Inflammation, particularly interleukin-6 (IL-6), is associated with chronic disease in older adults, but not all older adults have the same progression of poor health outcomes. Self-efficacy may play a role in buffering the inflammatory burden in chronic disease. To evaluate associations between self-efficacy and IL-6, 159 community-dwelling older adults (N = 159, Mage = 82 years, SD = 6.3 years) with one or more chronic illnesses were recruited for this cross-sectional study. Sweat IL-6 was collected using a noninvasive sweat patch worn for 72 hrs. Multiple linear regression with bootstrapping showed a significant association between social coping self-efficacy and IL-6 (β = −0.534, p = .010) after adjustment for age, sex, race, body mass index, financial strain, chronic conditions, and social support. Although preliminary, this study creates a rationale to explore the self-efficacy inflammatory biomarker association further. Enhancing self-efficacy might be a viable nonpharmacological treatment to lower or slow the inflammatory burden in older adults.
AndersonG. (2010). Chronic care: Making the case for ongoing care. Robert Woods Johnson Foundation.
2.
BanduraA. (1997). Self-efficacy: The exercise of control. W.H. Freeman.
3.
BanduraA.CioffiD.TaylorC. B.BrouillardM. E. (1988). Perceived self-efficacy in coping with cognitive stressors and opioid activation. Journal of Personality and Social Psychology, 55(3), 479–488.
4.
BanduraA.TaylorC. B.WilliamsS. L.MeffordI. N.BarchasJ. D. (1985). Catecholamine secretion as a function of perceived coping self-efficacy. Journal of Consulting and Clinical Psychology, 53(3), 406–414.
5.
BohnsV. K.FlynnF. J. (2010). “Why didn’t you just ask?” Underestimating the discomfort of help-seeking. Journal of Experimental Social Psychology, 46(2), 402–409.
6.
BremboE. A.KapstadH.Van DulmenS.EideH. (2017). Role of self-efficacy and social support in short-term recovery after total hip replacement: A prospective cohort study. Health & Quality of Life Outcomes, 15, 1–10.
7.
ButtorffC.RuderT.BaumanM. (2017). A multiple chronic conditions in the United States. RAND Corporation.
8.
CallahanC. M.UnverzagtF. W.HuiS. L.PerkinsA. J.HendrieH. C. (2002). Six-item screener to identify cognitive impairment among potential subjects for clinical research. Medical Care, 40(9), 771–781.
9.
ChesneyM. A.NeilandsT. B.ChambersD. B.TaylorJ. M.FolkmanS. (2006). A validity and reliability study of the coping self-efficacy scale. British Journal of Health Psychology, 11(Pt 3), 421–437.
10.
CizzaG.MarquesA. H.EskandariF.ChristieI. C.TorvikS.SilvermanM. N.PhillipsT. M.SternbergE. M. (2008). Elevated neuroimmune biomarkers in sweat patches and plasma of premenopausal women with major depressive disorder in remission: The POWER study. Biological Psychiatry, 64(10), 907–911.
11.
CohenS.KamarckT.MermelsteinR. (1983). A global measure of perceived stress. Journal of Health and Social Behavior, 24(4), 385–396.
12.
Cornoni-HuntleyJ.OstfeldA. M.TaylorJ. O.WallaceR. B.BlazerD.BerkmanL. F.EvansD. A.KohoutF. J.LemkeJ. H.ScherrP. A. (1993). Established populations for epidemiologic studies of the elderly: Study design and methodology. Aging, 5(1), 27–37.
13.
CroghanC.EgeghyP. (n.d.). Methods of dealing with values below the limit of detection using SAS. Presented at Southeastern SAS User Group, St. Petersburg, FL, September 22-24, 2003.
14.
EPA Quality Staff. (2006). Data quality assessment: Statistical methods for practitioners. EPA QA/G9-S.
15.
EverettB. M.PradhanA. D.SolomonD. H.PaynterN.MacfadyenJ.ZaharrisE.GuptaM.ClearfieldM.LibbyP.HasanA. A. K.GlynnR. J.RidkerP. M. (2013). Rationale and design of the cardiovascular inflammation reduction trial: A test of the inflammatory hypothesis of atherothrombosis. American Heart Journal, 166(2), 199–207.e15.
16.
EzzatiA.JiangJ.KatzJ. M.SliwinskiJ. M.ZimmermanE. M.LiptonB. R. (2014). Validation of the Perceived Stress Scale in a community sample of older adults. International Journal of Geriatric Psychiatry, 29(6), 645–652.
17.
FranceschiC.CampisiJ. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(Suppl. 1), S4–S9.
18.
GaffeyA. E.BergemanC. S.ClarkL. A.WirthM. M. (2016). Aging and the HPA axis: Stress and resilience in older adults. Neuroscience & Biobehavioral Reviews, 68, 928–945.
19.
