Unveiling Relationship Between Specific Domain,Intensity,and Dose of Physical Activity and Biological Age: A Cross-Sectional Study

Abstract

Existing studies have separately explored the association between specific intensity and domain of physical activity (PA) and biological age (BA), potentially impeding more precise guide. We used data of 5216 middle-aged and older adults aged 45 and over to explore and compare the relationship of different domains, intensities, and doses of PA and BA. Transport-related walking and leisure-time moderate-intensity PA (MPA) were significantly associated with younger BA, rather than other intensity of work-related PA. There were U-shaped dose-response relationships between transport-related BA or leisure-time MPA and BA. In subgroup analyses for older adults, all intensities of PA were significantly associated with decreased BA. These findings highlighted the importance of considering the domain, intensity, and dose of PA in designing effective age-delaying interventions.

Keywords

biological age dose-response relationship middle-aged adults older adults

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References

Alessa

H. B.

Chomistek

A. K.

Hankinson

S. E.

Barnett

J. B.

Rood

Matthews

C. E.

Rimm

E. B.

Willett

W. C.

F. B.

Tobias

D. K.

Tobias

D. K.

(2017). Objective measures of physical activity and Cardiometabolic and endocrine biomarkers. Medicine & Science in Sports & Exercise, 49(9), 1817–1825. https://doi.org/10.1249/mss.0000000000001287

Belsky

D. W.

Huffman

K. M.

Pieper

C. F.

Shalev

Kraus

W. E.

(2017). Change in the rate of biological aging in response to Caloric restriction: CALERIE Biobank analysis. J Gerontol A Biol Sci Med Sci, 73(1), 4–10. https://doi.org/10.1093/gerona/glx096

Bull

F. C.

Al-Ansari

S. S.

Biddle

Borodulin

Buman

M. P.

Cardon

Carty

Chaput

J. P.

Chastin

Chou

Dempsey

P. C.

DiPietro

Ekelund

Firth

Friedenreich

C. M.

Garcia

Gichu

Jago

Katzmarzyk

P. T.

Willumsen

J. F.

(2020). World Health Organization 2020 guidelines on physical activity and sedentary behaviour. British Journal of Sports Medicine, 54(24), 1451–1462. https://doi.org/10.1136/bjsports-2020-102955

Bull

F. C.

Maslin

T. S.

Armstrong

(2009). Global physical activity questionnaire (GPAQ): Nine country reliability and validity study. J Phys Act Health, 6(6), 790–804. https://doi.org/10.1123/jpah.6.6.790

Burtscher

Strasser

D'Antona

Millet

G. P.

Burtscher

(2023). How much resistance exercise is beneficial for healthy aging and longevity? J Sport Health Sci, 12(3), 284–286. https://doi.org/10.1016/j.jshs.2022.11.004

Buuren

S. v.

Groothuis-Oudshoorn

(2011). mice: Multivariate imputation by chained equations in R. Journal of Statistical Software, 45(3), 1–67. https://doi.org/10.18637/jss.v045.i03

Coenen

Huysmans

M. A.

Holtermann

Krause

van Mechelen

Straker

L. M.

van der Beek

A. J.

(2018). Do highly physically active workers die early? A systematic review with meta-analysis of data from 193 696 participants. British Journal of Sports Medicine, 52(20), 1320–1326. https://doi.org/10.1136/bjsports-2017-098540

Cohen

A. A.

Milot

Yong

Seplaki

C. L.

Fülöp

Bandeen-Roche

Fried

L. P.

(2013). A novel statistical approach shows evidence for multi-system physiological dysregulation during aging. Mechanism of Ageing and Development, 134(3-4), 110–117. https://doi.org/10.1016/j.mad.2013.01.004

Daskalopoulou

Stubbs

Kralj

Koukounari

Prince

Prina

A. M.

(2017). Physical activity and healthy ageing: A systematic review and meta-analysis of longitudinal cohort studies. Ageing Research Reviews, 38(2), 6–17. https://doi.org/10.1016/j.arr.2017.06.003

10.

