Abernathy, R.F., Peterson, M.J. and Gibson, F.H. (1969). Spectrochemical analyses of coal ash for trace elements. U.S. Bur. Mines., Rep. Invest. No. 7281.
2.
Admakin, L.A. (1970). Relation between ash and germanium content in coals, and its genetic significance. Dokl. Akad. Nauk SSSR192:1353-1355.
3.
Akbarov, A.A. (1981). Materials for the hygienic basis for maximum permissible germanium concentrations in the atmosphere. Gig. Sanit.12:57-58.
4.
Andreae, M.O. and Froelich, P.N. (1984). Arsenic, antimony and germanium biogeochemistry in the Baltic sea. Tellus, Ser. B, 36B:101-117.
5.
Andreae, M.O., Byrd, J.T. and Froelich, P.N. (1983). Arsenic, antimony, germanium, and tin in the Tejo estuary, Portugal: Modeling a polluted estuary. Environ. Sci. Technol.17:731-737.
6.
Andreae, M.O. and Froelich, P.N. (1981). Determination of germanium in natural water by graphite furnace atomic absorption spectrometry with hydride generation. Anal. Chem.53:287-291.
7.
Asai, K. (1977). Research data on the medical properties of organic germanium compounds. J. Appl. Nutr.29:53.
8.
Asai, K. and Kakimoto, N. (1975). Organogermanium sesquioxide composition for treating hypertension or hypotonia. Can. Patent No. 970277.
9.
Asai, K. and Kakimoto, N. (1973). Antihypertensive (carboxyethyl) germanium sequioxide . Ger. Offen. Patent No. 2226668.
10.
Asai Germanium Research Institute (1983). Enhancement of morphine analgesic activity by germanium compounds . Jpn Kokai Tokkyo Koho, Patent No. 83146507.
11.
Aso, H., Suzuki, F., Yamaguchi, T. et al. (1985). Induction of interferon and activation of natural killer cells and macrophages in mice by oral administration of Ge-132 carboxylethylgermanium sesquioxide, an organic germanium compound. Microbiol. Immunol.29:65-74.
12.
Aso, H., Suzuki, F., Yamaguchi, T. et al. (1982). Induction of interferon and activation of NK cells and macrophages in mice by oral administration of Ge-132, an organic germanium compound. Jpn J. Cancer Chemother.9:1976-1980.
13.
Aston, S.R. (1983). "Silicon Geochemistry and Biogeochemistry." New York: Academic Press.
14.
Azam, F. (1974b). Silicilic-acid uptake in diatoms studies with germanium-68 germanic acid as tracer. Planta (Berl.) 121:205-212.
15.
Azam, F. and Chrisholm, S.W. (1976). Silicilic acid uptake and incorporation by natural marine phytoplankton populations. Limnol. Oceanogr.21:427-435.
16.
Azam, F. and Volcani, B.E. (1974a) Role of silicon in diatom metabolism. Part 6: active transport of germanic-acid in the heterotrophic diatom Nitzschia alba . Arch. Microbiol.101:1-8.
17.
Azam, F., Hemmingsen, B.B. and Volcani, B.E. (1973). Germanium incorporation into the silica of diatom cell walls. Arch. Mikrobiol.92:11-20.
18.
Babina, M.D. (1975). Determination of germanium tetrahydride in air . Gig. Sanit.5:65-66.
19.
Bailey, G.H., Davidson, P.B. and Bunting, C.H. (1925). The effect of germanium dioxide on the rabbit . J. Am. Med. Assoc.84:1722-1724.
20.
Baiser, R.E. and Dutton, R.C. (1969). Initial events in interaction of blood with a foreign surface. J. Biomed. Mater. Res.3:191-206.
21.
Bendz, G. and Lindqvist, I. (eds.) (1978). "Biochemistry of Silicon and Related Problems." New York: Plenum Press.
22.
Bernhard, K. and Teutoner, J. (1983). Germanium—a new drug against influenza. From folk medicine to academic medicine. MMW. Muench. Mediz. Wochen.125:(13): A80-A81.
23.
Bertine, K.K. and Goldberg, E.D. (1971). Fossil fuel combustion and the major sedimentary cycle. Science173:233-235.
24.
Birge, W.J. (1978). Aquatic toxicity of trace elements of coal and fly ash. D.O.E. Symposium Series 48:219-240.
25.
Birge, W.J., Black, J.A. and Westerman, A.G. (1979). Evaluation of aquatic pollutants using fish and amphibian eggs as bioassay organisms. Symposium: Pathobiol. Environ. Pollut.: Animal models wildlife monitoring, pp. 108-118.
26.
Blancafort, P., Serradell, M.N. and Castaner J. (1980). Spirogermanium hydrochloride. Drugs Future5:149-150.
27.
Bowen, H.J.M. (1980). "Environmental Chemistry," v2. London: Royal Society of Chemistry .
28.
Bradley, D.C., Kay, L.J. and Wardlaw, W. (1956). Germanium esters. I. Parachors and molecular structure . J. Chem. Soc.4916-4926.
29.
Braman, R.S. and Tomkins, M.A. (1978). Atomic emission spectrometric determination of antimony, germanium, and methylgermanium compounds in the environment. Anal. Chem.50:1088-1093.
30.
Braungart, M. and Ruessel, H. (1984). Separation of molybdoheteropoly acids of phosphorus, arsenic, silicon and germanium as ion-associates by HPLC. Application to quantitative determination in water. Chromatographia19:185-187.
31.
Brenner, D.E., Jones, H.W., Rosenshein, N.B. et al. (1983). Phase II evaluation of spirogermanium in advanced ovarian carcinoma. Cancer Treat. Rep.67:193-194.
32.
Brown, H.R. and Swaine, D.J. (1964). Inorganic constituents of Australian coals. Part 1. Nature and mode of occurrence. J. Inst. Fuel37:422-440.
33.
