Pretreatment of hamster embryo cells or mouse C3H/10T-1/2 cells with sodium bisulfite (0.5, 2.5, 5.0 and 100 ppm) inhibits the oncogenic transformation of the cells following their exposure to x-rays or benzo(a)pyrene. The results suggest that low doses of bisulfite, a widely used food additive, can serve as a radioprotective and chemopreventive agent with anticarcinogenic potential.
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References
1.
Borek, C. (1982). Vitamins and micronutrients modify carcinogenesis and tumor promotion in vitro. In: Molecular Interrelations of Nutrition and Cancer (M.S. Arnott, J. van Eys and Y.M. Wang eds.), pp. 337-350. Raven Press, New York.
2.
Borek, C. and Troll, W. (1983). Modifiers of free radicals inhibit in vitro the oncogenic actions of x-rays, bleomycin, and the tumor promoter 12-0-tetradecanoylphorbol 13-acetate. Proc. Natn. Acad. Sci. U.S.A.80:5749-5752.
3.
Borek, C. (1984). In vitro cultures as tools in the study of free radical and free radical modifiers in carcinogenesis. In: Methods in Enzymology (L. Packer ed.) Vol. 105, pp. 464-479.
4.
Borek, C. (1984a). Permissive and protective factors in malignant transformation of cells in culture. In: The Biochemical Basis of Chemical Carcinogenesis (H. Greim, R. Juna, M. Kraemer, H. Marquardt and F. Oesch eds.), pp. 175-188. Raven Press, New York.
5.
Borek, C. and Biaglow, J.E. (1984). Factors controlling cellular peroxide breakdown: Relevance to selenium protection against radiation and chemically induced carcinogenesis: Proc. Am. Ass. Cancer Res.25:125 (abstract).
6.
Borek, C. (1985). The induction and control of radiogenic transformation in vitro: Cellular and molecular mechanisms. Pharmac. Ther.27:99-142.
7.
Borek, C.Ong, A., Donohue, L. and Biaglow, J.E. (1985, in press). Selenium protects against in vitro radiation and chemically induced transformation.
8.
Calle, L.M. and Sullivan P.D. (1982). Screening of antioxidants and other compounds for antimutagenic properties towards benzo(a)pyrene-induced mutagenicity in strain TA98 of Salmonella typhimurium. Mutat. Res.101:99-114.
9.
Dipaolo, J.A., Demarinis, A.J. and Doniger, J. (1981). Transformation of Syrian hamster embryo cells by sodium bisulfite. Cancer Letters12:203-208.
10.
Institute Of Food Technologists And Committee On Public Information. (1976). Sulfite as food additives. Nutr. Rev.34:58-62.
11.
Miller, R.C., Geard, C.R., Osmak, R.S., RUTLEDGE-FREEMAN, M., ONG, A., MASON, H., NAPHOLZ, A., PEREZ, N., HARISIADIS, L. and BOREK C. (1981). Modified of sister chromatid exchange and radiation-induced transformation in rodent cells by the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate and two retinoids. Cancer Res.41:655-659.
12.
Reznikoff, C.A., Bertram, J.S., Brankow, D.W. and Heidelberger, C. (1973). Quantitative and qualitative studies of chemical transformation of cloned mouse C3H/ 10T-1/2 mouse embryo cells sensitive to post confluence inhibition of cells division. Cancer Res.33:3239-3249.
13.
Schroeter, L.C. (1966). Sulfur dioxide. Applications in foods, beverages, and pharmaceuticals. Pergamon Press, Oxford.
