Proliferative Hepatocellular Lesions of the Rat: Review and Future Use in Risk Assessment

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Bannasch, P. (1976). Cytology and cytogenesis of neoplastic (hyperplastic) hepatic nodules. Cancer Res. 36:2555-2562.

Bannasch, P. , Mayer, D. and Hacker, H.J. (1980). Hepatocellular glycogenesis and hepatocarcinogenesis . Biochim. Biophys. Acta 605:217-245.

Bannasch, P. , Moore, M.A. , Klimek, F. and Zerban, H. (1982). Biological markers of preneoplastic foci and neoplastic nodules in rodent liver. Toxicol. Pathol. 10:19-37.

Berenblum, I. (1975). Sequential aspects of chemical carcinogenesis: Skin. In: Cancer: A Comprehensive Treatise ( F.F. Becker , ed.), V. 1, pp. 323-344. New York: Plenum.

DORLAND'S ILLUSTRATED MEDICAL DICTIONARY. (1974). 25th ed. Philadelphia: W.B. Saunders.

Emmelot, P. and Scherer, E. (1980). The first relevant stage in rat liver carcinogenesis. A quantitative approach. Biochim. Biophys. Acta 605:247-304.

Enomoto, K. and Farber, E. (1982). Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis. Cancer Res. 42:2330-2335.

Epstein, S. , Ito, N. , Merkow, L. and Farber, E. (1967). Cellular analysis of liver carcinogenesis: The induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism . Cancer Res. 27:1702-1711.

Farber, E. (1980). The sequential analysis of liver cancer induction . Biochim. Biophys. Acta 605:149-166.

10.

Farber, E. (1982). The biology of carcinogen-induced hepatocyte nodules and related liver lesions in the rat. Toxicol. Pathol. 10:197-205.

11.

Farber, E. (1984). Cellular biochemistry of the stepwise development of cancer with chemicals. G.H.A. Clowes Memorial Lecture. Cancer Res. 44:5463-5474.

12.

Farber, E. , Eriksson, L.C. , Roomi, M.W. , Cameron, R.G. and Hayes, M.A. (1984). Chemical carcinogenesis: Hepatocyte nodules with a special phenotype as a common step at the crossroads. Toxicol. Pathol. 12:288-290.

13.

Finklestein, S.D. , Lee, G. , Medline, A. , Tatematsu, M. , Makowka, M. and Farber, E. (1983). An experimental method for rapid growth of liver in spleen. The survival and proliferation of chemically induced preneoplastic hepatocytes in the spleen. Am. J. Pathol. 110:119-126.

14.

Goldfarb, S. (1973). A morphological and histochemical study of carcinogenesis of the liver in rats fed 3'-methyl-4-dimethylanimoazobenzene. Cancer Res. 33:1119-1128.

15.

Goldfarb, S. and Zak, F.G. (1961). Role of injury and hyperplasia in the induction of hepatocellular carcinoma. J. Am. Med. Assoc. 178:137-139.

16.

Goodman, D.G. , Ward, J.M. , SQUIRE, R.A., CHU, K.C. and LINHERT, M.S. (1979). Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol. Appl. Pharmacol. 48:237-248.

17.

Haseman, J.K. , Huff, J. and Boorman, G.A. (1984). Use of historical control data in carcinogenicity studies in rodents. Toxicol. Pathol. 12:126-135.

18.

Hirota, N. and Williams, G.M. (1979). Persistence and growth of rat liver neoplastic nodules following cessation of carcinogen exposure. J. Natl. Cancer Inst. 63:1257-1265.

19.

Kaufman, W.K. , Mackenzie, S.A. and Kaufman, D.G. (1985). Quantitative relationship between hepatocytic neoplasms and islands of cellular alteration during hepatocarcinogenesis in the male F344 rat. Am. J. Pathol. 119:171-174.

20.

Kimbrough, R.D. , Squire, R.A. , Linder, R.E. , Strandberg, J.D. , Mon-Talli, R.J. and Burse, V.W. (1975). Induction of liver tumors in Sherman strain female rats by polychlorinated biphenyl-Aroclor 1260. J. Natl. Cancer Inst. 55:1453-1459.

21.

Kitagawa, T. (1976). Sequential phenotypic changes in hyperplastic areas during hepatocarcinogenesis in the rat. Cancer Res. 36:2534-2539.

22.

Kitagawa, T. and Pitot, H.C. (1975). The regulation of serine dehydratase and glucose-6-phosphatase in hyperplastic nodules of rat liver during diethylnitrosamine and N-2-fluorenylacetamide feeding. Cancer Res. 35:1075-1084.