Brown, J.C. and Jones, W.E. (1972). Effect of germanium on utilization of boron in tomato (Lycopersion esculentum). Plant Physiol.49:651-653.
34.
Browning, E. (1969). Toxicity of Industrial Metals. 2d ed., London: Butterworths.
35.
Budman, D.R., Ginsberg, S., Perry, M. et al. (1982). Phase II trial of spirogermanium in breast adenocarcinoma, a cancer and leukemia group B study. Cancer Treat. Rep.66:1667-1668.
36.
Budman, D.R., Schulman, P., Vinciguerra, V. et al. (1982). Phase I trial of spirogermanium given by infusion in a multiple-dose schedule. Cancer Treat. Rep.66:173-175.
37.
Byington, K.H. and Hansbrough, E. (1979). Inhibition of the enzymatic activity of ligandin by organogermanium, organolead or organotin compounds and the biliary excretion of sulfobromophthalein by the rat. J. Pharmacol. Exp. Ther.208:248-253.
38.
Capes, C.E., Mcilhinney, A.E., Russell, D.E. et al. (1974). Rejection of trace metals from coal during benefication by agglomeration. Environ. Sci. Tech.8:35-38.
39.
Carter, J.M., Natiella, J.R., Baier, R.E. et al. (1984). Fibroblastic activities post implantation of cobalt chromium alloy and pure germanium in rabbits. Artif. Organs8:102-104.
40.
Caruso, J.A., Fricke, F.L. and Robbins, W.D. (1978). Determination of germanium, arsenic, tin, selenium, and antimony for plasma emission spectrometry with hydride generation and chromatographic separation. J. Assoc. Off. Anal. Chem.61:118-1123.
41.
Caujolle, F., Caujolle, D., Dao, H.G. et al. (1966a). Relation between the structure and toxicity of aliphatic germanium compounds. C. R. Acad. Sci. [D] 262:1302-1304.
42.
Caujolle, F., Huron, R., Moulas, F. et al. (1966b). Statistical comparison of the teratogenic actions of two products. Ann. Pharm. Fr.24:23-28.
43.
Chang, B.K. (1983). Differential sensitivity of pancreatic adenocarcinoma cell lines to chemotherapeutic agents in culture. Cancer Treat. Rep.67:355-362.
44.
Chmielowski, J. (1981). Bioaccumulation of germanium as a model for the nonspecific uptake of some metals by microorganisms. Biochem. Soc. Trans.9:906.
45.
Christensen, G.M. (1971). Effects of metal cations and other chemicals upon the in vitro activity of two enzymes in the blood plasma of the white sucker, Catostomus commersoni (Lacepede). Chem. Biol. Interact.4:351-361.
46.
Conzemius, R.J., Welcomer, T.D. and Suec, H.J. (1984). Elemental partitioning in ash depositories and material balances for a coal burning facility by spark source mass spectrometry . Environ. Sci. Technol.18:12-18.
47.
Corey, R.C., Myers, J.W., Schwarts, C.H. et al. (1959). Occurrence and determination of germanium in coal ash from powerplants. U.S. Bur. Mines, Bull. No. 575, p. 68.
48.
Cotton, F.S. and Wilkinson, G. (1980). "Advanced Inorganic Chemistry: A Comparative Text ." 4th ed. New York: Wiley.
49.
Crable, J.V., Keenan, R.G., Wolowicz, F.R. et al. (1967). The mineral content of bituminous coal miners' lungs. J. Am. Ind. Hyg. Assoc.28:8-12.
50.
Cremer, J.E. and Aldridge, W.N. (1964). Toxicological and biochemical studies on some trialkylgermanium compounds. Br. J. Ind. Med.21:214-217.
51.
Crowe, A.J. (1983). Organometallics in medicine. Chem. Ind.8:304-310.
52.
Cushman, R.M., Hildebrand, S.G., Strand, R.H. et al. (1977). The toxicity of 35 trace elements in coal to fresh water biota: A data base with automatic retrieval capabilities. Oak Ridge Nat. Lab., Environ. Sci. Div., Pub. No. 1048, ORNL/TM/5793 (NTIS).
53.
Darley, W.M. and Volcani, B.E. (1969). Role of silicon in diatom metabolism. A silicon requirement for deoxyribonucleic acid synthesis in the diatom Cylindrotheca fusiformis. Exp. Cell Res.58:334-342.
54.
Davie, E.I., Simpson, T.L. and Garrone, R. (1983). Experimental germanium incorporation into siliceous sponge spicules. Biol. Cell48:191-202.
55.
Davydov, V.I. (1966). "Germanium. Including Radioactive Isotopes of Germanium." Eds. Rudenko, P. and Kortum, L.V. Translated from the Russian by Peiperl, A.New York: Gordon and Breach.
56.
De Argollo, R.M. and Schilling, J.G. (1978). Ge/ Si and Ga/Al variations along the Reykjanes Ridge and Iceland. Nature (Lond.) 276:24-28.
57.
Dixon, C., Hagemeister, F., Legha, S. et al. (1984). Pulmonary toxicity associated with spirogermanium . Cancer Treat. Rep.68:907-908.
58.
Dong, A.E. (1970). Spectrochemical determination of microgram quantities of germanium in natural water containing high concentrations of heavy metals . U.S. Geol. Surv., Prof. Pap. No. 700-B, pp. 242-244.
59.
Dudley, H.C. (1953). Pharmacological studies of radiogermanium (Ge-71). Inhalation of dust. AMA Arch. Ind. Hyg. Occup. Med.8:528-530.
60.
Dudley, H.C. and Wallace, E.J. (1952). Pharmacological studies of radiogermanium. AMA Arch. Ind. Hyg. Occup. Med.6:263.
61.
Durst, R.W. and Loomis, W.D. (1984). Substitution of germanium for boron in suspension cultured carrot cells. Plant Physiol.75:14.
62.
Durum, W.H. and Haffty, J. (1961). Occurrence of minor elements in water. Washington, DC: Geol. Surv. Circular, No. 445.
