The Agency for Toxic Substances and Disease Registry prepares toxicological profiles, as part of its mandate, on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act National Priorities List sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for tungsten. The primary purpose of this article is to provide public health officials, physicians, toxicologists and other interested individuals and groups with an overall perspective on the toxicology of tungsten. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. Toxicology and Industrial Health 2007; 23: 347—387
Aamodt, R.L.1973: Retention and excretion of injected 181 labeled sodium tungstate by beagles. Health Physics24, 519—24.
2.
Aamodt, R.L.1975: Inhalation of 181-W labeled tungstic oxide by six beagle dogs. Health Physics28(6), 733—42.
3.
Acgih2003: Tungsten. Threshold limit values for chemical substances and physical agents and biological exposure indices. American Conference of Governmental Industrial Hygienists, Cincinnati, OH.
4.
Adinolfi, M.1985: The development of the human blood-CSFbrain barrier . Developmental Medicine and Child Neurology27, 532—37.
5.
Águas, A.P., Grande, N.R. and Carvalho, E.1991: Inflammatory macrophages in the dog contain high amounts of intravesicular ferritin and are associated with pouches of connective tissue fibers. American Journal of Anatomy190, 89—96.
6.
Altman, P.L. and Dittmer, D.S.1974: Biological handbooks: Biology data book, Vol. III. 2nd ed. Federation of American Societies for Experimental Biology, Bethesda, MD, 1987—2008, 2041.
7.
Anard, D., Kirsch-Volders, M., Elhajouji, A. et al. 1997: In vitro genotoxic effects of hard metal particles assessed by alkaline single cell gel and elution assays. Carcinogenesis18(1), 177—84.
8.
Andersen, M.E. and Krishnan, K.1994: Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. In Salem, H., editor, Animal test alternatives: Refinement, reduction, replacement. Marcel Dekker, Inc., New York, 9—25.
9.
Andersen, M.E., Clewell, H.J.III, Gargas, M.L. et al. 1987: Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicology and Applied Pharmacology87, 185—205.
10.
Ando, A., Ando, I., Hirako, T. et al. 1989: Relation between the location of elements in the periodic table and various organ-uptake rates. Nuclear Medicine and Biology16(1), 57—80.
Atsdr2004: Toxicological profile for cobalt. Agency for Toxic Substances and Disease Registry , Atlanta, GA (http://www.atsdr.cdc.gov/toxprofiles/tp33.pdf, 27 April 2005).
13.
Atsdr2005: Toxicological profile for nickel. Agency for Toxic Substances and Disease Registry, Atlanta, GA.
14.
Ballou, J.,E.1960: Metabolism of W185 in the rat. AEC Research and Development Report HW64112.
15.
Barborik, M.1972: Excretion of cobalt and tungsten in workers in the production of heavy metals. II. Daily excretion of tungsten in urine. Influence of CaNa 2EDT and penicillamine on its excretion. Pracovni Lékavštvi24(8), 295—97 (Czech).
16.
Bech, A.O.1974: Hard metal disease and tool room grinding. Journal of the Society of Occupational Medicine24, 11—16.
17.
Bech, A.O., Kipling, M.D. and Heather, J.C.1962: Hard metal disease. British Journal of Industrial Medicine19, 239—52.
18.
Callis, G.E. and Wentworth, R.A.1977: Tungsten vs. molybdenum in models for biological systems. Journal of Biological InorganicChemistry7, 57—70.
19.
Cardin, C.J. and Mason, J.1976: Molybdate and tungstate transfer by rat ileum competitive inhibition by sulphate. Biochimica et Biophysica Acta455, 937—46.
20.
Cdc2003: Cross sectional exposure assessment of environmental contaminants in Churchill County, Nevada . Centers for Disease Control and Prevention, Atlanta, GA, 1—47.
21.
ChemFinder.2004: Tungsten. Chemfinder.com: Database and internet searching. http://www.chemfinder.com . April 27, 2005.
22.