23.

Lee, G. , Tatematsu, M. and Makowka, L. (1983). The development of hepatocellular carcinoma from carcinogen-altered hepatocytes implanted in the spleen. Identification of a new cell population with relevance to cancer. AACR Proc. #422.

24.

Maronpot, R.R. (1985). Letter to B. Haberman, Carcinogen Assessment Group, August 14, 1985.

25.

Maronpot, R.R. and Boorman, G.A. (1982). Interpretation of rodent hepatocellular proliferative alterations and hepatocellular tumors in chemical safety assessment. Toxicol. Pathol. 10:71-80.

26.

Maronpot, R.R. , Montgomery, C.A. , JR., Boorman, G.A. and Mcconnell, E.E. (1986). National Toxicology Program nomenclature for hepatoproliferative lesions of rats. Toxicol. Pathol. 14:263-273.

27.

Mc Connell, E.E. , Solleveld, H.A. , Swenberg, H.A. and Boorman, G.A. (1986). Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies. J. Natl. Cancer Inst. 76:283-289.

28.

Moore, M.A. , Mayer, D. and Bannasch, P. (1982). The dose dependence and sequential appearance of putative preneoplastic populations induced in the rat liver by stop experiments with nitrosomorpholine. Carcinogenesis 3:1429-1436.

29.

Moore, M.A. , Hacker, H.J. and Bannasch, P. (1983). Phenotypic instability in focal and nodular lesions induced in a short-term system in the rat liver. Carcinogenesis 4:595-603.

30.

NATIONAL RESEARCH COUNCIL, National Academy of Sciences. (1983). Risk assessment in the federal government: Managing the process. Washington, D.C.: National Academy Press.

31.

National Toxicology Program (Ntp). (1984). Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation . U.S. Department of Health and Human Services. Public Health Service.

32.

Office Of Science And Technology Policy. ( 1985). Chemical carcinogens: A review of the science and its principles. Federal Register 50:10371-10442.

33.

Ogawa, K. , Medline, A. and Farber, E. (1979a). Sequential analysis of hepatic carcinogenesis: The comparative architecture of preneoplastic malignant, prenatal, postnatal and regenerating liver. Br. J. Cancer 40:782-790.

34.

Ogawa, K. , Medline, A. and Farber, E. (1979b). Sequential analysis of hepatic carcinogenesis: A comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal and regenerating liver. Br. J. Cancer 41:22-35.

35.

Ogawa, K. , Onoe, T. and Takeuchi, M. (1981). Spontaneous occurrence of gamma-glutamyl transpeptidase-positive hepatocytic foci in 105-week-old Wistar and 72-week-old Fischer 344 male rats . J. Natl. Cancer Inst. 67:407-412.

36.

Pitot, H.C. and Sirica, A.E. (1980). The stages of initiation and promotion in hepatocarcinogenesis . Biochim. Biophys. Acta 605:191-215.

37.

Pitot, H.C. , Barsness, L. , Goldsworthy, T. and Kitagawa, T. (1978). Biochemical characterization of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine. Nature 271:456-458.

38.

Popp, J.A. , Scortichini, B.H. and Carvey, L.K. (1985). Quantitative evaluation of hepatic foci of alteration occurring spontaneously in Fischer 344 rats. Fundam. Appl. Toxicol. 5:314-319.

39.

Popper, H. , Selikoff, I.J. , Maltoni, C. , Squire, R.A. and Thomas, L.B. (1977). Comparison of neoplastic hepatic lesions in man and experimental animals. In: Origins of Human Cancer ( H.H. Hiatt , J.D. Watson and J.A. Winsten , eds.), Book C, pp. 1359-1382. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory.

40.

Scherer, E. and Emelot, P. (1975). Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: Their contribution to hepatocarcinogenesis in the rat. Eur. J. Cancer 11:145-154.

41.

Scherer, E. and Emelot, P. (1976). Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis. Cancer Res. 36:2544-2554.

42.

Schulte-Hermann, R. , Timmermann-Trosiener, I. and Schuppler, J. (1982). Response of liver foci in rats to hepatic tumor promoters. Toxicol. Pathol. 10:63-71.

43.

Solt, D.B. , Medline, A. and Farber, E. (1977). Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis . Am. J. Pathol. 88:595-618.

44.

Squire, R.A. and Levitt, M.H. (1975). Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res. 35:3214-3223.

