Introduction: The impact of colorectal surgery on older adults’ (≥65 years) health-related quality of life (HRQoL) is rarely reported. Methods: This prospective multi-institutional cohort study involving 217 participants investigated factors affecting older colorectal cancer (CRC) patients’ HRQoL following surgery with the EORTC QLQ-C30 and the HADS. Results: The trend of the global QoL and individual subscales show an overall dip in QoL from baseline to pre-discharge, before slowly rising until the 6-month mark. Baseline score of individual outcome measures was the only constant predictor of the outcome measure over time. Conclusion: Age was not found to be a significant predictor of HRQoL in older adults undergoing colorectal surgery, while baseline scores of individual outcome measures consistently predicted post-operative HRQoL scores. Interventions should be targeted at specific subgroups of older adults scheduled for colorectal surgery, such as those with lower baseline scores.
AaronsonN. K.AhmedzaiS.BergmanB.BullingerM.CullA.DuezN. J.FilibertiA.FlechtnerH.FleishmanS. B.de HaesJ. C. (1993). The European organization for research and treatment of cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376. https://doi.org/10.1093/jnci/85.5.365
2.
AmemiyaT.OdaK.AndoM.KawamuraT.KitagawaY.OkawaY.YasuiA.IkeH.ShimadaH.KuroiwaK.NimuraY.FukataS. (2007). Activities of daily living and quality of life of elderly patients after elective surgery for gastric and colorectal cancers. Annals of Surgery, 246(2), 222–228. https://doi.org/10.1097/SLA.0b013e3180caa3fb
3.
AndreoniB.ChiappaA.BertaniE.BellomiM.OrecchiaR.ZampinoM.FazioN.VenturinoM.OrsiF.SonzogniA.PaceU.MonfardiniL. (2007). Surgical outcomes for colon and rectal cancer over a decade: Results from a consecutive monocentric experience in 902 unselected patients. World Journal of Surgical Oncology, 5, 73. https://doi.org/10.1186/1477-7819-5-73
4.
BirkelbachO.MörgeliR.SpiesC.OlbertM.WeissB.BraunerM.NeunerB.FrancisR. C. E.TreskatschS.BalzerF. (2019). Routine frailty assessment predicts postoperative complications in elderly patients across surgical disciplines – a retrospective observational study. BMC Anesthesiology, 19(1), 204. https://doi.org/10.1186/s12871-019-0880-x
5.
ChurrucaK.PomareC.EllisL. A.LongJ. C.HendersonS. B.MurphyL. E. D.LeahyC. J.BraithwaiteJ. (2021). Patient-reported outcome measures (PROMs): A review of generic and condition-specific measures and a discussion of trends and issues. Health Expectations: An International Journal of Public Participation in Health Care and Health Policy, 24(4), 1015–1024. https://doi.org/10.1111/hex.13254
FujitaS.AkasuT.MizusawaJ.SaitoN.KinugasaY.KanemitsuY.OhueM.FujiiS.ShiozawaM.YamaguchiT.MoriyaY.Colorectal Cancer Study Group of Japan Clinical Oncology Group. (2012). Postoperative morbidity and mortality after mesorectal excision with and without lateral lymph node dissection for clinical stage II or stage III lower rectal cancer (JCOG0212): Results from a multicentre, randomised controlled, non-inferiority trial. The Lancet Oncology, 13(6), 616–621. https://doi.org/10.1016/S1470-2045(12)70158-4
9.
Gonzalez-Saenz de TejadaM.BilbaoA.BaréM.BrionesE.SarasquetaC.QuintanaJ. M.EscobarA.CARESS-CCR Group. (2017). Association between social support, functional status, and change in health-related quality of life and changes in anxiety and depression in colorectal cancer patients. Psycho-Oncology, 26(9), 1263–1269. https://doi.org/10.1002/pon.4303
10.
HanD.-S.AhnJ.AhnH. S. (2021). Are the elderly patient’s changes in the health-related quality of life one year after gastrectomy for stomach cancer different from those in young patients?Annals of Surgical Treatment and Research, 100(1), 8–17. https://doi.org/10.4174/astr.2021.100.1.8
11.
LightnerA.RegenbogenS. E.EtzioniD. A. (2020). Outcomes of surgery in older adults. In RosenthalR. A.ZenilmanM. E.KatlicM. R. (Eds.), Principles and practice of geriatric surgery (pp. 529–540). Springer International Publishing. https://doi.org/10.1007/978-3-319-47771-8_32
12.
LinH.-S.WattsJ. N.PeelN. M.HubbardR. E. (2016). Frailty and post-operative outcomes in older surgical patients: A systematic review. BMC Geriatrics, 16(1), 157. https://doi.org/10.1186/s12877-016-0329-8
13.
MaillardJ.EliaN.HallerC. S.DelhumeauC.WalderB. (2015). Preoperative and early postoperative quality of life after major surgery—a prospective observational study. Health and Quality of Life Outcomes, 13(1), 12. https://doi.org/10.1186/s12955-014-0194-0
14.
