As part of its mandate, the Agency for Toxic Substances and Disease Registry prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation and Liability Act, National Priorities List sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Tungsten. The primary purpose of this article is to provide interested individuals with environmental information on tungsten that includes production data, environmental fate, potential for human exposure, analytical methods and a listing of regulations and advisories. Toxicology and Industrial Health 2007; 23: 309—345
Acgih.2003: Tungsten. Threshold limit values for chemical substances and physical agents and biological exposure indices. American Conference of Governmental Industrial Hygienists.
2.
Agency for Toxic Substances and Disease Registry.2003: Health consultation: Public comment release. Churchill County tap water. Fallon leukemia project. Fallon, Churchill County, Nevada, July 18, 2003. Agency for Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov. January 04, 2005.
3.
Agency for Toxic Substances and Disease Registry.2004: Toxicological profile for cobalt. Agency for Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov/toxprofiles/tp33.pdf. April 27, 2005 .
4.
Agency for Toxic Substances and Disease Registry.2005b: Toxicological profile for nickel. Agency for Toxic Substances and Disease Registry.
5.
Arnársson, S. and Lindvall, R.2001: The distribution of arsenic, molybdenum and tungsten in natural waters in basaltic terrain, N-Iceland. In Cidu, R., editor, Water-rock interaction: Proceedings of the tenth international symposium on water-rock interaction, WRI-10, Villasimius Italy, 10—15 July 2001. Rotterdam, Netherlands: AA. Balkema, 961—964.
Auchincloss, J.H., Abraham, J.L., Gilbert R. et al. 1992: Health hazard of poorly regulated exposure during manufacture of cemented tungsten carbides and cobalt. British Journal of Industrial Medicine49, 832—6.
8.
Bachthaler, M., Lenhart, M., Paetzel, C. et al. 2004: Corrosion of tungsten coils after peripheral vascular embolization therapy: Influence on outcome and tungsten load. Catheterization and Cardiovascular Interventions62(3), 380—84.
9.
Bárány, E., Bergdahl, I.A., Bratteby, L-E., et al. 2002a: Trace elements in blood and serum of Swedish adolescents: Relation to gender, age, residential area, and socioeconomic status. Environmental Research89(Section A), 72—84.
10.
Bárány, E., Bergdahl, I.A., Bratteby, L-E. et al. 2002b: Trace element levels in whole blood and serum from Swedish adolescents. Science of the Total Environment286, 129—41.
11.
Berg, T. and Steinnes, E.1997: Use of mosses (Hylocomium splendens and Pleurozium schreberi) as biomonitors of heavy metal deposition: From relative to absolute deposition values. Environmental Pollution98(1), 61—71.
12.
Bibak, A., Behrens, A., Sturup, S. et al. 1998: Concentrations of 63 major and trace elements in Danish agricultural crops measured by inductively coupled plasma mass spectrometry. 1. Onion (Allium cepa Hysam). Journal on Agricultural Food andChemistry46, 3139—45.
13.
Bidleman, T.F.1988: Atmospheric processes. Wet and dry deposition of organic compounds are controlled by their vapor-particle partitioning. EnvironmentScience and Technology22, 361—7.
14.
Bingham, E., Cohressen, B. and Powell, C.H.2001: Tungsten. In Patty's toxicology . John Wiley & Sons, 106—128.
15.
Bowen, H.J.M.1960: The determination of tungsten in biological material by activation analysis. Biochemical Journal77, 79—82.
16.
Bowen, H.J.M.1966: Trace elements in biochemistry. Academic Press, 118—84.
17.
Brune, D., Nordberg, G. and Wester, P.O.1980: Distribution of 23 elements in the kidney, liver and lungs of workers from a smeltery and refinery in north Sweden exposed to a number of elements and of a control group. Science of the Total Environmemt16, 13—35.
18.
CDC.2003a: Second national report on human exposure to environmental chemicals. Department of Health and Human Services, Centers for Disease Control and Prevention, 45—47.