ChemIDplus.2004: Division of Specialized Information Services, NLM. http://chem.sis.nlm.nih.gov/chemidplus/cmplxqry.html . April 27, 2005.
23.
Clewell, H.J.III and Andersen, M.E.1985: Risk assessment extrapolations and physiological modeling . Toxicology and Industrial Health1(4), 111—31.
24.
Coates, E.O. and Watson, J.H.L.1971a: Diffuse interstitial lung disease in tungsten carbide workers. Annals of Internal Medicine75, 709—16.
25.
Coates, E.O. and Watson, J.H.L.1971b: Pathology of the lung in tungsten carbide workers using light and electron microscopy. Journal of Occupational Medicine15(3), 280—86.
26.
Cugell, D.W., Morgan, W.K.C., Perkins, D.G. et al. 1990: The respiratory effects of cobalt. Archives ofInternal Medicine150, 177—83.
27.
Davison, A.G., Haslam, P.L., Corrin, B. et al. 1983: Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests. Thorax38, 119—28.
28.
Delahant, A.B.1955: An experimental study of the effects of rare metals on animal lungs. Archives of IndustrialHealth12, 116—20.
29.
De Renzo, EC1954. Studies of the nature of the xanthine oxidase factor . Annals of the New York Academy of Sciences57, 905—908.
30.
De Sousa Pereira, A., Grande, N.R., Carvalho, E. et al. 1992: Evidence of drainage of tungsten particles introduced in the pleural space through the visceral pleura into the lung parenchyma. Acta Anatomica145, 416—19.
31.
DiPaolo, J.A. and Casto, B.C.1979: Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts. Cancer Research39, 1008—13.
32.
Dow Chemical Company.1982: Tungsten chloride: Acute toxicological properties and industrial handling hazards. U.S. Environmental Protection Agency, Office of Toxic Substances. OTS8EH0-0592-3885S.
33.
Edel, J., Sabbioni, E., Pietra, R. et al. 1990: Trace metal lung disease: In vitro interaction of hard metals with human lung and plasma components. The Science of the Total Environment95, 107—18.
34.
Epa2005a: Effluent guidelines and standards. Nonferrous metals manufacturing point source category. U.S. Environmental Protection Agency, Washington, DC , Code of Federal Regulations 40 CFR 421.100.
35.
Epa2005b: Effluent guidelines and standards. Nonferrous metals manufacturing point source category. U.S. Environmental Protection Agency, Washington, DC , Code of Federal Regulations 40 CFR 421.310.
36.
Fomon, S.J.1966: Body composition of the infant: Part I: The male “reference infant”. In Falkner, F., editor, Human development. WB Saunders, Philadelphia, PA, 239—46.
37.
Fomon, S.J., Haschke, F., Ziegler, E.E. et al. 1982: Body composition of reference children from birth to age 10 years. The American Journal of Clinical Nutrition35, 1169—75.
38.
Fredrick, W.G. and Bradley, W.R.1946: Toxicity of some materials used in the manufacture of cemented tungsten carbide tools. Industrial Medicine15(8), 482—83.
39.
Grande, N.R., Moreira de Sá, C., Águas, A.P. et al. 1990: Time course and distribution of tungsten-laden macrophages in the hilar lymph nodes of the dog lung after experimental instillation of calcium tungstate into the left apical bronchus. Lymphology3, 171—82.
40.
Gunnison, A.F., Sellakumar, A., Snyder, E.A. et al. 1988: The effect of inhaled sulfur dioxide and systemic sulfite on the induction of lung carcinoma in rats by benzo[a]pyrene . Environmental Research46, 59—73.
41.
Guzelian, P.S., Henry, C.J. and Olin, S.S., editors. 1992: Similarities and differences between children and adults: Implications for risk assessment. International Life SciencesInstitute Press, Washington, DC.
42.
Harding, H.E.1950: Notes on the toxicology of cobalt metal. British Journal of Industrial Medicine7, 76—78.
43.
HazDat2005. HazDat database: ATSDR's hazardous substance release and health effects database. April 2005, Agency for Toxic Substances and Disease Registry , Atlanta, GA, www.atsdr.cdc.gov/hazdat.html
44.