Miguelena-HyckaJ.Lopez-MenendezJ.PradaP.-C.Rodriguez-RodaJ.MartinM.Vigil-EscaleraC.Hernandez-VaqueroD.MiguelenaJ. M.SilvaJ.Gonzalez-ColaçoM. (2019). Influence of preoperative frailty on health-related quality of life after cardiac surgery. The Annals of Thoracic Surgery, 108(1), 23–29. https://doi.org/10.1016/j.athoracsur.2018.12.028
15.
MontroniI.UgoliniG.SaurN. M.RostoftS.SpinelliA.Van LeeuwenB. L.De Liguori CarinoN.GhignoneF.JaklitschM. T.SomasundarP.GaruttiA.ZingarettiC.FocaF.VertogenB.NanniO.WexnerS. D.AudisioR. A.SIOG Surgical Task Force/ESSO GOSAFE Study Group. (2022). Quality of life in older adults after major cancer surgery: The GOSAFE international study. JNCI Journal of the National Cancer Institute, 114(7), 969–978. https://doi.org/10.1093/jnci/djac071
16.
MusoroJ. Z.CoensC.SprangersM. A. G.BrandbergY.GroenvoldM.FlechtnerH.-H.CocksK.VelikovaG.DirvenL.GreimelE.SingerS.PogodaK.GamperE. M.SodergrenS. C.EggermontA.KollerM.ReijneveldJ. C.TaphoornM. J. B.KingM. T.BottomleyA.EORTC Melanoma, Breast, Head and Neck, Genito-urinary, Gynecological, Gastro-intestinal, Brain, Lung and Quality of Life Groups. (2023). Minimally important differences for interpreting EORTC QLQ-C30 change scores over time: A synthesis across 21 clinical trials involving nine different cancer types. European Journal of Cancer, 188, 171–182. https://doi.org/10.1016/j.ejca.2023.04.027
QuintenC.CoensC.MauerM.ComteS.SprangersM. A. G.CleelandC.OsobaD.BjordalK.BottomleyA.EORTC Clinical Groups. (2009). Baseline quality of life as a prognostic indicator of survival: A meta-analysis of individual patient data from EORTC clinical trials. The Lancet Oncology, 10(9), 865–871. https://doi.org/10.1016/S1470-2045(09)70200-1
19.
RitterM.LingB. M.OberhauserI.MontagnaG.ZehnpfennigL.LévyJ.SoysalS. D.CastrezanaL. L.MüllerM.SchwabF. D.KurzederC.HaugM.WeberW. P.KapposE. A. (2021). The impact of age on patient-reported outcomes after oncoplastic versus conventional breast cancer surgery. Breast Cancer Research and Treatment, 187(2), 437–446. https://doi.org/10.1007/s10549-021-06126-6
20.
ScherK. S.HurriaA. (2012). Under-representation of older adults in cancer registration trials: Known problem, little progress. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 30(17), 2036–2038. https://doi.org/10.1200/JCO.2012.41.6727
21.
SharmaA.SharpD. M.WalkerL. G.MonsonJ. R. T. (2007). Predictors of early postoperative quality of life after elective resection for colorectal cancer. Annals of Surgical Oncology, 14(12), 3435–3442. https://doi.org/10.1245/s10434-007-9554-x
22.
SiegelR. L.WagleN. S.CercekA.SmithR. A.JemalA. (2023). Colorectal cancer statistics, 2023. CA: A Cancer Journal for Clinicians, 73(3), 233–254. https://doi.org/10.3322/caac.21772
Soria-UtrillaV.Sánchez-TorralvoF. J.González-PovedaI.Mera-VelascoS.PorrasN.Toval-MataJ. A.García-OlivaresM.Ruiz-LópezM.Gonzalo-MarínM.Carrasco-CamposJ.TapiaM. J.Santoyo-SantoyoJ.OlveiraG. (2022). Prevalence of anxiety and depression symptoms and their relationship with nutritional status and mortality in patients with colorectal cancer. International Journal of Environmental Research and Public Health, 19(20), Article 13548. https://doi.org/10.3390/ijerph192013548
25.
SouwerE. T. D.OerlemansS.van de Poll-FranseL. V.van ErningF. N.van den BosF.SchuijtemakerJ. S.van den BerkmortelF. W. P. J.Ten Bokkel HuininkD.HamakerM. E.DekkerJ. W. T.WientjesC. A.PortieljeJ. E. A.MaasH. A. A. (2019). The impact of colorectal surgery on health-related quality of life in older functionally dependent patients with cancer—a longitudinal follow-up study. Journal of Geriatric Oncology, 10(5), 724–732. https://doi.org/10.1016/j.jgo.2019.04.013
26.
StaibL.LinkK. H.BlatzA.BegerH. G. (2002). Surgery of colorectal cancer: Surgical morbidity and five- and ten-year results in 2400 patients--monoinstitutional experience. World Journal of Surgery, 26(1), 59–66. https://doi.org/10.1007/s00268-001-0182-5
WatanabeT.OhnoR.KajitaniR.SaharaK.MunechikaT.MatsumotoY.AisuN.KojimaD.YoshimatsuG.HasegawaS. (2023). Comparison of changes in health-related quality of life between elderly and non-elderly patients undergoing elective surgery for colorectal cancer. International Journal of Colorectal Disease, 38(1), 149. https://doi.org/10.1007/s00384-023-04440-7
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
