Male Fischer 344 rats and cynomolgus monkeys were treated with various doses of di(2-ethylhexyl)phthalate (DEHP) for at least 21 days. There was metabolic, biochemical, and morphological evidence for peroxisomal proliferation in rats that consumed diets containing 1000 ppm DEHP and above. These diets were estimated to provide average daily doses of about 100 mg/kg of DEHP. In contrast, peroxisomal proliferation was not observed in monkeys that received up to 500 mg/kg/day of DEHP by gavage. The results of this study suggest that rats do not provide a good model for predicting the results of DEHP exposure on peroxisomal proliferation in higher primates.
Albro, P.W., Thomas, R. and Fishbein, L. (1973). Metabolism of diethylhexyl phthalate by rats. Isolation and characterization of the urinary metabolites. J. Chromatography76:321-330.
2.
Albro, P.W., Haas, J.R., Peck, C.C., Odam, D.G., Corbert, J.T., Bailey, F.J., Blatt, H.E. and Barrett, B.B. (1981). Identification of the metabolites of di-(2-ethylhexyl)phthalate in urine from the African green monkey. Drug Metab. Dispos . 9:223-225.
3.
Albro, P.W., Corbett, J.T., Schroeder, J.L., Jordan, S. and Matthews, H.B. (1982). Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP. Environ. Health Perspect. 45:19-25.
4.
Astill, B., Barber, E., Lington, A., Moran, E., Mulholland, A., Robinson, E. and Schneider, B. (1986). Chemical Industry Voluntary Test Program for Phthalate Esters: Health Effects Studies. Environ. Health Perspect. 65:329-336.
5.
Gray, T.J.B., Beamand, J.A., Lake, B.G., Foster, J.R. and Gangolli, S.D. (1982). Peroxisome proliferation in cultured rat hepatocytes produced by clofibrate and phthalate ester metabolites. Toxicol. Lett. 10:273-279.
6.
Gray, T.J.B., Lake, B.G., Beamand, J.A., Foster, J.R. and Gangolli, S.D. (1983). Peroxisome proliferation in primary cultures of rat hepatocytes. Toxicol. Appl. Pharmacol. 67:15-25.
7.
Lake, B.G., Pels Rijcken, W.R., Gray, T.J.B., Foster, J.R. and Gangolli, S.D. (1984). Comparative studies on the hepatic effects of di- and mono-n-octyl phthalates, bis(2-ethylhexyl)phthalate and clofibrate in the rat. Acta. Pharmacol. Toxicol. 54:167-176.
8.
Little, A.D. (1982). Phthalates in Consumer Products. Contract No. CPSC-C-80-1001. Washington, D.C.: Consumer Product Safety Commission.
9.
National Toxicology Program (Ntp). (1982). NTP Technical Report on the Carcinogenesis Bioassay of Di(2-Ethylhexyl) Phthalate (CAS No. 117-81-7) in F344 Rats and B6C3F1 Mice (Feed Study). NIH Pub. No. 82-1773.
10.
Reddy, J.K., Warren, J.R., Reddy, M.K. and Lalwani, N.D. (1982). Hepatic and renal effects of peroxisome proliferators . Ann. NY Acad. Sci. 386:81-110.
11.
Steel, R.G.D. and Torrie, J.H. (1960). Principles and Procedures of Statistics, McGraw-Hill, New York.
12.
Warren, J.R., Lalwani, N.D. and Reddy, J.K. (1982). Phthalate esters as peroxisome proliferator carcinogens . Environ. Health Perspect. 45:35-40.