Heath, J.C.1954: Cobalt as a carcinogen. Nature173, 822—23.
45.
Heath, J.C.1956: The production of malignant tumours by cobalt in the rat . British Journal of Cancer10, 668—73.
46.
Heath, J.C. and Daniel, M.R.1964: The production of malignant tumours by nickel in the rat . British Journal of Cancer18, 261—64.
47.
Higgins, E.S., Richert, D.A. and Westerfield, W.W.1956a: Competitive role of tungsten in molybdenum nutrition. Federation Proceedings15, 274—75.
48.
Higgins, E.S., Richert, D.A. and Westerfield, W.W.1956b: Molybdenum deficiency and tungstate inhibition studies. Journal ofNutrition59, 539—59.
49.
Hsdb2004: Tungsten. Hazardous Substances Data Bank. National Library of Medicine. http://toxnet.nlm.nih.gov. December 2004.
50.
Huntingdon Life Sciences LTD.1999a: Sodium tungstate dihydrate. Acute (four-hour) inhalation study in rats. Cambridgeshire, England, ITU 007983498.
51.
Huntingdon Life Sciences LTD.1999b: Tungsten metal powder. Acute (four-hour) inhalation study in rats . Cambridgeshire, England, ITU 025983503.
52.
Huntingdon Life Sciences LTD.1999c: Sodium tungstate dihydrate. Eye irritation to the rabbit. Cambridgeshire, England, ITU 005982804SE.
53.
Huntingdon Life Sciences LTD.2000: Tungsten metal powder. Eye irritation to the rabbit. Cambridgeshire , England, ITU 023982949SE.
54.
Icrp1979: Limits for intakes of radionuclides by workers. Commission of Radiological Protection. ICRP Publication 30, Part 1. Pergamon Press, New York.
55.
Icrp1981: Limits for intakes of radionuclides by workers. Commission of Radiological Protection. ICRP Publication 30, Part 3. Pergamon Press, New York, 93—95.
56.
Icrp1994a: Human respiratory tract model for radiological protection. International Commission of Radiological Protection. ICRP Publication 66. Pergamon Press, New York.
57.
Icrp.1994b: Dose coefficients for intakes of radionuclides by workers. Replacement of ICRP Publication 61. International Commission of Radiological Protection. ICRP Publication 68. Pergamon Press, New York, 83.
58.
Icrp1995. Limits for intakes of radionuclides by workers. 5. Dosimetric model for the respitory system . In: Sowby FD (ed). Radiation Protection, ICRP Publication 30 (Part 1) — Limits for intakes of radionuclides by workers. International Commission of Radiological Protection. ICRP Publication 69. Pergamon Press, New York.
59.
Icrp2001: The ICRP database of dose coefficients: Workers and members of the public. Pergamon Press, New York, CD-ROM.
60.
Idiyatullina, F.K.1981: Data toward hygienic normalization of tungsten in atmospheric air. Gigiena i Sanitariia46(9), 79—81 (Russian).
61.
Iris2005: Integrated Risk Information System. U.S. Environmental Protection Agency, Washington, DC.
62.
Johanson, C.E.1980: Permeability and vascularity of the developing brain: Cerebellum vs cerebral cortex. Brain Research190, 3—16.
63.
Johnson, J.L. and Rajagopalan, K.V.1974: Molecular basis for the biological function of molybdenum: Effect of tungstate on xanthine oxidase and sulfite oxidase in the rat. Journal of Biological Chemistry249, 856—66.
64.
Johnson, J.L., Cohen, H.J. and Rajagopalan, K.V.1974: Molecular basis of the biological function of molybdenum: molybdenum-free sulfite oxidase from livers of tungsten-treated rats. Journal of Biological Chemistry249, 5046—55.
65.
Jordan, C., Whitman, R.D., Harbut, M. et al. 1990: Memory deficits in workers suffering from hard metal disease. Toxicology Letters54, 241—43.