GuzmánC.Hallal-CallerosC.López-GriegoL.Morales-MontorJ. (2009). Interleukin-6: A cytokine with a pleiotropic role in the neuroimmunoendocrine network. The Open Neuroendocrinology Journal, 3, 152–160.
20.
HeikenfeldJ. (2016). Non-invasive analyte access and sensing through eccrine sweat: Challenges and outlook circa 2016. Electroanalysis, 28(6), 1242–1249.
21.
HladekM.GillJ.LaiC.LorigK.SzantonS. (2020). High coping self-efficacy associated with lower sweat inflammatory cytokines in adults: A pilot study. Biological Research for Nursing, 22(1), 75–81.
22.
HladekM. D.SzantonS. L.ChoY.-E.LaiC.SackoC.RobertsL.GillJ. (2018). Using sweat to measure cytokines in older adults compared to younger adults: A pilot study. Journal of Immunological Methods, 454, 1–5.
23.
HolmesT. H.RaheR. H. (1967). The Social Readjustment Rating Scale. Journal of Psychosomatic Research, 11(2), 213–218.
24.
HoltE. W.MuntnerP.JoyceC.MoriskyD. E.WebberL. S.Krousel-WoodM. (2012). Life events, coping, and antihypertensive medication adherence among older adults: The cohort study of medication adherence among older adults. American Journal of Epidemiology, 176, S64–S71.
25.
JacksonE. B.CoultasB. D.AshmoreJ.RussoR.PeoplesJ.UhmM.SinghP. K.BaeS. (2014). Domain-specific self-efficacy is associated with measures of functional capacity and quality of life among patients with moderate to severe chronic obstructive pulmonary disease. Annals of the American Thoracic Society, 11(3), 310–315.
26.
KroenkeK.StrineT. W.SpitzerR. L.WilliamsJ. B. W.BerryJ. T.MokdadA. H. (2009). The PHQ-8 as a measure of current depression in the general population. Journal of Affective Disorders, 114(1–3), 163–173.
27.
LazarusR. S.FolkmanS. (1987). Transactional theory and research on emotions and coping. European Journal of Personality, 1(3), 141–169.
28.
LazzarinoA. I.HamerM.GazeD.CollinsonP.RumleyA.LoweG.SteptoeA. (2016). The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention. Preventive Medicine, 93, 46–52.
29.
LorigK.ChastainR. L.UngE.ShoorS.HolmanH. R. (1989). Development and evaluation of a scale to measure perceived self-efficacy in people with arthritis. Arthritis and Rheumatism, 32(1), 37–44.
30.
LukicL.LalicN. M.RajkovicN.JoticA.LalicK.MilicicT.SeferovicJ. P.MacesicM.GajovicJ. S. (2014). Hypertension in obese type 2 diabetes patients is associated with increases in insulin resistance and IL-6 cytokine levels: Potential targets for an efficient preventive intervention. International Journal of Environmental Research and Public Health, 11(4), 3586–3598.
31.
MackenzieC. S.HeathP. J.VogelD. L.ChekayR. (2019). Age differences in public stigma, self-stigma, and attitudes toward seeking help: A moderated mediation model. Journal of Clinical Psychology, 75(12), 2259–2272.
32.
MadduxJ. E. (1995). Self-efficacy, adaptation, and adjustment: Theory, research, and application. Plenum Press.
33.
Marques-DeakA.CizzaG.EskandariF.TorvikS.ChristieI. C.SternbergE. M.PhillipsT. M. (2006). Measurement of cytokines in sweat patches and plasma in healthy women: Validation in a controlled study. Journal of Immunological Methods, 315(1–2), 99–109.
34.
MausbachB. T.von KanelR.RoepkeS. K.MooreR.PattersonT. L.MillsP. J.DimsdaleJ. E.ZieglerM. G.Ancoli-IsraelS.AllisonM.GrantI. (2011). Self-efficacy buffers the relationship between dementia caregiving stress and circulating concentrations of the proinflammatory cytokine interleukin-6. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 19(1), 64–71.
35.
MccainN. L.GrayD. P.WalterJ.RobinsJ. (2005). Implementing a comprehensive approach to the study of health dynamics using the psychoneuroimmunology paradigm. Advances in Nursing Science, 28(4), 320–332.
36.
McGeerP. L.McGeerE. G. (2004). Inflammation and the degenerative diseases of aging. Annals of the New York Academy of Sciences, 1035, 104–116.
37.
Mena-BravoA.Luque de CastroM. D. (2014). Sweat: A sample with limited present applications and promising future in metabolomics. Journal of Pharmaceutical and Biomedical Analysis, 90, 139–147.
38.
MotlR. W.McAuleyE. (2010). Physical activity, disability, and quality of life in older adults. Physical Medicine & Rehabilitation Clinics of North America, 21(2), 299–308.
39.
OliveraA.LejbmanN.JerominA.FrenchL. M.KimH.-S.CashionA.MysliwiecV.Diaz-ArrastiaR.GillJ. (2015). Peripheral total tau in military personnel who sustain traumatic brain injuries during deployment. JAMA Neurology, 72(10), Article 1109.