Diebel

L. W. M.

Rockwood

(2021). Determination of biological age: Geriatric Assessment vs biological biomarkers. Current Oncology Reports, 23(9), 104. https://doi.org/10.1007/s11912-021-01097-9

11.

Ekelund

Brage

Griffin

S. J.

Wareham

N. J.

(2009). Objectively measured moderate- and vigorous-intensity physical activity but not sedentary time predicts insulin resistance in high-risk individuals. Diabetes Care, 32(6), 1081–1086. https://doi.org/10.2337/dc08-1895

12.

Ekelund

Tarp

Steene-Johannessen

Hansen

B. H.

Jefferis

Fagerland

M. W.

Whincup

Diaz

K. M.

Hooker

S. P.

Chernofsky

Larson

M. G.

Spartano

Vasan

R. S.

Dohrn

I. M.

Hagströmer

Edwardson

Yates

Shiroma

Anderssen

S. A.

Lee

I. M.

Lee

I. M.

(2019). Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: Systematic review and harmonised meta-analysis. Bmj, 366(20), l4570. https://doi.org/10.1136/bmj.l4570

13.

Fox

F. A. U.

Liu

Breteler

M. M. B.

Aziz

N. A.

(2023). Physical activity is associated with slower epigenetic ageing-Findings from the Rhineland study. Aging Cell, 22(6), Article e13828. https://doi.org/10.1111/acel.13828

14.

Frodermann

Rohde

Courties

Severe

Schloss

M. J.

Amatullah

McAlpine

C. S.

Cremer

Hoyer

F. F.

van Koeverden

I. D.

Herisson

Honold

Masson

G. S.

Zhang

Grune

Iwamoto

Schmidt

S. P.

Wojtkiewicz

G. R.

Nahrendorf

(2019). Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nat Med, 25(11), 1761–1771. https://doi.org/10.1038/s41591-019-0633-x

15.

Füzéki

Engeroff

Banzer

(2017). Health benefits of light-intensity physical activity: A systematic review of accelerometer data of the national health and Nutrition Examination survey (NHANES). Sports Medicine, 47(9), 1769–1793. https://doi.org/10.1007/s40279-017-0724-0

16.

Gao

Geng

Jiang

Huang

Zheng

Belsky

D. W.

Huang

(2023). Accelerated biological aging and risk of depression and anxiety: Evidence from 424,299 UK Biobank participants. Nature Communications, 14(1), 2277. https://doi.org/10.1038/s41467-023-38013-7

17.

Hastings

W. J.

Shalev

Belsky

D. W.

(2019). Comparability of biological aging measures in the national health and nutrition examination study, 1999-2002. Psychoneuroendocrinology, 106(24), 171–178. https://doi.org/10.1016/j.psyneuen.2019.03.012

18.

Holtermann

Krause

van der Beek

A. J.

Straker

(2018). The physical activity paradox: Six reasons why occupational physical activity (OPA) does not confer the cardiovascular health benefits that leisure time physical activity does. British Journal of Sports Medicine, 52(3), 149–150. https://doi.org/10.1136/bjsports-2017-097965

19.

Shao

Gao

Zeng

Shu

Huang

Shen

I. X. Y.

Xiao

L. D.

Feng

(2022). Effectiveness and acceptability of non-pharmacological interventions in people with mild cognitive impairment: Overview of systematic reviews and network meta-analysis. Journal of Affective Disorders, 311(14), 383–390. https://doi.org/10.1016/j.jad.2022.05.043

20.

Johnson

A. A.

English

B. W.

Shokhirev

M. N.

Sinclair

D. A.

Cuellar

T. L.

(2022). Human age reversal: Fact or fiction? Aging Cell, 21(8), Article e13664. https://doi.org/10.1111/acel.13664

21.