66.
Kalinich, J.F., Emond, C.A., Dalton, T.K. et al. 2005: Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 rats. Environmental Health Perspectives, 2005, 113(6): 729—34.
67.
Kaplun, Z.S. and Mezentseva, N.V.1959: Hygienic evaluation of aerosols formed in the manufacture of hard alloy. Gigiena i Sanitariia24, 16—22. (Russian)
68.
Karantassis, M.T.1924: Toxicity of tungsten and molybdenum compounds. Annales de Medecine Legale5, 44—50.
69.
Kaye, S.V.1968: Distribution and retention of orally administered radiotungsten in the rat. Health Physics15(5), 399—417.
70.
Kerley, C.R., Easterly, C.E., Eckerman, K.F. et al. 1996: Environmental acceptability of high-performance alternatives for depleted uranium penetrators. Oak Ridge National Laboratory, Oak Ridge, TN, ORNL/TM-13286.
71.
Kinard, F.W. and Aull, J.C.1945: Distribution of tungsten in the rat following ingestion of tungsten compounds. The Journal of Pharmacology and Experimental Therapeutics83, 53—55.
72.
Kinard, F.W. and Van de Erve, J.1940: Rat mortality following sodium tungstate injection . The American Journal of the Medical Sciences199, 668—70.
73.
Kinard, F.W. and Van de Erve, J.1941. The toxicity of orally ingested tungsten compounds in the rat. The Journal of Pharmacology and Experimental Therapeutics72, 196—201.
74.
Kinard, F.W. and Van de Erve, J.1943: Effects of tungsten metal diets in the rat. The Journal of Laboratory and Clinical Medicine28, 1541—43.
75.
Komori, M., Nishio, K., Kitada, M. et al. 1990: Fetus-specific expression of a form of cytochrome P-450 in human livers. Biochemistry29, 4430—33.
76.
Krishnan, K. and Andersen, M.E.1994: Physiologically based pharmacokinetic modeling in toxicology . In Hayes, A.W., editor, Principles and methods of toxicology, 3rd ed. Raven Press, Ltd., New York, NY, 149—88.
77.
Krishnan, K., Andersen, M.E., Clewell, H.J.III et al. 1994: Physiologically based pharmacokinetic modeling of chemical mixtures. In Yang, R.S.H. , editor, Toxicology of chemical mixtures: Case studies, mechanisms, and novel approaches. Academic Press, San Diego, CA, 399—437.
78.
Kruger, R.1912: Colloidal tungsten as substitute for bismuth in rontgen sketches of the gastro-intestinal canal. Müchener Medizinische Wochenschrift59, 1 (German).
79.
Lardot, C.G., Huaux, F.A., Broeckaert, F.R. et al. 1998: Role of urokinase in the fibrogenic response of the lung mineral particles. American Journal of Respiratory and Critical Care Medicine157, 617—28.
80.
Larramendy, M.L., Popescu, N.C. and DiPaolo, J.A.1981: Induction by inorganic metal salts of sister chromatid exchanges and chromosome aberrations in human and Syrian hamster cell strains . Environmental Mutagenesis3, 597—606.
81.
Lasfargues, G., Lison, D., Maldague, P. et al. 1992: Comparative study of the acute lung toxicity of pure cobalt powder and cobalt-tungsten carbide mixture in rat. Toxicology and Applied Pharmacology112(1), 41—50.
82.
Lasfargues, G., Wild, P., Moulin, J.J. et al. 1994: Lung cancer mortality in a French cohort of hard-metal workers. American Journal of Industrial Medicine26, 585—595.
83.
Lasfargues, G., Lardot, C., Delos, M. et al. 1995: The delayed lung responses to single and repeated intratracheal administration of pure cobalt and hard metal powder in the rat. Environmental Research69, 108—21.
84.
Lassner, E., Austria, G. and Schubert, W.-D.1996. Tungsten, tungsten alloys, and tungsten compounds . In Elvers, B. and Hawkins, S., editors, Ullmann's encyclopedia of industrial chemistry, Volume A27. VCH, Weinheim, Germany, 229—67.