63.
Elvin, D.W. (1972). Effect of germanium upon development of siliceous spicules of some fresh water sponges. Exp. Cell Res.72:551-553.
64.
El Wardani, S.A. (1957). On the geochemistry of germanium. Geochim. Cosmochim. Acta13:5-19.
65.
Falkson, G. and Falkson, H.C. (1983). Phase II trial of spirogermanium for treatment of advanced breast cancer. Cancer Treat. Rep.67:189-190.
66.
Fatome, M., Sentenac-Roumanou, H., Lion, C. et al. (1984). Radioprotective germanium dithioacetals of cysteamine and methylcysteamine. Eur. J. Med. Chem. Chim. Ther.19:119-122.
67.
Ferm, V.H. and Carpenter, S.J. (1970). Teratogenic and embryopathic effects of indium, gallium, and germanium. Toxicol. Appl. Pharmacol.16:166-170.
68.
Froelich, P.N. (1986). Personal communication.
69.
Froelich, P.N., Hambrick, G.A., Andreae, M.O. et al. (1985a). The geochemistry of inorganic germanium in natural waters. J. Geophys. Research-Oceans90:1130-1141.
70.
Froelich, P.N., Kaul, L.W., Byrd, J.T. et al. (1985b). Arsenic, barium, germanium, tin, dimethylsulfide and nutrient biogeochemistry in Charlotte Harbor, Florida, a phosphorus-enriched estuary. Estuarine Coast ShelfSci.20:239-264.
71.
Froelich, P.N. and Andreae, M.O. (1981). Marine geochemistry of germanium: Ekasilicon. Science213:205-207.
72.
Furst, A. (1986). Hormesis in pharmacology. Health Phys., in press.
73.
Furst, A. (1963). The Chemistry of Chelation in Cancer. Springfield, IL: C. C. Thomas. Fyfe, W.S. (1974). Geochemistry. Oxford: Clarendon Press, p. 8.
74.
Gastinger, E. (1955). Trends in the chemistry of germanium. Fortschr. Chem. Forsch.3:603-656.
75.
Glockling, F. (1969). The Chemistry of Germanium. New York: Academic Press.
76.
Goldschmidt, V.M. (1958). In: Geochemistry. Ed: Glareden, A. New York: Oxford Univ. Press.
77.
Goldschmidt, V.M. (1926). Uber das Krystallochemische und Geochemische Verhalten des Germaniums. Naturwissenschaften14:295-297.
78.
Goodbeer, W.C., Morgan, N.C. and Swaine, D.J. (1981). The use of moss to monitor trace elements. Proc. 7th Int. Clean Air Conf pp. 789-798.
79.
Gus'kova, E.I. (1974). Toxicology of germanium hydride. Gig. Tr. Prof. Zabol.18:56-57.
80.
Gus'kova, E.I. (1973). Prognostic significance of organism reactions in the initial period of chronic poisoning. Aktual. Vopr. Gig. Naselennykh, Mater. Vses Konf. Molodykh Uchenykh37-39.
81.
Hachisu, M., Takahashi, H., Koeda, T. et al. (1983). Analgesic effect of novel organogermanium compound Ge-132 carboxyethyl germanium sesquioxide. J. Pharmacobio-Dyn.6:814-820.
82.
Haguenoer, J.M. and Furon, D. (1982). "Industrial Toxicology and Hygiene." Vol. 2: Mineral derivatives, part 2. Paris: Editions Technique et Documentation.
83.
Hambrick, G.A., Froelich, P.N., Andreae, M.O. et al. (1984). Determination of methylgermanium species in natural waters by graphite furnace atomic absorption spectrometry with hydride generation. Anal. Chem.56:421-424.
84.
Hamilton, E.I. and Minski, M.J., (1972/73). Abundance of the chemical elements in man's diet and possible relationships with the environmental factors. Sci. Total Environ.1:375-394.
Harris, K.L. (1978). Tin. Washington, DC: Bureau of Mines. 17 p.
87.
Harrold, G.C. (1944). Physiologic properties of germanium. Ind. Med.13:236-238.
88.
Harvey, W.W. and Gatos, H.C. (1960). The reaction of germanium with aqueous solutions. II. Solution kinetics in electrolytes and the role of specific adsorption . J. Electrochem. Soc.107:65-72.
89.
Harvey, W.W. and Gatos, H.C. (1958). The reaction of germanium with aqueous solutions. I. Dissolution kinetics in water containing dissolved oxygen. J. Electrochem. Soc.105:654-659.
90.
Hatano, M., Ishimura, K., Fuchigami, K. et al. (1981). Toxicological studies on germanium dioxide (GeO2). 1. Acute, subacute, chronic toxicity and successive irritation to the eye. Pharmacometrics [Oyo Yakuri] 21:773-796.
91.
Hatano, M., Ishimura, K. and Fuchigami, K. (1981). Toxicological studies on germanium dioxide (GeO 2). 2. Teratological test(s) in rats. Pharmacometrics [Oyo Yakuri] 21:797-807.
92.
Henry, M.C., Rosen, E., Port, C.D. et al. (1980). Toxicity of spirogermanium in mice and dogs after iv or im administration. Cancer Treat. Rep.64:1207-1210.
93.
Henry, R.A. and Byington, K.A. (1976). Inhibition of glutathione-S-aryltransferase from rat liver by organogermanium, lead and tin compounds. Biochem. Pharmacol.25:2291- 2295.
94.
Hill, B.T., Whatley, S.A., Bellamy, A.S. et al. (1982). Cytotoxic effects and biological activity of 2-aza-8-germanspiro[4,5]-decane-2-propanamine-8,8-diethyl-N, N-dimethyl dichloride (NSC 192965; spirogermanium) in vitro. Cancer Res.42:2852-2856.
95.
Hill, J.O., Giere, M.S., Pickrell, J.A. et al. (1979). Toxic effects of organometallic compounds on lymphoid tissue in-vitro and in-vivo. Fed. Proc.39:623.
