To review the various pharmacological and nonpharmacological factors associated with the induction of rapid cycling in bipolar mood disorder, and to introduce the idea that parturition may also have a role. Factors known to contribute to bipolar mood disorder rapid cycling include antidepressant agents, female gender and middle age. Currently, there is evidence that hypothyroidism may also play a role.
Method:
A critical review of the literature was undertaken.
Conclusion:
Caution should be exercised in the use of antidepressants in patients with bipolar mood disorders.
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