19.
CDC.2003b: Cross sectional exposure assessment of environmental contaminants in Churchill County, Nevada . Centers for Disease Control and Prevention, 1—47.
20.
CDC.2003c: Churchill County (Fallon), Nevada exposure assessment. Follow-up investigation: Exposure to tungsten in three Nevada communities. Centers for Disease Control and Prevention. http://www.cdc.gov/nceh/clusters/fallon/tungsten_report.pdf. December 28, 2004.
21.
Cotton, F.A. and Wilkinson, G., editors. 1980: Chemistry of the transition elements. In Advanced inorganic chemistry: A comprehensive text. John Wiley and Sons, 844—83.
22.
Dames, R., Robbins, J.A. and Rahn, K.A.1970: Nondestructive neutron activation analysis of air pollution particulates. Analytical Chemistry42(8), 861—7.
23.
Dermatas, D., Braida, W., Christodoulatos, C. et al. 2004: Solubility, sorption, and soil respiration effects of tungsten and tungsten alloys. Environmental Forensics5(1), 5—13.
24.
EPA.1997: Automated Form R for Windows: User's guide (RY97). U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics.
25.
EPA.2005a: Effluent guidelines and standards. Nonferrous metals manufacturing point source category. U.S. Environmental Protection Agency. Code of Federal Regulations 40CFR 421.100.
26.
EPA.2005b: Effluent guidelines and standards. Nonferrous metals manufacturing point source category. U.S. Environmental Protection Agency. Code of Federal Regulations 40CFR 421.310.
27.
Fedrip.2004: Dialog Information Systems, IncPalo Alto, CA: Federal Research in Progress.
28.
Feldmann, J. and Cullen, W.R.1997: Occurrence of volatile transition metal compounds in landfill gas: synthesis of molybdenum and tungsten carbonyls in the environment. EnvironmentScience and Technology31, 2125—9.
29.
Fernandez, M.A., Martinez, L., Segarra, M. et al. 1992: Behavior of heavy metals in the combustion gases of urban waste incinerators. EnvironmentScience and Technology26(5), 1040—7.
30.
Ferri, T., Morabito, R., Sangiorgio, P. et al. 1999: Determination of As, Mo, V, W in environmental samples. Annali di Chimica89(9—10), 699—710.
31.
Frank, A. and Peterson, L.R.1983: Selection of operating conditions and analytical procedure in multimetal analysis of animal tissue by d.c. plasma-atomic emission spectroscopy . Spectrochimica Acta, Part B38B(1—2), 207—20.
32.
Freitas, M.C., Vaz Carreiro, M.C.Reid, M.F. et al. 1988: Determination of the level of some heavy metals in an aquatic ecosystem by instrumental neutron activation analysis . Environment Technology and Letters9, 969—76.
33.
Fu, M.H. and Tabatabai, M.A.1988: Tungsten content of soils, plants, and sewage sludges in Iowa USA. Journal of EnvironmentalBiology17(1), 146—8.
34.
Furr, A.K., Lawrence, A.W., Tong, S.S.C. et al. 1976: Multielement and chlorinated hydrocarbon analysis of municipal sewage sludges of American cities. EnvironmentScience and Technology10(7), 683—7.
35.
Germani, M.S., Small, M.Z. et al. 1981: Fractionation of elements during copper smelting. EnvironmentScience and Technology15(3), 299—305.
36.
Graney, J.R., Landis, M.S., Norris, G.A.2004: Concentrations and solubility of metals from indoor and personal exposure PM2.5 samples. Atmospheric Environment38(2), 237—47.
37.
Haddad, E. and Zikovsky, L.1985: Determination of Al, As, Cr, Cs, Fe, Mn, Sb, Sc, W and Zn in the workroom air by instrumental neutron activation analysis. Journal of Radioanalytical and NuclearChemistry93(6), 371—8.
38.