85.
Leanderson, P. and Sahle, W.1995: Formation of hydroxyl radicals and toxicity of tungsten oxide fibres. Toxicology In Vitro9(2), 175—81.
86.
Leeder, J.S. and Kearns, G.L.1997: Pharmacogenetics in pediatrics: Implications for practice. Pediatric Clinics of NorthAmerica44(1), 55—77.
87.
Leggett, R.W.1997: A model of the distribution and retention of tungsten in the human body. The Science of the Total Environment206, 147—65.
88.
Le Lamer, S., Poucheret, P., Cros, G. et al. 2000: Pharmacokinetics of sodium tungstate in rat and dog: A population approach. The Journal of Pharmacology and Experimental Therapeutics294(2), 714—21.
89.
Le Lamer, S., Cros, G., Serrano, J.J. et al. 2001: Estimation of pharmacokinetic parameters of sodium tungstate after multiple-dose during preclinical studies in beagle dogs. EuropeanJournal of Pharmaceutical Sciences14, 323—29.
90.
Leung, H.-W.1993: Physiologically-based pharmacokinetic modelling . In Ballantyne, B., Marro, T. and Turner, P., editors, General and applied toxicology, Volume 1. Stockton Press, New York, NY, 153—64.
91.
Lewis RJ1997: Hewley's condensed chemical dictionary. New York, NY: John Wiley & Sons, Inc. , 354, 1147—1148.
Lison, D. and Lauwerys, R.1995: The interaction of cobalt metal with different carbides and other mineral particles on mouse peritoneal macrophages. Toxicology In Vitro9(3), 341—47.
94.
Lison, D., Lauwerys, R., Demedts, M. et al. 1996: Experimental research into the pathogenesis of cobalt/hard metal lung disease. The European Respiratory Journal9, 1024—28.
95.
Lison, D., Buchet, J.P. and Hoet, P.1997: Toxicity of tungsten. Lancet349, 58—59.
96.
Luo, X.M. et al. 1983: Inhibitory effects of molybdenum on esophageal and forestomach carcinogenesis in rats. Journal of theNational Cancer Institute71, 75—88.
97.
Lusky, L.M., Braun, H.A. and Laug, E.P.1949: The effect of BAL on experimental lead, tungsten, vanadium, uranium, copper and copper-arsenic poisoning. Journal of Industrial Hygiene and Toxicology31, 301—305.
98.
Marquet, P., Francois, B., Lotfi, H. et al. 1997: Tungsten determination in biological fluids, hair and nails by plasma emission spectrometry in a case of severe acute intoxication in man. Journal of Forensic Sciences42(3), 527—30.
99.
Mezentseva, N.V.1967: Tungsten. In Izreal'son, Z.I., editor. Toxicology of the rare metals (Toksikologiya redkikh metallov). Isreal Program for Scientific Translations, Jerusalem, AEC-tr 6710, 28—35.
100.
Miller, A.C. and Page, N.1999: Mutagenicity of heavy metals used in military applications: comparison of depleted uranium, tungsten, and nickel. Environmental Mutagenesis Society Abstract141, 45.
101.
Miller, C.W., Davis, M.W., Goldman, A. et al. 1953: Pneumoconiosis in the tungsten carbide tool industry. American Medical AssociationArchives of Industrial Hygiene and Occupational Medicine8, 453—65.
102.
Miller, A.C., Mog, S. and McKinney, L.2001: Neoplastic transformation of human osteoblast cells to the tumorigenic phenotype by heavy metal-tungsten alloy particles: Induction of genotoxic effects. Carcinogenesis22(1), 115—25.
103.
Miller, A.C., Kalinich, J.F. and McClain, D.E.2002: Carcinogenicity and immunotoxicity of embedded depleted uranium and heavy-metal tungsten alloy in rodents. U.S. Army Medical Research and Material Command, Fort Detrick, Maryland.
104.
