Cr (III) genotoxicity and oxidative stress: An occupational health risk for leather tannery workers of South Asian developing countries

Abstract

In the leather industry, Cr (III) is used as a basic tanning agent. The wastewater discharged from the tannery industry contains a high concentration of chromium. Recent studies indicate the genotoxic effects especially DNA damage and oxidative stress of Cr (III) in tannery workers. Cr (III) interacts with DNA to form DNA cross-links and DNA strand breaks. It also modifies the oxidative DNA base through the Haber–Weiss reaction. The present study is based on an overview of scientific literature and previous observations regarding the effects of tannery chromium effluents on exposed workers and the population in the vicinity. This study strongly suggests for use of a non-toxic substitute of chromium to be used for the tanning process and placement of tannery industries on the outskirts of the city. In South Asian developing countries like India, Pakistan and Bangladesh where the economy is strongly dependent on leather manufacturing industries, there is a need to spread proper information regarding the harmful effects of chromium toxicity to the workforce employed in the tannery and also to the people living in the surrounding area. Workers should be provided with the required safety protections like gloves, aprons, foot/shoe covers, masks, etc. Last but most important on an immediate basis is the installation of the proper efficient waste treatment plant, so that, waste should be treated before moving out of the industry.