Hall, G.E.M., Jefferson, C.A., Michel, F.A.1988: Determination of tungsten and molybdenum in natural spring waters by ICP-AES (inductively coupled plasma atomic emission spectrometry) and ICP-MS (inductively coupled plasma mass spectrometry): Application to South Nahanni River area, N.W.T., Canada. Journal of Geochemical Exploration30(1), 63—84.
39.
Hartung, M.1991: Tungsten. In Merian, E. , ed. Metals and their compounds in the environment. Weinheim, VCH, 1269—72.
40.
HazDat.2005: HazDat database: ATSDR's Hazardous Substance Release and Health Effects Database. Agency for Toxic Substances and Disease Registry. www.atsdr.cdc.gov/hazdat.html. April 2005.
41.
Hsdb.2004: Tungsten. Hazardous Substances Data Bank. National Library of Medicine. http://toxnet.nlm.nih.gov. December 2004.
42.
Huang, C-Y., Ming, L.N., Shu-Yu, L. et al. 2002: Determination of vanadium, molybdenum and tungsten in complex matrix samples by chelation ion chromatography and on-line detection with inductively coupled plasma mass spectrometry. Analytica Chimica Acta466(1), 161—74.
43.
Hull, R.D. and Haartz, J.C.1980: Determination of soluble/ insoluble tungsten compounds as discrete entities in industrial hygiene samples. Analytica Chimica Acta121, 187—96.
44.
Iris.2005: Integrated Risk Information System. U.S. Environmental Protection Agency.
45.
Itia.2003: The lone ranger may have used silver bullets, but the US Army plans to go green. International Tungsten Industry Association. http://www.itia.org.uk/resources/resources_1.html. April 27, 2005.
46.
Itia.2004: December 2004 Newsletter . International Tungsten Industry Association. http://www.itia.org.uk/FileLib/newsletter_dec04.pdf. December 30, 2006.
47.
Iyengar, G.V., Kollmer, W.E., Bowen, H.J.M.1978: The elemental composition of human tissues and body fluids: A compilation of values for adults. Verlag Chemie.
48.
Jagielak, J. and Mamont-Ciesla, K.1979: Relationships among concentrations of airborne metals in industrial districts. Journal of Radioanalytical chemistry52(2), 461—70.
49.
Jeran, Z., Jacimovic, R., Batic, F. et al. 1996: Atmospheric heavy metal pollution in Slovenia derived from results for epiphytic lichens. Fresenius Journal of Analytical Chemistry354(5—6), 681—7.
50.
Johannesson, K.H., Lyons, W.B., Graham, E.Y. et al. 2000: Oxyanion concentrations in eastern Sierra Nevada rivers - 3 boron, molybdenum, vanadium, and tungsten. AquaticGeochemistry6(1), 19—46.
51.
Kist, A.A.1994: Investigation of element speciation in atmosphere . Biological Trace Element Research43—44, 259—66.
52.
Konhauser, K.O., Powell, M.A., Fyfe, W.S. et al. 1997: Trace element chemistry of major rivers in Orissa State, India. EnvironmentalGeology29(1/2), 132—41.
53.
Korrey, J.S. and Goulden, P.D.1975: Determination of microgram quantities of tungsten in natural water by solvent extraction and atomic absorption spectroscopy . Atomic Absorption Newsletter14(2), 33—5.
54.
Kraus, T., Schramel, P., Schaller, K.H. et al. 2001: Exposure assessment in the hard metal manufacturing industry with special regard to tungsten and its compounds. Occupational and Environmental Medicine58(10), 631—34.
55.
Lassner, E. and Schubert, W.D.1999: Tungsten. Properties, chemistry, technology of the element, alloys, and chemical compounds. Kluwer Academic , 82—83; 119—26; 133—77; 283—305; 353—63; 365—75.
56.
Lassner, E., Austria, G. and Schubert, W-D.1996: Tungsten, tungsten alloys, and tungsten compounds . In Elvers, B., Hawkins, S. eds., Ullmann's encyclopedia of industrial chemistry . VCH, A27, 229—67.