96.
Holness, H. (1948). The precipitation of germanium by tannin. Anal. Chim. Acta2:254-260.
97.
Horne, R.A. (1969). Marine Chemistry. New York : Wiley-Interscience.
98.
Iler, R.K. (1955). The Colloid Chemistry of Silica and Silicates . New York: Cornell Univ. Press .
99.
Ishikawa, A. and Sato, T. (1972). An experimental study on blood pressure increasing mechanism and hypertension maintaining mechanism in rats with spontaneous hypertension using organic germanium bis-beta ethyl carbonic acid germanium sesquioxide. Exp. Anim. (Tokyo) 21:145-146.
100.
Ivanov, N.G., Germanova, A.L. and Gus'kova, E.I. (1976). Comparison of the body's reactions to the repeated action of germanium hydride and tetrachloride. Gig. Tr. Prof. Zabol.1:34-38.
101.
Jacobson, D.M. and Evans, D.S. (1984). Pulverized fuel ash as a metal resource for the U.K. Water Supply8:29-36.
102.
Johnson, D.L. and Braman, R.S. (1975). The speciation of arsenic and the content of germanium and mercury in members of the pelagic Sargassum community. Deep-Sea Res. Oceanogr. Abstr.22:503-508.
103.
Johnson, O.H. (1952). Germanium and its inorganic compounds. Chem. Rev.51:431-469.
104.
Jolly, W.L. and Latimer, W.M. (1952). The solubility of hydrous germanous oxide and potential of the germanous oxide-germanic oxide couple. J. Amer. Chem. Soc.74:5751-5752.
105.
Kaars, S.A. (1968). Growth inhibition of bacteria by tributylgermanium acetate and its reversal by blood constituents. Antonie LeeuwenhoekJ. Microbiol.34:85-92.
106.
Kada, T., Mochizuki, H. and Miyao, K. (1984). Antimutagenic effects of germanium oxide on Trp-P-2-induced frameshift mutations in Salmonella typhimurium TA98 and TA1538. Mutat. Res.125:145-151.
107.
Kada, T., Hirano, K. and Shirasu, Y. (1980). Screening of environmental chemical mutagens by the rec-assay system with Bacillus subtilis. Chem. Mutagens6:149-173.
108.
Kakimoto, N. and Miyao, K. (1979). Germanium compounds as anticancer agents. Jpn Kokai Tokkyo Koho, Patent No. 79160742.
109.
Kal'sada, I.N. (1961). Data on the toxicology of germanium compounds (Review of foreign literature). Gig. Tr. Prof. Zabol.5:24-28.
110.
Kal'sada, I.N. (1964). A propos of the toxic properties of germanium tetrachloride. Gig. Tr. Prof. Zabol.8:57-60.
111.
Kanematsu, K. and Kada, T. (1978). Mutagenicity of metal compounds. Mutat. Res.53:207-208.
112.
Kanisawa, M. and Schroeder, H.A. (1969). Life-term studies on the effect of trace elements on spontaneous tumors in mice and rats. Cancer Res.29:892-895.
113.
Kanisawa, M. and Schroeder, H.A. (1967). Life-term studies on the effects of arsenic, germanium, tin, vanadium on spontaneous tumors in mice. Cancer Res.27:1192-1195.
114.
Kavanagh, J.J., Saul, P.B., Copeland, L.J. et al. (1985). Continuous-infusion spirogermanium for the treatment of refractory carcinoma of the ovary: a phase II trial. Cancer Treat. Rep.69:139-140.
115.
Kirita, M. (1970). The effect of germanium dioxide, a diatom-eliminating chemical, on the growth of free-living conchocelis of Parphyra yezoensis. Jpn. Soc. Phycol.18:167-170.
116.
Klaveness, D. and Guillard, R.R.L. (1975). The requirement for silicon in Synura petersenii Chrysophyceae. J. Phycol.11:349-355.
117.
Koga, A. (1967). Germanium, molybdenum, copper and zinc in New Zealand thermal waters. N. Z. J. Sci.10:428-446.
118.
Kraynov, S.R. (1967). Geochemistry of germanium in the thermal carbonate waters (Illustrated by examples from the Pamirs and Greater Caucasus). Geochem . Intl.4:309-320.
119.
Krigman, M.R. and Silverman, A.P. (1984). General toxicology of tin and its organic compounds . Neurotoxicol.5:129-139.
120.
Kuebler, J.P., Tormey, D.C., Harper, G.R. et al. (1984). Phase II study of spirogermanium in advanced breast cancer. Cancer Treat. Rep.68:1515-1516.
121.
Kuga, N., Oboshi, S., Sato, H. et al. (1976). Inhibition of senile amyloidosis of mice by biscarboxyethyl germanium sesquioxide. Acta Pathol. Jpn.26:63-71.
122.
Kumano, N., Nakai, Y., Ishikawa, T. et al. (1978). Effect of carboxyethylgermanium sesquioxide on the methylcholanthrene-induced tumorigenesis in mice. Sci. Rep. Res. Inst . Tohoku Univ.25:89-95.
123.
Kurliandskii, B.A., Klochkova, S.I., Mashbits, F.D. et al. (1968). Toxicologic assessment of, and hygienic standards for germanium tetrachloride. Gig. Tr. Prof. Zabol.12:51-53.
124.
Kwapulinski, J. and Sarosiek, J. (1981). Germanium cumulation by the selected species of moss. Environ. Prot. Eng. (Poland) 7:207-214.
125.
Larsson, H., Trope, C., Mattsson, W. et al. (1980). Clinical pharmacokinetics of intravenously administered spirogermanium. Proc. Am. Assoc. Cancer Res.21:334.
126.
Laubengayer, A.W. and Morton, D.S. (1932). Germanium. XXXIX. The polymorphism of germanium dioxide. J. Amer. Chem. Soc.54:2303-2320.
127.