40.
PriorA.Fenger-GrønM.LarsenK. K.LarsenF. B.RobinsonK. M.NielsenM. G.ChristensenK. S.MercerS. W.VestergaardM. (2016). The association between perceived stress and mortality among people with multimorbidity: A prospective population-based cohort study. American Journal of Epidemiology, 184(3), 199–210.
41.
Puzianowska-KuźnickaM.OwczarzM.Wieczorowska-TobisK.NadrowskiP.ChudekJ.SlusarczykP.SkalskaA.JonasM.FranekE.MossakowskaM. (2016). Interleukin-6 and C-reactive protein, successful aging, and mortality: The PolSenior study. Immunity & Ageing: I & A, 13, Article 21.
42.
Quanterix Corporation. (2016). Data sheet for human cytokine 3-plex A: TNFα, IL-6, and IL-10 for Simoa HD-1 analyzer.
43.
RissinD. M.FournierD. R.PiechT.KanC. W.CampbellT. G.SongL.ChangL.RivnakA. J.PatelP. P.ProvuncherG. K.FerrellE. P.HowesS. C.PinkB. A.MinnehanK. A.WilsonD. H.DuffyD. C. (2011). Simultaneous detection of single molecules and singulated ensembles of molecules enables immunoassays with broad dynamic range. Analytical Chemistry, 83(6), 2279–2285.
44.
RozziniR.SabatiniT.BarbisoniP.TrabucchiM. (2004). How to measure comorbidity in elderly persons. Journal of Clinical Epidemiology, 57(3), 321–322; author reply 323.
45.
SagaK. (2002). Structure and function of human sweat glands studied with histochemistry and cytochemistry. Progress in Histochemistry and Cytochemistry, 37(4), 323–386.
46.
SarkarU.AliS.WhooleyM. A. (2009). Self-efficacy as a marker of cardiac function and predictor of heart failure hospitalization and mortality in patients with stable coronary heart disease: Findings from the Heart and Soul Study. Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association, 28(2), 166–173.
47.
SinghT.NewmanA. B. (2011). Inflammatory markers in population studies of aging. Ageing Research Reviews, 10(3), 319–329.
48.
SonnerZ.WilderE.HeikenfeldJ.KastingG.BeyetteF.SwaileD.ShermanF.JoyceJ.HagenJ.Kelley-LoughnaneN.NaikR. (2015). The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications. Biomicrofluidics, 9(3), Article 031301.
49.
TovarE.RayensM. K.GokunY.ClarkM. (2015). Mediators of adherence among adults with comorbid diabetes and depression: The role of self-efficacy and social support. Journal of Health Psychology, 20(11), 1405–1415.
50.
VaglioJ.ConardM.PostonW. S.O’KeefeJ.HaddockC. K.HouseJ.SpertusJ. A. (2004). Testing the performance of the ENRICHD social support instrument in cardiac patients. Health and Quality of Life Outcomes, 2(1), Article 24.
51.
VaradhanR.YaoW.MatteiniA.BeamerB. A.XueQ.-L.YangH.ManwaniB.ReinerA.JennyN.ParekhN.FallinM. D.NewmanA.Bandeen-RocheK.TracyR.FerrucciL.WalstonJ. (2014). Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 69(2), 165–173.
52.
WalkerJ. R.SmallsL. B.Hernandez-TejadaA. M.CampbellA. J.EgedeE. L. (2014). Effect of diabetes self-efficacy on glycemic control, medication adherence, self-care behaviors, and quality of life in a predominantly low-income, minority population. Ethnicity & Disease, 24(3), 349–355.
53.
WalstonJ. D.MatteiniA. M.NievergeltC.LangeL. A.FallinD. M.BarzilaiN.ZivE.PawlikowskaL.KwokP.CummingsS. R.KooperbergC.LaCroixA.TracyR. P.AtzmonG.LangeE. M.ReinerA. P. (2009). Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. Experimental Gerontology, 44(5), 350–355.
54.
WiedenfeldS. A.O’LearyA.BanduraA.BrownS.LevineS.RaskaK. (1990). Impact of perceived self-efficacy in coping with stressors on components of the immune system. Journal of Personality and Social Psychology, 59(5), 1082–1094.
55.
WilkeK.MartinA.TerstegenL.BielS. S. (2007). A short history of sweat gland biology. International Journal of Cosmetic Science, 29(3), 169–179.
56.
YudkinJ. S.KumariM.HumphriesS. E.Mohamed-AliV. (2000). Inflammation, obesity, stress and coronary heart disease: Is interleukin-6 the link?Atherosclerosis, 148(2), 209–214.
57.
ZulmanD. M.RoslandA. M.ChoiH.LangaK. M.HeislerM. (2012). The influence of diabetes psychosocial attributes and self-management practices on change in diabetes status. Patient Education and Counseling, 87(1), 74–80.