Miller, A.C., Brooks, K., Smith, J. et al. 2004: Effect of the militarily-relevant heavy metals, depleted uranium and heavy metal tungsten-alloy on gene expression in human liver carcinoma cells (HepG2). Molecular and CellularBiochemistry255(1—2), 247—56.
105.
Morselli, P.L., Franco-Morselli, R. and Bossi, L.1980: Clinical pharmacokinetics in newborns and infants: Age-related differences and therapeutic implications. Clinical Pharmacokinetics5, 485—527.
106.
Moulin, J.J., Wild, P., Romazini, S. et al. 1998: Lung cancer risk in hard-metal workers. American Journal of Epidemiology148(3), 241—48.
107.
Mullen, A.L., Bretthauer, E.W. and Stanley, R.E.1976. Absorption, distribution and milk secretion of radionuclides by the dairy cow — V. Radiotungsten. Health Physics31, 417—24.
108.
Nadeenko, V.G.1966: Maximum permissible concentrations of tungsten in water basins. Hygiene and Sanitation31, 197—204 (Russian).
109.
Nadeenko, V.G. and Lenchenko, V.G.1977: The nature of the combined action of small doses of certain element-antagonists. Gigiena i Sanitariia8, 30—34 (Russian).
110.
Nadeenko, V.G., Lenchenko, V.G., Oschepkova, A.N. et al. 1977: New data for standardization of tungsten and molybdenum in their separate and simultaneous presence in water bodies . Gigiena i Sanitariia3, 7—11 (Russian).
111.
Nadeenko, V.G., Lenchenko, V.G., Genkina, S.B. et al. 1978: Effect of tungsten, molybdenum, copper and arsenic on the intrauterine development of the fetus. Farmakologiya i Toksikologiya41(5), 620—23 (Russian).
112.
Nas/Nrc1989: Report of the oversight committee. In Biologic markers in reproductive toxicology. National Academy of Sciences, National Research Council, National Academy Press, Washington, DC.
113.
Nicolaou, G., Pietra, R., Sabbioni, E. et al. 1987: Multielement determination of metals in biological specimens of hard metal workers: A study carried out by neutron activation analysis. Journal of Trace Elements and Electrolytes in Health and Disease1, 73—77.
114.
Niosh1977: Occupational exposure to tungsten and cemented carbide, 21—171, National Institute of Occupational Safety and Health (NIOSH).
115.
Niosh.2000: Tungsten. NIOSH pocket guide to chemical hazards. National Institute for Occupational Safety and Health. http://www.cdc.gov . March 13, 2000.
116.
NIOSH2005: NIOSH pocket guide to chemical hazards. Tungsten. National Institute for Occupational Safety and Health, Washington, DC (http://www.cdc.gov/niosh/npg/npg.html, 23 April 2005 ).
117.
Nrc1993: Pesticides in the diets of infants and children. National Research Council, National Academy Press, Washington, DC.
118.
Nto2003: Substance nominated to the NTP for toxicological studies and testing recommendations made by the NTP inter-agency committee for chemical evaluation and coordination (ICCEC) on June 20, 2003. National Toxicology Program, Research Triangle Park, NC: (http://ntp-server.niehs.nih.gov/ntpweb/printFriendly.cfm?objectid=25BEBA08-BDB7-CEBA-FC56EAD78615ADCF, 27 April 2005).
119.
O'Neil, M.J., Smith, A., Heckelman, P.E. et al. 2001: The Merck index. An encyclopedia of chemicals, drugs, and biologicals. Merck Research Laboratories, Whitehouse Station, NJ, 1748.
120.
Osha2005a: Occupational safety and health standards for ship-yard employment. Air contaminants. Occupational Safety and Health Administration, Washington, DC, Code of Federal Regulations 29 CFR 1915.1000.
121.
Osha2005b: Safety and health regulations for construction. Gases, vapors, fumes, dusts, and mists. Occupational Safety and Health Administration, Washington, DC. Code of Federal Regulations 29 CFR 1926 .55, Appendix A.
122.
