for uveitis. Unpublished study received July 30, 1980 under EPA Reg. No. 524-285; submitted by Monsanto Co., Washington, D.C.; CDL: 242943-A. (Confidential business information.)

Daly, I.W. , Hagan, G.K. , Plutnick, R. et al. (1981a). An eighteen-month chronic feeding study of alachlor in mice. Project No. 77-1064. Final report. Unpublished Study received July 1, 1981 under EPA Reg. No. 524-285; submitted by Monsanto Co., Washington, D.C., CDL: 070168-A, 070169. (Confidential business information.)

Daly, I.W. , McCandless, J.B. , Jonassen, H. et al. (1981b). A chronic feeding study of alachlor in rats. Project No. 77-2065. Final report. Unpublished study received Jan. 5, 1982 under EPA Reg. No. 524-285, prepared by Bio-Dynamics, Inc. (BD-77-421, 11/13/81), submitted by Monsanto Co., Washington, D.C. CDL: 070586-A, 070587, 8, 9 & 90. (Confidential business information.)

DeFilippi, R.P. , Kyukonis, V.J. , Robey, R.J. and Modell, M. (1980). Supercritical fluid regeneration of activated carbon for adsorption of pesticides. U.S. EPA Document EPA-600/2-80-054. U.S. EPA. Research Triangle Park.

Ese. (1984). Environmental Science and Engineering. Review of treatability data for removal of twenty-five synthetic organic chemicals from drinking water. Prepared for Office of Drinking Water, U.S. EPA.

IRDC. (1984). International Research and Development Corporation, Mattawan, Michigan 49071 (initial study, IRDC Study #401-060, IR-79-022, dated 11/24/80, submitted to the Agency on 1/15/81 and was classified as Invalid by the Agency in a review dated 6/5/81). The repeat study (IRDC Study #401-208) submitted to the Agency on 3/1/84 under Accession #252570 for review was classified as Core-Supplementary-Data on 8/29/84. (Confidential business information.)

Monsanto Co (1978a). Acute oral-rat, acute dermal rabbit. Submitted by Bio-Dynamics, Inc., PD-77-433 on June 28, 1978. Unpublished study received 1978; CDL: 241273. (Confidential business information.)

Monsanto Co (1978b). Primary eye and primary dermal irritation—rabbit . Submitted by Bio-Dynamics, Inc., PD-77-433 on March 22, 1978. Unpublished study received 1978; CDL: 241273. (Confidential business information.)

Monsanto Co (1981a). Elimination of 14C-alachlor in monkeys. Study No. MA-81-261, prepared by the Univ. of California School of Medicine. Submitted by Monsanto Co., Washington, D.C., on Nov. 28, 1981. CDL: 070592, 247937. (Confidential business information.)

Monsanto Co (1981b). Acute inhalation LD50—rat. Submitted by Bio-Dynamics, Inc., PD-1-183 on Dec. 3, 1981. Unpublished study received 1/81; CDL: (Confidential business information.)

Monsanto Co (1982). Environmental fate of microencapsulated alachlor: Vol. I & II. Unpublished study received May 26, 1982 under EPA Reg. No. 524-344, prepared by Monsanto Agricultural Products Co. , Washington, D.C. CDL: 070841. 248053. (Confidential business information.)

Monsanto Co (1983). Rat metabolism study. MSL-3198, R.D. 493. Part I and II. Unpublished study received Oct. 1983 under EPA Reg. No. 524-316; prepared by Monsanto Agricultural Products Co., submitted by Monsanto Co., Washington, D.C.; CDL: 251543 and 251544. (Confidential business information.)

Monsanto Co (1984a). Dermal sensitization—guinea pig. Submitted on March 24,1984. Unpublished study received 1984; CDL: 252772. (Confidential business information.)

Monsanto Co (1984b). Teratology study-rabbit. Submitted on August 29, 1984. Unpublished study received 1985; IRDC # 401-208, Accession #252570. (Confidential business information.)

Naylor, M.W. , Ribelin, W.E. , Thake, D.E. , Stout, L.D. and Folks, R.M. (1984). Chronic study of Alachlor administered by gelatin capsule to dogs. Unpublished Study No. 820165, Environmental Health Laboratory, Monsanto Company, St. Louis, MO for Monsanto Company. Accession No. 25593. (Confidential business information.)

Rodwell, D.E. and Tracher, E.J. (1980). Teratology study in rats. IRDC No. 401-058; IR-79-020 . Unpublished study including submitter summary, received Oct. 16, 1980 under EPA Reg. No. 524-385; prepared by International Research & Development Corp. Submitted by Monsanto Co., Washington, D.C.; CDL: 252570. (Confidential business information.)

Schroeder, R.D. , Hogan, G.K. , Smock, M.E. et al. (1981). A three-generation reproduction study in rats with alachlor. Project No. 77-2066. Final report. Unpublished study received July 10, 1981 under EPA Reg. No. 524-285; prepared by Bio-Dynamics, Inc., submitted by Monsanto Co., Washington, D.C . CDL: 070177-A. (Confidential business information.)

Shirasu, S. et al. (1980). Microbial mutagenicity study. Received Feb. 20, 1980 under EPA Reg. No. 524-316. Prepared by Institute of Environmental Toxicology; Kodira Japan; submitted by Monsanto Co., Washington, D.C.; CDL: 248053. (Confidential business information.)

Stout, L.D. et al. (1983a). A chronic study of alachlor administered in feed to Long-Evans rats. EHL #800218, Project # ML-80-186, Report MSL-3282/3284. Vol. I&II. Unpublished study received Feb. 28, 1984 under U.S. EPA Reg. No. 524-316, prepared by Monsanto Environmental Health Laboratory (EHL), submitted by Monsanto Co., Washington, D.C., CDL: 252496-7. (Confidential business information.)

Stout, L.D. et al. (1983b). A chronic study of alachlor administered in feed to Long-Evans rats. Project # ML-80-224. Unpublished study received 4/16/84 under EPA Reg. No. 524-316, prepared by Monsanto Environmental Health Laboratory (EHL), submitted by Monsanto Co., Washington, D.C. , CDL: 252498. (Confidential business information.)

U.S. Epa (1983a). U.S. Environmental Protection Agency. Occurrence of pesticides in drinking water, food, and air. Office of Drinking Water.

U.S. Epa (1983b). U.S. Environmental Protection Agency. Method 102. Determination of alachlor, butachlor, and propachlor in wastewater. Effluent Guidelines Division , Washington, D.C. 20460.

U.S. Epa (1984). U.S. Environmental Protection Agency. Alachlor. Special review position document 1. Office of Pesticide Programs, Office of Toxic Substances, published December 31, 1984. Washington, D.C. 20460.

U.S. Epa (1985). U.S. Environmental Protection Agency. Draft health effects criteria document. Office of Drinking Water.

U.S. Epa (1986a). Environmental Protection Agency. Office of Pesticide Programs Alachlor Special Review, Position 2/3. Office of Pesticides and Toxic Substances . 401 'M' Street, S.W., Washington, D.C. 20460.

U.S. Epa (1986b). U.S. Environmental Protection Agency. Guidance for carcinogen risk assessment. Federal Register, 51(185):33992-34003. September 24.

U.S. Fda (1984). U.S. Environmental Protection Agency. Surveillance index for Pesticides. Bureau of Foods.

Windholz, M. (1983). The Merck Index. 10th Edition. Merck and Co., Inc., Rahway, N.J., p. 31.