57.
Le Lamer-Déchamps, S., Poucheret, P., Pérez, J., et al. 2003: Validation of an inductively coupled plasma-mass spectrometry method to quantify tungsten in human plasma. Determination of percentage binding to plasma proteins. Clinicia Chimica Acta327(1—2), 39—46.
58.
Lewis, R.J.1997: Hawley's condensed chemical dictionary. John Wiley & Sons, Inc., 354, 1147—8.
59.
Lichtenstein, M.E., Bartl, F. and Pierce, R.T.1975: Control of cobalt exposures during wet process tungsten carbide grinding. American Industrial Hygienic Association Journal36, 879—85.
60.
Lide, D.R.2000: Tungsten. In CRC handbook of chemistry and physics. 81st edn. CRC Press LLC, CRC Press LLC, 3—207.
61.
Maenhaut, W., Zoller, W.H., Duce, R.A. et al. 1979: Concentration and size distribution of particulate trace elements in the South Polar atmosphere. Journal of Geophysical Research84, 2421—31.
62.
Mamuro, T., Marsuda, Y., Mizohata, A. et al. 1971: Activation analysis of polluted river water . Radioisotopes20(3), 111—6.
63.
Meijer, A., Wroblicky, G., Thuring, S. et al. 1998: Environmental effects of tungsten and tantalum alloys. Air Force Res Lab. AFRL-MN-EG-TR-2000-7017.
64.
Mumma, R.O., Raupach, D.C., Waldman, J.P. et al. 1984: National survey of elements and other constituents in municipal sewage sludges. Archives of Environment Contamination andToxicology13, 75—83.
65.
Nadeenko, V.G.1966: Maximum permissible concentrations of tungsten in water basins. Hygienic Sanitation31, 197—204 (Russian).
66.
Nazarov, V.M., Frontasyeva, M.V., Peresdov, V.F. et al. 1995: Resonance neutrons for determination of elemental content of moss, lichen and pine needles in atmospheric deposition monitoring. Journal of Radioanalytical and NuclearChemistry192(2), 229—38.
67.
Niosh.1977: Occupational exposure to tungsten and cemented carbide, 21—171.
68.
Niosh.1983: National occupational exposure Survey (NOES) (CD-ROM).
69.
Niosh.1994: NIOSH manual for analytical methods. Tungsten. National Institute for Occupational Safety and Health, 7074—6.
70.
Niosh.2005: NIOSH pocket guide to chemical hazards. Tungsten. National Institute for Occupational Safety and Health. http://www.cdc.gov/niosh/npg/npg.html . April 23, 2005.
71.
NRC.1993: Pesticides in the diets of infants and children. National Research Council. National Academy Press.
72.
Ondov, J.M., Choquette, C.E., Zoller, W.H. et al. eds. 1989: Atmospheric behavior of trace elements on particles emitted from a coal-fired power plant. Atmospheric Environment23(10), 2193—2204.
73.
O'Neil, M.J., Smith, A., Heckelman, P.E. et al. 2001: In The Merck index. An encyclopedia of chemicals, drugs, and biologicals. Merck Research Laboratories, 1748.
74.
Osha.2005a: Occupational safety and health standards for ship-yard employment. Air contaminants. Occupational Safety and Health Administration. Code of Federal Regulations 29 CFR 1915.1000.
75.
Osha.2005b: Safety and health regulations for construction. Gases, vapors, fumes, dusts, and mists. Occupational Safety and Health Administration. Code of Federal Regulations29 CFR 1926.55, Appendix A.
76.
Parker, G.A. and Boltz, D.F.1968: Ultraviolet spectrophotometric determination of tungsten as peroxytungstic acid. Analytical Letters1(11), 679—86.
77.
Paschal, D.C., Ting, B.G., Morrow, J.C. et al. 1998: Trace metals in urine of United States residents: Reference range concentrations. Environmental ResearchA76, 53—9.
78.