Lee, R.E. (1978). Formation of scales in Paraphysomonas vestita and the inhibition of growth by germanium dioxide. J. Protozool.25:163-166.
128.
Legha, S.S., Ajani, J.A. and Bodey, G.P. (1983). Phase I study of spirogermanium given daily. J. Clin. Oncol.1:331-336.
129.
Lewin, J.C. (1966). Silicon metabolism in diatoms. V. Germanium dioxide, a specific inhibitor of diatom growth. Phycologia6:1-12.
130.
Lewis, B.L., Froelich, P.N. and Andreae, M.O. (1985). Methylgermanium in natural waters. Nature (Lond.) 313:303-305.
131.
Lewis, C.E. (1960). The toxicology of organometallic compounds. Part I. J. Occup. Med.2:183-187.
132.
Li, A.P., Dahl, A.R., and Hill, J.D. (1982). In-vitro cytotoxicity and genotoxicity of dibutyl tin dichloride and dibutyl germanium dichloride. Toxicol. Appl. Pharmacol.64:482-485.
133.
Lisk, D.J. (1972). Trace metals in soils, plants and animals. Adv. Agron.24:267-325.
134.
Lovell, M.A. and Farmer, J.G. (1985). Arsenic speciation in urine from humans intoxicated by inorganic arsenic compounds. Human Toxicol.4:203-214.
135.
Lugo, G., Cassady, G. and Palmisano, P. (1969). Acute maternal areseniontoxication with neonatal death. Am. J. Dis. Child.117:328-330.
136.
Mantell, C.L. (1949). Tin. 2d Ed. ACS Monograph Series. New York: Reinhold Pub. Co.
137.
Markham, J.W. and Hagmeier, E. (1982). Observations on the effects of germanium dioxide on the growth of macro algae and diatoms. Phycologia21:125-130.
138.
Marshall, C.E. (1949). The Colloidal Chemistry of the Silicate Minerals . New York: Academic Press.
139.
Matsumoto, H. and Takahashi, E. (1976). In vitro binding of germanium to proteins of shoots . Soil Sci. Plant Nutr.22:191-197.
140.
Matsumoto, K., Ishiwatari, T. and Fuwa, K. (1984). Hydride generation and atomic emission spectrometry with helium glow discharge detection for analysis of biological samples. Anal. Chem.56:1545-1548.
141.
Mclachlan, J. (1977). Effects of nutrients on growth and development of embryos of Fucus edentatus phaeophyceae fucales. Phycologia16:329-338.
142.
Mehard, C.W. and Volcani, B.E. (1975a). Evaluation of silicon and germanium retention in rat tissues and diatoms during cell and organelle preparation for the electron probe microanalysis. J. Histochem. Cytochem.23:348-358.
143.
Mehard, C.W. and Volcani, B.E. (1975b). Similarity in uptake and retention of trace amounts of 31-silicon and 68-germanium in rat tissues and cell organelles. Bioinorg. Chem.5:107-124.
144.
Mehard, C.W., Sullivan, C.W., Azam, F. et al. (1974). Role of silicon in diatom metabolism. IV. Subcellular localization of silicon and germanium in Nitzschia alba and Cylindrotheca fusiformis. Physiol. Plant30:265-272.
145.
Mehard, C.W. and Volcani, B.E. (1973). Germanium-68, a tracer of silicon in rat tissues and cells. J. Cell Biol.59:223.
146.
Miller, K.J. (1961). Dissolution rate of germanium in aqueous hydrogen peroxide and saturated ozone solutions. J. Electrochem. Soc.108:296-297.
147.
Mino, Y., Ota, N., Sakao, S. et al. (1980). Determination of germanium in medicinal plants by atomic absorption spectrometry with electrothermal atomization. Chem. Pharm. Bull.28:2687-2691.
148.
Mizushima, Y., Shoji, Y. and Kaneko, K. (1980). Restoration of impaired immunoresponse by germanium in mice. Int. Arch. Allergy Appl. Immunol.63:338-339.
149.
Mochizuki, H. and Kada, T. (1982). Antimutagenic effect of Ge-132 on gamma-ray-induced mutations in Escherichia coli B/r WP2 trp-. Int. J. Radiat. Biol.42:635-659.
150.
Monier-Williams, G.W. (1950). "Trace Elements in Food."New York: Wiley and Sons.
151.
Moore, L.F. and Traquair, J.A. (1976). Silicon, a required nutrient for Cladophora glomerata . Planta (Berl.) 128:179-182.
152.
Mortlock, R.A. and Froelich, P.N. (1986). Hydrothermal germanium over the southern East Pacific rise. Science231:43-45.
153.
Ema, J.E., Slavik, M. and Davis, J. (1983). Spirogermanium: a new drug with antimalarial activity against chloroquine-resistant Plasmodium falciparum. Int. J. Clin. Pharmacol.21:167-171.
154.
Mueller, J.H. and Iszard, M.S. (1922). Erythopoietic action, cumulative effect and elimination of germanium dioxide. Am. J. Med. Sci.163:364-384.
155.
Mulinos, M.G. and Amin, P. (1980). Toxicology and Phase I study of a new anticancer agent, spirogermanium HCl. Fed. Proc.39:747.
156.
Muller, J.H. (1931). Toxicity of several allotrophic modifications of germanic oxide. J. Pharmacol. Exp. Ther.42:277-297.
157.
Nagata, M. (1951). Spectrographic analysis of minute quantities of metals in plant materials (II). J. Chem. Soc. Japan72:344-350.
158.
National Research Council (1980). Trace-Element Geochemistry of Coal Resource Development Related to Environmental Quality and Health. Washington, DC: National Academy Press, 73p.
159.
Nazarenko, V.A. (1961). Analytical chemistry of germanium. Metody Opredelen. i Analiza Redkikh Elementov. Akad. Nauk SSSR, Inst. Geokhim. i Anal. Khim., A.P. Vinogradov and D.I. Ryabchikov, eds., Moscow: Izdatel. Akad. Nauk SSSR, pp. 400-461.