Owen, E.C. and Proudfoot, R.1968: The effect of tungstate ingestion on xanthine oxidase in milk and liver. TheBritish Journal of Nutrition22, 331—40.
123.
Owen, G.M. and Brozek, J.1966: Influence of age, sex and nutrition on body composition during childhood and adolescence. In Falkner, F., editor, Human development. WB Saunders , Philadelphia, PA, 222—38.
124.
Peão, M.N.D., Águas, A.P., De Sa, C.M. et al. 1993: Inflammatory response of the lung to tungsten particles: An experimental study in mice submitted to intratracheal instillation of a calcium tungstate powder. Lung171, 187—201.
125.
Penrice, T.W.1997a: Tungsten. In Kirk-Othmer encyclopedia of chemical technology. John Wiley & Sons, New York, NY, 4th edition, Volume 24, 572—88.
126.
Penrice, T.W.1997b: Tungsten. In Kirk-Othmer encyclopedia of chemical technology. John Wiley & Sons, New York, NY, 4th edition, Volume 24, 590.
127.
Poucheret, P., Le Lamer, S., Cros, G. et al. 2000: Tungsten determination in rat and dog plasma samples by inductively coupled plasma emission spectrometry application to preclinical pharmacokinetic studies. Analytica Chimica Acta405, 221—26.
128.
Rengasamy, A., Kommineni, C., Jones, J.A. et al. 1999: Effects of hard metal on nitric oxide pathways and airway reactivity to methacholine in rat lungs. Toxicology and Applied Pharmacology157, 178—91.
129.
Rossman, T.G., Molina, M. and Meyer, L.W.1984: The genetic toxicology of metal compounds. I. Induction of λ prophage in E. coli WP2s. Environmental Mutagenesis6, 59—69.
130.
Rossman, T.G., Molina, M., Meyer, L. et al. 1991: Performance of 133 compounds in the lambda prophage induction endpoint of the Microscreen assay and a comparison with S. typhimurium mutagenicity and rodent carcinogenicity assays. Mutatation Research260, 349—67.
131.
Rtecs.2004: Tungsten. Registry of Toxic Effects of Chemical Substances. National Institute for Occupational Safety and Health. June, 2004.
132.
Sahle, W.1992: Possible role of tungsten oxide whiskers in hard-metal pneumoconiosis. Chest102, 1310.
133.
Sahle, W., Laszlo, I., Krantz, S. et al. 1994: Airborne tungsten oxide whiskers in a hard-metal industry. Preliminary findings. The Annals of Occupational Hygiene38(1), 37—44.
134.
Schepers, G.H.W.1955a: The biological action of particulate tungsten metal. Archives of IndustrialHealth12, 134—36.
135.
Schepers, G.H.W.1955b: Biological action of tungsten carbide and carbon. Experimental pulmonary histopathology. American Medical Association Archives of IndustrialHealth12, 137—39.
136.
Schroeder, H.A. and Mitchener, M.1975a: Life-term studies in rats: effects of aluminum, barium, beryllium, and tungsten. Journal ofNutrition105, 421—27.
137.
Schroeder, H.A. and Mitchener, M.1975b: Life-term effects of mercury, methyl mercury, and nine other trace metals on mice. Journal ofNutrition105, 452—58.
138.
Schwartz, L., Peck, S.M., Blair, K.E. et al. 1945: Allergic dermatitis due to metallic cobalt. Journal ofAllergy16, 51.
139.
Setchell, B.P. and Waites, G.M.H.1975: The blood-testis barrier. In Creep, R.O., Astwood, E.B. and Geiger, S.R., editors, Handbook of physiology : EndocrinologyV. American Physiological Society, Washington, DC.
140.
Singh, I.1983: Induction of reverse mutation and mitotic gene conversion by some metal compounds in Saccharomyces cerevisiae. Mutation Research117, 149—52.
141.
Sivjakov, K.I. and Braun, H.A.1959: The treatment of acute selenium, cadmium, and tungsten intoxication in rats with calcium disodium ethylenediaminetetraacetate. Toxicology and Applied Pharmacology1, 602—608.