45.

STEDMAN'S MEDICAL DICTIONARY. (1982). 24th ed. Baltimore: Williams and Wilkins .

46.

Stenback, R. , Mori, H. , Furuya, K. and Williams, G.M. (1986). The pathogenesis of dimethylnitrosamine-induced hepatocellular cancer in hamster liver and a lack of enhancement by phenobarbital . J. Natl. Cancer Inst. 76:327-333.

47.

Stewart, H.L. (1980). Histological typing of liver tumors of the rat . J. Natl. Cancer Inst. 64:178-190.

48.

Stewart, H.L. , Williams, G.M. , Keysser, C.H. , Lombard, L.S. and Mon-Tali, R.J. (1980). Histologic typing of liver tumors of the rat. J. Natl. Cancer Inst. 64:177-207.

49.

SYMPOSIUM PANEL DISCUSSION. (

1982). Rodent liver nodules: Significance and human cancer risk. Toxicol. Pathol. 10:208-226.

50.

Tatematsu, M. , Nagamine, Y. and Farber, E. (1983). Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver. Cancer Res. 43:5049-5058.

51.

Teebor, G.E. and Becker, F.F. (1971). Regression and persistence of hyperplastic hepatic nodules induced by N-2-fluorenylacetamide and their relationship to hepatocarcinogenesis . Cancer Res. 31:1-3.

52.

Thorpe, E. , Bolt, H.M. , Elcombe, C.R. , Grasso, P. , Paglialunga, S. and Roe, F. (1982). Hepatocarcinogenesis in laboratory rodents: Relevance for man. Monograph No. 4. Brussels: European Chemical Industry Ecology and Toxicology Centre.

53.

Ulland, B.M. , Page, N.P. , Squire, R.A. , Weisburger, E.K. and Cypher, R.L. (1977). A carcinogenicity assay of Mirex in Charles River CD rats. J. Natl. Cancer Inst. 58:133-140.

54.

U.S. Environmental Protection Agency. (1986 ). Guidelines for carcinogen risk assessment. Federal Register 51:33992-34003 (September 24, 1986).

55.

Van Der Heijden, C.A. and Dormans, J.A.M.A. (1981). Short-term induction of neoplastic nodules in the rat liver. II. Study of their development and the effects of withdrawal of 2-acetylaminofluorene. Carcinogenesis 2:147-156.

56.

Wanson, J.C. , De Ridder, L. and Mosselmans, R. (1981). Invasiveness of hyperplastic nodule cells from diethylnitrosamine-treated rat liver. Cancer Res. 41:5162-5175.

57.

Ward, J.M. (1984). Morphology of potential preneoplastic hepatocyte lesions and liver tumors in mice and a comparison with other species. In: Mouse Liver Neoplasia ( J.J. Popp , ed.), pp. 1-26. New York: Hemisphere Publishing Corp.

58.

Ward, J.M. and Lynch, P.H. (1984). Transplantability of naturally occurring benign and malignant neoplasms and age-associated non-neoplastic lesions of the aging F344 rat as biological evidence for the histological diagnosis of neoplasms . Cancer Res. 44:2608-2615.

59.

Ward, J.M. , Sontag, J.M. , Weisburger, E.K. and Brown, C.A. (1975). Effect of lifetime exposure to aflatoxin B 1 in rats. J. Natl. Cancer Inst. 55:107-113.

60.

Watanabe, K. and Williams, G.M. (1978). Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: Evidence that foci are precursors of neoplasms and that the promoter acts on carcinogen-induced lesions. J. Natl. Cancer Inst. 61::1311-1314.

61.

Williams, G.M. (1976). Functional markers and growth behavior of preneoplastic hepatocytes. Cancer Res. 36:2540-2543.

62.

Williams, G.M. (1980). The pathogenesis of rat liver cancer caused by chemical carcinogens. Biochim. Biophys. Acta 605:167-189.

63.

Williams, G.M. (1981). Liver carcinogenesis: The role for some chemicals of an epigenetic mechanism of liver-tumor promotion involving modification of the cell membrane. Food Cosmet. Toxicol. 19:577-583.

64.

Williams, G.M. (1982). Phenotypic properties of preneoplastic rat liver lesions and applications to detection of carcinogens and tumor promoters. Toxicol. Pathol. 10:3-10.

65.

Williams, G.M. and Watanabe, K. (1978). Quantitative kinetics of development of N-2-fluorenylacetamide-induced altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen. J. Natl. Cancer Inst. 61:113-121.