Kankaanpää

Tolvanen

Bollepalli

Leskinen

Kujala

U. M.

Kaprio

Ollikainen

Sillanpää

(2021). Leisure-time and occupational physical activity associates differently with epigenetic aging. Medicine & Science in Sports & Exercise, 53(3), 487–495. https://doi.org/10.1249/mss.0000000000002498

22.

Kazemi

Soltani

Aune

Hosseini

Mokhtari

Hassanzadeh

Jayedi

Pitanga

Akhlaghi

(2024). Leisure-time and occupational physical activity and risk of cardiovascular disease incidence: A systematic-review and dose-response meta-analysis of prospective cohort studies. Int J Behav Nutr Phys Act, 21(1), 45. https://doi.org/10.1186/s12966-024-01593-8

23.

Kennedy

B. K.

Berger

S. L.

Brunet

Campisi

Cuervo

A. M.

Epel

E. S.

Franceschi

Lithgow

G. J.

Morimoto

R. I.

Pessin

J. E.

Rando

T. A.

Richardson

Schadt

E. E.

Wyss-Coray

Sierra

(2014). Geroscience: Linking aging to chronic disease. Cell, 159(4), 709–713. https://doi.org/10.1016/j.cell.2014.10.039

24.

Kikuchi

Inoue

Lee

I. M.

Odagiri

Sawada

Inoue

Tsugane

(2018). Impact of moderate-intensity and vigorous-intensity physical activity on mortality. Medicine & Science in Sports & Exercise, 50(4), 715–721. https://doi.org/10.1249/mss.0000000000001463

25.

Klemera

Doubal

(2006). A new approach to the concept and computation of biological age. Mechanism of Ageing and Development, 127(3), 240–248. https://doi.org/10.1016/j.mad.2005.10.004

26.

Kwon

Belsky

D. W.

(2021). A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge. Geroscience, 43(6), 2795–2808. https://doi.org/10.1007/s11357-021-00480-5

27.

Laaksonen

D. E.

Lakka

H. M.

Salonen

J. T.

Niskanen

L. K.

Rauramaa

Lakka

T. A.

(2002). Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care, 25(9), 1612–1618. https://doi.org/10.2337/diacare.25.9.1612

28.

Lee

I. M.

Shiroma

E. J.

(2014). Using accelerometers to measure physical activity in large-scale epidemiological studies: Issues and challenges. British Journal of Sports Medicine, 48(3), 197–201. https://doi.org/10.1136/bjsports-2013-093154

29.

Levine

M. E.

Crimmins

E. M.

(2014). Evidence of accelerated aging among African Americans and its implications for mortality. Social Science & Medicine, 118(20), 27–32. https://doi.org/10.1016/j.socscimed.2014.07.022

30.

Levine

M. E.

A. T.

Quach

Chen

B. H.

Assimes

T. L.

Bandinelli

Hou

Baccarelli

A. A.

Stewart

J. D.

Whitsel

E. A.

Wilson

J. G.

Reiner

A. P.

Aviv

Lohman

Liu

Ferrucci

Horvath

(2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY), 10(4), 573–591. https://doi.org/10.18632/aging.101414

31.

Levis

Benedetti

Thombs

B. D.

(2019). Accuracy of patient health questionnaire-9 (PHQ-9) for screening to detect major depression: Individual participant data meta-analysis. Bmj, 365(20), l1476. https://doi.org/10.1136/bmj.l1476

32.

Lin

Y. H.

Chen

Y. C.

Tseng

Y. C.

Tsai

S. T.

Tseng

Y. H.

(2020). Physical activity and successful aging among middle-aged and older adults: A systematic review and meta-analysis of cohort studies. Aging (Albany NY), 12(9), 7704–7716. https://doi.org/10.18632/aging.103057

33.

Liu

Kuo

P. L.

Horvath

Crimmins

Ferrucci

Levine

(2018). A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study. PLoS Medicine, 15(12), Article e1002718. https://doi.org/10.1371/journal.pmed.1002718

34.