Penrice, T.W.1997a: Tungsten. In Kirk-Othmer encyclopedia of chemical technology. John Wiley & Sons, 572—88.
79.
Penrice, T.W.1997b: Tungsten. In Kirk-Othmer encyclopedia of chemical technology. John Wiley & Sons, 590.
80.
Perez-Jordan, M.Y., Soldevila, J., Salvador, A. et al. 1998: Inductively coupled plasma mass spectrometry analysis of wines. Journal of Analytical Atomic Spectrometry14(1), 33—39.
81.
Peuster, M., Fink, C. and von Schnakenburg, C.2003: Biocompatibility of corroding tungsten coils: In vitro assessment of degradation kinetics and cytotoxicity on human cells. Biomaterials24(22), 4057—61.
82.
Piatak, N.M.Seal, R.R.Hammarstrom, J.M.2004: Mineralogical and geochemical controls on the release of trace elements from slag produced by base- and precious-metal smelting at abandoned mine sites. Applied Geochemistry19(7), 1039—64.
83.
Pires, M., Fielder, H. and Teiceira, E.C.1997: Geochemical distribution of trace elements in coal: Modeling and environmental aspects. Fuel76(14/15), 1425—37.
84.
Poucheret, P., Le Lamer, S., Cros, G. et al. 2000: Tungsten determination in rat and dog plasma samples by inductively coupled plasma emission spectrometry application to preclinical pharmacokinetic studies. Analytica Chimica Acta405, 221—6.
85.
Quin, B.F. and Brooks, R.R.1972a: The rapid determination of tungsten in soils, stream sediments, rocks and vegetation. Analytica Chimica Acta58, 301—9.
86.
Quin, B.F. and Brooks, R.R.1972b: Tungsten content of some plants from a mineralized area in New Zealand. New Zealand Journal of Science15, 308—12.
87.
Reimann, C., Bjorvatn, K., Frengstad, B. et al. 2003: Drinking water quality in the Ethiopian section of the East African Rift Valley I - data and health aspects. Science of the Total Environment311(1—3), 65—80.
88.
Rizzato, G., Cicero, S.L., Barberis, M. et al. 1986: Trace of metal exposure in hard metal lung disease. Chest90(1), 101—106.
89.
Rodushkin, I., Odman, F., Holmstrom, H.1999: Multi-element analysis of wild berries from northern Sweden by ICP techniques. Science of the Total Environment231, 53—65.
90.
Sadiq, M., Mian, A.A. and Althagafi, K.M.1992: Inter-city comparison of metals in scalp hair collected after the Gulf War 1991. Journal of Environmental Science Health Part A27(6), 1415—31.
91.
Sahle, W., Krantz, S. and Christensson, B. et al. 1996: Preliminary data on hard metal workers exposed to tungsten oxide fibers. Science of the Total Environment191(1—2), 153—167.
92.
Sahle, W., Laszlo, I., Krantz, S. et al. 1994: Airborne tungsten oxide whiskers in a hard-metal industry. Preliminary findings. Annals of Occupational Hygiene38(1), 37—44.
93.
Schramel, P., Wendler, I. and Angerer, J.1997: The determination of metals (antimony, bismuth, lead, cadmium, mercury, palladium, platinum, tellurium, thallium, tin and tungsten) in urine samples by inductively coupled plasma-mass spectrometry . International Archives of Occupational and Environmental Health69, 219—23.
94.
Schwarz, Y., Kivity, S., Fischbein, A. et al. 1998: Evaluation of workers exposed to dust containing hard metals and aluminum oxide. American Journal of Industrial Medicine34, 177—82.
95.
Senesi, N., Padovano, G. and Brunetti, G.1988: Scandium, titanium, tungsten and zirconium content in commercial inorganic fertilizers and their contribution to soil. Environment Technology and Letters9(9), 1011—20.
96.
Sheridan, P.J. and Zoller, W.H.1989: Elemental composition of particulate material sampled from the Arctic haze aerosol. Journal of AtmosphericChemistry9, 363—81.
