A group of patients with chronic schizophrenia were evaluated according to the form of neuroleptic treatment they were receiving: depot, oral or combined (depot/oral or oral/oral). The patients treated with the combined therapy received significantly higher dosages of neuroleptic than those treated with either depot or oral therapy, which did not differ from each other. Daily maintenance dosages were generally well above recent guidelines.
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JannMW, EreshefskyL, SakladSRClinical pharmacokinetics of the depot antipsychotics.Clin Pharmacokinet1985; 10: 315–333.
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ReardonGT, RifkinA, SchwartzA.Changing patterns of neuroleptic dosage over a decade.Am J Psychiatry1989; 146: 726–729.
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BaldessariniRJ, KatzB, CottonPDissimilar dosing with high-potency and low-potency neuroleptics.Am J Psychiatry1984; 141: 748–752.