Lowsky

D. J.

Olshansky

S. J.

Bhattacharya

Goldman

D. P.

(2014). Heterogeneity in healthy aging. J Gerontol A Biol Sci Med Sci, 69(6), 640–649. https://doi.org/10.1093/gerona/glt162

35.

Murabito

J. M.

Zhao

Larson

M. G.

Rong

Lin

Benjamin

E. J.

Levy

Lunetta

K. L.

Lunetta

K. L.

(2018). Measures of biologic age in a Community sample predict mortality and age-related disease: The Framingham Offspring study. J Gerontol A Biol Sci Med Sci, 73(6), 757–762. https://doi.org/10.1093/gerona/glx144

36.

Pan

Xun

Y. Q.

Chen

Y. J.

Gao

C. Y.

Han

Zuo

L. Q.

Shan

H. Q.

Yang

K. H.

Ding

G. W.

Tian

J. H.

Tian

J. H.

(2018). Exercise training modalities in patients with type 2 diabetes mellitus: A systematic review and network meta-analysis. Int J Behav Nutr Phys Act, 15(1), 72. https://doi.org/10.1186/s12966-018-0703-3

37.

Partridge

Deelen

Slagboom

P. E.

(2018). Facing up to the global challenges of ageing. Nature, 561(7721), 45–56. https://doi.org/10.1038/s41586-018-0457-8

38.

Shreves

A. H.

Small

S. R.

Travis

R. C.

Matthews

C. E.

Doherty

(2023). Dose-response of accelerometer-measured physical activity, step count, and cancer risk in the UK Biobank: A prospective cohort analysis. Lancet, 402(Suppl 1), S83. https://doi.org/10.1016/s0140-6736(23)02147-5

39.

Stavseth

M. R.

Clausen

Røislien

(2019). How handling missing data may impact conclusions: A comparison of six different imputation methods for categorical questionnaire data. SAGE Open Med, 7(2), 2050312118822912. https://doi.org/10.1177/2050312118822912

40.

Sung

Kim

Choe

Han

Yoon

Ryu

Kim

Y. S.

Kim

Y. S.

(2022). Physical activity Trends in Korean adults from Korea national health and Nutritional Examination survey from 2014 to 2019. Int J Environ Res Public Health, 19(9), 5213. https://doi.org/10.3390/ijerph19095213

41.

Thomas

Belsky

D. W.

(2023). Healthy lifestyle behaviors and biological aging in the US national health and nutrition examination surveys 1999-2018. J Gerontol A Biol Sci Med Sci, 78(9), 1535–1542. https://doi.org/10.1093/gerona/glad082

42.

White

R. L.

Babic

M. J.

Parker

P. D.

Lubans

D. R.

Astell-Burt

Lonsdale

(2017). Domain-specific physical activity and mental health: A meta-analysis. American Journal of Preventive Medicine, 52(5), 653–666. https://doi.org/10.1016/j.amepre.2016.12.008

43.

Wang

Liu

Shi

Zhuang

Qian

Mei

Zhang

(2024). Relationship between domain-specific physical activity and cognitive function in older adults - findings from NHANES 2011-2014. Frontiers in Public Health, 12(9), 1390511. https://doi.org/10.3389/fpubh.2024.1390511

44.

Wang

Belsky

D. W.

McCall

W. V.

Liu

(2023). Blunted Rest-activity Circadian Rhythm is associated with increased rate of biological aging: An analysis of NHANES 2011-2014. J Gerontol A Biol Sci Med Sci, 78(3), 407–413. https://doi.org/10.1093/gerona/glac199

45.

Zhu

Yang

Zeng

Han

Chen

Yang

Valdimarsdóttir

U. A.

Fang

Song

(2023). The association of physical activity behaviors and patterns with aging acceleration: Evidence from the UK Biobank. J Gerontol A Biol Sci Med Sci, 78(5), 753–761. https://doi.org/10.1093/gerona/glad064

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