97.
SRI.2003: Directory of chemical producers — United States. SRI, International.
98.
Tanizaki, Y., Shimokawa, T. and Yamazaki, M.1992a: Physicochemical speciation of trace elements in urban streams by size fractionation. Water Research26(1), 55—63.
99.
Tanizaki, Y., Shimokawa, T. and Nakamura, M.1992b: Physicochemical speciation of trace elements in river waters by size fractionation. EnvironmentScience and Technology26(7), 1433—44.
100.
Taylor, H.E., Garbarino, J.R. and Brinton, T.I.1990: The occurrence and distribution of trace metals in the Mississippi River and its tributaries. Science of the Total Environment97—98, 369—84.
101.
Tomiyasu, T. and Yonehara, N.1996: Spectrophotometric determination of trace amounts of tungsten(VI) based on its inhibitory effect for the red intermediate formation of the iron (II) catalyzed chloropromazine-hydrogen peroxide reaction. Analytical Science12(6), 899—903.
102.
Tong, S.S.C. et al. 1974: Trace metals in Lake Cayuga lake trout (Salvelinus namaycush) in relation to age. Journal of the Fishery Research Board of Canada31, 238—9.
103.
U.S. Army.2000: Elimation of toxic heavy metals from small caliber ammunition. SERPD Final Report (Project PP/1057/78). U.S. Army Armament Research, Development, and Engineering Center.
104.
Usgs.1999: Tungsten 1998. U.S. geological survey. http://minerals.usgs.gov/minerals/pubs/commodity/tungsten/680498.pdf . April 26, 2005.
105.
Usgs.2001: Tungsten. U.S. geological survey, mineral commodity summaries. http://minerals.usgs.gov/minerals/pubs/commodity/tungsten . April 27, 2005.
106.
Usgs.2002: Recycling-metals . United States Geological Survey, 62.13. http://minerals.usgs.gov/minerals/pubs/commodity/recycle/recycmyb02r.pdf . December 28, 2004.
107.
Usgs.2003a: Tungsten. Minerals yearbook. http://minerals.usgs.gov/minerals/pubs/commodity/tungsten/tungsmyb03.pdf . December 28, 2004.
108.
Usgs.2004a: Tungsten statistics . In Kelly, T., Buckingham, D., DiFrancesco, C. et al., eds. Historical statistics for mineral and material commodities in the United States. United States Geological Survey. U.S. Geological Survey Open-File Report 01-006. http://minerals.usgs.gov/minerals/pubs/of01-006/tungsten.pdf. December 28, 2004.
109.
Usgs.2004b: Tungsten. Mineral commodity summary2004, 180—1. http://minerals.usgs.gov/minerals/pubs/commodity/tungsten/tungsmcs04.pdf. December 28, 2004.
110.
Usgs.2005: USGS national geochemical survey database. U.S. Department of the Interior. U.S. Geological Survey. http://www.-tin.er.usgs.gov/geochem/method.php?element=W. April 27, 2005.
111.
Usnrc.2005: Standards for protection against radiation. Annual limits on intake (ALIs) and derived air concentrations (DACs) of radionuclides for occupational exposure; effluent concentrations; concentrations for release to sewage. U.S. Nuclear Regulatory Commission. Code of Federal Regulations 10 CFR 20, Appendix B.
112.
Van der Sloot, H.A., Wals, G.D. and Das, H.A.1977: The determination of molybdenum and tungsten in sea and surface water. Analytica Chimica Acta90(1), 193—200.
113.
Zhang, F-S., Yamasaki, S. and Kimura, K.2002: Waste ashes for use in agricultural production. II. Contents of minor and trace metals. Science of the Total Environment286(1—3), 111—8.
114.
Zinabu, G.M. and Pearce, N.J.G.2003: Concentrations of heavy metals and related trace elements in some Ethiopian rift-valley lakes and their in-flows. Hydrobiologia429, 171—8.