160.
Neuberger, J.S. and Hollowell, J.G. (1982). Lung cancer excess in an abandoned lead-zinc mining and smelting area. Sci. Total Environ.25:287-294.
161.
Ninomiya, S., Liu, F.Z., Nakagawa, H. et al. (1986). Studies on chemical carcinogens and mutagens. 39. Effects of silicon and germanium substitutions on physicochemical properties and cytotoxicity of N-alkyl-N-nitrosoureas. Chem. Pharm. Bull. (Tokyo) 34:3273-3278.
162.
Nordberg, G.F. (1984). Metal interactions in carcinogenesis. Effects of mixed exposures on carcinogenic response. Toxicol. Environ. Chem.9:63-78.
163.
Ono, M., Oka, T., Yoshihara, H. et al. (1982). Effect of NK-421 (Bestatin) and Ge-132 on the cytotoxicity of spleen cells obtained from the tumor-bearing mice. Gan To Kagaku Ryoho9:1771-1777.
164.
Orimo, H., Onda, K., Kaseki, H. et al. (1984). Chronic intoxication test on germanium containing Spirulina product fed to Wistar strain rats. Eiyogaku Zasshi42:43-49.
165.
Oustrin, J., Clavel, M.J. and Pitet, G. (1968). Study of excretory forms of tetraethyl-germanium in rats. C. R. Soc. Biol.162:1226-1229.
166.
Paneth, F. and Joachimoglu, G. (1924). The pharmacological properties of tin hydride and germanium hydride. Chem. Ber.57B: 1925-1930.
167.
Paone J. (1970). Germanium. In: "Mineral Facts and Problems." Washington, DC: U.S. Bur. Mines Bull. No. 650, pp. 563-571.
168.
Pelmore, H. and Somers, P.J. (1982). Effect of oxyanions on the glucose isomerase catalysed equilibrium. 1. Complexes of D-glucose and D-fructose with germanate. Enzyme Microb. Technol.4:390-394.
169.
Pinnamaneni, K., Yap, H.Y., Legha, S.S. et al. (1984). Phase II study of spirogermanium in the treatment of metastatic breast cancer. Cancer Treat. Rep.68:1197-1198.
170.
Pollard, F.H., Nickless, G. and Uden, P.C. (1965). Chromatographic studies on group IVB elements. I. Redistribution reactions of the tetraalkyls. J. Chromatogr.19:28-56.
171.
Poluektoff, N.S. (1935). On some reactions common to germanium dioxide and boric acid. Mikrochemie18:48-49.
172.
Prough, R.A., Stalmach, M.A., Wiebkin, P. et al. (1981). The microsomal metabolism of the organometallic derivatives of the group-IV elements, germanium, tin and lead. Biochem J.196:763-770.
173.
Radding, S.B. and Furst, A. (1980). A review of metals and carcinogenicity. In: Bhatnagar, R.S., Ed. "Molecular Basis of Environmental Toxicity." Ann Arbor, MI: Ann Arbor Science Pub., pp. 359-372.
174.
Reimann, B.E.F., Lewin, J.C. and Volcani, B.E. (1965). Studies on the biochemistry and fine structure of silica shell formation in diatoms. I. The structure of the cell wall of Cylindrotheca fusiformis. Cell Biol.24:39-55.
175.
Rice, G.W. (1983). Atmospheric-pressure nitrogen (APAN): a new source for analytical emission spectroscopy. Gov. Rep. Announce.134: Jan. 1982. NTIS D.E. 83-004985.
176.
Rice, L.M., Wheeler, J.W. and Geschickler, C.F. (1976). Spirans XXII. Synthesis of 4,4-dialkyl-4-germancyclohexanone and 8,8-dialkyl-8-germaaza-spiro(4,5)decanes . J. Heterocyc. Chem.11:1041-1046.
177.
Richter, O. (1906). Zur Physiologie der Diatomeen (I. Mitteiling) . Akad. Wiss. Wien, Math. Naturwiss. KL.115:27-119.
178.
Rochow, E.G. (1973). Germanium. In: Comprehensive Inorganic Chemistry. Eds. Bailar, J.C. et al. Oxford: Pergamon Press, vol. 2, pp. 1-41.
179.
Rochow, E.G. (1951). Introduction to the Chemistry of the Silicones. 2d Ed. New York: Wiley & Sons .
180.
Rosenfeld, G. (1954). Studies of the metabolism of germanium. Arch. Biochem. Biophys.48:84-94.
181.
Rosenfeld, G. and Wallace, E.J. (1953). Studies of the acute chronic toxicity of germanium. Arch. Indus. Hyg. Occup. Med.8:466-479.
182.
Rosenfeld, G. (1952). Studies of the determination, metabolism and acute toxicity of germanium. Ph.D. Thesis. Washington, DC: Georgetown Univ.
183.
Roth, R. and Werner, D. (1977). Thin layer chromatography studies with germanium-68 and germanium-71 as a tracer and extracts of the marine centric diatom Cyclotella cryptica. Z. Pflanzenphysiol.83:363-374.
184.
Salikova, G.E. and Sevryukov, N.N. (1970). Determination of germanium in hard coals. Zavod. Lab.36:25-27.
185.
Sandhu, G.K. and Sandhu, G.K. (1983). Toxicology of organometallic compounds of silicon, germanium, tin and lead. J. Chem. Sci.9:36-50.
186.
Sato, I., Yuan, B.D., Nishimura, T. et al. (1985). Inhibition of tumor growth and metastasis in association with modification of immune response by novel germanium compounds . J. Biol. Response Modif.4:159-168.
187.
Schein, P.S., Slavik, M., Smythe, T. et al. (1980). Phase I. Clinical trial of spirogermanium . Cancer Treat. Rep.64:1051-1056.
Schroeder, H.A. and Darrow, D.K. (1972). Relation of trace metals to human health. Environ. Affairs11:222-236.
190.
