In examining the heterogeneity of symptomatology in schizophrenia, several theoretical models have been advanced. These models are useful in understanding the psychopathology of the disease, as well as possibly guiding treatment and determining prognosis. This paper discusses the two-syndrome and three-syndrome models for the primary symptoms of schizophrenia and their relationship to other symptoms often encountered. In addition, their significance and relevance for treatment are explored.
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