Despite the wide use of cosmetic products, they exert a number of health effects on tissues ranging from irritation to cancer. Our study aimed at assessing the effect of formaldehyde on lipid peroxidation and verifying the susceptibility to carcinogenesis using p53 as a biomarker among workers exposed to formaldehyde in cosmetic industry. Our entire exposed group (n = 40) and the controls (n = 20) were subjected to estimation of formate in urine, serum malondialdehyde (MDA), and p53. Also, complete blood picture, liver, and kidney function tests were carried out. The study revealed significant increase in the levels of formate, MDA, and p53 in the exposed group compared with their control group. Our results showed that workers in cosmetic industry had significant exposure to formaldehyde. Furthermore, the study pointed to the negative impact of formaldehyde as a cause of oxidative stress and suspicious carcinogen.
ATSDR (1999) Agency for Toxic Substances and Disease Registry, Public Health Statement for Formaldehyde, the Summary Chapter from the Toxicological Profile for Formaldehyde. Atlanta, GA: Department of Health and Human Services.
2.
BarnhamKJMastersCLBushAI (2004) Neurodegenerative diseases and oxidative stress. Nature Reviews Drug Discover3: 205–214.
3.
BoenigerMF (2000) Formate in urine as a biological indicator of formaldehyde exposure. American Industrial Hygiene Association Journal48(11): 900–908.
4.
BojJRMarcoICortésO. (2003) The acute nephrotoxicity of systemically administered formaldehyde in rats. European Journal of Pediatric Dentistry4(1): 16–20.
5.
BoyapatiAKanbeEZhangDE (2004) p53 alterations in myeloid leukemia. Acta Hematologica111: 100–106.
6.
ChangJRXuDQ (2006) Effects of formaldehyde on the activity of superoxide dismutases and glutathione peroxidase and the concentration of malondialdehyde. Journal of Hygiene Research35(5): 653–655.
7.
CikmazSKutogluTKanterM. (2010) Effect of formaldehyde on rat liver: alight and electron microscopic study. Journal of Toxicology and Industrial Health26(2): 113–119.
8.
CoggonDHarrisECPooleJ. (2003) Extended follow-up of a cohort of British chemical workers exposed to formaldehyde. Journal of National Cancer Institute95(21): 1608–1615.
9.
De TataVLorenziniGCecchiL. (2001) Age-related changes in the urinary excretion of aldehydes in ad libitum fed and food-restricted rats. Experimental Gerontology36(3): 507–518.
10.
DonggeunSHyunsookKEunhaO. (2007) Gene expression profiling in lung tissues from rate exposed to formaldehyde. Archives of Toxicology81(8): 589–587.
11.
DynnesDStig-EgilBAnneTBorgeN (2007) Tumor supperssor p53 Arg72pro polymorphism and longevity, cancer survival, and risk of cancer in the general population. Journal of Experimental Medicine204(6): 1295–1301.
12.
El-MisseryASamahaHHamayS (2007) Renal toxicity by free radicals. Egyptian Journal of Occupational Medicine31: 140–145.
13.
El-ZayadiA (2006) Heavy smoking and liver. World Journal of Gastroenterology12(38): 6098–6101.
14.
Environmental Protection Agency (EPA) (2010) An introduction to indoor air quality (IAQ), formaldehyde. Washington: National Center for Environmental Assessment, Office of Research and Development.
15.
FarmerEEDavoineC (2007) Reactive electrophile species. Journal of Current Opinion of Plant Biology10(4): 380–386.
16.
FranksJ (2005) A mathematical model for the absorption and metabolism of formaldehyde vapour by humans. Toxicology and Applied Pharmacology206(3): 309–320.
17.
FreemanBLBlairALubinJH (2009) Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries. Journal of the National Cancer Institute101(10): 751–761.
18.
GaballahIFarahatS (2001) Chromosomal aberrations and lymphocyte subsets in workers chronically exposed to formaldehyde vapor. Medical Journal of Cairo University69(4): 803–810.
19.
GalbiatiGMuracaMMitryRR. (2010) Bilirubin, a physiological antioxidant, can improve cryopreservation of human hepatocytes. Journal of Pediatric Gastroenterology and Nutrition50(6): 691–693.
20.
HansenROrenM (1997) p53: from inductive signal to cellular effect. Current Opinion in Genetics and Development7(1): 46–51.
21.
HauptmannMLubinJHStewartPA. (2003) Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries. Journal of the National Cancer Institute95(21): 1615–1623.
22.
HauptmannMStewartPALubinJH (2009) Mortality from lymphohematopoietic malignancies and brain cancer among embalmers exposed to formaldehyde. Journal of the National Cancer Institute101(24): 2010–2020.
23.
