This paper describes EPA's recent efforts to ensure consistency and technical competence of the agency's risk assessments. These include five risk assessment guidelines proposed in November 1984 and January 1985 and establishment of a Risk Assessment Forum. The technical provisions of the five guidelines have been outlined.
Get full access to this article
View all access options for this article.
References
1.
Alm, A.L. (1984). Risk assessment, May 21, 1984, unpublished memorandum.
2.
Anderson, E.L. (1983). Report of the Risk Assessment Subcommittee, November 17, 1983, unpublished memorandum.
3.
Anderson, E.L. and Carcinogen Assessment Group Of The U.S. Environmental Protection Agency. (1983). Quantitative approaches in use to assess cancer risk. Risk Analysis3: 277-295.
4.
Anderson, E.L. (1985). EPA's new risk assessment guidelines—Their application in regional operations. Paper presented at the Risk Assessment Conference, sponsored by EPA Region IV, Atlanta, GA.
5.
Dellarco, V.L., Voytek, P.E. and Hollaender, A., eds. ( 1985). Aneuploidy: Etiology and Mechanisms. Proceedings of a Conference held March 25-29, 1985. Plenum Press, New York. (In press).
6.
International Agency For Research On Cancer. ( 1982). IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Supplement 4, Lyon, France.
7.
National Research Council. (1982). Identifying and Estimating the Genetic Impact of Chemical Mutagens. National Academy Press, Washington, DC .
8.
National Research Council. (1983). Risk Assessment in the Federal Government: Managing the Process. National Academy Press, Washington, DC.
9.
Nelson, N. (1985). Letter to Lee M. Thomas, Administrator, U.S.E.P.A., June 19, unpublished letter. Available from Science Advisory Board, U.S.E.P.A., Washington, DC 20460.
10.
U.S. Environmental Protection Agency. (1976 ). Interim procedures and guidelines for health risk and economic impact assessments of suspect carcinogens. Federal Register41: 21402-21405.
11.
U.S. Environmental Protection Agency. (1980 a). Mutagenicity risk assessments: proposed guidelines. Federal Register45: 74984-74988.
12.
U.S. Environmental Protection Agency. (1980 b). Ambient water quality criteria documents: notice of availability . Federal Register45: 79317-79379.
13.
U.S. Environmental Protection Agency. (1982 ). Assessment of Risks to Human Reproduction and to Development of the Human Conceptus from Exposure to Environmental Substances. Proceedings of U.S.E.P.A.-sponsored conferences, October 1-3, 1980 and December 7-10, 1980. EPA-600/9-82-001 and ORNL/EIS-197. Available from National Technical Information Service, Springfield, VA 22161, DE82-007897.
14.
U.S. Environmental Protection Agency. (1983 ). Guidance for performing exposure assessments. Unpublished agency draft. Available from Science Advisory Board, U.S. E.P.A. , Washington, DC 20460.
15.
U.S. Environmental Protection Agency. (1984 a). Approaches to Risk Assessment for Multiple Chemical Exposures: Workshop Proceedings. EPA-600/9-84-008. Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office , Cincinnati. Available from National Technical Information Service, Springfield, VA 22161.PB84-182369.
16.
U.S. Environmental Protection Agency. (1984 b). Selected Approaches to Risk Assessment for Multiple Chemical Exposures. Progress Report on Guideline Development. EPA-600/ 9-84-014a. Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati. Available from National Technical Information Service, Springfield, VA 22161.PB84-226992.
17.
U.S. Environmental Protection Agency. (1984 c). Proposed guidelines for carcinogen risk assessment. Federal Register49: 46294-46301.
18.
U.S. Environmental Protection Agency. (1984 d). Proposed guidelines for exposure assessment. Federal Register49: 46304-46312.
19.
U.S. Environmental Protection Agency. (1984 e). Proposed guidelines for mutagenicity risk assessment. Federal Register49: 46314-46321.
20.
U.S. Environmental Protection Agency. (1984 f). Proposed guidelines for the health assessment of suspect developmental toxicants. Federal Register49:46324-46331.
21.
U.S. Environmental Protection Agency. (1984 g). Risk Assessment and Management: Framework for Decision Making. EPA-600/9-85-002. Available from Office of Policy, Planning, and Evaluation, U.S.E.P.A., Washington, DC 20460.
22.
U.S. Environmental Protection Agency. (1984 h). Workshop Proceedings: Approaches for Improving the Assessment of Human Genetic Risk—Human Biomonitoring. Office of Health and Environmental Assessment. EPA 600/9-84-016. Available from National Technical Information Service, Springfield, VA 22161.PB85-103018.
23.
U.S. Environmental Protection Agency. (1985 ). Proposed guidelines for the health risk assessment of chemical mixtures. Federal Register50:1170-1176.
24.
U.S. Office Of Science And Technology Policy. ( 1985). Chemical carcinogens: A review of the science and its associated principles, February 1985. Federal Register50:10372-10442.
25.
World Health Organization. (1984). Principles for evaluating health risks to progeny exposed to chemicals during pregnancy. Environmental Health Criteria #30. International Programme on Chemical Safety, Vienna, Austria. Available from WHO Centre-USA, 49 Sheridan Avenue, Albany, NY 12210 or UN Bookshop, New York, NY 10017.