142.
Skog, E.1963: Skin affections caused by hard metal dust. Industrial Medicine and Surgery32, 266—68.
143.
Smyth, H.F., Carpenter, C., Weil, C. et al. 1969: Range-finding toxicity data: List VII. American Industrial Hygiene Association Journal30, 470—76.
144.
Sora, S., Carbone, M.L.A., Pacciarini, M. et al. 1986: Disomic and diploid meiotic products induced in Saccharomyces cerevisiae by the salts of 27 elements. Mutagenesis1(1), 21—28.
145.
Ulitzur, S. and Barak, M.1988: Detection of genotoxicity of metallic compounds by the bacterial bioluminescence test. Journal of Bioluminescence and Chemiluminescence2, 95—99.
146.
Usnrc2005: Standards for protection against radiation. Annual limits on intake (ALIs) and derived air concentrations (DACs) of radionuclides for occupational exposure; effluent concentrations; concentrations for release to sewage. U.S. Nuclear Regulatory Commission, Washington, DC, Code of Federal Regulations 10 CFR 20, Appendix B.
147.
Van Goethem, F., Lison, D. and Kirsch-Volders, M.1997: Comparative evaluation of the in vitro micronucleus test and the alkaline single cell gel electrophoresis assay for the detection of DNA damaging agents: genotoxic effects of cobalt powder, tungsten carbide and cobalt-tungsten carbide. Mutation Research392, 31—43.
148.
Vengerskaya, K.Y. and Salikhodzhaev, S.S.1962. Some problems relating to the effects of tungsten powder on humans. Gigiena Truda i Professionalnye Zabolevaniia6, 27—29.
149.
Vieira, I., Sonnier, M. and Cresteil, T.1996: Developmental expression of CYP2E1 in the human liver: Hypermethylation control of gene expression during the neonatal period . European Journal of Biochemistry238, 476—83.
150.
Wase, A.W.1955: Absorption and distribution of radio-tungstate in bone and soft tissues. Archives of Biochemistry andBiophysics61, 272—77.
151.
Wei, H., Luo, X. and Yang, X.1987: Effect of molybdenum and tungsten on mammary carcinogenesis in Sprague-Dawley SD rats. Zhonghua Zhong Liu Za Zhi9(3), 204—207.
152.
West, J.R., Smith, H.W. and Chasis, H.1948: Glomerular filtration rate, effective renal blood flow, and maximal tubular excretory capacity in infancy. Journal ofPediatrics32, 10—18.
153.
Wester, P.O.1974: Trace elements in relation to variations in calcium intake . Atherosclerosis20, 207—15.
154.
Widdowson, E.M. and Dickerson, J.W.T.1964: Chemical composition of the body. In Comar, C.L. and Bronner, F., editors, Mineral metabolism: An advanced treatise, Volume II: The elements Part A. Academic Press, New York.
155.
Wide, M.1984: Effect of short-term exposure to five industrial metals on the embryonic and fetal development of the mouse. Environmental Research33, 47—53.
156.
Wide, M., Danielsson, B.R.G. and Dencker, L.1986: Distribution of tungstate in pregnant mice and effect in embryonic cells in vitro. Environmental Research40, 487—98.
157.
Wild, P., Perdrix, A., Romazini, S. et al. 2000: Lung cancer mortality in a site producing hard metals. Journal of Occupational and Environmental Medicine57, 568—73.
158.
Zanetti, G. and Fubini, B.1997: Surface interaction between metallic cobalt and tungsten carbide particles as a primary cause of hard metal lung disease. Journal of MaterialChemistry7(8), 1647—54.
159.
Zelikoff, J.T., Atkins, N. and Rossman, T.G.1986: Mutagenicity of soluble metal salts using the V79/HGPRT mutation assay. Environmental Mutagenesis8, 95.
160.
Ziegler, E.E., Edwards, B.B., Jensen, R.L. et al. 1978: Absorption and retention of lead by infants . Pediatric Research12, 29—34.