HopnerTKnappeJ (1974) Formate determination with formate dehydrogenase. In: BergmeyerHUx
(ed) Methods of Enzymatic Analysis. 2nd ed., Vol. 3. New York: Academic press, p. 1551.
24.
HPA (2008) Formaldehyde, summary of health effects. Health Protection Agency8: 156–160.
25.
JiCRouzerCAMarnettLJ. (1998) Induction of cell cycle arrest by the endogenous product of lipid peroxidation, malondialdehyde. Journal of Carcinogenesis19(7): 1275–1283.
26.
KimREmiMTanabeK (2007) Cancer immune-editing from immune surveillance to immune escape. Journal of Immunology121(1): 1–14.
27.
MillikanLE (2001) Cosmetology, cosmetics, cosmeceuticals: definitions and regulations. Journal of Clinical Dermatology19(4): 371–374.
28.
National Toxicological Program (2010) Final report on carcinogens background document for formaldehyde. Report on Carcinogens (10–5981): 1–512.
29.
National Cancer Institute (NCI) (2009) Formaldehyde exposure among industrial workers is associated with increased risk of cancers of the blood and lymphatic system. Washington: National Cancer Institute, National Center for Environmental Assessment, Office of Research and Development.
30.
NiranjanakumariSLasdaEBrazasR. (2002) Reversible cross-linking combined with immunoprecipitation to study RNA–protein interactions in vivo methods. Journal of Cancer26(2): 182–190.
31.
OttMGTetaMJGreenberg (1989) Lymphatic and hematopoietic tissue cancer in a chemical manufacturing environment. American Journal of Industrial Medicine16(6): 631–643.
32.
PartanenTKauppinenTLuukkonenR. (1993) Malignant lymphoma and leukemia and exposures in wood industry an industry based case-referent study. International Archive of Occupational Environmental Health64(8): 593–596.
33.
PekmezHNerimanCCDsmailZ. (2008) The effect of melatonin hormone on formaldehyde-induced liver injury: a light microscopic and biochemical study. Fırat Tıp Dergisi13(2): 92–97.
34.
PetushokNEPetushokBGEl’chaninovaMA. (2005) Functional activity of blood and liver cells under formaldehyde intoxication via inhalation. Journal of Biomeditsinskaia Khimiia51(1): 76–80.
35.
PinheiroNAVillaLL (2001) Low frequency of p53 mutations in cervical carcinomas among Brazilian women. Brazilian Journal of Medical Biology34(6): 727–733.
36.
PinkertonLEHeinMJStaynerLT (2004) Mortality among a cohort of garment workers exposed to formaldehyde: an update. Occupational and Environmental Medicine61(3): 193–200.
37.
RastogiCJeanneDTorkilM (2006) Natural ingredients based cosmetics. Contact Dermatitis Journal34: 423–426.
38.
RenJ (2007) Influence of gender on oxidative stress, lipid peroxidation, protein damage and apoptosis in hearts and brains from hypertensive rats. Clinical and Experimental Pharmacology and Physiology34: 432–438.
39.
SatohK (1978) Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clinica Chimica Acta90: 37–43.
40.
ShahamBomstein YGurvichR. (2003) DNA–protein crosslinks and p53 protein expression in relation to occupational exposure to formaldehyde. Occupational and Environmental Medicine60(6): 403–409.
41.
SternFB (2003) Mortality among chrome leather tannery workers: an update. American Journal of Industrial Medicine44(2): 197–206.
42.
SugimotoKSasakiMIsobeY. (2008) Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1. Oncogene Journal27(22): 3091–3101.
43.
TangMXieYYiY. (2003) Effects of formaldehyde on germ cells of male mice. Journal of Hygiene Research32(6): 544–548.
44.
TangXQRenYKChenRQ. (2011) Formaldehyde induces neurotoxicity to PC12 cells involving inhibition of paraoxonase-1 expression and activity. Clinical and Experimental Pharmacology and Physiology3: 160–167.
45.
TengSBeardKPourahmadJ. (2001) The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes. Chemico-biological Interactions130–132(1–3): 285–296.
46.
ThomasRJanisMKennethE. (2004) Formaldehyde poisoning. Journal of American Medical Association11: 1237–1238.
47.
ValkoMRhodesbCJMoncolaJ. (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological Interactions160(1): 150–160.
48.
UpadhyaSSubramanyaUSKrishnaMK. (2004) Oxidant–antioxidant status in colorectal cancer patients before and after treatment. Indian Journal of Clinical Biochemistry19(2): 80–83.
49.
YingCJYeXLXieH. (1999) Lymphocyte subsets and sister chromatid exchanges in the students exposed to formaldehyde. Biochemical and Environmental Sciences12: 88–94.
50.
ZhangLStienmausCEastmondDA. (2009) Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutation Research Journal681(2–3): 150–168.
