Historical Background of 6-Mercaptopurine

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Elion, G.B. , Singer, S. and Hitchings, G.H. (1954). Microbiological effects of 6-mercaptopurine. Ann. N.Y. Acad. Sci. 60:200-206.

Elion, G.B. , Callahan, S. , Rundles, R.W. and Hitchings, G.H. (1963). Relationship between metabolic fates and antitumor activities of thiopurines. Cancer Res. 23:1207-1217.

Elion, G.B. (1967). The biochemistry and pharmacology of purine analogs . Fed. Proc. 26:898-904.

Elion, G.B. (1975). Interaction of anticancer drugs with enzymes. In: Pharmacological Basis of Cancer Chemotherapy, M.D. Anderson Hospital and Tumor Institute, pp. 547-564. Baltimore: Williams and Wilkins Co.

Elion, G.B. (1985). Selectivity-Key to Chemotherapy: Presidential Address. Cancer Res. 45:2943-2950.

Hitchings, G.H. , Elion, G.B. , Falco, E.A. , Russell, P.B. and Vander Werff, H. (1950). Studies on analogs of purines and pyrimidines. Ann. N.Y. Acad. Sci. 52:1318-1355.

Hitchings, G.H. and Elion, G.B. (1972a). Mechanism of action of purine and pyrimidine analogues. In: Cancer Chemotherapy II, The Twenty-Second Hahnemann Symposium (ed. I. Brodsky , S.B. Kahn and J.H. Moyer ), pp. 23-32. New York: Grune and Stratton.

Hitchings, G.H. and Elion, G.B. (1972b). Specificities of purine metabolizing enzymes and implications for chemotherapy. In: The Purines-Theory and Experiment. The Jerusalem Symposia on Quantum Chemistry and Biochemistry IV , pp. 565-578. Jerusalem: Israel Academy of Sciences and Humanities .

Hitchings, G.H. and Elion, G.B. (1985). Layer on Layer: The Bruce F. Cain Memorial Lecture . Cancer Res. 45:2415-2420.

Philips, F.S. , Sternberg, S.S. , Hamilton, L. and Clarke, D.A. (1954). The toxic effects of 6-mercaptopurine and related compounds. Ann. N.Y. Acad. Sci. 60:283-296.

Zimmerman, T.P. , Chu, L.-C. , Bugge, C.J.L. , Nelson, D.J. , Lyon, G.M. and Elion, G.B. (1974). Identification of 6-methylmercaptoribonucleoside 5'-diphosphate and 5'-triphosphate as metabolites of 6-mercaptopurine in man . Cancer Res. 34:221- 224.