Schroeder, H.A. (1968a). Serum cholesterol levels in rats fed thirteen trace elements. J. Nutr.94:475-480.
191.
Schroeder, H.A., Kanisawa, M., Frost, D.V. et al. (1968b). Germanium, tin and arsenic in rats: Effects on growth, survival, pathological lesions and life span. J. Nutr.96:37-45.
192.
Schroeder, H.A. and Balassa, J.J. (1967a). Arsenic, germanium, tin and vanadium in mice: Effects on growth, survival and tissue levels. J. Nutr.92:245-252.
193.
Schroeder, H.A. and Balassa, J.J. (1967b). Abnormal trace metals in man: germanium. J. Chronic. Dis.20:211-224.
194.
Schulman, P., Davis, R.B., Rafla, S. et al. (1984). Phase II trial of spirogermanium in advanced renal cell carcinoma: A cancer and leukemia group B study. Cancer Treat. Rep.68:1305-1306.
195.
Schwartz, G.N., Biegel, J.A., Fisher, B. et al. (1983). Spirogermanium: Effects on hematopoietic stem cells and survival of normal and tumor-bearing mice. Proc. Soc. Exp. Biol. Med.173:176-180.
196.
Schwartz, G.N., Biegel, J.A. and Klein, I. (1981). Spirogermanium, a new chemotherapeutic agent. Evaluation on normal and malignant cell populations. Clin. Res.29:737A.
197.
Seinen, U. and Penninks, A. (1979). Immune suppression as a consequence of a selective cytotoxic activity of certain organometallic compounds on thymus and thymus-dependent lymphocytes. Ann. N. Y. Acad. Sci.320:499-517.
198.
Sijpesteijn, A.K. (1968). Growth inhibition of bacteria by tributylgermanium acetate and its reversal by blood constituents. Antonie LeeuwenhoekJ. Microbiol.34:85-92.
199.
Simpson, T.L., Gil, M. and Connes, R. (1985). Effects of germanium (Ge) on the silica spicules of the marine sponge Suberites domuncula transformation of spicule type. J. Morphol.183:117-128.
200.
Simpson, T.L. and Langenbruch, P.F. (1984). Effects of germanium on the morphogenesis of a complex silica structure and the assembly of the collagenous gemmule coat in a freshwater sponge. Biol. Cell50:181-190.
201.
Simpson, T.L., Garrone, R. and Mazzorana, M. (1983). Interaction of germanium (Ge) with biosilification in the freshwater sponge Ephydatia mulleri: evidence of localized membrane domains in the silicalemma. J. Ultrastruct. Res.85:159-174.
202.
Simpson, T.L. and Volcani, B. (1981). "Silicon and Siliceous Structures in Biological Systems." New York: Springer-Verlag .
203.
Simpson, T.L., Refolo, L.M. and Kaby, M.E. (1979). Effects of germanium on the morphology of silica deposition in a fresh water sponge. J. Morphol.159:343-354.
204.
Simpson, T.L. and Vaccaro, C.A. (1974). An ultrastructural study of silica deposition in the freshwater sponge Spongilla lacustris. J. Ultrastruct. Res.47:296-309.
205.
Slater, D. (1974). Tin. London: H.M.S.O., 41 p.
206.
Slavik, M., Blanc, O. and Davis, J. (1983). Spirogermanium: a new investigational drug of novel structure and lack of bone marrow toxicity. Invest. New Drugs1:225-234.
207.
Slavik, M., Elias, L., Ema, J. et al. (1982). Laboratory and clinical studies of spirogermanium, a novel heterocyclic anticancer drug. Drugs Under Exp. Clin. Res.8:379-386.
208.
Smith, R.D., Campbell, J.A. and Nielson, K.K. (1979). Concentration dependence upon particle size of volatilized elements in fly ash. Environ. Sci. Technol.13:553-558. Srivastava, T.N., Bhattacharya , S.N., Fandon, S.K. et al. (1968 ). Antifungal and antibacterial activity of aryltin and aryl-germanium compounds in-vitro Aspergillus niger, Trichophyton mentagrophytes, Candida albicans, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Salmonella typhimurium. Indian J. Microbiol.8:65-68. Stoemer, E.F., Pankratz , H.S. and Bowen, C.C. (1965). Fine structure of the diatom Amphypleura pellucida. II. Cytoplasmic fine structure and frustule formation. J. Bot.52:1067-1078.
209.
Subba Roa, D.V. (1980). Measurement of primary production in phytoplankton groups by size-fractionation and by germanic acid inhibition techniques. Oceanologica Acta3:31-42. Sullivan, C.W. and Volcani, B.E. (1973). Role of silicon in diatom metabolism. III. The effects of silicilic acid on DNA polymerase, TMP kinase, ethymidylate kinase and DNA synthesis in Cylindrothecafusiformis . Biochim. Biophys. Acta308:212-229. Summers, K.V., Rupp, G.L. and Gherini, S.A. (1983). Physical-chemical characteristics of utility solid wastes. E.P.R.I. Report EA-3236; Project 1487-12.
210.
Suzuki, F. and Pollard, R.B. (1984). Prevention of suppressed interferon gamma production in thermally injured mice by administration of a novel organogermanium compound, Ge-132. J. Interferon Res.4:223-233.
211.
Suzuki, T., Ishikawa, S., Motoyama, T. et al. (1980). Suppression and acceleration of experimental amyloidosis in mouse model. Acta Pathol. Jpn.30:557-564.
212.
Swaine, D.J. (1977a). Trace elements in coal. In: Trace Substances in Environmental Health - XI. Ed. Hemphill, D.D. Columbia, MO.: Univ. Missouri, pp. 107-116. Swaine , D.J. (1977b). Trace elements in fly ash. Bull. New Zealand DSIR127-131. Sweet, D.V., Crouse, W.E. and Crable, J.V. (1978). Chemical and statistical studies of contaminants in urban lungs. J. Am. Ind. Hyg. Assoc.39:515-526.
213.
Syo, S., Matsumoto, H. and Takahashi, E. (1975). Translocation and some forms of germanium in rice plants. Soil Sci. Plant Nutr.21:273-279.
214.
Tabor, E.C. and Warren, W.V. (1958). Distribution of certain metals in the atmosphere of some American cities. AMA. Arch. Ind. Health17:145-151.
215.
Takahashi, I., Fukumoto, M., Inagaki, N. et al. (1984). Effects of interferon and its inducers on neutrophil chemiluminescence. Gan To Kagaku Ryoho11:1439-1443. Tanaka, N., Ohida , J., Ono, M. et al. (1984). Augmentation of NK activity in peripheral blood lymphocytes of cancer patients by intermittent Ge-132 administration. Gan To Kagaku Ryoho11:1303-1306.
216.
Tatewaki, M. and Mitzumo, M. (1979). Growth inhibition by germanium dioxide in various algae, especially in brown algae. Jpn. J. Phycol.27:205-212.
217.
Tensho, K. and Yeh, K.L. (1972). Tracer study on preferential uptake of germanium by rice plants. Soil Sci. Plant Nutr.18:173-178.
218.
Tesarik, B. (1971). Germanium chloride and occupational safety. Pracovni Lekarstvi23:370-371.
219.
Thomas, W.H., Hollibaugh, J.T. and Seibert, D.L.R. (1980). Effects of heavy metals on the morphology of some marine phytoplankton. Phycologia19:202-209. Tomizawa, S., Suguro, N. and Kagoshima, M. (1978). Studies on general pharmacological effects of germanium compounds. Oyo Yakuri16:671-682.
220.
Trope, C., Mattsson, W., Gynning, I. et al. (1981). Phase II study of spirogermanium in advanced ovarian malignancy. Cancer Treat. Rep.65:119-120.
221.
Tsintsadze, K.I., Kvezereli, E.A., Lezhava, A.P. et al. (1984). Effect of some coordination compounds of germanium on the arterial pressure, electrocardiogram, and rheology of blood in dogs. Soobshch. Akad. Nauk. Gruz. SSR. 115:633-636.
222.
Valkovic, V., Makjanic, J., Jaksic, M. et al. (1984). Analyses of fly ash by x-ray emission spectroscopy and proton microbeam analysis. Fuel63:1357-1362.
223.
Vargo, G.A., Fanning, K.A. and Bell, L.M. (1983). Antarctic plankton and the marine geochemistry of radium-226, barium, and germanium. Antarct. J. U.S.18:174-176.
224.
Venugopal, B. and Luckey, T.D. (1978). Metal toxicity in mammals, Vol. 2. In: "Chemical Toxicity of Metals and Metalloids." New York: Plenum Press.
225.
Vinogradov, A.P. (1959). "The Geochemistry of Rare and Dispersed Chemical Elements in Soils." 2nd Ed. (Translated from the Russian). New York: Consultants Bureau.
226.
Volcani, B.J. (1977). The role of silicon in diatom metabolism and silification . In: "Biochemistry of Silicon and Related Problems." Eds. Bendz, G. and Lindqvist, I.New York: Plenum Press, pp. 177-204.
227.
Vouk, V.B. (1980). Germanium. In: "Handbook on the Toxicology of Metals." Eds. Friberg, L., Nordberg, G.F. and Vouk, V.B.Amsterdam: Elsevier, North-Holland , pp. 421-428.
228.
Vouk, V.B. (1977). Toxicology of metals. GermaniumU.S. Environ. Prot. Agency, Off. Res. Dev. [Rep.] EPA-600/1-77-022. Toxicol. Met., Vol. 2, 222-233.
229.
Wai, N. and Wang, J.S. (1969). Analysis of germanium in Taiwan coals. Bull. Inst. Chem. Acad. Sinica16:59-67.
230.
Weber, J.N., Ed. (1973). "Geochemistry of Germanium." Benchmark Papers in Geology, Vol. 11. Stroudsberg, PA: Dowden, Hutchinson & Ross, Inc.
231.
Weiselberg, L., Budman, D.R., Schulman, P. et al. (1982). Phase II trial of spirogermanium in advanced epithelial carcinoma of the ovary. Cancer Treat. Rep.66:1675-1676.
232.
Werner, D. and Petersen, M. (1973). Silicate metabolism in diatoms: tracer studies with germanium-71. Z. Pflanzenphysiol.70:54-65.
233.
Werner, D. (1971). The physiology and biochemistry of silicic acid . Ber. Mikrobiol.57:51-60.
234.
Werner, D. (1966). Die Kieselsaure im stoffwechsel von Cyclotella cryptica. Arch. Mikrobiol.55:278-308.
235.
Weser, U. (1968a). Inhibition of yeast alcohol dehydrogenase activity in the presence of germanate and borate. Hoppe-Seyler'sZ. Physiol. Chem.349:1479-1482.
236.
Weser, U. (1968b). Inhibition of o-diphenol oxidase activity by borate and germanate. Hoppe-Seyler'sZ. Physiol. Chem.349:982-988.
237.
Weser, U. (1968c). Influence of borates and germanate on the biosynthesis of RNA. Hoppe-Seyler'sZ. Physiol. Chem.349:989-994.
238.
Wooley, P.V., Ahlgren, J.D., Byrne, P.J. et al. (1984). A Phase I trial of spirogermanium administered on a continuous infusion schedule. Invest. New Drugs2:305-309.
239.
Wunderlich, E. and Gohring, E. (1959). Volumetric determination of germanium as pyrocatechol germanic acid. Z. Analyt. Chem.169:346-350.
240.
Yagi, Y. (1981). Structure of the reaction product of germanium dioxide and L-cysteine. Yakugaku Zasshi101:747-748.
241.
Yang, S.J. and Rafla, S. (1983). Effect of spirogermanium on V79 Chinese hamster cells. Am. J. Clin. Oncol.6:331-337.
